Jens Lykkesfeldt
Professor
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Circadian Variation in the Response to Experimental Endotoxemia and Modulatory Effects of Exogenous Melatonin
Alamili, M., Klein, M., Lykkesfeldt, Jens, Rosenberg, J. & Gögenur, I., 2013, In: Chronobiology International. 30, 9, p. 1174-1180 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of melatonin on human nighttime endotoxaemia: randomized, double-blinded, cross-over study
Alamili, M., Bendtzen, K., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, 2014, In: In Vivo. 28, 6, p. 1057-1063 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model
Alamili, M., Bendtzen, K., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, 2014, In: Journal of Critical Care. 29, 1, p. 184.e9-184.e13 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial
Alamili, M., Bendtzen, K., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, I., 2014, In: PloS one. 9, 1, 7 p., e87413.Research output: Contribution to journal › Journal article › Research › peer-review
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Thick methacrylate sections devoid of lost caps simplify stereological quantifications based on the optical fractionator design
Andersen, S. H., Lykkesfeldt, Jens & Larsen, J. O., 15 Sep 2015, In: Anatomical Record. 298, 12, p. 2141-2150 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs
Andersen, S. H., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2015, In: British Journal of Nutrition. 113, 10, p. 1539-1549 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vitamin C and its role in brain development and cognition
Andersen, S. H., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2012, Nutrition and mental performance: a develomental perspective. Riby, L., Smith, M. & Foster, J. (eds.). Palgrave Macmillan, p. 29-52 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes
Andreasen, L. J., Kirk, R. K., Fledelius, C., Yorek, M. A., Lykkesfeldt, Jens & Akerstrom, T., 2020, In: Journal of Diabetes Research. 2020, 13 p., 9626398.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-terminal blood sampling techniques in Guinea pigs
Birck, M. M., Tveden-Nyborg, Pernille, Lindblad, M. M. & Lykkesfeldt, Jens, 2014, In: Journal of Visualized Experiments. 92, e51982.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased expression of the GLP-1 receptor after segmental artery injury in mice
Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Skovsted, Gry Freja, 2021, In: The Journal of endocrinology. 248, 3, p. 289-301 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis, and affects genes involved in vascular remodelling and inflammation
Bjørnholm, K. D., Skovsted, Gry Freja, Mitgaard-Thomsen, A., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Povlsen, G. K., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 103-114Research output: Contribution to journal › Journal article › Research › peer-review
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Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs
Boonen, H. C. M., Moesgaard, S. G., Birck, M. M., Christoffersen, B. Ø., Cirera, Susanna, Heegaard, P. M. H., Højbøge, T. R., Jensen, Lars Jørn, Mortensen, A., Olsen, Lisbeth Høier, Sheykhzade, Majid, Tang, J. & Lykkesfeldt, Jens, 2014, In: Pflügers ARchiv (European Journal of Physiology). 466, 12, p. 2167-2176 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG
Boysen, L., Sprinkel, A. M. E., Lauritzen, B., Breinholt, J., Lykkesfeldt, Jens, Viuff, B. M. & Landsy, L. H., 2019, In: Biologicals. 60, p. 42-48 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An ELISA for detection of complement-bound circulating immune complexes in mice
Boysen, L., Lauritzen, B., Viuff, B. M., Lykkesfeldt, Jens & Landsy, L. H., 2019, In: Journal of Immunotoxicology. 16, 1, p. 82-86 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formation and Glomerular Deposition of Immune Complexes in Mice Administered Human Antibodies: Evaluation of Dose, Frequency, and Biomarkers
Boysen, L., Viuff, B. M., Landsy, L. H., Lykkesfeldt, Jens, Raymond, J. T., Price, S. A., Pelzer, H. & Lauritzen, B., 2020, In: Toxicologic Pathology. 48, 4, p. 570-585 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers
Boysen, L., Viuff, B. M., Landsy, L. H., Price, S. A., Raymond, J. T., Lykkesfeldt, Jens & Lauritzen, B., 2019, In: Journal of Immunotoxicology. 16, 1, p. 191-200 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats
Brewer, C., Otto-Duessel, M., Lykkesfeldt, Jens, Nick, H. & Wood, J. C., 2012, In: Experimental Hematology. 40, 10, p. 820-827 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Co-bedding of Preterm Newborn Pigs Reduces Necrotizing Enterocolitis Incidence Independent of Vital Functions and Cortisol Levels
Brunse, Anders, Peng, Y., Li, Y., Lykkesfeldt, Jens & Sangild, Per Torp, 2021, In: Frontiers in Pediatrics. 9, 636638.Research output: Contribution to journal › Journal article › Research › peer-review
