Adnan Halim
Associate Professor
Glycomics Program
Blegdamsvej 3, 2200 København N.
Member of:
- 2024
- Published
Molecular-level architecture of Chlamydomonas reinhardtii’s glycoprotein-rich cell wall
Poulhazan, A., Arnold, A. A., Mentink-Vigier, F., Muszyński, A., Azadi, P., Halim, Adnan, Vakhrushev, Sergey, Joshi, Hiren Jitendra, Wang, T., Warschawski, D. E. & Marcotte, I., 2024, In: Nature Communications. 15, 1, 15 p., 986.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Identification of global inhibitors of cellular glycosylation
Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, , 2023, In: Nature Communications. 14, 1, 19 p., 948.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase
Larsen, I. S. B., Povolo, Lorenzo, Zhou, L., Tian, W., Mygind, Kasper Johansen, Hintze, John, Jiang, C., Hartill, V., Prescott, K., Johnson, C. A., Mullegama, S. V., McConkie-Rosell, A., McDonald, M., Hansen, Lars, Vakhrushev, Sergey, Schjoldager, Katrine Ter-Borch Gram, Clausen, Henrik, Worzfeld, T., Joshi, Hiren Jitendra & Halim, Adnan, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 21, p. e2302584120Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides
Hütte, H. J., Tiemann, B., Shcherbakova, A., Grote, V., Hoffmann, M., Povolo, Lorenzo, Lommel, M., Strahl, S., Vakhrushev, Sergey, Rapp, E., Buettner, F. F. R., Halim, Adnan, Imberty, A. & Bakker, H., 2022, In: Analytical Chemistry. 94, 20, p. 7329–7338Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycoproteomics
Bagdonaite, Ieva , Malaker, S. A., Polasky, D. A., Riley, N. M., Schjoldager, Katrine Ter-Borch Gram, Vakhrushev, Sergey, Halim, Adnan, Aoki-Kinoshita, K. F., Nesvizhskii, A. I., Bertozzi, C. R., Wandall, Hans H., Parker, B. L., Thaysen-Andersen, M. & Scott, N. E., 2022, In: Nature Reviews Methods Primers. 2, 1, 29 p., 48.Research output: Contribution to journal › Review › Research › peer-review
- 2021
- Published
Display of the human mucinome with defined O-glycans by gene engineered cells
Nason, R., Büll, C., Konstantinidi, A., Sun, L., Ye, Z., Halim, A., Du, W., Sørensen, D. M., Durbesson, F., Furukawa, S., Mandel, U., Joshi, H. J., Dworkin, L. A., Hansen, L., David, L., Iverson, T. M., Bensing, B. A., Sullam, P. M., Varki, A., Vries, E. D. & 6 others, , 2021, In: Nature Communications. 12, 1, 16 p., 4070.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes
Akan, I., Halim, Adnan, Vakhrushev, Sergey, Clausen, Henrik & Hanover, J. A., 2021, In: Cells. 10, 5, 13 p., 1026.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR
Tajadura-Ortega, V., Gambardella, G., Skinner, A., Halim, Adnan, Van Coillie, Julie, Schjoldager, Katrine Ter-Borch Gram, Beatson, R., Graham, R., Achkova, D., Taylor-Papadimitriou, J., Ciccarelli, F. D. & Burchell, J. M., 2021, In: Glycobiology. 31, 3, p. 200–210Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation
Graham, J. B., Sunryd, J. C., Mathavan, K., Weir, E., Larsen, I. S. B., Halim, Adnan, Clausen, Henrik, Cousin, H., Alfandari, D. & Hebert, D. N., 2020, In: Molecular Biology of the Cell. 31, 3, p. 167-183 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody
Steentoft, C., Fuhrmann, M., Battisti, F., Van Coillie, Julie, Madsen, Thomas Daugbjerg, Campos, D., Halim, Adnan, Vakhrushev, Sergey, Joshi, Hiren Jitendra, Schreiber, H., Mandel, Ulla & Narimatsu, Yoshiki, 2019, In: Glycobiology. 29, 4, p. 307-319 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics
Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Schjoldager, Katrine Ter-Borch Gram, Hintze, John, Halim, Adnan, Steentoft, C., Nason, R., Mandel, Ulla, Bennett, Eric Paul, Clausen, Henrik & Vakhrushev, Sergey, 2019, In: Molecular and Cellular Proteomics. 18, 7, p. 1396-1409Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple distinct O-Mannosylation pathways in eukaryotes
Larsen, I. S. B., Narimatsu, Yoshiki, Clausen, Henrik, Joshi, Hiren Jitendra & Halim, Adnan, 2019, In: Current Opinion in Structural Biology. 56, p. 171-178 8 p.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
GlycoDomainViewer: A bioinformatics tool for contextual exploration of glycoproteomes
Joshi, Hiren Jitendra, Jørgensen, A., Schjoldager, Katrine Ter-Borch Gram, Halim, Adnan, Dworkin, L. A., Steentoft, C., Wandall, Hans H., Clausen, Henrik & Vakhrushev, Sergey, 1 Mar 2018, In: Glycobiology. 28, 3, p. 131-136 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane
