Chuna Ram Choudhary
professor, group leader
Choudhary Group
Blegdamsvej 3, 2200 København N., 06 Bygning 6, Building: 06-6-14
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p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.Research output: Contribution to journal › Journal article › Research › peer-review
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lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1
Chakraborty, D., Paszkowski-Rogacz, M., Berger, N., Ding, L., Mircetic, J., Fu, J., Iesmantavicius, V., Choudhary, Chunaram, Anastassiadis, K., Stewart, A. F. & Buchholz, F., 12 Dec 2017, In: Cell Reports. 21, 11, p. 3012-3021 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage
Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, Brian Tate, Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chunaram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β
J D'Souza, R. C., Knittle, A. M., Nagaraj, N., van Dinther, M., Choudhary, Chunaram, Ten Dijke, P., Mann, Matthias & Sharma, K., Jul 2014, In: Science Signaling. 7, 335, p. rs5 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Weinert, Brian Tate, Narita, Takeo, Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chunaram, 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The growing landscape of lysine acetylation links metabolism and cell signalling
Choudhary, Chunaram, Weinert, Brian Tate, Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.Research output: Contribution to journal › Review › Research › peer-review
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The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity
Wild, T., Larsen, M. S. Y., Narita, Takeo, Schou, J., Nilsson, Jakob & Choudhary, Chunaram, 1 Mar 2016, In: Cell Reports. 14, 8, p. 1829-40 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation
Satpathy, S., Wagner, S. A., Beli, P., Gupta, R., Kristiansen, T. A., Malinova, D., Francavilla, C., Tolar, P., Bishop, G. A., Hostager, B. S. & Choudhary, Chunaram, 2015, In: Molecular Systems Biology. 11, 6, 810.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells
Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry
Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sequencing of the First Draft of the Human Acetylome
Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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STK3 is a therapeutic target for a subset of acute myeloid leukemias
Camgoz, A., Paszkowski-Rogacz, M., Satpathy, S., Wermke, M., Hamann, M. V., von Bonin, M., Choudhary, Chunaram, Knapp, S. & Buchholz, F., 2018, In: OncoTarget. 9, 39, p. 25458-25473 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes
Wagner, S. A., Satpathy, S., Beli, P. & Choudhary, Chunaram, 1 Sep 2016, In: E M B O Journal. 35, 17, p. 1868-1884Research output: Contribution to journal › Journal article › Research › peer-review
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SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control
Reddy, P. N. G., Serve, H., Brandts, C. H., Sargin, B., Choudhary, Chunaram, Müller-Tidow, C., Berdel, W. E., Stein, S. & Grez, M., 23 Aug 2012, In: Blood. 120, 8, p. 1691-1702 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SIK2 orchestrates actin-dependent host response upon Salmonella infection
Hahn, M., Covarrubias-Pinto, A., Herhaus, L., Satpathy, S., Klann, K., Boyle, K. B., Münch, C., Rajalingam, K., Randow, F., Choudhary, Chunaram & Dikic, I., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, 10 p., e2024144118.Research output: Contribution to journal › Journal article › Research › peer-review
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Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response
Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, Brian Tate, Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3
Sol, E. M., Wagner, S. A., Weinert, Brian Tate, Kumar, A., Kim, H., Deng, C. & Choudhary, Chunaram, 7 Dec 2012, In: PloS one. 7, 12, p. e50545Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic exploration of lysine acetylation signaling
Choudhary, Chunaram, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S25 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
Lundby, Alicia, Hansen, K. L., Weinert, Brian Tate, Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, Chunaram, Lundby, C. & Olsen, Jesper Velgaard, 30 Aug 2012, In: Cell Reports. 2, 2, p. 419-431 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, Brian Tate, Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation
Weinert, Brian Tate, Wagner, S. A., Horn, H., Henriksen, P., Liu, W. R., Olsen, Jesper Velgaard, Jensen, Lars Juhl & Choudhary, Chunaram, 2011, In: Science Signaling. 4, 183, p. ra48Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae
Henriksen, P., Wagner, S. A., Weinert, Brian Tate, Sharma, S., Bacinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, Michael & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics. 11, 11, p. 1510-1522 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Predicting post-translational lysine acetylation using support vector machines
Gnad, F., Ren, S., Choudhary, Chunaram, Cox, J. & Mann, M., 1 Jul 2010, In: Bioinformatics. 26, 13, p. 1666-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, Chunaram, Dötsch, V., Bumann, D. & Dikic, I., 8 Jul 2011, In: Science. 333, 6039, p. 228-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
