The Brain's Glymphatic System: Current Controversies

Research output: Contribution to journalReviewResearchpeer-review


The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.

Original languageEnglish
JournalTrends in Neurosciences
Issue number7
Pages (from-to)458-466
Number of pages9
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

    Research areas

  • amyloid-β, aquaporin-4, brain clearance, cerebrospinal fluid, glymphatic system, meningeal lymphatics, perivascular spaces

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 269518530