David Paul Drucker Woldbye
Associate Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
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Neuropeptide y promotes neurogenesis in murine subventricular zone
Agasse, F., Bernardino, L., Kristiansen, H., Christiansen, S. H., Ferreira, R., Silva, B., Grade, S., Woldbye, David Paul Drucker, Malva, J. O. & Kristiansen, H., 2008, In: Stem Cells. 26, 6, p. 1636-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The neuropeptide galanin promotes neuronal differentiation in murine subventricular zone cultures
Agasse, F., Christiansen, S. H. O., Malva, J. & Woldbye, David Paul Drucker, 2013, In: Stem Cells and Development. 22, 11, p. 1693-1708 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Optogenetic control of human neurons in organotypic brain cultures
Andersson, M., Avaliani, N., Svensson, A., Wickham, J., Pinborg, Lars Hageman, Jespersen, B., Christiansen, S. H., Bengzon, J., Woldbye, David Paul Drucker & Kokaia, M., 21 Apr 2016, In: Scientific Reports. 6, 5 p., 24818.Research output: Contribution to journal › Journal article › Research › peer-review
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DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue
Avaliani, N., Andersson, M., Thomsen, A. H. R., Woldbye, David Paul Drucker & Kokaia, M., Oct 2016, In: Gene Therapy. 23, 10, p. 760-766 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene therapy for Parkinson's disease, an update
Axelsen, T. M. & Woldbye, David Paul Drucker, 2018, In: Journal of Parkinson's Disease. 8, 2, p. 195-215 21 p.Research output: Contribution to journal › Review › Research › peer-review
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Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform
Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.Research output: Contribution to journal › Journal article › Research › peer-review
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Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A beta oligomers to rats
Baerends, E., Soud, K., Folke, J., Pedersen, Anna-Kathrine, Henmar, S., Konrad, Lisa, Lycas, M. D., Mori, Yuki, Pakkenberg, B., Woldbye, David Paul Drucker, Dmytriyeva, O. & Pankratova, Stanislava, 2022, In: Acta Neuropathologica Communications. 10, 1, 21 p., 113.Research output: Contribution to journal › Journal article › Research › peer-review
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MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro
Bin Wei, Y., Melas, P. A., Villaescusa, J. C., Liu, J. J., Xu, N., Christiansen, S. H., Elbrønd-Bek, H., Woldbye, David Paul Drucker, Wegener, G., Mathe, A. A. & Lavebratt, C., Dec 2016, In: International Journal of Neuropsychopharmacology. 19, 12, 9 p., pyw069.Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive therapy as an anticonvulsant: A possible role of neuropeptide Y (NPY)
Bolwig, T. G., Woldbye, David Paul Drucker & Mikkelsen, J. D., 1999, In: Journal of ECT. 15, 1, p. 93-101Research output: Contribution to journal › Journal article › Research › peer-review
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The norepinephrine transporter gene is a candidate gene for panic disorder
Buttenschøn, H. N., Kristensen, A. S., Buch, H. N., Andersen, J. H., Bonde, Jens Peter, Grynderup, M. B., Hansen, Åse Marie, Kolstad, H., Kaergaard, A., Kaerlev, L., Mikkelsen, S., Thomsen, Jane Frølund, Koefoed, P., Erhardt, A., Woldbye, David Paul Drucker, Børglum, A. & Mors, O., 1 Jun 2011, In: Journal of Neural Transmission. 118, 6, p. 969-76 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task
Caballero Puntiverio, M., Fitzpatrick, C. M., Woldbye, David Paul Drucker & Andreasen T., Jesper, 2017, In: Journal of Psychopharmacology. 31, 2, p. 272-283Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model
Campos, E. J., Martins, J., Brudzewsky, D., Woldbye, David Paul Drucker & Ambrósio, A. F., 2020, In: Annals of Anatomy. 227, 8 p., 151419.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina
Campos, E. J., Martins, J., Brudzewsky, D., Correia, S., Santiago, A. R., Woldbye, David Paul Drucker & Ambrósio, A. F., 2018, In: Clinical and Experimental Ophthalmology. 46, 7, p. 783-795 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unaltered neuropeptide Y (NPY)-stimulated [35S]GTPgamma-S binding suggests a net increase in NPY signalling after repeated electroconvulsive seizures in mice
