Jesper Velgaard Olsen
Professor, Deputy Head of Centre, Professor
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Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia
Aasebø, E., Berven, F. S., Bartaula-Brevik, S., Stokowy, T., Hovland, R., Vaudel, M., Døskeland, S. O., McCormack, E., Batth, Tanveer Singh, Olsen, Jesper Velgaard, Bruserud, Ø., Selheim, F. & Hernandez-Valladares, M., 2020, In: Cancers. 12, 3, 26 p., 709.Research output: Contribution to journal › Journal article › Research › peer-review
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α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
Absalom, N., Karim, N., Eghorn, L. F., Villumsen, I. S., Bay, T., Bräuner, Hans, Frølund, Bente, Clausen, Rasmus Prætorius, Olsen, Jesper Velgaard, Knudsen, Gitte Moos, Chebib, M. & Wellendorph, Petrine, 14 Aug 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 33, p. 13404-13409 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
Adachi, J., Kumar, C., Zhang, Y., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Genome Biology. 7, 9, p. R80Research output: Contribution to journal › Journal article › Research › peer-review
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UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Akimov, V., Barrio-Hernandez, I., Hansen, S. V. F., Hallenborg, P., Pedersen, A., Bekker-Jensen, D. B., Puglia, M., Christensen, S. D. K., Vanselow, J. T., Nielsen, M. M., Kratchmarova, I., Kelstrup, C. D., Olsen, Jesper Velgaard & Blagoev, B., 2018, In: Nature Structural & Molecular Biology. 25, p. 631-640 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking
Andersen, M. N., Hefting, L. L., Steffensen, Annette Buur, Schmitt, Nicole, Olesen, Søren-Peter, Olsen, Jesper Velgaard, Lundby, Alicia & Rasmussen, Hanne Borger, 15 Nov 2015, In: American Journal of Physiology: Cell Physiology. 309, 10, p. C693-C706 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dörr, M., Müller-Nurasyid, M., Lahtinen, A. M. & 31 others, , 22 Jun 2014, In: Nature Genetics. 46, 8, p. 826-838 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation
Askeland, A., Borup, A., Østergaard, Ole, Olsen, Jesper Velgaard, Lund, S. M., Christiansen, G., Kristensen, S. R., Heegaard, N. H. H. & Pedersen, S., 2020, In: Biomedicines. 8, 8, 15 p., 246.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics
Bache, N., Geyer, P. E., Bekker-Jensen, D. B., Hørning, O., Falkenby, L., Treit, P. V., Doll, S., Paron, I., Müller, J. B., Meier, F., Olsen, Jesper Velgaard, Vorm, O. & Mann, Matthias, 2018, In: Molecular and Cellular Proteomics. 17, 11, p. 2284-2296 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Multi-spectra peptide sequencing and its applications to multistage mass spectrometry
Bandeira, N., Olsen, Jesper Velgaard, Mann, M. & Pevzner, P. A., 2008, In: Bioinformatics. 24, 13, p. i416-23Research output: Contribution to journal › Journal article › Research › peer-review
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Off-Line High-pH Reversed-Phase Fractionation for In-Depth Phosphoproteomics
Batth, Tanveer Singh, Francavilla, C. & Olsen, Jesper Velgaard, 4 Nov 2014, In: Journal of Proteome Research. 13, 12, p. 6176-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Offline High pH Reversed-Phase Peptide Fractionation for Deep Phosphoproteome Coverage
Batth, Tanveer Singh & Olsen, Jesper Velgaard, 2016, Phospho-Proteomics: Methods and Protocols. Stechow, L. V. (ed.). Springer, Vol. 1355. p. 179-92 14 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling
Batth, Tanveer Singh, Papetti, M., Pfeiffer, A., Tollenaere, M. A. X., Francavilla, C. & Olsen, Jesper Velgaard, 2018, In: Cell Reports. 22, 10, p. 2784-2796 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A seven-transmembrane methyltransferase catalysing N-terminal histidine methylation of lytic polysaccharide monooxygenases
