Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

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Erythrina alkaloids represent a rich source of complex polycyclic, bioactive natural products. In addition to their sedative and hypotensive effect, their curare-like activity and structural framework have made them attractive targets for synthetic and medicinal chemists. (+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine acetylcholine receptor antagonist (nAChR) of the Erythrina family, is synthesized for the first time in 13 steps from commercially available material.

Original languageEnglish
JournalJournal of the American Chemical Society
Issue number22
Pages (from-to)8783-8786
Publication statusPublished - May 2019

ID: 218709893