Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor

ORCID: 0000-0002-5613-1267

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  1. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

    Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conference › Conference abstract for conference › Research

  5. Published

    Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes

    Bartuzi, D., Kędzierska, E., Targowska-Duda, K. M., Koszła, O., Wróbel, T. M., Jademyr, S., Karcz, T., Szczepańska, K., Stępnicki, P., Wronikowska-Denysiuk, O., Biała, G., Handzlik, J., Kristensen, Jesper Langgaard, Poso, A. & Kaczor, A. A., 2022, In: Scientific Reports. 12, 1, 14 p., 21192.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 2020, In: Psychopharmacology. 237, p. 431–442

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    In vivo effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in rodents: Drug discrimination and thermoregulation

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 1 Mar 2020, In: Drug and Alcohol Dependence. 208, 8 p., 107850.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Synthesis of enantiopure 3-substituted morpholines

    Bornholdt, J., Felding, J. & Kristensen, Jesper Langgaard, 2010, In: Journal of Organic Chemistry. 75, 21, p. 7454-7457

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Ring opening of pymisyl-protected aziridines with organocuprates

    Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides

    Bornholdt, J., Fjære, K. W., Felding, J. & Kristensen, Jesper Langgaard, 2009, In: Tetrahedron. 65, 45, p. 9280-9284

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain

    Breusova, K., Ernstsen, K. G., Palner, M., Linnet, Kristian, Kristensen, Jesper Langgaard & Kretschmann, A. C., 2021, In: Journal of Pharmaceutical and Biomedical Analysis. 199, 114016.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Ortho lithiation-in situ borylation of substituted morpholine benzamides

    Cederbalk, A., Lysén, M., Kehler, J. & Kristensen, Jesper Langgaard, 23 Mar 2017, In: Tetrahedron. 73, 12, p. 1576–1582 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The Alkaloids from Lophophora diffusa and Other “False Peyotes”

    Chan, Camilla Bachmand, Poulie, Christian Bernard Matthijs, Wismann, S. S., Soelberg, Jens & Kristensen, Jesper Langgaard, 2021, In: Journal of Natural Products. 84, 8, p. 2398–2407

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Deprotection of 2-nitrobenzenesulfonamides using fluorous and solid phase reagents

    rtc312, rtc312, Clausen, Rasmus Prætorius, Begtrup, M. & Kristensen, Jesper Langgaard, 18 Oct 2004, In: Tetrahedron Letters. 45, 43, p. 7991-7993

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Nye NMDA-receptor-ligander til udforskning af hjernen

    Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In: Dansk Kemi. 91, 6/7, p. 21-23

    Research output: Contribution to journal › Journal article › Communication

  16. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

    Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Ind i hjernen med nye stoffer

    Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In: Lægemiddelforskning. p. 34-36

    Research output: Contribution to journal › Journal article › Communication

  18. Published

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

    Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, Jesper Langgaard, May 2019, In: Journal of the American Chemical Society. 141, 22, p. 8783-8786

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Development of a Divergent Route to Erythrina Alkaloids

    Clementson, S., Jessing, M., Vital, P. J. & Kristensen, Jesper Langgaard, 3 Mar 2020, In: Synlett. 31, 4, p. 327-333 7 p., st-2019-a0679-a.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

    Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In: Journal of Medicinal Chemistry. 61, p. 1719-1729

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

    Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In: Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150

    Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Herth, Matthias Manfred, Oct 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Convergent synthesis of 3-arylated 1-hydroxypyrazoles via 3-metalated pyrazole-1-oxides

    Eskildsen, J., Kristensen, Jesper Langgaard, Vedsø, P., Begtrup, M. & Kristensen, Jesper Langgaard, 14 Dec 2001, In: Journal of Organic Chemistry. 66, 25, p. 8654-8656 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36

    Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36

    Ettrup, A., Holm, S., Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In: Molecular Imaging and Biology. 15, 4, p. 376-83

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, Mar 2015, In: Psychopharmacology. 232, 6, p. 1039-47 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Palladium-Catalyzed Arylation and Acylation of 1-Benzyloxy-1,2,3-triazole Through a Directed Ortho Lithiation-Transmetalation Strategy.

    Felding, J., Uhlmann, P., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1998, In: Synthesis. 8, p. 1181-1184 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole

    Felding, J., Kristensen, Jesper Langgaard, Bjerregaard, T., Sander, L., Vedsø, P. & Begtrup, M., 28 May 1999, In: Journal of Organic Chemistry. 64, 11, p. 4196-4198 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Direct Cu-mediated aromatic18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

    García-Vázquez, R., Battisti, Umberto Maria, Jørgensen, Jesper Tranekjær, Shalgunov, Vladimir, Hvass, Lars, Stares, D. L., Petersen, I. N., Crestey, F., Löffler, A., Svatunek, D., Kristensen, Jesper Langgaard, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: Chemical Science. 12, 35, p. 11668-11675

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36

    Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  34. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Synthesis of azaphenanthridines via anionic ring closure

    Hansen, H. M., Lysén, M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Oct 2005, In: Tetrahedron. 61, 42, p. 9955-9960 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis

    Hansen, K. B., Clausen, Rasmus Prætorius, Bjerrum, E. J., Bechmann, C., Greenwood, J. R., Christensen, C., Kristensen, Jesper Langgaard, Egebjerg, J. & Bräuner, Hans, Dec 2005, In: Molecular Pharmacology. 68, 6, p. 1510-23

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

    Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner, Hans & Kristensen, Jesper Langgaard, 2015, In: Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs

    Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

    Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

    Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor

    Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.

    Research output: Contribution to conference › Conference abstract for conference › Research

  47. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging

    Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors

    Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In: P L o S One. 8, 11, e78515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography

    Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, Matthias Manfred, Kristensen, Jesper Langgaard, Palner, M. & Janfelt, Christian, 2021, In: Molecular Imaging and Biology. 23, p. 676–685

    Research output: Contribution to journal › Journal article › Research › peer-review

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