Lackman, J. J., Goth, C. K., Halim, Adnan, Vakhrushev, Sergey, Clausen, Henrik & Petäjä-Repo, U. E., Jan 2018, In: Cellular Signalling. 42, p. 184-193 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SnapShot: O-Glycosylation Pathways across Kingdoms
Joshi, Hiren Jitendra, Narimatsu, Yoshiki, Schjoldager, Katrine Ter-Borch Gram, Tytgat, H. L. P., Aebi, M., Clausen, Henrik & Halim, Adnan, Jan 2018, In: Cell. 172, 3, p. 632–632.e2Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetically engineered cell factories produce glycoengineered vaccines that target antigen-presenting cells and reduce antigen-specific T-cell reactivity
Mathiesen, C. B. K., Carlsson, M. C., Brand, S., Möller, S. R., Idorn, M., Straten, P. T., Pedersen, Anders Elm, Dabelsteen, Sally, Halim, Adnan, Würtzen, P. A., Brimnes, J., Ipsen, H., Petersen, Bent L & Wandall, Hans H., 2018, In: Journal of Allergy and Clinical Immunology. 142, 6, p. 1983-1987Research output: Contribution to journal › Letter › Research › peer-review
- 2017
- Published
Microbial glycoproteomics
Halim, Adnan & Anonsen, J. H., Jun 2017, In: Current Opinion in Structural Biology. 44, p. 143-150 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells
King-Smith, S. L., Joshi, Hiren Jitendra, Schjoldager, Katrine Ter-Borch Gram, Halim, Adnan, Madsen, Thomas Daugbjerg, Dziegiel, Morten Hanefeld, Woetmann, Anders , Vakhrushev, Sergey & Wandall, Hans H., 2017, In: Blood advances. 1, 7, p. 429-442 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins
Larsen, I. S. B., Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Siukstaite, L., Harrison, O. J., Brasch, J., Goodman, K. M., Hansen, Lars, Shapiro, L., Honig, B., Vakhrushev, Sergey, Clausen, Henrik & Halim, Adnan, 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11163-11168 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mammalian O-mannosylation of Cadherins and Plexins is Independent of Protein O-mannosyltransferase 1 and 2
Larsen, I. S. B., Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Yang, Zhang, Harrison, O. J., Brasch, J., Shapiro, L., Honig, B., Vakhrushev, Sergey, Clausen, Henrik & Halim, Adnan, 2017, In: The Journal of Biological Chemistry. 292, p. 11586-11598Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity
El Qaidi, S., Chen, K., Halim, Adnan, Siukstaite, L., Rueter, C., Hurtado-Guerrero, R., Clausen, Henrik & Hardwidge, P. R., 2017, In: The Journal of Biological Chemistry. 292, p. 11423-11430Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae
Neubert, P., Halim, Adnan, Zauser, M., Essig, A., Joshi, Hiren Jitendra, Zatorska, E., Larsen, I. S. B., Loibl, M., Castells-Ballester, J., Aebi, M., Clausen, Henrik & Strahl, S., Apr 2016, In: Molecular and Cellular Proteomics. 15, 4, p. 1323-37 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation
Goth, C. K., Halim, Adnan, Khetarpal, S. A., Rader, D. J., Clausen, Henrik & Schjoldager, Katrine Ter-Borch Gram, 24 Nov 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. 14623-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shaping Glycans by DNA Scissors: Turning Glycosciences Into Lego Toying
Clausen, Henrik, Schjoldager, Katrine Ter-Borch Gram, Yang, Zhang, Steentoft, C., Halim, Adnan, Bennett, E. & Vakhrushev, Sergey, Nov 2015, In: Glycobiology. 25, 11, p. 1233-1233 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions
Rubinstein, R., Thu, C. A., Goodman, K. M., Wolcott, H. N., Bahna, F., Mannepalli, S., Ahlsen, G., Chevee, M., Halim, Adnan, Clausen, Henrik, Maniatis, T., Shapiro, L. & Honig, B., 22 Oct 2015, In: Cell. 163, 3, p. 629-42 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineered CHO cells for production of diverse, homogeneous glycoproteins
Yang, Zhang, Wang, S., Halim, Adnan, Schulz, M. A., Frödin, Morten, Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, Sergey, Bennett, Eric Paul, Wandall, Hans H. & Clausen, Henrik, 20 Jul 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner
Nordén, R., Halim, Adnan, Nyström, K., Bennett, Eric Paul, Mandel, Ulla, Olofsson, S., Nilsson, J. & Larson, G., 20 Feb 2015, In: The Journal of Biological Chemistry. 290, 8, p. 5078-91 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Advances in mass spectrometry driven O-glycoproteomics
