Maiken Nedergaard

Maiken Nedergaard

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    1. When the air hits your brain: Decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

      Plog, B. A., Lou, N., Pierre, C. A., Cove, A., Kenney, H. M., Hitomi, E., Kang, H., Iliff, J. J., Zeppenfeld, D. M., Nedergaard, Maiken & Vates, G. E., 2020, In: Journal of Neurosurgery. 133, 1, p. 210-223 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Voluntary running enhances glymphatic influx in awake behaving, young mice

      Holstein-Rønsbo, Stephanie, Petersen, Nicolas Caesar & Nedergaard, Maiken, 2018, In: Neuroscience Letters. 662, p. 253-258 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model

      Parka, A., Volbracht, C., Hall, B., Bastlund, J. F., Nedergaard, Maiken, Laursen, B., Botta, P. & Sotty, F., 2023, In: Journal of Alzheimer's Disease. 93, 1, p. 247-262 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice

      Carlsen, Eva Maria Meier, Nedergaard, Maiken & Rasmussen, R. N., 2022, In: STAR Protocols. 3, 4, 14 p., 101701.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Vascular dysfunction-The disregarded partner of Alzheimer's disease

      Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M. & 49 others, Markus, H. S., Salman, R. A., Allan, S. M., Quinn, T. J., Kalaria, R. N., Werring, D. J., Carare, R. O., Touyz, R. M., Williams, S. C. R., Moskowitz, M. A., Katusic, Z. S., Lutz, S. E., Lazarov, O., Minshall, R. D., Rehman, J., Davis, T. P., Wellington, C. L., Gonzalez, H. M., Yuan, C., Lockhart, S. N., Hughes, T. M., Chen, C. L. H., Sachdev, P., O'Brien, J. T., Skoog, I., Pantoni, L., Gustafson, D. R., Biessels, G. J., Wallin, A., Smith, E. E., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, M. M. B., Roman, G. C., Hamel, E., Seshadri, S., Gottesman, R. F., van Buchem, M. A., Arvanitakis, Z., Schneider, J. A., Drewes, L. R., Hachinski, V., Finch, C. E., Toga, A. W., Wardlaw, J. M. & Zlokovic, B. V., 2019, In: Alzheimers & Dementia. 15, 1, p. 158-167

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep

      Andersen, Mie, Tsopanidou, Anastasia, Radovanovic, Tessa, Compere, V. N., Hauglund, Natalie Linea, Nedergaard, Maiken & Kjærby, Celia, 2023, In: Bio-protocol. 13, 15, 17 p., e4734.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Understanding the role of the perivascular space in cerebral small vessel disease

      Brown, R., Benveniste, H., Black, S. E., Charpak, S., Dichgans, M., Joutel, A., Nedergaard, Maiken, Smith, K. J., Zlokovic, B. V. & Wardlaw, J. M., 2018, In: Cardiovascular Research. 114, 11, p. 1462-1473 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

      Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, Maiken & Kipnis, J., 1 Sep 2017, In: The Journal of Clinical Investigation. 127, 9, p. 3210-3219 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    9. Published

      Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma

      Rangroo Thrane, V., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J. & Nedergaard, Maiken, 2021, In: Acta Ophthalmologica. 99, 2, p. e283-e284 2 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    10. Published

      Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

      Delle, Christine, Wang, X., Giannetto, M., Newbold, E., Peng, W., Gomolka, Ryszard Stefan, Ladrón-de-Guevara, A., Cankar, Neza, Nielsen, Elise Schiøler, Kjærby, Celia, Weikop, Pia, Mori, Yuki & Nedergaard, Maiken, 2024, In: Fluids and Barriers of the CNS. 21, 1, 13 p., 26.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The state of brain activity modulates cerebrospinal fluid transport

      Miyakoshi, L. M., Stæger, Frederik Filip Vinggaard, Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A. & Nedergaard, Maiken, 2023, In: Progress in Neurobiology. 229, 11 p., 102512.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      The homeostatic astroglia emerges from evolutionary specialization of neural cells

