Adnan Halim

Adnan Halim

Associate Professor


  1. 2024
  2. Published

    Molecular-level architecture of Chlamydomonas reinhardtii’s glycoprotein-rich cell wall

    Poulhazan, A., Arnold, A. A., Mentink-Vigier, F., Muszyński, A., Azadi, P., Halim, Adnan, Vakhrushev, Sergey, Joshi, Hiren Jitendra, Wang, T., Warschawski, D. E. & Marcotte, I., 2024, In: Nature Communications. 15, 1, 15 p., 986.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2023
  4. Published

    Identification of global inhibitors of cellular glycosylation

    Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, Clausen, Henrik & Narimatsu, Yoshiki, 2023, In: Nature Communications. 14, 1, 19 p., 948.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase

    Larsen, I. S. B., Povolo, Lorenzo, Zhou, L., Tian, W., Mygind, Kasper Johansen, Hintze, John, Jiang, C., Hartill, V., Prescott, K., Johnson, C. A., Mullegama, S. V., McConkie-Rosell, A., McDonald, M., Hansen, Lars, Vakhrushev, Sergey, Schjoldager, Katrine Ter-Borch Gram, Clausen, Henrik, Worzfeld, T., Joshi, Hiren Jitendra & Halim, Adnan, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 21, p. e2302584120

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2022
  7. Published

    A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides

    Hütte, H. J., Tiemann, B., Shcherbakova, A., Grote, V., Hoffmann, M., Povolo, Lorenzo, Lommel, M., Strahl, S., Vakhrushev, Sergey, Rapp, E., Buettner, F. F. R., Halim, Adnan, Imberty, A. & Bakker, H., 2022, In: Analytical Chemistry. 94, 20, p. 7329–7338

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glycoproteomics

    Bagdonaite, Ieva , Malaker, S. A., Polasky, D. A., Riley, N. M., Schjoldager, Katrine Ter-Borch Gram, Vakhrushev, Sergey, Halim, Adnan, Aoki-Kinoshita, K. F., Nesvizhskii, A. I., Bertozzi, C. R., Wandall, Hans H., Parker, B. L., Thaysen-Andersen, M. & Scott, N. E., 2022, In: Nature Reviews Methods Primers. 2, 1, 29 p., 48.

    Research output: Contribution to journalReviewResearchpeer-review

  9. 2021
  10. Published

    Display of the human mucinome with defined O-glycans by gene engineered cells

    Nason, R., Büll, C., Konstantinidi, A., Sun, L., Ye, Z., Halim, A., Du, W., Sørensen, D. M., Durbesson, F., Furukawa, S., Mandel, U., Joshi, H. J., Dworkin, L. A., Hansen, L., David, L., Iverson, T. M., Bensing, B. A., Sullam, P. M., Varki, A., Vries, E. D. & 6 others, de Haan, C. A. M., Vincentelli, R., Henrissat, B., Vakhrushev, Sergey, Clausen, Henrik & Narimatsu, Yoshiki, 2021, In: Nature Communications. 12, 1, 16 p., 4070.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes

    Akan, I., Halim, Adnan, Vakhrushev, Sergey, Clausen, Henrik & Hanover, J. A., 2021, In: Cells. 10, 5, 13 p., 1026.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR

    Tajadura-Ortega, V., Gambardella, G., Skinner, A., Halim, Adnan, Van Coillie, Julie, Schjoldager, Katrine Ter-Borch Gram, Beatson, R., Graham, R., Achkova, D., Taylor-Papadimitriou, J., Ciccarelli, F. D. & Burchell, J. M., 2021, In: Glycobiology. 31, 3, p. 200–210

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2020
  14. Published

    Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation

    Graham, J. B., Sunryd, J. C., Mathavan, K., Weir, E., Larsen, I. S. B., Halim, Adnan, Clausen, Henrik, Cousin, H., Alfandari, D. & Hebert, D. N., 2020, In: Molecular Biology of the Cell. 31, 3, p. 167-183 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2019
  16. Published

    A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody

    Steentoft, C., Fuhrmann, M., Battisti, F., Van Coillie, Julie, Madsen, Thomas Daugbjerg, Campos, D., Halim, Adnan, Vakhrushev, Sergey, Joshi, Hiren Jitendra, Schreiber, H., Mandel, Ulla & Narimatsu, Yoshiki, 2019, In: Glycobiology. 29, 4, p. 307-319 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics

    Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Schjoldager, Katrine Ter-Borch Gram, Hintze, John, Halim, Adnan, Steentoft, C., Nason, R., Mandel, Ulla, Bennett, Eric Paul, Clausen, Henrik & Vakhrushev, Sergey, 2019, In: Molecular and Cellular Proteomics. 18, 7, p. 1396-1409

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Multiple distinct O-Mannosylation pathways in eukaryotes