Batth, Tanveer Singh, Simonsen, J. L., Hernandez Rollan, Cristina, Brander, Søren, Morth, J. P., Johansen, Katja Salomon, Nørholm, M. H. H., Hoof, J. B. & Olsen, Jesper Velgaard, 2023, In: Nature Communications. 14, 15 p., 4202.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation
Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
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An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes
Bekker-Jensen, D. B., Kelstrup, C. D., Batth, Tanveer Singh, Buch-Larsen, Sara Charlotte, Haldrup, C., Bramsen, J. B., Sørensen, K. D., Høyer, S., Ørntoft, T. F., Andersen, C. L., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2017, In: Cell Systems. 4, 6, p. 587-599, e1-e4 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries
Bekker-Jensen, D. B., Bernhardt, O. M., Hogrebe, A., Martinez Del Val, Ana, Verbeke, L., Gandhi, T., Kelstrup, C. D., Reiter, L. & Olsen, Jesper Velgaard, 2020, In: Nature Communications. 11, 1, 12 p., 787.Research output: Contribution to journal › Journal article › Research › peer-review
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A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients
Bekker-Jensen, D. B., Martinez Del Val, Ana, Steigerwald, S., Rüther, P., Fort, K. L., Arrey, T. N., Harder, A., Makarov, A. & Olsen, Jesper Velgaard, 2020, In: Molecular and Cellular Proteomics. 19, 4, p. 716-729 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls
Midjord-Belstrøm, Daniel, Jersie-Christensen, R. R., Lyon, D., Damgaard, Christian, Jensen, Lars Juhl, Holmstrup, Palle & Olsen, Jesper Velgaard, 2016, In: PeerJ. 4, 17 p., e2433.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular evidence of use of hide glue in 4th millennium BC Europe
Bleicher, N., Kelstrup, C., Olsen, Jesper Velgaard & Cappellini, Enrico, 2015, In: Journal of Archaeological Science. 63, p. 65-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias
Boulanger, M., Aqrouq, M., Tempé, D., Kifagi, C., Ristic, M., Akl, D., Hallal, R., Carusi, A., Gabellier, L., de Toledo, M., Sigurdsson, J-O., Kaoma, T., Andrieu-Soler, C., Forné, T., Soler, E., Hicheri, Y., Gueret, E., Vallar, L., Olsen, J. V., Cartron, G. & 2 others, , 2023, In: Nucleic Acids Research. 51, 16, 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome
Bozal-Basterra, L., Martín-Ruíz, I., Pirone, L., Liang, Y., Sigurðsson, J. O., Gonzalez-Santamarta, M., Giordano, I., Gabicagogeascoa, E., de Luca, A., Rodríguez, J. A., Wilkie, A. O. M., Kohlhase, J., Eastwood, D., Yale, C., Olsen, Jesper Velgaard, Rauchman, M., Anderson, K. V., Sutherland, J. D. & Barrio, R., 2018, In: American Journal of Human Genetics. 102, 2, p. 249-265 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Species identification of archaeological skin objects from Danish bogs: comparison between mass spectrometry-based peptide sequencing and microscopy-based methods
Brandt, Luise Ørsted, Schmidt, A. L., Mannering, U., Sarret, M., Kelstrup, C., Olsen, Jesper Velgaard & Cappellini, Enrico, 2014, In: PloS one. 9, 9, 10 p., e106875.Research output: Contribution to journal › Journal article › Research › peer-review
De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis
Budnik, B. A., Olsen, Jesper Velgaard, Egorov, T. A., Anisimova, V. E., Galkina, T. G., Musolyamov, A. K., Grishin, E. V. & Zubarev, R. A., 2004, In: Journal of Mass Spectrometry. 39, 2, p. 193-201 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Can relative cleavage frequencies in peptides provide additional sequence information?
