Birthe Brandt Kragelund
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
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(S)Pinning down protein interactions by NMR
Teilum, Kaare, Kunze, M. B. A., qrc243, qrc243 & Kragelund, Birthe Brandt, Mar 2017, In: Protein Science. 26, 3, p. 436-451 16 p.Research output: Contribution to journal › Review › Research › peer-review
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1H, 13C, and 15N assignments of un-myristoylated Ca2+-frequenin, a synaptic efficacy modulator
Kragelund, Birthe Brandt, Hauenschild, A., Carlström, G., Pongs, O. & Finn, B. E., Jan 2000, In: Journal of Biomolecular N M R. 16, 1, p. 85-6 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Far UV CD study of de novo designed antimicrobial coiled coils upon interaction with model membranes
Søndergaard, S. L., Kragelund, Birthe Brandt, Thulstrup, Peter Waaben, Brahm, Jesper, Siegumfeldt, Henrik, Frimodt-Møller, N. & Hansen, Paul Robert, 2010, In: Journal of Peptide Science. S2Research output: Contribution to journal › Conference abstract in journal › Research
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A combined computational and structural model of the full-length human prolactin receptor
Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.Research output: Contribution to journal › Journal article › Research › peer-review
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A context-dependent and disordered ubiquitin-binding motif
Dreier, Jesper Elmsted, Prestel, Andreas, Martins, J. M., Brøndum, S. S., Nielsen, Olaf, Garbers, Anna Engstrøm, Suga, H., Boomsma, Wouter, Rogers, Joseph Matthew, Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2022, In: Cellular and molecular life sciences : CMLS. 79, 9, 21 p., 484.Research output: Contribution to journal › Journal article › Research › peer-review
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A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template
Malik, L., Nygård, Jesper, Christensen, Niels Johan, Madsen, C. S., Rösner, Heike Ilona, Kragelund, Birthe Brandt, Høiberg-Nielsen, R., Streicher, W., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2015, In: ChemBioChem. 16, 13, p. 1905-1918 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Kristensen, Kristian Kølby, Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, Nicholas, Beigneux, A. P., Kragelund, Birthe Brandt, Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, Michael, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A glutamine-based single α-helix scaffold to target globular proteins
Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Mateos, B., Garcia-Cabau, C., Sanchez-Navarro, M., Topal, B., Biesaga, M., Staby, L., Kragelund, Birthe Brandt, Garcia, J., Millet, O., Orozco, M., Coles, M., Crehuet, R. & Salvatella, X., 2022, In: Nature Communications. 13, 18 p., 7073.Research output: Contribution to journal › Journal article › Research › peer-review
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A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation
Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, Birthe Brandt, Brooks, A. J. & Waters, M. J., 2018, In: Oncogene. 37, p. 489-501 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A highly compliant protein native state with a spontaneous-like mechanical unfolding pathway
Heiðarsson, P. O., Valpapuram, I., Camilloni, C., Imparato, A., Tiana, G., Poulsen, F. M., Kragelund, Birthe Brandt & Cecconi, C., 2012, In: Journal of the American Chemical Society. 134, 41, p. 17068-17075 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A loop of coagulation factor VIIa influencing macromolecular substrate specificity.
Bjelke, J. R., Persson, E., Rasmussen, H. B., Kragelund, Birthe Brandt & Olsen, O. H., 2006, In: FEBS Letters. 581, 1, p. 71-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A residue quartet in the extracellular domain of the prolactin receptor selectively controls mitogen-activated protein kinase signaling
Zhang, C., Nygaard, M., Haxholm, G. W., Boutillon, F., Bernadet, M., Hoos, S., England, P., Broutin, I., Kragelund, Birthe Brandt & Goffin, V., 2015, In: Journal of Biological Chemistry. 290, 19, p. 11890-11904 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast
Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA.
Faergeman, N. J., Wadum, M., Feddersen, S., Burton, M., Kragelund, Birthe Brandt & Knudsen, J., 2007, In: Molecular and Cellular Biochemistry. 299, 1-2, p. 55-65 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells.