Christensen, D. Z., Olesen, M. V., Kristiansen, H., Mikkelsen, J. D. & Woldbye, David Paul Drucker, 2006, In: Journal of Neuroscience Research. 84, 6, p. 1282-1291 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y treatment induces retinal vasoconstriction and causes functional and histological retinal damage in a porcine ischaemia model
Christiansen, A. T., Sørensen, N. B., Haanes, K. A., Blixt, F. W., la Cour, Morten, Warfvinge, K., Klemp, Kristian, Woldbye, David Paul Drucker & Kiilgaard, Jens Folke, 2018, In: Acta Ophthalmologica. 96, 8, p. 812-820 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas: A comparative study
Christiansen, A. T., Kiilgaard, Jens Folke, Klemp, Kristian, Woldbye, David Paul Drucker & Hannibal, Jens, 2018, In: The Journal of Comparative Neurology. 526, 12, p. 1877-1895Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of the galanin system by repeated electroconvulsive seizures in mice
Christiansen, S. H. & Woldbye, David Paul Drucker, 1 Dec 2010, In: Journal of Neuroscience Research. 88, 16, p. 3635-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice
Christiansen, S. H. O., Olesen, M. V., Wörtwein, Gitta & Woldbye, David Paul Drucker, 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice
Christiansen, S. H. O., Olesen, M. V., Gøtzsche, C. R. & Woldbye, David Paul Drucker, 16 Sep 2014, In: Neuropeptides. 48, 6, p. 335-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions
Clausen, T. R., Møller, M. & Woldbye, David Paul Drucker, 2001, In: Journal of Neuroscience Research. 64, 4, p. 410-417Research output: Contribution to journal › Journal article › Research › peer-review
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No loss of hippocampal hilar somatostatinergic neurons after repeated electroconvulsive shock: a combined stereological and in situ hybridization study
Dalby, N. O., Tonder, N., Woldbye, David Paul Drucker, West, M., Finsen, B. & Bolwig, T. G., 1996, In: Biological Psychiatry. 40 (1), p. 54-60Research output: Contribution to journal › Journal article › Research › peer-review
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Towards automatic glaucoma assessment: An Encoder-decoder CNN for Retinal Layer Segmentation in Rodent OCT images
Del Amor, R., Morales, S., Colomer, A., Mossi, J. M., Woldbye, David Paul Drucker, Klemp, Kristian, Larsen, M. & Naranjo, V., Sep 2019, EUSIPCO 2019 - 27th European Signal Processing Conference. European Signal Processing Conference, EUSIPCO, (European Signal Processing Conference, Vol. 2019-September).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline
Dencker, D., Wörtwein, Gitta, Weikop, Pia, Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, David Paul Drucker, Wess, J. & Fink-Jensen, Anders, 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y is Up-regulated and Induces Antinociception in Cancer-induced Bone Pain.
Diaz del Castillo, M., Christiansen, S. H., Appel, C., Falk, S., Woldbye, David Paul Drucker & Heegaard, Anne-Marie, 29 May 2018, In: Neuroscience. 384, p. 111-119Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y and its involvement in chronic pain
Diaz-delCastillo, M., Woldbye, David Paul Drucker & Heegaard, Anne-Marie, 1 Sep 2018, In: Neuroscience. 387, p. 162-169 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Neurotrophic effects of vascular endothelial growth factor B and novel mimetic peptides on neurons from the central nervous system
Dmytriyeva, O., de Diego Ajenjo, A., Jørgensen, Kathrine Lundø, Hertz, H., Rasmussen, K. K., Christiansen, A. T., Klingelhofer, J., Nielsen, A. L., Hoeber, J., Kozlova, E. N., Woldbye, David Paul Drucker & Pankratova, Stanislava, 2020, In: ACS Chemical Neuroscience. 11, 9, p. 1270–1282 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta-induced pathology
Dmytriyeva, O., Belmeguenai, A., Bezin, L., Soud, K., Woldbye, David Paul Drucker, Gotzsche, C. R. & Pankratova, Stanislava, 2019, In: Neurobiology of Aging. 81, p. 88-101 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.