      Verkhratsky, A. & Nedergaard, Maiken, 5 Aug 2016, In: Royal Society of London. Philosophical Transactions B. Biological Sciences. 371, 1700, p. 1-11 11 p., 20150428.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The glymphatic system: reactive gliosis as a negative regulator

      Nedergaard, Maiken, 2019, In: Glia. 67, S1, p. E91 1 p., S26-02.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    14. Published

      The glymphatic system and Amyotrophic lateral sclerosis

      Eisen, A., Nedergaard, Maiken, Gray, E. & Kiernan, M. C., 2024, In: Progress in Neurobiology. 234, 10 p., 102571.

      Research output: Contribution to journal › Review › Research › peer-review

    15. Published

      The glymphatic system: implications for drugs for central nervous system diseases

      Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The glymphatic system: Current understanding and modeling

      Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Yuki, Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H. & Nedergaard, Maiken, 2022, In: iScience. 25, 9, 33 p., 104987.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      The glymphatic system: A novel component of fundamental neurobiology

      Hablitz, L. M. & Nedergaard, Maiken, 2021, In: Journal of Neuroscience. 41, 37, p. 7698-7711 14 p.

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      The glymphatic pathway in neurological disorders

      Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2018, In: The Lancet Neurology. 17, 11, p. 1016-1024 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    19. Published

      The effect of long-duration spaceflight on perivascular spaces within the brain

      Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, 1 p., e2207724119.

      Research output: Contribution to journal › Letter › Research › peer-review

    20. Published

      The Ocular Glymphatic Clearance System

      Wang, X., Lou, N., Eberhardt, A., Jørgensen, P. K., Xu, Q., Foerstera, B., Peng, S., Yang, Y., Shi, M., L R Xavier, Anna , Ertürk, A., Libby, R. T., Lu, C., Thrane, A. & Nedergaard, Maiken, 30 Dec 2019, bioRxiv, 23 p.

      Research output: Working paper › Preprint › Research

    21. Published

      The Glymphatic System and Pain

      Goldman, N., Hablitz, L. M., Mori, Yuki & Nedergaard, Maiken, 2020, In: Medical Acupuncture. 32, 6, p. 373-376 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The Glymphatic System (En)during Inflammation

      Mogensen, F. L., Delle, Christine & Nedergaard, Maiken, 2021, In: International Journal of Molecular Sciences. 22, 14, 20 p., 7491.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      The Brain's Glymphatic System: Current Controversies

      Mestre, H., Mori, Yuki & Nedergaard, Maiken, 2020, In: Trends in Neurosciences. 43, 7, p. 458-466 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

      Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      TUBE project: Transport-derived ultrafines and the brain effects

      Martikainen, M. V., Aakko-Saksa, P., Broek, L. V. D., Cassee, F. R., Carare, R. O., Chew, S., Dinnyes, A., Giugno, R., Kanninen, K. M., Malm, T., Muala, A., Nedergaard, M., Oudin, A., Oyola, P., Pfeiffer, T. V., Rönkkö, T., Saarikoski, S., Sandström, T., Schins, R. P. F., Topinka, J. & 4 others, Yang, M., Zeng, X., Westerink, R. H. S. & Jalava, P. I., 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 14 p., 311.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Surface periarterial spaces of the mouse brain are open, not porous

      Min Rivas, F., Liu, J., Martell, B. C., Du, T., Mestre, H., Nedergaard, Maiken, Tithof, J., Thomas, J. H. & Kelley, D. H., 2020, In: Journal of the Royal Society, Interface. 17, 172, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used

      Rasmussen, R., Nedergaard, Maiken & Petersen, Nicolas Caesar, 2016, In: Scientific Reports. 6, 9 p., 30433.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Structural characterization of SLYM—a 4th meningeal membrane

      Pla Requena, Virginia Teresa, Bitsika, S., Giannetto, M. J., Ladron-de-Guevara, A., Gahn-Martinez, D., Mori, Yuki, Nedergaard, Maiken & Møllgård, Kjeld, 2023, In: Fluids and Barriers of the CNS. 20, 1, 18 p., 93.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      State-Dependent Changes in Brain Glycogen Metabolism

      DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    30. Published

      Secondary brain stem hemorrhage in stroke

      Nedergaard, Maiken, Klinken, L. & Paulson, Olaf B., 1 Jul 1983, In: Stroke. 14, 4, p. 501-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

      Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain

      Shalgunov, Vladimir, Lilius, T., Sigurosson, B., Baerentzen, S. L., Hauglund, Natalie Linea, Herth, Matthias Manfred, Palner, M. & Nedergaard, Maiken, 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supplement 1, p. S404-S405 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    33. Published

      SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions

      Sun, W., Cornwell, A., Li, J., Peng, S., Joana Osorio, M., Aalling, Nadia, Wang, S., Benraiss, A., Lou, N., Goldman, Steven Alan & Nedergaard, Maiken, 2017, In: Journal of Neuroscience. 37, 17, p. 4493-4507 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      SDREAMER: Self-distilled Mixture-of-Modality-Experts Transformer for Automatic Sleep Staging

      Chen, J., Yao, Y., Anderson, M., Hauglund, Natalie Linea, Kjærby, Celia, Untiet, Verena, Nedergaard, Maiken & Luo, J., 2023, p. 131-142. 12 p.

      Research output: Contribution to conference › Paper › Research › peer-review

    35. Published

      Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study

      Kananen, J., Helakari, H., Korhonen, V., Huotari, N., Jarvela, M., Raitamaa, L., Raatikainen, V., Rajna, Z., Tuovinen, T., Nedergaard, Maiken, Jacobs, J., LeVan, P., Ansakorpi, H. & Kiviniemi, V., 2020, In: Brain Communications. 2, 2, 14 p., 076.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Reply to: 'Do all norepinephrine surges disrupt sleep?'

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    37. Published

      Reply to: Rethink the classical view of cerebrospinal fluid production

      Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Charpak, S., Smith, K. J. & Black, S. E., 2021, In: Nature Reviews Neurology. 17, 9, p. 590-591

      Research output: Contribution to journal › Letter › Research › peer-review

    38. Published

      Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

      Lee, H., Mortensen, K., Sanggaard, S., Koch, P., Brunner, H., Quistorff, B., Nedergaard, Maiken & Benveniste, H., 2018, In: Magnetic Resonance in Medicine. 79, 3, p. 1568-1578 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier

      Lou, N., Takano, T., Pei, Y., L R Xavier, Anna , Goldman, Steven Alan & Nedergaard, Maiken, 26 Jan 2016, In: National Academy of Sciences. Proceedings. 113, 4, p. 1074-1079 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging

      Esmail, Tina, Nedergaard, Maiken & Beinlich, Felix Ralf Michael, 2023, In: STAR Protocols. 4, 4, 18 p., 102652.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?

      Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

      Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Physiology of astroglia

      Verkhratsky, A. & Nedergaard, Maiken, 2018, In: Physiological Reviews. 98, 1, p. 239-389 151 p.

      Research output: Contribution to journal › Review › Research › peer-review

    44. Published

      Physiological Mechanisms and Significance of Intracranial B Waves

      Newell, D. W., Nedergaard, Maiken & Aaslid, R., 2022, In: Frontiers in Neurology. 13, 13 p., 872701.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Perivascular spaces, glymphatic dysfunction, and small vessel disease

      Mestre, H., Kostrikov, S., Mehta, R. I. & Nedergaard, Maiken, 1 Sep 2017, In: Clinical Science. 131, 17, p. 2257-2274 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Published

      Perivascular spaces in the brain: anatomy, physiology and pathology

      Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., Tannenbaum, A., Ballerini, L., Rungta, R. L., Boido, D., Sweeney, M., Montagne, A., Charpak, S., Joutel, A., Smith, K. J. & Black, S. E., 2020, In: Nature Reviews. Neurology. 16, p. 137-153 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    47. Published

      Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism

      Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

      Ladrón-de-Guevara, A., Shang, J. K., Nedergaard, Maiken & Kelley, D. H., 2022, In: Journal of Theoretical Biology. 542, 111103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

      Mestre, H., Verma, N., Greene, T. D., Lin, L. J. A., Ladron-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., de Mesy Bentley, K. L., Nedergaard, Maiken & Mehta, R. I., 2022, In: Nature Communications. 13, 1, 8 p., 3897.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections

      Cai, R., Pan, C., Ghasemigharagoz, A., Todorov, M. I., Foerstera, B., Zhao, S., Bhatia, H. S., Parra-Damas, A., Mrowka, L., Theodorou, D., Rempfler, M., Xavier, A. L. R., Kress, B. T., Benakis, C., Steinke, H., Liebscher, S., Bechmann, I., Liesz, A., Menze, B., Kerschensteiner, M. & 2 others, Nedergaard, Maiken & Ertuerk, A., 2019, In: Nature Neuroscience. 22, 2, p. 317-327

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      PDGF-B Is Required for Development of the Glymphatic System

      Munk, A. S., Wang, W., Bèchet, N. B., Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, Kjeld, Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2019, In: Cell Reports. 26, 11, p. 2955-2969.e3 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

      Beinlich, Felix Ralf Michael, Asiminas, Antonios, Untiet, Verena, Bojarowska, Zuzanna, Pla Requena, Virginia Teresa, Sigurdsson, B., Timmel, V., Gehrig, L., Graber, M. H., Hirase, Hajime & Nedergaard, Maiken, 2024, In: Science (New York, N.Y.). 383, 6690, p. 1471-1478 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

      Kounda, S., Elkin, R., Nadeem, S., Xue, Y., Constantinou, S., Sanggaard, S., Liu, X., Monte, B., Xu, F., Van Nostrand, W., Nedergaard, Maiken, Lee, H., Wardlaw, J., Benveniste, H. & Tannenbaum, A., 2020, In: Scientific Reports. 10, 1, 18 p., 1990.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature

      Battistella, R., Kritsilis, M., Matuskova, H., Haswell, D., Cheng, A. X., Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2021, In: International Journal of Molecular Sciences (Online). 22, 21, 11554.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      NREM sleep upregulates human brain pulsation detected by Ultrafast Magnetic Resonance Encephalography

      Larsen, S. M. U., Holst, S. C., Olsen, A. S., Zilstorff, D. B., Pleinert, S., Kiviniemi, V., Jennum, Poul, Nedergaard, Maiken & Knudsen, Gitte Moos, 2021, In: European Neuropsychopharmacology. 53, p. S361-S362 3 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    56. Published

      Modeling of brain efflux: Constraints of brain surfaces

      Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Mori, Yuki, Møllgård, Kjeld, Hjorth, P. G. & Nedergaard, Maiken, 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 16, 12 p., e2318444121.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Modeling cognition and disease using human glial chimeric mice

      Goldman, Steven Alan, Nedergaard, Maiken & Windrem, M. S., Aug 2015, In: Glia. 63, 8, p. 1483-1493 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes

      Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

      Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.

      Research output: Contribution to journal › Review › Research › peer-review

    61. Published

      Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia

      Stanton, E. H., Persson, N. D. Å., Gomolka, Ryszard Stefan, Lilius, T., Sigurðsson, B., Lee, H., L R Xavier, Anna , Benveniste, H., Nedergaard, Maiken & Mori, Yuki, 2021, In: Magnetic Resonance in Medicine. 85, 6, p. 3326-3342 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Managing noradrenaline after traumatic brain injury

      Hussain, R. & Nedergaard, Maiken, 2024, In: Clinical and Translational Medicine. 14, 1, 3 p., e1562.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    63. Published

      Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

      Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

      Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons

      Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    66. Published

      Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

      Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

      Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

      Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, Nedergaard, Maiken, Paquet, M. E., Drobizhev, M., Podgorski, K. & Campbell, R. E., 2023, In: Nature Communications. 14, 1, 17 p., 6598.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Inverse correlation of fluctuations of cerebral blood and water concentrations in humans

      Borchardt, V., Korhonen, V., Helakari, H., Nedergaard, Maiken, Myllylä, T. & Kiviniemi, V., 2021, In: European Physical Journal Plus. 136, 5, 497.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Interstitial ions: A key regulator of state-dependent neural activity?