Acosta-Alvear, D., Cho, M. Y., Wild, T., Buchholz, T. J., Lerner, A. G., Simakova, O., Hahn, J., Korde, N., Landgren, O., Maric, I., Choudhary, Chunaram, Walter, P., Weissman, J. S. & Kampmann, M., 1 Sep 2015, In: eLife. 4, p. 1-19 e08153.Research output: Contribution to journal › Journal article › Research › peer-review
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OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X., Choudhary, Chunaram, Luke, B., Krejci, L. & Lisby, Michael, 2016, In: Genes & Development. 30, 6, p. 700-717 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Weinert, Brian Tate, Schölz, C., Wagner, S. A., Iesmantavicius, V., Su, D., Daniel, J. A. & Choudhary, Chunaram, 29 Aug 2013, In: Cell Reports. 4, 4, p. 842-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)
Kindler, T., Breitenbuecher, F., Kasper, S., Estey, E., Giles, F., Feldman, E., Ehninger, G., Schiller, G., Klimek, V., Nimer, S. D., Gratwohl, A., Choudhary, Chunaram, Mueller-Tidow, C., Serve, H., Gschaidmeier, H., Cohen, P. S., Huber, C. & Fischer, T., 2005, In: Blood. 105, 1, p. 335-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
Khoa, L. T. P., Tsan, Y., Mao, F., Kremer, D. M., Sajjakulnukit, P., Zhang, L., Zhou, B., Tong, X., Bhanu, N. V., Choudhary, Chunaram, Garcia, B. A., Yin, L., Smith, G. D., Saunders, T. L., Bielas, S. L., Lyssiotis, C. A. & Dou, Y., 2020, In: Cell Stem Cell. 27, 3, p. 441-458.e10 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HDAC6 modulates myofibril stiffness and diastolic function of the heart
Lin, Y., Major, J. L., Liebner, Tim, Hourani, Z., Travers, J. G., Wennersten, S. A., Haefner, K. R., Cavasin, M. A., Wilson, C. E., Jeong, M. Y., Han, Y., Gotthardt, M., Ferguson, S. K., Ambardekar, A. V., Lam, M. P., Choudhary, Chunaram, Granzier, H. L., Woulfe, K. C. & McKinsey, T. A., 2022, In: Journal of Clinical Investigation. 132, 10, 14 p., e148333.Research output: Contribution to journal › Journal article › Research › peer-review
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HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y., Weng, C., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nghi Nguyen, Stupple, P. A., Peat, T. S., Zhang, M., De Silva, M., Carrasco-Pozo, C., Avery, V. M., Khoo, S., Dolezal, O., Dennis, M. L., Nuttall, S., Surjadi, R., Newman, J., Ren, B., Leaver, D. J., Sun, Y., Baell, J. B., Dovey, O., Vassiliou, G. S., Grebien, F., Dawson, S., Street, I. P., Monahan, B. J., Burns, C. J., Choudhary, Chunaram, Blewitt, M. E., Voss, A. K., Thomas, T. & Dawson, M. A., 2020, In: Nature. 577, 7789, p. 266-270Research output: Contribution to journal › Journal article › Research › peer-review
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Functions and mechanisms of non-histone protein acetylation
Narita, Takeo, Weinert, Brian Tate & Choudhary, Chunaram, 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Equilibrium between nascent and parental MCM proteins protects replicating genomes
Sedlackova, H., Rask, M., Gupta, R., Choudhary, Chunaram, Somyajit, K. & Lukas, Jiri, 2020, In: Nature. 587, p. 297-302 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
Narita, Takeo, Ito, S., Higashijima, Y., Chu, W. K., Neumann, K., Walter, Jonas, Satpathy, S., Liebner, Tim, Hamilton, W. B., Maskey, E., Prus, G., Shibata, M., Iesmantavicius, V., Brickman, Joshua Mark, Anastassiadis, K., Koseki, H. & Choudhary, Chunaram, 2021, In: Molecular Cell. 81, 10, p. 2166-2182.e6Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M., Chiang, G. G., Karukurichi, K., Langston, J. W., Weinert, Brian Tate, Choudhary, Chunaram, de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In: Nature. 550, 7674, p. 128-132 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
Nguyen, T. H., Andrejeva, D., Gupta, R., Choudhary, Chunaram, Hong, X., Eichhorn, P. J., Loya, Anand Chainsukh & Cohen, S. M., 29 Mar 2016, In: Cell Discovery. 2, 13 p., 16001.Research output: Contribution to journal › Journal article › Research › peer-review
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Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint
Wild, T., Budzowska, M., Hellmuth, S., Eibes, S., Karemore, Gopal, Barisic, Marin, Stemmann, O. & Choudhary, Chunaram, 2018, In: Cell Reports. 25, 9, 18 p., 2317-2328.e5.Research output: Contribution to journal › Journal article › Research › peer-review
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Decoding signalling networks by mass spectrometry-based proteomics
Choudhary, Chunaram & Mann, Matthias, 1 Jun 2010, In: Nature Reviews. Molecular Cell Biology. 11, 6, p. 427-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13781159
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
Published -
279
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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
Research output: Contribution to journal › Journal article › Research › peer-review
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256
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Research output: Contribution to journal › Journal article › Research › peer-review
Published