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Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study
Busch, S. V. E., Godthaab, C., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, I., Feb 2019, In: European Journal of Anaesthesiology. 36, 2, p. 130-134 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Malnutrition predisposes to endotoxin-induced edema and impaired inflammatory response in parenterally fed piglets
Bæk, Ole, Fabiansen, C., Friis, Henrik, Ritz, C., Koch, Jørgen, Willesen, Jakob, Heegaard, P. M. H., Lykkesfeldt, Jens, Briend, A., Golden, M. H., Sangild, Per Torp & Thymann, Thomas, 2020, In: Journal of Parenteral and Enteral Nutrition. 44, 4, p. 668-676Research output: Contribution to journal › Journal article › Research › peer-review
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Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone
Böttcher, T., Ren, H., Goiny, M., Gerber, J., Lykkesfeldt, Jens, Kuhnt, U., Lotz, M., Bunkowski, S., Werner, C., Schau, I., Spreer, A., Christen, S. & Nau, R., 2004, In: Journal of Neurochemistry. 91, 6, p. 1450-1460 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives
Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Critical Reviews in Food Science and Nutrition. 61, 5, p. 742-755 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations
Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 7, 19 p., 1657.Research output: Contribution to journal › Journal article › Research › peer-review
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Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity
Carr, A. C., Block, G. & Lykkesfeldt, Jens, 2022, In: Nutrients. 14, 7, 8 p., 1460.Research output: Contribution to journal › Journal article › Research › peer-review
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Vitamin C: From Bench to Bedside
Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Nutrients. 13, 4, 3 p., 1102.Research output: Contribution to journal › Editorial › Research › peer-review
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Does Aging Affect Vitamin C Status Relative to Intake? Findings from NHANES 2017-2018
Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 4, 10 p., 892.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment
Christen, S., Schaper, M., Lykkesfeldt, Jens, Siegenthaler, C., Bifrare, Y., Banic, S. O., Leib, S. L. & Täuber, M. G., 2001, In: Free Radical Biology & Medicine. 31, 6, p. 754-762 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation
Christen, S., Finckh, B., Lykkesfeldt, Jens, Gessler, P., Frese-Schaper, M., Nielsen, P., Schmid, E. R. & Schmitt, B., 2005, In: Free Radical Biology & Medicine. 38, 10, p. 1323-1332 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Obese Prone Rats on high- and low-fat diets gain weight equally
Christensen, B. T., Hellgren, L., Sejrsen, K., Lykkesfeldt, Jens & Hansen, Axel Kornerup, 2010.Research output: Contribution to conference › Poster › Research
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High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice
Christensen, B. T., Hansen, Axel Kornerup & Lykkesfeldt, Jens, 2014, In: European Journal of Nutrition. 53, 6, p. 1441-1444 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Whey protein reduces early life weight gain in mice fed a high-fat diet
Christensen, B. T., Hellgren, L., Lykkesfeldt, Jens, Sejrsen, K., Jeamet, A., Rune, Ida, Ellekilde, M., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2013, In: PLOS ONE. 8, 8, 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease
Christiansen, L. B., Morsing, Malene Kjelin, Reimann, Maria Josefine, Martinussen, Torben, Birlie, Z., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2020, In: Antioxidants. 9, 9 p., 827.Research output: Contribution to journal › Journal article › Research › peer-review
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Depleted myocardial coenzyme Q10 in cavalier king charles spaniels with congestive heart failure due to myxomatous mitral valve disease
Christiansen, L. B., Reimann, Maria Josefine, Schou-Pedersen, A. M. V., Larsen, Steen, Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Antioxidants. 10, 2, p. 1-13 13 p., 161.Research output: Contribution to journal › Journal article › Research › peer-review
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Accelerated atherosclerosis caused by serum amyloid A response in lungs of ApoE−/− mice
Christophersen, D. V., Møller, Peter, Thomsen, Morten Bækgaard, Lykkesfeldt, Jens, Loft, Steffen, Wallin, H., Vogel, U. & Jacobsen, N. R., 2021, In: FASEB Journal. 35, 3, 14 p., e21307.Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice
Christophersen, D. V., Raun Jacobsen, N., Guerra Andersen, M. H., Connell, S. P., Barfod, K. K., Thomsen, Morten Bækgaard, Miller, M. R., Duffin, R., Lykkesfeldt, Jens, Vogel, U. B., Wallin, E. H. R., Loft, Steffen, Roursgaard, Martin & Møller, Peter, 14 Sep 2016, In: Toxicology. 371, p. 29-40 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antioxidant supplementation for lung disease in cystic fibrosis