      Rasmussen, R., O'Donnell, J., Ding, F. & Nedergaard, Maiken, 2020, In: Progress in Neurobiology. 98, 101802.

      Research output: Contribution to journal › Review › Research › peer-review

    71. Published

      Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

      Karimy, J. K., Reeves, B. C., Damisah, E., Duy, P. Q., Antwi, P., David, W., Wang, K., Schiff, S. J., Limbrick, D. D. ,. J., Alper, S. L., Warf, B. C., Nedergaard, Maiken, Simard, J. M. & Kahle, K. T., 2020, In: Nature Reviews Neurology. 16, p. 285–296 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    72. Published

      Increased interictal synchronicity of respiratory related brain pulsations in epilepsy

      Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

      Hablitz, L. M., Vinitsky, H. S., Sun, Q., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Mortensen, K. N., Lilius, T. O. & Nedergaard, Maiken, 2019, In: Science Advances. 5, 2, 9 p., eaav5447.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

      Sweeney, A. M., Pla, V., Du, T., Liu, G., Sun, Q., Peng, S., Plog, B. A., Kress, B. T., Wang, X., Mestre, H. & Nedergaard, Maiken, 2019, In: Journal of Visualized Experiments. 149, 7 p., e59774.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Implications of the discovery of brain lymphatic pathways

      Iliff, J. J., Goldman, Steven Alan & Nedergaard, Maiken, 2015, In: Lancet Neurology. 14, 10, p. 977-979 3 p.

      Research output: Contribution to journal › Journal article › Communication

    76. Published

      Impairment of the glymphatic system after diabetes

      Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., Sadry, N., Nedergaard, Maiken, Chopp, M. & Zhang, Z., 1 Apr 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 4, p. 1326-1337 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

      Nygaard Mortensen, K., Sanggaard, S., Mestre, H., Lee, H., Kostrikov, S., L R Xavier, Anna , Gjedde, Albert, Benveniste, H. & Nedergaard, Maiken, 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 32, p. 6365-6377 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia

      Windrem, M. S., Osipovitch, M., Liu, Z., Bates, J., Chandler-Militello, D., Zou, L., Munir, J., Schanz, S., McCoy, K., Miller, R. H., Wang, S., Nedergaard, Maiken, Findling, R. L., Tesar, P. J. & Goldman, Steven Alan, 3 Aug 2017, In: Cell Stem Cell. 21, 2, p. 195-208.e6

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

      Benraiss, A., Wang, S., Herrlinger, S., Li, X., Chandler-Militello, D., Mauceri, J., Burm, H. B., Toner, M., Osipovitch, M., Jim Xu, Q., Ding, F., Wang, F., Kang, N., Kang, J., Curtin, P. C., Brunner, D., Windrem, M. S., Munoz-Sanjuan, I., Nedergaard, Maiken & Goldman, Steven Alan, 7 Jun 2016, In: Nature Communications. 7, 13 p., 11758.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. E-pub ahead of print

      Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood

      van Osch, M. J. P., Wåhlin, A., Scheyhing, P., Mossige, I., Hirschler, L., Eklund, A., Mogensen, K., Gomolka, Ryszard Stefan, Radbruch, A., Qvarlander, S., Decker, A., Nedergaard, Maiken, Mori, Yuki, Eide, P. K., Deike, K. & Ringstad, G., 2024, (E-pub ahead of print) In: NMR in Biomedicine.