Hansen, J. S., Færgeman, N. J., Kragelund, Birthe Brandt & Knudsen, J., 2008, In: Biochemical Journal. 410, 3, p. 463-472 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acyl-coenzyme A binding protein (ACBP)
Kragelund, Birthe Brandt, Knudsen, J. & Poulsen, F. M., 23 Nov 1999, In: B B A - Reviews on Cancer. 1441, 2-3, p. 150-61 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alginate Trisaccharide Binding Sites on the Surface of β-Lactoglobulin Identified by NMR Spectroscopy: Implications for Molecular Network Formation
Stender, E. G. P., Birch, J., Kjeldsen, C., Nielsen, L. D., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2019, In: ACS Omega. 4, 4, p. 6165-6174 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site
Wilkens, C., Andersen, S., Petersen, B. O., Li, A., Busse-Wicher, M., Birch, J., Cockburn, D., Nakai, H., Christensen, H. E. M., Kragelund, Birthe Brandt, Dupree, P., McCleary, B., Hindsgaul, O., Abou Hachem, M. & Svensson, B., 2016, In: Applied Microbiology and Biotechnology. 100, 14, p. 6265-6277 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An efficient method for estimating the hydrodynamic radius of disordered protein conformations
Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analyzing temperature-induced transitions in disordered proteins by NMR spectroscopy and secondary chemical shift analyses
Kjærgaard, M., Poulsen, F. M. & Kragelund, Birthe Brandt, 2012, Intrinsically disordered protein analysis: methods and experimental tools. Uversky, V. N. & Dunker, A. K. (eds.). Springer, Vol. 2. p. 249-256 8 p. (Methods in Molecular Biology, Vol. 896).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Application of Hydrogen Exchange Kinetics to Studies of Protein Folding
Teilum, Kaare, Kragelund, Birthe Brandt & Poulsen, F. M., 2005, Protein Folding Handbook. Buchner, J. & Kiefhaber, T. (eds.). Weinheim: Wiley-VCH, p. 634-672Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness
Olsen, Johan Gotthardt, Teilum, Kaare & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Binding Sites for Oligosaccharide Repeats from Lactic Acid Bacteria Exopolysaccharides on Bovine β-Lactoglobulin Identified by NMR Spectroscopy
Birch, J., Khan, S., Madsen, M., Kjeldsen, C., Møller, M. S., Stender, E. G. P., Peters, G. H. J., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2021, In: ACS Omega. 6, 13, p. 9039-9052 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.
Jensen, G. A., Andersen, O. M., Bonvin, A. M. J. J., Bjerrum-Bohr, I., Etzerodt, M., Thøgersen, H. C., O'Shea, Charlotte, Poulsen, F. M. & Kragelund, Birthe Brandt, 2006, In: Journal of Molecular Biology. 362, 4, p. 700-16 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CECAM workshop on intrinsically disordered proteins
Rösner, Heike Ilona, Papaleo, E., Haxholm, G. W., Best, R. B., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2014, In: Intrinsically Disordered Proteins. 2, 1, p. 1-5 5 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Characterization of Dynamic IDP Complexes by NMR Spectroscopy
Prestel, Andreas, Bugge, K., Staby, L., Hendus-Altenburger, R. & Kragelund, Birthe Brandt, 2018, Intrinsically Disordered Proteins. Rhoades, E. (ed.). Academic Press, p. 193-226 34 p. (Methods in Enzymology, Vol. 611).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs
Olsen, Johan Gotthardt, Prestel, Andreas, Kassem, N., Broendum, S. S., Hossain, Mohammad Shamim, Simonsen, Signe, Grysbæk, M., Mortensen, J., Rytkjær, L. L., Haxholm, G. W., Marabini, R., Holmberg, Christian, Carr, A. M., Crehuet, R., Nielsen, Olaf & Kragelund, Birthe Brandt, 2024, In: Nucleic acids symposium series. 52, 4, p. 2030–2044 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Choreography by Structural Disorder in Membrane Proteins
Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, suppl. 1, p. 12A 1 p., 65-Subg.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Class I Cytokine Receptors: Towards the Inside
Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Cold denaturation of the HIV-1 protease monomer
Rösner, Heike Ilona, Caldarini, M., Prestel, Andreas, Vanoni, M. A., Broglia, R. A., Aliverti, A., Tiana, G. & Kragelund, Birthe Brandt, 7 Feb 2017, In: Biochemistry. 56, 8, p. 1029-1032 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comment on “Intrinsic protein disorder uncouples affinity from binding specificity”
Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 4, 2 p., e4602.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Conformational entropy in molecular recognition of intrinsically disordered proteins
Skriver, Karen, Theisen, Frederik Friis & Kragelund, Birthe Brandt, 2023, In: Current Opinion in Structural Biology. 83, 8 p., 102697.Research output: Contribution to journal › Review › Research › peer-review
