Dorte Frees

Dorte Frees

Associate Professor

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    1. Published

      Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase

      Alqarzaee, A. A., Chaudhari, S. S., Islam, M. M., Kumar, V., Zimmerman, M. C., Saha, R., Bayles, K. W., Frees, Dorte & Thomas, V. C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2109671118.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

      Baek, K. T., Bowman, L., Millership, C., Sogaard, M. D., Kaever, V., Siljamaki, P., Savijoki, K., Varmanen, P., Nyman, T. A., Grundling, A. & Frees, Dorte, 2016, In: mBio (Print). 7, 4, 11 p., 01228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

      Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

      Baldry, M., Nakamura, Y., Nakagawa, S., Frees, Dorte, Matsue, H., Nunez, G. & Ingmer, Hanne, 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      SosA in Staphylococci: an addition to the paradigm of membrane-localized, SOS-induced cell division inhibition in bacteria

      Bojer, Martin Saxtorph, Frees, Dorte & Ingmer, Hanne, 2020, In: Current Genetics. 66, p. 495-499

      Research output: Contribution to journal › Review › Research › peer-review

    6. Published

      SosA inhibits cell division in Staphylococcus aureus in response to DNA damage

      Bojer, Martin Saxtorph, Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, Dorte, Veening, J. W., Foster, S. J. & Ingmer, Hanne, 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis

      Breüner, A., Frees, Dorte, Varmanen, P., Boguta, A. M., Hammer, K., Martinussen, J. & Kilstrup, M., Oct 2016, In: Microbiology. 162, 10, p. 1829-1839 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA

      Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, Viktor Hundtofte, Vestergaard, M., Brown, E. D. & Frees, Dorte, 2021, In: Frontiers in Molecular Biosciences. 8, 691569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene

      Bæk, K. T., Thøgersen, L., Mogensen, R. G., Pedersen, M. M., Thomsen, Line Elnif, Petersen, A., Skov, Søren, Cameron, D. R., Peleg, A. Y. & Frees, Dorte, Nov 2015, In: Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983-6991 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing

      Bæk, K. T., Frees, Dorte, Renzoni, A., Barras, C., Rodriguez, N., Manzano, C. & Kelley, W. L., 2013, In: P L o S One. 8, 9, 16 p., e77122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      β-lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease

      Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W. E. A. & Frees, Dorte, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4593-4603 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Clp-dependent proteolysis of the LexA N-terminal domain in Staphylococcus aureus

      Cohn, M. T., Kjelgaard, P. M., Frees, Dorte, Penadés, J. R. & Ingmer, Hanne, 2011, In: Microbiology. 157, 3, p. 677-684 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling

      Eld, H. M. S., Nielsen, E. M., Johnsen, Peter Riber, Marengo, M., Kamper, I. W., Frederiksen, L., Bonomi, F., Frees, Dorte, Iametti, S. & Frøkiær, Hanne, 2021, In: Molecular Immunology. 134, p. 1-12 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus

      Engman, J., Rogstam, A. H., Frees, Dorte, Ingmer, Hanne & Wachenfeldt, C. V., 2012, In: Journal of Bacteriology. 194, 5, p. 1186-1194 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus

      Farrand, A. J., Friedman, D. B., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., Apr 2015, In: Pathogens and Disease. 73, 3, 6 p., ftv004.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system

      Farrand, A. J., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., 2013, In: Journal of Bacteriology. 195, 22, p. 5041-5050 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus

      Feng, J., Michalik, S., Varming, A. N., Andersen, J. H., Albrecht, D., Jelsbak, L., Krieger, S., Ohlsen, K., Hecker, M., Gerth, U., Ingmer, Hanne & Frees, Dorte, 2013, In: Journal of Proteome Research. 12, 2, p. 547-558 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis

      Frees, Dorte, Varmanen, P. & Ingmer, Hanne, 2001, In: Molecular Microbiology. 41, 1, p. 93-103 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

      Frees, Dorte, Chastanet, A., Quzi, S., Sørensen, K., Hill, P., Msadek, T. & Ingmer, Hanne, 2004, In: Molecular Microbiology. 54, 5, p. 1445-1462 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Stress toelrance mechanisms influencing virulence and survival of food borne pathogens

      Frees, Dorte, Varmanen, P. ;., SavijokiK.;, Andersen, M. T., Brønsted, L. & Ingmer, Hanne, 2003. 1 p.

      Research output: Contribution to conference › Paper › Research

    21. Published

      Alternative roles of CIpX and CIpP in Staphylococus aureus stress toelrance and virulence.