Budnik, B. A., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Haselmann, K. F., Horth, P., Haehnel, W. & Zubarev, R. A., 2002, In: International Journal of Mass Spectrometry. 219, 1, p. 283-294 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Predicting Kinase Activity in Angiotensin Receptor Phosphoproteomes Based on Sequence-Motifs and Interactions
Bøgebo, R., Horn, H., Olsen, Jesper Velgaard, Gammeltoft, S., Jensen, Lars Juhl, Hansen, J. L. & Christensen, G. L., 2014, In: PLOS ONE. 9, 4, p. 1-9 9 p., e94672.Research output: Contribution to journal › Journal article › Research › peer-review
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Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny
Cappellini, E., Welker, F., Pandolfi, L., Ramos-Madrigal, J., Samodova, D., Rüther, P. L., Fotakis, A. K., Lyon, D., Moreno-Mayar, J. V., Bukhsianidze, M., Rakownikow Jersie-Christensen, R., Mackie, M., Ginolhac, A., Ferring, R., Tappen, M., Palkopoulou, E., Dickinson, M. R., Stafford, T. W., Chan, Y. L., Götherström, A. & 23 others, , 2019, In: Nature. 574, 7776, p. 103-107Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins
Cappellini, Enrico, Jensen, Lars Juhl, Szklarczyk, D. M., Ginolhac, A., Rodrigues da Fonseca, Rute Andreia, Stafford jr., T., Holen, S. R., Collins, M. J., Orlando, L. A. A., Willerslev, Eske, Gilbert, M Thomas P & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. 11, 2, p. 917-926 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resolution of the type material of the Asian elephant, Elephas maximus Linnaeus, 1758 (Proboscidea, Elephantidae)
Cappellini, Enrico, Gentry, A., Palkopoulou, E., Ishida, Y., Cram, D., Roos, A., Watson, M., Johansson, U. S., Fernholm, B., Agnelli, P., Barbagli, F., Littlewood, D. T. J., Kelstrup, C., Olsen, Jesper Velgaard, Lister, A. M., Roca, A. L., Dalén, L. & Gilbert, M Thomas P, 2014, In: Zoological Journal of the Linnean Society. 170, 1, p. 222-232 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enamel proteome sequences from Dmanisi (Georgia) enable molecular phylogeny beyond the limits of ancient DNA preservation
Cappellini, Enrico, Welker, Frido, Olsen, Jesper Velgaard, Lordkipanidze, D. & Willerslev, Eske, 2019, In: American Journal of Physical Anthropology. 168, suppl. 68, p. 35 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells
Carreras Puigvert, J., von Stechow, L., Siddappa, R., Pines, A., Bahjat, M., Haazen, L. C. J. M., Olsen, Jesper Velgaard, Vrieling, H., Meerman, J. H. N., Mullenders, L. H. F., van de Water, B. & Danen, E. H. J., 2013, In: Science Signaling. 6, 259, p. ra5 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative phosphoproteomics dissection of 7TM receptor signaling using full and biased agonists
Christensen, G. L., Kelstrup, C., Lyngsø, C., Sarwar, U., Bøgebo, R., Sheikh, S. P., Gammeltoft, S., Olsen, Jesper Velgaard & Hansen, J. L., Jul 2010, In: Molecular and Cellular Proteomics. 9, 7, p. 1540-53 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae
Coordes, B., Brünger, K. M., Burger, K., Soufi, B., Horenk, J., Eick, D., Olsen, Jesper Velgaard & Sträßer, K., Jan 2015, In: Eukaryotic Cell (Online Edition). 14, 1, p. 86 95 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Andromeda - a peptide search engine integrated into the MaxQuant environment
Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, Jesper Velgaard & Mann, Matthias, 1 Apr 2011, In: Journal of Proteome Research. 10, 4, p. 1794-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics
Cox, J., Matic, I., Hilger, M., Nagaraj, N., Selbach, M., Olsen, Jesper Velgaard & Mann, M., 2009, In: Nature Protocols (Print Edition). 4, 5, p. 698-705 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complete Mapping of Complex Disulfide Patterns with Closely-Spaced Cysteines by In-Source Reduction and Data-Dependent Mass Spectrometry
Cramer, C. N., Kelstrup, C. D., Olsen, Jesper Velgaard, Haselmann, K. F. & Nielsen, P. K., 6 Jun 2017, In: Analytical Chemistry. 89, 11, p. 5949-5957 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disulfide Linkage Characterization of Disulfide Bond-Containing Proteins and Peptides by Reducing Electrochemistry and Mass Spectrometry