Ciofu, Oana & Lykkesfeldt, Jens, 2014, In: The Cochrane library. 2014, 8, 87 p., CD007020.Research output: Contribution to journal › Journal article › Research › peer-review
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Antioxidant supplementation for lung disease in cystic fibrosis
Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2019, In: Cochrane Database of Systematic Reviews. 2019, 10, CD007020.Research output: Contribution to journal › Review › Research › peer-review
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A systematic Cochrane Review of antioxidant supplementation lung disease for cystic fibrosis
Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2020, In: Paediatric Respiratory Reviews. 33, p. 28-29Research output: Contribution to journal › Comment/debate › Research › peer-review
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On the possible connection between vitamin C, cardiovirus and guinea pig lameness
Clausen, F. B., Lykkesfeldt, Jens & Hansen, Axel Kornerup, 2000, Ikke angivet. Laboratory Animals Ltd, p. 101-104 4 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Involvment of cytochrome P450 in Oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomale enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba
Du, L., Lykkesfeldt, Jens, Olsen, C. E. & Halkier, B. A., 1995, In: Proceedings of the National Academy of Science of the United States of America. 92, 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba L.
Du, L., Lykkesfeldt, Jens, Olsen, C. E. & Halkier, Barbara Ann, 19 Dec 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12505-12509 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypophosphatemic Hypovitaminosis D Induces Osteomalacia in the Adult Female Rat
Durup, D., Diaz-delCastillo, M., Morgenlykke, J., Jensen, Lars Thorbjørn, Frandsen, E., Abelson, Klas, Pedersen, L., Lykkesfeldt, Jens, Ding, M., Jørgensen, Niklas Rye, Syberg, S., Petersen, S. & Heegaard, Anne-Marie, 2020, In: Endocrinology. 161, 8, bqaa100.Research output: Contribution to journal › Journal article › Research › peer-review
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Endothelial dysfunction and myocardial injury after major emergency abdominal surgery: a prospective cohort study
Ekeloef, S., Oreskov, J. O., Falkenberg, A., Burcharth, J., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, Ismail, 2020, In: BMC Anesthesiology. 20, 9 p., 67.Research output: Contribution to journal › Journal article › Research › peer-review
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Endothelial dysfunction in the early postoperative period after major colon cancer surgery.
Ekeløf, S., Larsen, M. H., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, Feb 2017, In: British Journal of Anaesthesia. 118, 2, p. 200-206Research output: Contribution to journal › Journal article › Research › peer-review
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Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen‐related genes
Fager Ferrari, M., Zetterberg, E., Rossing, Caroline Maria, Manon‐jensen, T., Pehrsson, M., Karsdal, M. A., Lykkesfeldt, Jens & Leinoe, E., 2021, In: Haemophilia. 27, 1, p. e69-e77Research output: Contribution to journal › Journal article › Research › peer-review
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What is the optimum intake of vitamin C in humans?
Frei, B., Birlouez-Aragon, I. & Lykkesfeldt, Jens, 2012, In: Critical Reviews in Food Science and Nutrition. 52, 9, p. 815-829 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells
Frikke-Schmidt, H. R., Roursgaard, Martin, Lykkesfeldt, Jens, Loft, Steffen, Nøjgaard, J. K. & Møller, Peter, 2011, In: Toxicology Letters. 203, 3, p. 181-189 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C-Vitamin mod åreforkalkning
Frikke-Schmidt, H. R. & Lykkesfeldt, Jens, 2009, In: Aktuel Naturvidenskab. 3, p. 26-29 4 p.Research output: Contribution to journal › Journal article › Communication
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Role of marginal vitamin C deficiency in atherogenesis: In vivo models and clinical studies
Frikke-Schmidt, H. R. & Lykkesfeldt, Jens, 2009, In: Basic & Clinical Pharmacology & Toxicology. 104, 6, p. 419-433 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs
Frikke-Schmidt, H. R., Tveden-Nyborg, Pernille, Birck, M. M. & Lykkesfeldt, Jens, 2011, In: British Journal of Nutrition. 105, 1, p. 54-61 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4231856
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Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats
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Increased systemic oxidatively generated DNA and RNA damage in schizophrenia
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Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies
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