      Frees, Dorte, Saara, N. A. Q., Philip, J. H. & Ingmer, Hanne, 2003, In: Molecular Microbiology. (2003) 48 (6), p. 1565 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      ClpP participaytes in the degradation of misfolded protein in Lactococcuss lactis

      Frees, Dorte & Ingmer, Hanne, 1999, In: Molecular Microbiology. 31, 1, p. 79 - 87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Stress Responses in Staphylococcus aureus

      Frees, Dorte & Ingmer, Hanne, Oct 2016, Staphylococcus: Genetics and Physiology. Somerville, G. A. (ed.). Caister Academic Press, p. 221-248

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    24. Published

      PhD course "Infection Microbiology": time schedule for module A, 2010

      Frees, Dorte, Nielsen, M. & Thomsen, Line Elnif, 2010, Department of Veterinary Disease Biology, University of Copenhagen. 72 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    25. Published

      Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network

      Frees, Dorte, Sørensen, K. & Ingmer, Hanne, 2005, In: Infection and Immunity. 73, 12, p. 8100-8108 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

      Frees, Dorte, Gerth, U. & Ingmer, Hanne, 2014, In: International Journal of Medical Microbiology. 304, 2, p. 142-149 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle

      Frees, Dorte & Ingmer, Hanne, 2022, In: mBio. 13, 4, e0073722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Bacterial proteases and virulence

      Frees, Dorte, Brøndsted, Lone & Ingmer, Hanne, 2013, Regulated proteolysis in microorganisms. Dougan, D. A. (ed.). Springer, p. 161-192 32 p. (Subcellular biochemistry, Vol. 66).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    29. Published

      A hitherto not recognized phenotype of spvA in Salmonella

      Frees, Dorte, Gram, L., Holmstrøm, K. & Olsen, John Elmerdahl, 2010, Proceedings: 13S international symposium salmonella and salmonellosis. p. 33-34 2 p.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

    30. Published

      Staphylococcus aureus ClpYQ plays a minor role in stress survival

      Frees, Dorte, Thomsen, Line Elnif & Ingmer, Hanne, 2005, In: Archives of Microbiology. 183, 4, p. 286-291 6 p.

      Research output: Contribution to journal › Journal article › Research

    31. Published

      New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564

      Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria

      Frees, Dorte, Savijoki, K., Varmanen, P. & Ingmer, Hanne, 2007, In: Molecular Microbiology. 63, 5, p. 1285-1295 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Identification of proteins induced at low pH in Lactococcus lactis

      Frees, Dorte, Vogensen, Finn Kvist & Ingmer, Hanne, 2003, In: International Journal of Food Microbiology. 87, 87, p. 293-300 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Planktonic aggregates of Staphylococcus aureus protect against common antibiotics

      Haaber, J. K., Cohn, M. T., Frees, Dorte, Andersen, Thorbjørn Joest & Ingmer, Hanne, 2012, In: P L o S One. 7, 7, 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice

      Harslund, J. L. F., Frees, Dorte, Leifsson, Páll S., Offenberg, H. K., Rømer, M. U. K., Brünner, N. & Olsen, John Elmerdahl, 2013, In: Pathogens and Disease. 68, 3, p. 96-104 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division

      Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, Dorte, 2024, In: Molecular Microbiology. 121, 1, p. 98-115

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Salmonella isolates with different behavior in adhesion to surfaces studied by DNA micro array assisted analysis

      Holmstrøm, K., Olsen, K. N., Meldgaard, H., Bagge-Ravn, D., Frees, Dorte, Lauritsen, D., Gram, L. & Olsen, John Elmerdahl, 2005. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    38. Published

      Fødevaresikkerhed i udvikling

      Ingmer, Hanne, Larsen, M. H., Leisner, Jørgen, Frees, Dorte, Brøndsted, Lone & Dalsgaard, Anders, 2019, In: Dansk Veterinaertidsskrift. 2019, 7, p. 10-13

      Research output: Contribution to journal › Journal article › Communication

    39. Published

      Identification of the ClpX Regulon in Staphylococcus aureus

      Jelsbak, L., Thomsen, Line Elnif, Ingmer, Hanne, Donat, S., Ohlsen, K. & Frees, Dorte, 2006. 1 p.

      Research output: Contribution to conference › Poster › Research

    40. Published

      Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus

      Jelsbak, L., Hemmingsen, L., Donat, S., Ohlsen, K., Boye, K., Westh, H., Ingmer, Hanne & Frees, Dorte, 2010, In: International Journal of Medical Microbiology. 300, 4, p. 229-236 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by rot dependent and independent pathways

      Jelsbak, L., Ingmer, Hanne, Valihrach, L., Cohn, M. T., Christiansen, M. H. G., Kallipolitis, B. H. & Frees, Dorte, 2010, In: PLoS ONE. 5, 9, 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

      Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, Lijuan, Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, Dorte, 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus

      Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision

      Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, Dorte, 2019, In: Scientific Reports. 9, 11 p., 16456.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      A porcine model of heamatogenous osteomyelitis: pathogenesis and pathology

      Jensen, Louise Kruse, Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Buelund, Lene Elisabeth, Svalastoga, Eiliv Lars & Jensen, Henrik Elvang, 2012. 1 p.

      Research output: Contribution to conference › Poster › Research

    46. Published

      Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis

      Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study

      Jensen, Louise Kruse, Frees, Dorte, Aalbæk, Bent, Koch, J., Iburg, T. M., Nielsen, O. L., Leifsson, Páll S. & Jensen, Henrik Elvang, 2011, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 119, 2, p. 111-118 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Therapy of haematogenous osteomyelitis: a comparative study in a porcine model and Angolan children

      Jensen, Louise Kruse, Koch, J., Kirketerp-Møller, K., Wamsler, O. J., Nielsen, O. L., Leifsson, Páll S., Frees, Dorte, Aalbæk, Bent & Jensen, Henrik Elvang, 2013, In: In Vivo. 27, 3, p. 305-312 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis

      Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Antigen uptake in zebrafish (Danio rerio)

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Poster › Research

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