Levery, S. B., Steentoft, C., Halim, Adnan, Narimatsu, Yoshiki, Clausen, Henrik & Vakhrushev, Sergey, Jan 2015, In: B B A - Reviews on Cancer. 1850, 1, p. 33-42 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex Regulation of Prolyl-4-Hydroxylases Impacts Root Hair Expansion
Velasquez, S. M., Ricardi, M. M., Poulsen, C. P., Oikawa, A., Dilokpimol, A., Halim, A., Mangano, S., Denita Juarez, S. P., Marzol, E., Salgado Salter, J. D., Dorosz, J. G., Borassi, C., Möller, S. R., Buono, R., Ohsawa, Y., Matsuoka, K., Otegui, M. S., Scheller, H. V., Geshi, N., Petersen, B. L. & 2 others, , 2015, In: Molecular Plant. 8, 5, p. 734-46 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast
Halim, Adnan, Larsen, I. S. B., Neubert, P., Joshi, Hiren Jitendra, Petersen, Bent L, Vakhrushev, Sergey, Strahl, S. & Clausen, Henrik, 2015, In: Glycobiology. 25, 11, p. 1235 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast
Halim, Adnan, Larsen, I. S. B., Neubert, P., Joshi, Hiren Jitendra, Petersen, Bent L, Vakhrushev, Sergey, Strahl, S. & Clausen, Henrik, 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. 15648-15653 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycoproteomic analysis of seven major allergenic proteins reveals novel post-translational modifications
Halim, Adnan, Carlsson, M. C., Mathiesen, C. B. K., Brand, S., Möller, S. R., Olsen, C. E., Vakhrushev, Sergey, Brimnes, J., Wurtzen, P. A., Ipsen, H., Petersen, Bent L & Wandall, Hans H., 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 191-204 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Assignment of Saccharide Identities through analysis of oxonium ion fragmentation profiles in LC-MS/MS of glycopeptides
Halim, Adnan, Westerlind, U., Pett, C., Schorlemer, M., Rüetschi, U., Brinkmalm, G., Sihlbom, C., Lengqvist, J., Larson, G. & Nilsson, J., 5 Dec 2014, In: Journal of Proteome Research. 13, 12, p. 6024-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GalNAc-type O-glycoproteome of CHO cells characterized by the SimpleCell strategy
Yang, Zhang, Halim, Adnan, Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Steentoft, C., Schjoldager, Katrine Ter-Borch Gram, Schulz, M. A., Sealover, N. R., Kayser, K. J., Bennett, Eric Paul, Levery, S. B., Vakhrushev, Sergey & Clausen, Henrik, Dec 2014, In: Molecular & Cellular Proteomics. 13, 12, p. 3224-3235 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of Binding Epitopes of CA125 Monoclonal Antibodies
da Silva, L. P. M., Narimatsu, Yoshiki, Halim, Adnan, Vieira Campos, D. A., Yang, Zhang, Tarp, M. P. A., Pereira, P. J. B., Mandel, Ulla, Bennett, Eric Paul, Vakhrushev, Sergey, Levery, S. B., David, L. & Clausen, Henrik, 3 Jul 2014, In: Journal of Proteome Research. 13, 7, p. 3349-59 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions
Pedersen, N. B., Wang, S., Narimatsu, Yoshiki, Yang, Zhang, Halim, Adnan, Schjoldager, Katrine Ter-Borch Gram, Madsen, Thomas Daugbjerg, Seidah, N. G., Bennett, Eric Paul, Levery, S. B. & Clausen, Henrik, 20 Jun 2014, In: The Journal of Biological Chemistry. 289, 25, p. 17312-17324 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
LC-MS/MS characterization of combined glycogenin-1 and glycogenin-2 enzymatic activities reveals their self-glucosylation preferences
Nilsson, J., Halim, Adnan, Larsson, E., Moslemi, A., Oldfors, A., Larson, G. & Nilsson, J., Feb 2014, In: B B A - Reviews on Cancer. 1844, 2, p. 398-405 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins
Vester-Christensen, M. B., Halim, Adnan, Joshi, Hiren Jitendra, Steentoft, C., Bennett, Eric Paul, Levery, S. B., Vakhrushev, Sergey & Clausen, Henrik, 24 Dec 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 21018-23 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 40443472
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275
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Multiple distinct O-Mannosylation pathways in eukaryotes
Research output: Contribution to journal › Review › Research › peer-review
Published -
234
downloads
Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
75
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Display of the human mucinome with defined O-glycans by gene engineered cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published