Dyrvig, M., Hansen, H. H., Christiansen, S. H. O., Woldbye, David Paul Drucker, Mikkelsen, Jens D. & Lichota, J., 2012, In: Brain Research Bulletin. 88, p. 507-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat
Dyrvig, M., Gotzsche, C. R., Woldbye, David Paul Drucker & Lichota, J., Jul 2015, In: Molecular and Cellular Neuroscience. 67, p. 137-143 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Temporal gene expression profile after acute electroconvulsive stimulation in the rat.
Dyrvig, M., Christiansen, S. H. O., Woldbye, David Paul Drucker & Lichota, J., 2014, In: Gene. 539, 1, p. 8-14 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice
Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, 9 Jul 2014, In: Synapse. 68, 10, p. 427-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of Functional Neuropeptide Y Receptors in the Mouse Hippocampus and Neocortex Using [35S]GTPγS Binding
Elbrønd-Bek, H., Gøtzsche, C. R., Skinbjerg, M., Christensen, D. Z., Plenge, P. K. & Woldbye, David Paul Drucker, 2015, In: International Journal of Peptide Research and Therapeutics. 21, 3, p. 269-278 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Replication and meta-analysis of TMEM132D gene variants in panic disorder.
Erhardt, A., Akula, N., Schumacher, J., Czamara, D., Karabalai, N., Müller-Myhsok, B., Mors, O., Borglum, A., Kristensen, AS., Woldbye, D. P. D., Koefoed, P., Eriksson, E., Maron, E., Metspalu, A., Nurnberger, J., Philibert, RA., Kennedy, J., Domschke, K., Reif, A., Deckert, J. & 10 others, , 2012, In: Translational Psychiatry. 2:e156Research output: Contribution to journal › Journal article › Research › peer-review
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Role for M5 muscarinic acetylcholine receptors in cocaine addiction
Fink-Jensen, A., Fedorova, I., Wörtwein, Gitta, Woldbye, David Paul Drucker, Rasmussen, T., Thomsen, M., Bolwig, T. G., Knitowski, K. M., McKinzie, D. L., Yamada, M., Wess, J. & Basile, A., 2003, In: Journal of Neuroscience Research. 74, 1, p. 91-6Research output: Contribution to journal › Journal article › Research › peer-review
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Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.
Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task
Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, Ulrik, Habekost, Thomas, Bundesen, C., Vangkilde, Signe, Woldbye, David Paul Drucker, Andreasen T., Jesper & Petersen, Anders, 2017, In: Psychopharmacology. 234, 5, p. 845-855Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task
Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, A., Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GENOME-WIDE ASSOCIATION STUDY OF PANIC DISORDER
Forstner, A. J., Wolf, C., Maron, E., Erhardt, A., Eriksson, E., Hovatta, L., Lavebratt, C., Allgulander, C., Woldbye, David Paul Drucker, Mors, O., Mueller-Myhsok, B., Binder, E. B., Rueck, C., Deckert, J. & Schumacher, J., 2017, In: European Neuropsychopharmacology. 27, S2, p. S217-S218Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., Mcmahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P. & 55 others, , 2021, In: Molecular Psychiatry. 26, p. 4179–4190 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deep-Learning-Based Classification of Rat OCT Images After Intravitreal Injection of ET-1 for Glaucoma Understanding
Fuentes-Hurtado, F., Morales, S., Mossi, J. M., Naranjo, V., Fedulov, V., Woldbye, David Paul Drucker, Klemp, Kristian, Torm, M. & Larsen, M., 2018, Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Proceedings. Yin, H., Novais, P., Camacho, D. & Tallón-Ballesteros, A. J. (eds.). Springer, p. 27-34 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 11314 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment.