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Connecting the αα-hubs: same fold, disordered ligands, new functions
Staby, L., Bugge, K., Falbe-Hansen, R. G., Salladini, Edoardo, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Cell Communication and Signaling. 19, 5 p., 2.Research output: Contribution to journal › Letter › Research › peer-review
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Context Matters in Disorder Based Protein Communication
Kragelund, Birthe Brandt, Prestel, Andreas, Wickmann, N., Martins, J., Boomsma, Wouter, Staby, L., Hendus-Altenburger, R. & Skriver, Karen, 2020, In: Biophysical Journal. 118, 3, suppl. 1, p. 491A 2407-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
Broutin, I., Jomain, J., Tallet, E., Van Agthoven, J., Raynal, B., Hoos, S., Kragelund, Birthe Brandt, Kelly, P., Ducroix, A., England, P. & Goffin, V., 2010, In: Journal of Biological Chemistry. 285, 11, p. 8422-8433 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2
Bjarnason, S., McIvor, J. A. P., Prestel, Andreas, Demény, K. S., Bullerjahn, J. T., Kragelund, Birthe Brandt, Mercadante, D. & Heidarsson, P. O., 2024, In: Nature Communications. 15, 1, 16 p., 1445.Research output: Contribution to journal › Journal article › Research › peer-review
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DSS1/Sem1, a multifunctional and intrinsically disordered protein
Kragelund, Birthe Brandt, Schenstrøm, S. M., Rebula, C. A., Panse, V. G. & Hartmann-Petersen, Rasmus, 2016, In: Trends in Biochemical Sciences. 41, 5, p. 446-459 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties
Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.Research output: Contribution to journal › Journal article › Research › peer-review
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Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication
Fleck, O., Fahnøe, Ulrik, Løvschal, K. V., Gasasira, M. U., Marinova, I. N., Kragelund, Birthe Brandt, Carr, A. M., Hartsuiker, E., Holmberg, Christian & Nielsen, Olaf, 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding.
Hansen, M. J. K., Olsen, Johan Gotthardt, Bernichtein, S., O'Shea, Charlotte, Sigurskjold, B. W., Goffin, V. & Kragelund, Birthe Brandt, 2011, In: Journal of Molecular Recognition. 24, 4, p. 533-547 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles
Teilum, Kaare, Thormann, T., Caterer, N. R., Poulsen, H. I., Jensen, P. H., Knudsen, J., Kragelund, Birthe Brandt & Poulsen, F. M., 2005, In: Proteins - Structure Function and Bioinformatics. 59, 1, p. 80-90Research output: Contribution to journal › Journal article › Research › peer-review
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Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1
Heiðarsson, P. O., Naqvi, M. M., Otazo, M. R., Mossa, A., Kragelund, Birthe Brandt & Cecconi, C., 2014, In: Proceedings of the National Academy of Sciences U.S.A.. 111, 36, p. 13069-13074 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry
Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior
Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065Research output: Contribution to journal › Journal article › Research › peer-review
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Dss1 is a 26S proteasome ubiquitin receptor
Paraskevopoulos, K., Kriegenburg, F., Tatham, M. H., Rösner, Heike Ilona, Medina, B., Larsen, I. B., Brandstrup, R., Hardwick, K. G., Hay, R. T., Kragelund, Birthe Brandt, Hartmann-Petersen, Rasmus & Gordon, C., 2014, In: Molecular Cell. 56, 3, p. 453-461 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation
Sjøgaard-Frich, Lise Margrethe, Prestel, Andreas, Pedersen, E. S., Severin, M., Kristensen, Kristian Kølby, Olsen, Johan Gotthardt, Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2021, In: eLife. 10, 29 p., e60889.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions
Cragnell, C., Staby, L., Lenton, S., Kragelund, Birthe Brandt & Skepö, M., 2019, In: Biomolecules. 9, 5, 20 p., 168.Research output: Contribution to journal › Journal article › Research › peer-review
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Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing
Teilum, Kaare, Maki, K., Kragelund, Birthe Brandt, Poulsen, F. M. & Roder, H., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, 15, p. 9807-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding Protein
Sonar, P., Bellucci, L., Mossa, A., Heidarsson, P. O., Kragelund, Birthe Brandt & Cecconi, C., 2020, In: Biophysical Journal. 119, 9, p. 1821-1832 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer
Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.Research output: Contribution to journal › Journal article › Research › peer-review
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Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa.
