The glymphatic system: Current understanding and modeling

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  • Tomas Bohr
  • Poul G. Hjorth
  • Sebastian C. Holst
  • Sabina Hrabětová
  • Vesa Kiviniemi
  • Tuomas Lilius
  • Iben Lundgaard
  • Kent Andre Mardal
  • Erik A. Martens
  • Mori, Yuki
  • U. Valentin Nägerl
  • Charles Nicholson
  • Allen Tannenbaum
  • John H. Thomas
  • Jeffrey Tithof
  • Helene Benveniste
  • Jeffrey J. Iliff
  • Douglas H. Kelley
  • Nedergaard, Maiken

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

Original languageEnglish
Article number104987
JournaliScience
Volume25
Issue number9
Number of pages33
ISSN2589-0042
DOIs
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

    Research areas

  • Neuroanatomy, Neuroscience, Systems biology

ID: 319648723