Gonçalves, J., Baptista, S., Olesen, M., Malva, J., Woldbye, David Paul Drucker & Silva, A., 2012, In: Journal of Neurochemistry. 123, 6, p. 1041-53 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice
Gotzsche, C. R., Woldbye, David Paul Drucker, Hundahl, C. A. & Hay-Schmidt, Anders, 2022, In: Journal of Neuroscience Research. 100, 10, p. 1921-1932 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Gregersen, N., Dahl, H. A., Buttenschøn, H. N., Nyegaard, M., Hedemand, A., Als, T. D., Wang, August Gabriel, Joensen, S., Woldbye, David Paul Drucker, Koefoed, P., Kristensen, A. S., Kruse, T. A., Børglum, A. & Mors, O., 2012, In: European Journal of Human Genetics. 20, p. 84-90 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association between genes on chromosome 19p13.2 and panic disorder
Gregersen, N. O., Buttenschon, H. N., Hedemand, A., Nielsen, M. N., Dahl, H. A., Kristensen, A. S., Johansen, O., Woldbye, David Paul Drucker, Erhardt, A., Krusee, T. A., Wang, August Gabriel, Borglum, A. D. & Mors, O., Dec 2016, In: Psychiatric Genetics. 26, 6, p. 287-292Research output: Contribution to journal › Journal article › Research › peer-review
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The role of NPY in learning and memory
Gøtzsche, C. R. & Woldbye, David Paul Drucker, 1 Feb 2016, In: Neuropeptides. 55, p. 79-89 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.
Gøtzsche, C. R., Nikitidou, L., Sørensen, Andreas Toft, Olesen, M. V., Sørensen, G., Christiansen, S. H. O., Ängehagen, M., Woldbye, David Paul Drucker & Kokaia, M., 2012, In: Neurobiology of Disease. 45, p. 288-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway by electroconvulsive shock in the rat prefrontal cortex is not associated with TrkB neurotrophin receptor activation
Hansen, H. H., Rantamaki, T. P. J., Larsen, M. H., Woldbye, David Paul Drucker, Mikkelsen, J. D. & Castren, E. H., 2007, In: Cellular and Molecular Neurobiology. 27, 5, p. 585-594 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.Research output: Contribution to journal › Journal article › Research › peer-review
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Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways
Howe, A. S., Buttenschön, H. N., Bani-Fatemi, A., Maron, E., Otowa, T., Erhardt, A., Binder, E. B., Gregersen, N. O., Mors, O., Woldbye, D. P., Domschke, K., Reif, A., Shlik, J., Kks, S., Kawamura, Y., Miyashita, A., Kuwano, R., Tokunaga, K., Tanii, H., Smoller, J. W. & 3 others, , 2016, In: Molecular Psychiatry. 21, 5, p. 665-679 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis
Johnsen, Cecilie Hundahl, Kotzbeck, P., Burm, Hayley Beth, Christiansen, S. H., Pedersen, Lola Julie Torz, zmw799, zmw799, Madsen, M. P., Ratner, C., Serup, A. K., Thompson, J. J., Eichmann, T. O., Pers, Tune H, Woldbye, David Paul Drucker, Piomelli, D., Kiens, Bente, Zechner, R., Skov, Louise Julie & Holst, Birgitte, 2021, In: Molecular Metabolism. 47, 16 p., 101174.Research output: Contribution to journal › Journal article › Research › peer-review
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Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala
Jensen, M., Ratner, C., Rudenko, Olga, Christiansen, S. H., Skov, Louise Julie, Johnsen, Cecilie Hundahl, Woldbye, David Paul Drucker & Holst, Birgitte, 1 May 2016, In: International Journal of Neuropsychopharmacology. 19, 5, 12 p., pyv123.Research output: Contribution to journal › Journal article › Research › peer-review
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Current and Future Prospects for Gene Therapy for Rare Genetic Diseases Affecting the Brain and Spinal Cord
Jensen, T. L., Gøtzsche, C. R. & Woldbye, David Paul Drucker, 2021, In: Frontiers in Molecular Neuroscience. 14, 27 p., 695937.Research output: Contribution to journal › Review › Research › peer-review
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A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors
Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C-X., Fink-Jensen, A., Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A. & 8 others, , 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress.