Larsen, K. S., Østergaard, H., Bjelke, J. R., Olsen, O. H., Rasmussen, H. B., Christensen, L., Kragelund, Birthe Brandt & Stennicke, H. R., 2007, In: Biochemical Journal. 405, 3, p. 429-38 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Eukaryotic transcription factors: paradigms of protein intrinsic disorder
Staby, L., O'Shea, Charlotte, Willemoës, Martin, Theisen, F., Kragelund, Birthe Brandt & Skriver, Karen, 12 Jul 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.Research output: Contribution to journal › Review › Research › peer-review
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Evolution of A bHLH Interaction Motif
Millard, P. S., Kragelund, Birthe Brandt & Burow, Meike, 2021, In: International Journal of Molecular Sciences. 22, 1, 18 p., 447.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome
Christensen, L. F., Staby, L., Bugge, K., O'Shea, Charlotte, Kragelund, Birthe Brandt & Skriver, Karen, 2019, In: Scientific Reports. 9, 15 p., 18927.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime
Elkjær, Steffie Martina H, Due, Amanda Duncan, Christensen, L. F., Theisen, Frederik Friis, Staby, L., Kragelund, Birthe Brandt & Skriver, Karen, 2023, In: Communications Biology . 6, 11 p., 63.Research output: Contribution to journal › Journal article › Research › peer-review
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Expanded Interactome of the Intrinsically Disordered Protein Dss1
Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, Birthe Brandt & Hartmann-Petersen, Rasmus, 23 Oct 2018, In: Cell Reports. 25, 4, p. 862-870Research output: Contribution to journal › Journal article › Research › peer-review
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Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy
Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring the Protein-Membrane Interactions on the Intracellular Side of PRLR
Araya-Secchi, R., Bugge, K., Kragelund, Birthe Brandt & Arleth, Lise, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl.1, p. 57A-57A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Exploring the minimally frustrated energy landscape of unfolded ACBP
Ozenne, V., Noel, J. K., Heiðarsson, P. O., Brander, S., Poulsen, F. M., Jensen, M. R., Kragelund, Birthe Brandt, Blackledge, M. & Danielsson, J. A., 2014, In: Journal of Molecular Biology. 426, 3, p. 722-734 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme disorder in an ultrahigh-affinity protein complex
Borgia, A., Borgia, M. B., Bugge, K. Ø., Kissling, V. M., Heidarsson, P. O., Fernandes, Catarina, Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., Kragelund, Birthe Brandt, Best, R. B. & Schuler, B., 1 Mar 2018, In: Nature. 555, p. 61-66 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fast and one-step folding of closely and distantly related homologous proteins of a four-helix bundle family
Kragelund, Birthe Brandt, Højrup, P., Jensen, M. S., Schjerling, C. K., Juul, E., Knudsen, J. & Poulsen, F., 1996, In: J. Mol. Biol.. 256, p. 187-200Research output: Contribution to journal › Journal article › Research › peer-review
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Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution: Flanking disorder tunes the RCD1-RST ensemble
Staby, L., Due, Amanda Duncan, Kunze, M. B. A., Jørgensen, M. L. M., Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 24, 15 p., 167320.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescently labelled bovine acyl-CoA-binding protein acting as an acyl-CoA sensor: interaction with CoA and acyl-CoA esters and its use in measuring free acyl-CoA esters and non-esterified fatty acids
Wadum, M. C., Villadsen, J. K., Feddersen, S., Moller, R. S., Neergaard, T. B., Kragelund, Birthe Brandt, Hojrup, P., Faergeman, N. J. & Knudsen, J., 2002, In: Biochemical Journal. 365, p. 165-172 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Folding of a four-helix bundle. Studies of acyl-coenzyme A binding protein
Kragelund, Birthe Brandt, Robinson, C. R., Knudsen, J., Dobson, C. M. & Poulsen, F., 1995, In: Biochemistry. 34, p. 7217-7224Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP
Teilum, Kaare, Kragelund, Birthe Brandt, Knudsen, J. & Poulsen, F. M., 2000, In: Journal of Molecular Biology. 301, 5, p. 1307-14 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional aspects of protein flexibility
Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2009, In: Cellular and Molecular Life Sciences. 66, 14, p. 2231-47 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities
Guo, Y., Kragelund, Birthe Brandt, White, M. F. & Peng, Xu, 2015, In: Journal of Molecular Biology. 427, 12, p. 2179-2191 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functions of intrinsic disorder in transmembrane proteins
Kjærgaard, M. & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin
Dagil, Robert, O'Shea, Charlotte, Nykjær, A., Bonvin, A. M. J. J. & Kragelund, Birthe Brandt, 2013, In: The Journal of Biological Chemistry. 288, 6, p. 4424-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Globular and disordered-the non-identical twins in protein-protein interactions
Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2015, In: Frontiers in Bioscience. 2, 6 p., 40.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How phosphorylation impacts intrinsically disordered proteins and their function
Newcombe, Estella Anne, Delaforge, Elise, Hartmann-Petersen, Rasmus, Skriver, Karen & Kragelund, Birthe Brandt, 2022, In: Essays in Biochemistry. 66, 7, p. 901-913 13 p.Research output: Contribution to journal › Review › Research › peer-review
Hydrophobic core substitutions in calbindin D9k: effects on Ca2+ binding and dissociation
Kragelund, Birthe Brandt, Jönsson, M., Bifulco, G., Chazin, W. J., Nilsson, H., Finn, B. E. & Linse, S., 23 Jun 1998, In: Biochemistry. 37, 25, p. 8926-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydroxylation of the Herbicide Isoproturon by Fungi Isolated from Agricultural soil
Rønhede, S., Jensen, B., Rosendahl, Søren, Kragelund, Birthe Brandt, Juhler, R. K. & Aamand, J., 2005, In: Applied and Environmental Microbiology. 71, 12, p. 7927-7932Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions—Insights from transcription factors
Millard, P. S., Bugge, K., Marabini, R., Boomsma, Wouter, Burow, Meike & Kragelund, Birthe Brandt, 2020, In: Protein Science. 29, 1, p. 169-183 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions by Disorder - A Matter of Context
Bugge, K., Brakti, Inna, Fernandes, Catarina, Dreier, J. E., Lundsgaard, J. E., Olsen, Johan Gotthardt, Skriver, Karen & Kragelund, Birthe Brandt, 2020, In: Frontiers in Molecular Biosciences. 7, 16 p., 110.Research output: Contribution to journal › Review › Research › peer-review
- Published
Intrinsically Disordered Proteins: Methods and Protocols
Skriver, Karen (ed.) & Kragelund, Birthe Brandt (ed.), 2020, New York: Humana Press. 777 p. (Methods in Molecular Biology, Vol. 2141).Research output: Book/Report › Book › Research › peer-review
- Published
Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching
Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, , 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes
Haxholm, G. W., Nikolajsen, L. F., Olsen, Johan Gotthardt, Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, Stine Helene Falsig, Brooks, A. J., Waters, M. J. & Kragelund, Birthe Brandt, 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Local perturbations by ligand binding on hydrogen exchange kinetics in a four-helix bundle protein, acyl-coenzyme A binding protein (ACBP)
Kragelund, Birthe Brandt, Knudsen, J. & Poulsen, F., 1995, In: J. Mol. Biol.. 250, p. 695-706Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the lifetimes of local opening events in a native state protein
Kragelund, Birthe Brandt, Heinemann, B., Knudsen, J. & Poulsen, F., 1998, In: Protein Sci.. 7, p. 2237-2248Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity
Bjelke, J. R., Olsen, O. H., Fodje, M., Svensson, L. A., Bang, S., Bolt, G., Kragelund, Birthe Brandt & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 38, p. 25863-70 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturonand linuron produced by the soil fungus Mortierella sp.