      Research output: Contribution to journal › Review › Research › peer-review

    81. Published

      Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations

      Helakari, H., Korhonen, V., Holst, S. C., Piispala, J., Kallio, M., Väyrynen, T., Huotari, N., Raitamaa, L., Tuunanen, J., Kananen, J., Järvelä, M., Tuovinen, T., Raatikainen, V., Borchardt, V., Kinnunen, H., Nedergaard, Maiken & Kiviniemi, V., 2022, In: Journal of Neuroscience. 42, 12, p. 2503-2515 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

      Windrem, M. S., Schanz, S. J., Zou, L., Chandler-Militello, D., Kuypers, N. J., Nedergaard, Maiken, Lu, Y., Mariani, J. N. & Goldman, Steven Alan, 2020, In: Cell Reports. 31, 7, 23 p., 107658.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

      Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., May 2020, In: PLOS Biology. 18, 5, 14 p., e3000623.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

      Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Glymphatic system dysfunction in neurodegenerative diseases

      Beschorner, Natalie & Nedergaard, Maiken, 2024, In: Current Opinion in Neurology. 37, 2, p. 182-188 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    86. Published

      Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome

      Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    87. Published

      Glymphatic system

      Benveniste, H. & Nedergaard, Maiken, 2016, Neuroscience in the 21st Century: From Basic to Clinical. 2 ed. Springer, p. 1945-1962 18 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    88. Published

      Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]

      Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271

      Giannetto, M. J., Gomolka, Ryszard Stefan, Gahn-Martinez, D., Newbold, E. J., Bork, Peter Aleksander Rousing, Chang, E., Gresser, M., Thompson, T., Mori, Yuki & Nedergaard, Maiken, 2024, In: Glia. 72, 5, p. 982-998 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Glymphatic failure as a final common pathway to dementia

      Nedergaard, Maiken & Goldman, Steven Alan, 2020, In: Science (New York, N.Y.). 370, 6512, p. 50-56 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    91. Published

      Glymphatic clearance controls state-dependent changes in brain lactate concentration

      Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R. & Nedergaard, Maiken, Jun 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2112-2124 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

      Reeves, B. C., Karimy, J. K., Kundishora, A. J., Mestre, H., Cerci, H. M., Matouk, C., Alper, S. L., Lundgaard, I., Nedergaard, Maiken & Kahle, K. T., 2020, In: Trends in Molecular Medicine. 26, 3, p. 285-295 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    93. Published

      Glial cells in schizophrenia: a unified hypothesis

      Dietz, Andrea Grostøl, Goldman, Steven Alan & Nedergaard, Maiken, 2020, In: Lancet Psychiatry. 7, 3, p. 272-281 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    94. Published

      Genetic haplotype of the glymphatic-associated water channel aquaporin 4 modulates slow waves in human non-rapid eye movement sleep

      Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S563-S564 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    95. Published

      Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

      Wang, M., Ding, F., Deng, S., Guo, X., Wang, W., Iliff, J. J. & Nedergaard, Maiken, 15 Mar 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 11, p. 2870-2877 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Fluid Transport in the Brain

      Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    97. Published

      Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

      Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, Maiken & Kelley, D. H., 2018, In: Nature Communications. 9, 1, 9 p., 4878.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

      Wei, H. S., Kang, H., Rasheed, I. D., Zhou, S., Lou, N., Gershteyn, A., McConnell, E. D., Wang, Y., Richardson, K. E., Palmer, A. F., Xu, C., Wan, J. & Nedergaard, Maiken, 17 Aug 2016, In: Neuron. 91, 4, p. 851-862 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Enlargement of Perivascular Spaces as a Downstream Consequence of Spaceflight Analog-Induced Alterations in Cerebral Venous Hemodynamics

      Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2024, In: American Journal of Neuroradiology. 45, 5, p. E6 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    100. Published

      Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations

      Helakari, H., Järvelä, M., Väyrynen, T., Tuunanen, J., Piispala, J., Kallio, M., Ebrahimi, S. M., Poltojainen, V., Kananen, J., Elabasy, A., Huotari, N., Raitamaa, L., Tuovinen, T., Korhonen, V., Nedergaard, Maiken & Kiviniemi, V., 2023, In: Frontiers in Neuroscience. 17, 17 p., 1275184.

      Research output: Contribution to journal › Journal article › Research › peer-review

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