K, H., Woldbye, David Paul Drucker & Wiborg, O., 2013, In: European Neuropsychopharmacology. 23, 12, p. 1789-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA receptor antisense epilepsy: histological changes following infusion of antisense oligodeoxynucleotide to GABAA receptor gamma 2 subunit into rat hippocampus
Karle, J., Woldbye, David Paul Drucker & Diemer, N. H., 2001, In: Neurological Research. 23, p. 39-46Research output: Contribution to journal › Journal article › Research › peer-review
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Antisense oligonucleotide to GABAA receptor 2 subunit induces limbic status epilepticus
Karle, J., Woldbye, David Paul Drucker, Elster, L., Diemer, N. H., Bolwig, T. G., Olsen, R. W. & Nielsen, M., 1998, In: Journal of Neuroscience Research. 54, p. 863-869Research output: Contribution to journal › Journal article › Research › peer-review
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Differential Expression of the β3 Subunit of Voltage-Gated Ca2+ Channel in Mesial Temporal Lobe Epilepsy
Kjær, C., Palasca, Oana, Barzaghi, G., Bak, Lasse Kristoffer, Durhuus, R. K. J., Jakobsen, Emil, Pedersen, Louise, Bartels, Emil Daniel, Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2023, In: Molecular Neurobiology. 60, p. 5755–5769Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptome analysis in patients with temporal lobe epilepsy
Kjær, C., Barzaghi, G., Bak, Lasse Kristoffer, Goetze, Jens P. , Yde, C. W., Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2019, In: Brain. 142, 10, p. 49-64 16 p., e55.Research output: Contribution to journal › Letter › Research › peer-review
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Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dog shakes
Klemp, K. & Woldbye, David Paul Drucker, 2001, In: Peptides. 22, 3, p. 523-527Research output: Contribution to journal › Journal article › Research › peer-review
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An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males
Koefoed, P., Hansen, T. V. O., Woldbye, D. P. D., Werge, T., Mors, O., Hansen, T., Jakobsen, K. D., Nordentoft, M., Wang, A., Bolwig, T. G., Rehfeld, J. F., Koefoed, P., Hansen, T. V. O., Woldbye, D. P. D., Werge, T., Mors, O., Hansen, T. F., Jakobsen, K. D., Nordentoft, M., Wang, A. & 2 others, , 2009, In: Acta Psychiatrica Scandinavica. 120, 4, p. 281-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Koefoed, P., Woldbye, D. P. D., Hansen, T. V. O., Eplov, L. F., Christiansen, S. H. O., Mors, O., Kessing, L. V., Werge, T., Kaipio, K., Pesonen, U., Fahmy, T., Mellerup, E. T., Jakobsen, K. D., Hansen, E. S., Knudsen, G. M., Bukh, J. D., Bock, C., Lindberg, C., Kristensen, A. S., Dam, H. & 6 others, , 23 Mar 2012, In: Acta Neuropsychiatrica. 24, 2, p. 81-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene variations in the cholecystokinin system in patients with panic disorder
Koefoed, P., Woldbye, David Paul Drucker, Hansen, T. O., Hansen, E. S., Knudsen, Gitte Moos, Bolwig, T. G., Rehfeld, Jens Frederik, Kofoed, P., Woldbye, D. P. D., Hansen, T. O., Hansen, E., Knudsen, G. M., Bolwig, T. G. & Rehfeld, J. F., 1 Apr 2010, In: Psychiatric Genetics. 20, 2, p. 59-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electroconvulsive shock (ECS) does not facilitate the development of kindling
Kragh, J., Bruhn, T., Woldbye, David Paul Drucker & Bolwig, T. G., 1993, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17, p. 985-989Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term effect of repeated electroconvulsive shock on exploratory behaviour and seizure susceptibility to lidocaine in rats
Kragh, J., Woldbye, David Paul Drucker & Bolwig, T. T., 1993, In: Journal of Psychiatric Research. 27, p. 89-94Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein
Kragh, J., Bolwig, T. G., Woldbye, David Paul Drucker & Jørgensen, O. S., 1993, In: Biological Psychiatry. 33, p. 794-800Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of activity-regulated cytoskeleton protein (Arc) mRNA after acute and chronic electroconvulsive stimulation in the rat.
