Jette Sandholm Jensen Kastrup
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
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Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors
Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46Research output: Contribution to journal › Journal article › Research › peer-review
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Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution
Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780Research output: Contribution to journal › Journal article › Research › peer-review
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Biostructure-based drug design
Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites
Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 234Research output: Contribution to journal › Conference abstract in journal › Research
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Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atomic resolution structure of human HBP/CAP37/Azurocidin
Karlsen, S., Iversen, L. F., Larsen, I. K., Flodgaard, H. J. & Kastrup, Jette Sandholm Jensen, 1998, In: Acta Crystallographica. Section D: Biological Crystallography. 54, p. 598-609 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis of cell-cell adhesion by NCAM
Kasper, C., Rasmussen, H., Kastrup, Jette Sandholm Jensen, Ikemizu, S., Jones, E. Y., Berezin, V., Bock, E. & Larsen, I. K., 2000, In: Nature Structural and Molecular Biology. 7, 5, p. 389-393 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
Kasper, C., Lunn, M., Liljefors, T., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 6 Nov 2002, In: F E B S Letters. 531, 2, p. 173-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the C-type lectin carbohydrate recognition domain of human Tetranectin
Kastrup, Jette Sandholm Jensen, Nielsen, B. B., Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1998, In: Acta Crystallographica. Section D: Biological Crystallography. 54, p. 757-766 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein
Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Nielsen, B. B., Larsen, I. K., Las Holtet, T., Graversen, J. H., Etzerodt, M. & Thøgersen, H. C., 1997, In: Acta Crystallographica. Section D: Biological Crystallography. 53, p. 108-111 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. Comparison with the truncated 146-amino-acid Form
Kastrup, Jette Sandholm Jensen, Eriksson, E. S., Dalbøge, H. & Flodgaard, H., 1997, In: Acta Crystallographica. Section D: Biological Crystallography. 53, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary X-ray analysis of a PNA-DNA complex
Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In: FEBS Letters. 363, 1-2, p. 115-117 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain
Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2
Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors
Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases
Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor
Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914Research output: Contribution to journal › Journal article › Research › peer-review
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Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family
Kristensen, O., Laurberg, M., Liljas, A., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2004, In: Biochemistry. 43, 28, p. 8894-900 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate
Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2016, In: Structure. 24, 9, p. 1582-1589 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A unique set of SH3-SH3 interactions controls IB1 homodimerization
Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In: E M B O Journal. 25, 4, p. 785-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, Tri Hien Viet, Hansen, S. W., Nielsen, Birgitte, Bowie, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of NCAM2 IgIV-Fn3I
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009Research output: Non-textual form › Dataset › Research
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Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1
Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008Research output: Non-textual form › Dataset › Research
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dimerization effect of sucrose octasulfate on rat FGF1.
Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of NCAM2 IgIV-Fn3II
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009Research output: Non-textual form › Dataset › Research
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Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1
Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule
Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In: Structure. 19, 2, p. 203-211Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site
Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface
Nørgrd Larsen, Andreas, Perozzo, A. M., Biggin, P. C., Bowie, D. & Kastrup, Jette Sandholm Jensen, 2024, In: Journal of Biological Chemistry. 300, 3, 10 p., 105717.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states
Nørgrd Larsen, Andreas, Dorosz, J., Thorsen, T. S., Johansen, Nicolai Tidemand, Darwish, T., Midtgaard, S. R., Arleth, Lise & Kastrup, Jette Sandholm Jensen, Nov 2018, In: IUCrJ. 5, p. 780-793Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors
Larsen, A. P., Francotte, P., Frydenvang, Karla Andrea, Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors
Larsen, A. P., Fièvre, S., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Kastrup, Jette Sandholm Jensen & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor
Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, Karla Andrea & Kastrup, Jette Sandholm Jensen, 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Guaiane Esters from Thapsia villosa
Lemmich, E., Smitt, U. W., Kastrup, Jette Sandholm Jensen & Christensen, Søren Brøgger, 1991, In: Phytochemistry. 30, p. 2987-2990 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipopolysaccharide affinity measurement by scintillation proximity assay: application to human heparin binding protein
Linde, V., Bjørn, S., Kastrup, Jette Sandholm Jensen & Flodgaard, H., Feb 2000, In: BioTechniques. 28, 2, p. 218-20, 222Research output: Contribution to journal › Journal article › Research › peer-review
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Measurement of apoptosis by the TUNEL method using scintillating microplates
Linde, V., Flodgaard, H., Kastrup, Jette Sandholm Jensen & Bjørn, S., 10 Apr 2000, In: Analytical Biochemistry. 280, 1, p. 186-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity
Lunn, M., Hogner, A., Stensbøl, T. B., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 27 Feb 2003, In: Journal of Medicinal Chemistry. 46, 5, p. 872-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics
Masternak, Magdalena, Koch, A., Laulumaa, S., Tapken, D., Hollmann, M., Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2023, In: F E B S Journal. 290, 15, p. 3781-3801Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1
Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.Research output: Contribution to journal › Journal article › Research › peer-review
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Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering
Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S. J. & 3 others, , Jan 2018, In: F E B S Journal. 285, 2, p. 357-371 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion
Mirza, Osman Asghar, Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments
Mohr, A. Ø., Riise, E. S., Pickering, Darryl S, Jensen, A. A., Madden, D., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Skottrup, P. D., 16 Jun 2011.Research output: Contribution to conference › Poster › Research › peer-review
ID: 1298590
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Research output: Contribution to journal › Journal article › Research › peer-review
Published