Cramer, C. N., Haselmann, K. F., Olsen, Jesper Velgaard & Nielsen, P. K., 2 Feb 2016, In: Analytical Chemistry. 88, 3, p. 1585-1592 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generic Workflow for Mapping of Complex Disulfide Bonds Using In-Source Reduction and Extracted Ion Chromatograms from Data-Dependent Mass Spectrometry
Cramer, C. N., Kelstrup, C., Olsen, Jesper Velgaard, Haselmann, K. F. & Nielsen, P. K., 2018, In: Analytical Chemistry. 90, 13, p. 8202-8210Research output: Contribution to journal › Journal article › Research › peer-review
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
Daub, H., Olsen, Jesper Velgaard, Bairlein, M., Gnad, F., Oppermann, F. S., Körner, R., Greff, Z., Kéri, G., Stemmann, O. & Mann, M., 2008, In: Molecular Cell. 31, 3, p. 438-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Davydova, E., Shimazu, T., Schuhmacher, M. K., Jakobsson, M. E., Willemen, H. L. D. M., Liu, T., Moen, A., Ho, A. Y. Y., Małecki, J., Schroer, L., Pinto, R., Suzuki, T., Grønsberg, I. A., Sohtome, Y., Akakabe, M., Weirich, S., Kikuchi, M., Olsen, J. V., Dohmae, N., Umehara, T. & 8 others, , 2021, In: Nature Communications. 12, 14 p., 891.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein sequences bound to mineral surfaces persist into deep time
Demarchi, B., Hall, S., Roncal-Herrero, T., Freeman, C. L., Woolley, J., Crisp, M. K., Wilson, J., Fotakis, A. K., Fischer, R., Kessler, B. M., Jersie-Christensen, R. R., Olsen, J. V., Haile, J., Thomas, J., Marean, C. W., Parkington, J., Presslee, S., Lee-Thorp, J., Ditchfield, P., Hamilton, J. F. & 16 others, , 2016, In: eLife. 5, 50 p., e17092.Research output: Contribution to journal › Journal article › Research › peer-review
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A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos
Demeter, F., Zanolli, C., Westaway, K. E., Joannes-Boyau, R., Duringer, P., Morley, M. W., Welker, F., Rüther, P. L., Skinner, M. M., McColl, H., Gaunitz, C., Vinner, L., Dunn, T. E., Olsen, J. V., Sikora, M., Ponche, J-L., Suzzoni, E., Frangeul, S., Boesch, Q., Antoine, P-O. & 20 others, , 2022, In: Nature Communications. 13, 17 p., 2557.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative proteomic assessment of very early cellular signaling events
Dengjel, J., Akimov, V., Olsen, Jesper Velgaard, Bunkenborg, J., Mann, Matthias, Blagoev, B. & Andersen, J. S., 2007, In: Nature Biotechnology. 25, 5, p. 566-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic identification of beer brewing products in the ground layer of Danish Golden Age paintings
Di Gianvincenzo, Fabiana, Andersen, C. K., Filtenborg, T., Mackie, Meaghan, Ernst, M., Ramos Madrigal, Jazmin, Olsen, Jesper Velgaard, Wadum, J. & Cappellini, Enrico, 2023, In: Science Advances. 9, 21, 13 p., eade7686.Research output: Contribution to journal › Journal article › Research › peer-review
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Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
Dugourd, A., Kuppe, C., Sciacovelli, M., Gjerga, E., Gabor, A., Emdal, Kristina Bennet, Vieira, V., Bekker-Jensen, D. B., Kranz, J., Bindels, E. M. J., Costa, A. S. H., Sousa, A., Beltrao, P., Rocha, M., Olsen, Jesper Velgaard, Frezza, C., Kramann, R. & Saez-Rodriguez, J., 2021, In: Molecular Systems Biology. 17, 1, 17 p., e9730.Research output: Contribution to journal › Journal article › Research › peer-review
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A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin
Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphoproteomic investigation of targets of protein phosphatases in EGFR signaling
Eguchi, A. & Olsen, Jesper Velgaard, 2024, In: Scientific Reports. 14, 11 p., 7908.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9925376
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Molecular basis of Tousled-Like Kinase 2 activation
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52 Genetic Loci Influencing Myocardial Mass
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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