Larsen, M. H., Olesen, M., Woldbye, David Paul Drucker, Hay-Schmidt, Anders, Hansen, H. H., Rønn, L. C. B. & Mikkelsen, J. D., 2005, In: Brain Research. 1064, 1-2, p. 161-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors
Ledri, L. N., Melin, E., Christiansen, S. H., Gøtzsche, C. R., Cifra, A., Woldbye, David Paul Drucker & Kokaia, M., Feb 2016, In: Neurobiology of Disease. 86, p. 52-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus
Ledri, M., Sørensen, Andreas Toft, Madsen, M. G., Christiansen, S. H., Ledri, L. N., Cifra, A., Bengzon, J., Lindberg, E., Pinborg, L. H., Jespersen, B., Gotzsche, C. R., Woldbye, David Paul Drucker, Andersson, M. & Kokaia, M., 1 Jul 2015, In: Journal of Neuroscience. 35, 26, p. 9622-9631 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial: Gene Therapy in the CNS – Progress and Prospects for Novel Therapies
Ledri, M., Sørensen, Andreas Toft, Kokaia, M., Woldbye, David Paul Drucker & Gøtzsche, C. R., 2021, In: Frontiers in Molecular Neuroscience. 14, 778134.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population
Lindberg, C., Koefoed, P., Hansen, E. S., Bolwig, T. G., Rehfeld, J. F., Mellerup, E., Jorgensen, O. S., Kessing, L. V., Werge, T., Haugbol, S., Wang, A. G. & Woldbye, David Paul Drucker, 2006, In: Acta Psychiatrica Scandinavica. 113, 1, p. 54-58 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kainic acid seizure suppression by neuropeptide Y is not correlated to immediate early gene mRNA levels in rats
Madsen, T. M., Woldbye, David Paul Drucker, Bolwig, T. G. & Mikkelsen, J. D., 1999, In: Neuroscience Letters. 271, p. 21-24Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro
Martins, J., Elvas, F., Brudzewsky, D., Martins, T., Kolomiets, B., Tralhão, P., Gøtzsche, C. R., Cavadas, C., Castelo-Branco, M., Woldbye, David Paul Drucker, Picaud, S., Santiago, A. R. & Ambrósio, A. F., 2015, In: A S N Neuro. 7, 4, p. 1-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures
Melin, Esbjörn Aage Anders, Andersson, M., Gøtzsche, C. R., Wickham, J., Huang, Y., Szczygiel, Julia Alicja, Boender, A., Christiansen, S. H., Pinborg, Lars Hageman, Woldbye, David Paul Drucker & Kokaia, M., 2023, In: Gene Therapy. 30, p. 649-658 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy
Melin, E., Nanobashvili, A., Avdic, U., Gøtzsche, C. R., Andersson, M., Woldbye, David Paul Drucker & Kokaia, M., 2019, In: Molecular Therapy - Methods and Clinical Development. 15, p. 179-193 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A dual-immunocytochemical method to localize c-fos protein in specific neurons based on their content of neuropeptides and connectivity.
Mikkelsen, J. D., Larsen, Jacob, Sørensen, G. G., Woldbye, David Paul Drucker, Bolwig, T. G., Hastings, M. H. & Ebling, F. J., 1994, In: Histochemistry. 101, 4, p. 245-51 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accumulated increase in neuropeptide Y and somatostatin gene expression of the rat in response to repeated electroconvulsive stimulation
Mikkelsen, J. D. & Woldbye, David Paul Drucker, 2006, In: Journal of Psychiatric Research. 40, 2, p. 153-159 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus
Mikkelsen, J. D., Woldbye, David Paul Drucker, Kragh, J., Larsen, P. J. & Bolwig, T. G., 1994, In: Molecular Brain Research. 23, p. 317-322Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway
Mikroulis, A., Waloschková, E., Bengzon, J., Woldbye, David Paul Drucker, Pinborg, Lars Hageman, Jespersen, B., Avila, A. S., Laszlo, Z. I., Henstridge, C., Ledri, M. & Kokaia, M., 2022, In: International Journal of Molecular Sciences. 23, 21, 12 p., 13190.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Retinal layer segmentation in rodent OCT images: Local intensity profiles & fully convolutional neural networks
Morales, S., Colomer, A., Mossi, J. M., del Amor, R., Woldbye, David Paul Drucker, Klemp, Kristian, Larsen, M. & Naranjo, V., 2021, In: Computer Methods and Programs in Biomedicine. 198, 105788.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism
Møller, Lisbeth L V, Sylow, Lykke, Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, Pia, Kiens, Bente, Woldbye, David Paul Drucker & Richter, Erik A., 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Are TMEM genes potential candidate genes for panic disorder?