Badawi, N., Rønhede, S., Olsson, S., Kragelund, Birthe Brandt, Johnsen, A. H., Jacobsen, O. S. & Aamand, J., 2009, In: Environmental Pollution. 157, 10, p. 2806-2812 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modeling of flexible membrane-bound biomolecular complexes for solution small-angle scattering
Barclay, A., Kragelund, Birthe Brandt, Arleth, Lise & Pedersen, Martin Cramer, Apr 2023, In: Journal of Colloid and Interface Science. 635, p. 611-621 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular insights into alginate beta-lactoglobulin A multivalencies: The foundation for their amorphous aggregates and coacervation
Madsen, M., Prestel, Andreas, Madland, E., Westh, P., Tondervik, A., Sletta, H., Peters, G. H. J., Aachmann, F. L. L., Kragelund, Birthe Brandt & Svensson, B., 2023, In: Protein Science. 32, 2, 15 p., 4556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants
Theisen, Frederik Friis, Prestel, Andreas, Elkjær, Steffie Martina H, Leurs, Y. H. A., Morffy, N., Strader, L. C., O'Shea, Charlotte, Teilum, Kaare, Kragelund, Birthe Brandt & Skriver, Karen, 2024, In: Nature Communications. 15, 1, 13 p., 592.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monomeric α-synuclein activates the plasma membrane calcium pump
Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water
Kampmeyer, Caroline, Johansen, Jens Vilstrup, Holmberg, Christian, Karlson, M., Gersing, S. K., Nunes Bordallo, Heloisa, Kragelund, Birthe Brandt, Lerche, M. H., Jourdain, I., Winther, Jakob R. & Hartmann-Petersen, Rasmus, 2020, In: A C S Synthetic Biology. 9, 4, p. 733-748 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction
Weidner, P., Saar, D., Söhn, M., Schroeder, T., Yu, Y., Zöllner, F. G., Ponelies, N., Zhou, X., Zwicky, A., Rohrbacher, F. N., Pattabiraman, V. R., Tanriver, M., Bauer, A., Ahmed, H., Ametamey, S. M., Riffel, P., Seger, R., Bode, J. W., Wade, R. C., Ebert, M. P. A. & 2 others, , 2024, In: Cancer Letters. 588, 19 p., 216783.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New horizons for lipoprotein receptors: communication by β-propellers
Andersen, O. M., Dagil, Robert & Kragelund, Birthe Brandt, 2013, In: Journal of Lipid Research. 54, p. 2763-2774 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins
Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.Research output: Contribution to journal › Review › Research › peer-review
- Published
On the specificity of protein-protein interactions in the context of disorder
Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2021, In: Biochemical Journal. 478, 11, p. 2035-2050 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Orchestration of signaling by structural disorder in class 1 cytokine receptors
Seiffert, P., Bugge, K., Nygaard, M., Haxholm, G. W., Martinsen, J. H., Pedersen, M. N., Arleth, Lise, Boomsma, Wouter & Kragelund, Birthe Brandt, 24 Aug 2020, In: Cell Communication and Signaling. 18, 1, 30 p., 132.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Order and disorder - An integrative structure of the full-length human growth hormone receptor
Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Order by disorder in plant signaling
Kragelund, Birthe Brandt, Jensen, M. K. & Skriver, Karen, 2012, In: Trends in Plant Science. 17, 11, p. 625-632 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PPARγ antagonists induce aromatase transcription in adipose tissue cultures
Ardenkjær-Skinnerup, J., Saar, Daniel, Petersen, Patricia Stephanie S, Pedersen, M., Svingen, T., Kragelund, Birthe Brandt, Hadrup, N., Ravn-Haren, G., Emanuelli, Brice, Brown, K. A. & Vogel, U., 2024, In: Biochemical Pharmacology. 222, 13 p., 116095.Research output: Contribution to journal › Journal article › Research › peer-review
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Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2
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Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing
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Dss1 is a 26S proteasome ubiquitin receptor
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