    Larsen, I. S. B., Narimatsu, Yoshiki, Clausen, Henrik, Joshi, Hiren Jitendra & Halim, Adnan, 2019, In: Current Opinion in Structural Biology. 56, p. 171-178 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  19. 2018
  20. Published

    GlycoDomainViewer: A bioinformatics tool for contextual exploration of glycoproteomes

    Joshi, Hiren Jitendra, Jørgensen, A., Schjoldager, Katrine Ter-Borch Gram, Halim, Adnan, Dworkin, L. A., Steentoft, C., Wandall, Hans H., Clausen, Henrik & Vakhrushev, Sergey, 1 Mar 2018, In: Glycobiology. 28, 3, p. 131-136 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane

    Lackman, J. J., Goth, C. K., Halim, Adnan, Vakhrushev, Sergey, Clausen, Henrik & Petäjä-Repo, U. E., Jan 2018, In: Cellular Signalling. 42, p. 184-193 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    SnapShot: O-Glycosylation Pathways across Kingdoms

    Joshi, Hiren Jitendra, Narimatsu, Yoshiki, Schjoldager, Katrine Ter-Borch Gram, Tytgat, H. L. P., Aebi, M., Clausen, Henrik & Halim, Adnan, Jan 2018, In: Cell. 172, 3, p. 632–632.e2

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Genetically engineered cell factories produce glycoengineered vaccines that target antigen-presenting cells and reduce antigen-specific T-cell reactivity

    Mathiesen, C. B. K., Carlsson, M. C., Brand, S., Möller, S. R., Idorn, M., Straten, P. T., Pedersen, Anders Elm, Dabelsteen, Sally, Halim, Adnan, Würtzen, P. A., Brimnes, J., Ipsen, H., Petersen, Bent L & Wandall, Hans H., 2018, In: Journal of Allergy and Clinical Immunology. 142, 6, p. 1983-1987

    Research output: Contribution to journalLetterResearchpeer-review

  24. 2017
  25. Published

    Microbial glycoproteomics

    Halim, Adnan & Anonsen, J. H., Jun 2017, In: Current Opinion in Structural Biology. 44, p. 143-150 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins

    Larsen, I. S. B., Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Siukstaite, L., Harrison, O. J., Brasch, J., Goodman, K. M., Hansen, Lars, Shapiro, L., Honig, B., Vakhrushev, Sergey, Clausen, Henrik & Halim, Adnan, 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11163-11168 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Mammalian O-mannosylation of Cadherins and Plexins is Independent of Protein O-mannosyltransferase 1 and 2

    Larsen, I. S. B., Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Yang, Zhang, Harrison, O. J., Brasch, J., Shapiro, L., Honig, B., Vakhrushev, Sergey, Clausen, Henrik & Halim, Adnan, 2017, In: The Journal of Biological Chemistry. 292, p. 11586-11598

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity

    El Qaidi, S., Chen, K., Halim, Adnan, Siukstaite, L., Rueter, C., Hurtado-Guerrero, R., Clausen, Henrik & Hardwidge, P. R., 2017, In: The Journal of Biological Chemistry. 292, p. 11423-11430

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2016
  31. Published

    Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae

    Neubert, P., Halim, Adnan, Zauser, M., Essig, A., Joshi, Hiren Jitendra, Zatorska, E., Larsen, I. S. B., Loibl, M., Castells-Ballester, J., Aebi, M., Clausen, Henrik & Strahl, S., Apr 2016, In: Molecular and Cellular Proteomics. 15, 4, p. 1323-37 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2015
  33. Published

    A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

    Goth, C. K., Halim, Adnan, Khetarpal, S. A., Rader, D. J., Clausen, Henrik & Schjoldager, Katrine Ter-Borch Gram, 24 Nov 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. 14623-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Shaping Glycans by DNA Scissors: Turning Glycosciences Into Lego Toying

    Clausen, Henrik, Schjoldager, Katrine Ter-Borch Gram, Yang, Zhang, Steentoft, C., Halim, Adnan, Bennett, E. & Vakhrushev, Sergey, Nov 2015, In: Glycobiology. 25, 11, p. 1233-1233 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  35. Published

    Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions

    Rubinstein, R., Thu, C. A., Goodman, K. M., Wolcott, H. N., Bahna, F., Mannepalli, S., Ahlsen, G., Chevee, M., Halim, Adnan, Clausen, Henrik, Maniatis, T., Shapiro, L. & Honig, B., 22 Oct 2015, In: Cell. 163, 3, p. 629-42 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Engineered CHO cells for production of diverse, homogeneous glycoproteins

    Yang, Zhang, Wang, S., Halim, Adnan, Schulz, M. A., Frödin, Morten, Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, Sergey, Bennett, Eric Paul, Wandall, Hans H. & Clausen, Henrik, 20 Jul 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner

    Nordén, R., Halim, Adnan, Nyström, K., Bennett, Eric Paul, Mandel, Ulla, Olofsson, S., Nilsson, J. & Larson, G., 20 Feb 2015, In: The Journal of Biological Chemistry. 290, 8, p. 5078-91 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Advances in mass spectrometry driven O-glycoproteomics

    Levery, S. B., Steentoft, C., Halim, Adnan, Narimatsu, Yoshiki, Clausen, Henrik & Vakhrushev, Sergey, Jan 2015, In: B B A - Reviews on Cancer. 1850, 1, p. 33-42 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Complex Regulation of Prolyl-4-Hydroxylases Impacts Root Hair Expansion

    Velasquez, S. M., Ricardi, M. M., Poulsen, C. P., Oikawa, A., Dilokpimol, A., Halim, A., Mangano, S., Denita Juarez, S. P., Marzol, E., Salgado Salter, J. D., Dorosz, J. G., Borassi, C., Möller, S. R., Buono, R., Ohsawa, Y., Matsuoka, K., Otegui, M. S., Scheller, H. V., Geshi, N., Petersen, B. L. & 2 others, Iusem, N. D. & Estevez, J. M., 2015, In: Molecular Plant. 8, 5, p. 734-46 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast

    Halim, Adnan, Larsen, I. S. B., Neubert, P., Joshi, Hiren Jitendra, Petersen, Bent L, Vakhrushev, Sergey, Strahl, S. & Clausen, Henrik, 2015, In: Glycobiology. 25, 11, p. 1235 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  41. Published

    Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast

    Halim, Adnan, Larsen, I. S. B., Neubert, P., Joshi, Hiren Jitendra, Petersen, Bent L, Vakhrushev, Sergey, Strahl, S. & Clausen, Henrik, 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. 15648-15653 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Glycoproteomic analysis of seven major allergenic proteins reveals novel post-translational modifications

    Halim, Adnan, Carlsson, M. C., Mathiesen, C. B. K., Brand, S., Möller, S. R., Olsen, C. E., Vakhrushev, Sergey, Brimnes, J., Wurtzen, P. A., Ipsen, H., Petersen, Bent L & Wandall, Hans H., 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 191-204 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2014
  44. Assignment of Saccharide Identities through analysis of oxonium ion fragmentation profiles in LC-MS/MS of glycopeptides

    Halim, Adnan, Westerlind, U., Pett, C., Schorlemer, M., Rüetschi, U., Brinkmalm, G., Sihlbom, C., Lengqvist, J., Larson, G. & Nilsson, J., 5 Dec 2014, In: Journal of Proteome Research. 13, 12, p. 6024-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The GalNAc-type O-glycoproteome of CHO cells characterized by the SimpleCell strategy

    Yang, Zhang, Halim, Adnan, Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Steentoft, C., Schjoldager, Katrine Ter-Borch Gram, Schulz, M. A., Sealover, N. R., Kayser, K. J., Bennett, Eric Paul, Levery, S. B., Vakhrushev, Sergey & Clausen, Henrik, Dec 2014, In: Molecular & Cellular Proteomics. 13, 12, p. 3224-3235 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Characterization of Binding Epitopes of CA125 Monoclonal Antibodies

    da Silva, L. P. M., Narimatsu, Yoshiki, Halim, Adnan, Vieira Campos, D. A., Yang, Zhang, Tarp, M. P. A., Pereira, P. J. B., Mandel, Ulla, Bennett, Eric Paul, Vakhrushev, Sergey, Levery, S. B., David, L. & Clausen, Henrik, 3 Jul 2014, In: Journal of Proteome Research. 13, 7, p. 3349-59 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions

    Pedersen, N. B., Wang, S., Narimatsu, Yoshiki, Yang, Zhang, Halim, Adnan, Schjoldager, Katrine Ter-Borch Gram, Madsen, Thomas Daugbjerg, Seidah, N. G., Bennett, Eric Paul, Levery, S. B. & Clausen, Henrik, 20 Jun 2014, In: The Journal of Biological Chemistry. 289, 25, p. 17312-17324 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. LC-MS/MS characterization of combined glycogenin-1 and glycogenin-2 enzymatic activities reveals their self-glucosylation preferences

    Nilsson, J., Halim, Adnan, Larsson, E., Moslemi, A., Oldfors, A., Larson, G. & Nilsson, J., Feb 2014, In: B B A - Reviews on Cancer. 1844, 2, p. 398-405 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2013
  50. Published

    Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins

    Vester-Christensen, M. B., Halim, Adnan, Joshi, Hiren Jitendra, Steentoft, C., Bennett, Eric Paul, Levery, S. B., Vakhrushev, Sergey & Clausen, Henrik, 24 Dec 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 21018-23 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 40443472