NO, G., Buttenschøn, H. N., Hedemand, A., Dahl, H. A., Kristensen, A. S., B, C., Woldbye, David Paul Drucker, Koefoed, P., Erhardt, A., Kruse, T. A., Wang, August Gabriel, Børglum, A. & Mors, O., 2014, In: Psychiatric Genetics. 24, 1, p. 37-41 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuropeptide Y Y5 receptors suppress in vitro spontaneous epileptiform in the rat hippocampus
Nanobashvili, A., Woldbye, David Paul Drucker, Husum, H., Bolwig, T. G. & Kokaia, M., 2004, In: NeuroReport. 15, 2, p. 339-43Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine
Nielsen, D. D., Weikop, Pia, Sørensen, G., Woldbye, David Paul Drucker, Wörtwein, Gitta, Wess, J. & Fink-Jensen, Anders, 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genterapi til sygdomme i centralnervesystemet
Nissen, K., Klem, Louise Bomholt, Jeppesen, R., Axelsen, T. M., Christiansen, S. H., Gøtzsche, C. R., Pinborg, Lars Hageman, Jespersen, B., Klemp, Kristian & Woldbye, David Paul Drucker, 2020, In: Ugeskrift for Laeger. 182, 3, 6 p., V09190535.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic-like and proconvulsant effects in mice.
Olesen, M. V., Christiansen, S. H. O., Gøtzsche, C. R., Nikitidou, L., Kokaia, M. & Woldbye, David Paul Drucker, Feb 2012, In: Journal of Neuroscience Research. 90, 2, p. 498-507 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.
Olesen, M. V., Christiansen, S. H. O., Gøtzsche, C. R., Holst, Birgitte, Kokaia, M. & Woldbye, David Paul Drucker, 2012, In: Neuropeptides (Sheffield). 46, 2, p. 71-9Research output: Contribution to journal › Journal article › Research › peer-review
Differential plastic changes in synthesis and binding in the mouse somatostatin system after electroconvulsive stimulation
Olesen, M. V., Gøtzsche, C. R., Christiansen, S. H. & Woldbye, David Paul Drucker, 2018, In: Acta Neuropsychiatrica. 30, 4, p. 192-202 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The short/long polymorphism in the serotonin transporter gene promoter is not associated with panic disorder in a Scandinavian sample
Olesen, O. F., Bennike, B. G., Steno-Hansen, E., Koefoed, P., Woldbye, David Paul Drucker, Bolwig, T. G. & Mellerup, Erling Thyge, 2005, In: Psychiatric Genetics. Vol. 15, p. 159Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain
Olling, J. D., Ulrichsen, J., Christensen, D. Z., Woldbye, David Paul Drucker, Olling, J. D., Ulrichsen, J., Christensen, D. Z. & Woldbye, D. P. D., 2009, In: Journal of Neuroscience Research. 87, 10, p. 2386-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats
Olling, J. D., Ulrichsen, J., Haugbøl, S., Glenthøj, Birte Yding, Hemmingsen, R. & Woldbye, David Paul Drucker, 2007, In: Neuroscience Letters. 424, 3, p. 160-164 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression in the neuropeptide Y system during ethanol withdrawal kindling in rats
Olling, J. D., Ulrichsen, J., Correll, M., Woldbye, David Paul Drucker, Olling, J. D., Ulrichsen, J., Correll, M. & Woldbye, D. P. D., 1 Mar 2010, In: Alcoholism: Clinical and Experimental Research. 34, 3, p. 462-70 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo characterization of high Basal signaling from the ghrelin receptor
Petersen, P. S., Woldbye, David Paul Drucker, Madsen, A. N., Egerod, Kristoffer Lihme, Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G. & Holst, Birgitte, 2009, In: Endocrinology. 150, 11, p. 4920-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.
Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges
Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice
Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, David Paul Drucker, Fink-Jensen, Anders & Wörtwein, Gitta, 2010, In: Psychopharmacology. 207, 4, p. 547-58 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.
Schmidt, L. S., Thomsen, M., Weikop, Pia, Nielsen, D. D., Wess, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Fink-Jensen, Anders, 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus
Silva, A. P., Lourenco, J., Xapelli, S., Ferreira, R., Kristiansen, H., Woldbye, David Paul Drucker, Oliveira, C. R. & Malva, J. O., 2007, In: The FASEB Journal. 21, 3, p. 671-681 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
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