An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine
Research output: Contribution to journal › Journal article › Research › peer-review
The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.
|Number of pages||11|
|Publication status||Published - 2012|