Thue W. Schwartz

Thue W. Schwartz

Professor

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    ORCID: 0000-0002-0261-6904

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    1. Published

      The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR

      Nygaard, R., Nielbo, S., Schwartz, Thue W. & Poulsen, F. M., 2006, In: Biochemistry. 45, 27, p. 8350-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening.

      Norn, C., Pedersen, M. H., Engelstoft, M. S., Kim, S. H., Lehmann, J., Jones, R. M., Schwartz, Thue W. & Frimurer, Thomas Michael, 2015, In: Structure. 23, 12, p. 2377-2386 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies

      Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3

      Nielsen, S. M., Elling, C. E. & Schwartz, Thue W., 1998, In: European Journal of Biochemistry. 251, p. 217-226

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

      Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Ghrelin

      Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S. & 37 others, Dickson, S. L., Dieguez, C., Granata, R., Grill, H. J., Grove, K., Habegger, K. M., Heppner, K., Heiman, M. L., Holsen, L., Holst, Birgitte, Inui, A., Jansson, J. O., Kirchner, H., Korbonits, M., Laferrere, B., LeRoux, C. W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P. T., Schwartz, Thue W., Seeley, R. J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M. O., van der Lely, A. J., van der Ploeg, L. H. T., Zigman, J. M., Kojima, M., Kangawa, K., Smith, R. G., Horvath, T. & Tschoep, M. H., Jun 2015, In: Molecular Metabolism. 4, 6, p. 437-460 24 p.

      Research output: Contribution to journal › Review › Research › peer-review

    7. Published

      Glucagon-like peptide 1 (GLP-1)

      Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, Stemmer, K., Tang-Christensen, M., Woods, S. C., DiMarchi, R. D. & Tschoep, M. H., 2019, In: Molecular Metabolism. 30, p. 72-130

      Research output: Contribution to journal › Review › Research › peer-review

    8. Published

      Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

      Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine

      Mizoue, L. S., Sullivan, S. K., King, D. S., Kledal, T. N., Schwartz, Thue W., Bacon, K. B. & Handel, T. M., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33906-14 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

      Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Immunohistochemical and chromatographic Identification of Peptides derived from Proneuropeptide Y in the human frontal Cortex

      Mikkelsen, J. D., Larsen, P. J., Kruse-Larsen, C., O'Hare, M. M. T. & Schwartz, Thue W., 1993, In: Brain Research Bulletin. 31, p. 415-425

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors

      Michel, M. C., Beck-Sickinger, A., Cox, H., Doods, H. N., Herzog, H., Larhammer, D., Quirion, R., Schwartz, Thue W. & Westfall, T., 1998, In: Pharmacological Reviews. 50, no. 1, p. 143-150

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

      Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, Kuipers, F., Nieuwdorp, M. & Groen, A. K., 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Microbiome-derived ethanol in nonalcoholic fatty liver disease

      Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, Vonghia, L., Francque, S., Beuers, U., Gerdes, V. E. A., Bäckhed, F., Groen, A. K. & Nieuwdorp, M., 2022, In: Nature Medicine. 28, p. 2100-2106

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

      Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74

      McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype

      Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1

      Manfra, O., Van Craenenbroeck, K., Skieterska, K., Frimurer, Thomas Michael, Schwartz, Thue W., Levy, F. O. & Andressen, K. W., Jul 2015, In: A C S Chemical Neuroscience. 6, 7, p. 1206–1218 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      The dual nature of the NK-1 receptor

      Maggi, C. & Schwartz, Thue W., 1997, In: TIPS - Trends in Pharmacological Sciences. 18, no. 10, p. 351-355

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors

      Madsen, J. J., Petersen, Jacob Emil, Christensen, D. P., Hansen, J. B., Schwartz, Thue W., Frimurer, Thomas Michael & Olsen, O. H., 2023, In: Journal of Biological Chemistry. 299, 12, 11 p., 105438.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor

      Lüttichau, H. R., Lewis, I. C., Gerstoft, J. & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31 (4), p. 1217-1220

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Validation of chemokine receptors as drug targets

      Lüttichau, H. R. & Schwartz, Thue W., 2000, In: Current Opinion in Drug Discovery & Development. 3, no. 5, p. 610-623

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

      Lüttichau, H. R., J., S., Boesen, T. P., Johnsen, A. H., Chantry, D., Gerstoft, J. & Schwartz, Thue W., 2000, In: Journal of Experimental Medicine. 191, no. 1, p. 171-80

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3

      Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6

      Lüttichau, H. R., Clark-Lewis, I., Jensen, Peter Østrup, Moser, C., Gerstoft, Jan & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, Vol. 278 (13), p. 10928-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor

      Lüttichau, H. R., Lewis, I. C., Gerstoft, Jan & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31, 4, p. 1217-20 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8

      Lüttichau, H. R., Gerstoft, Jan & Schwartz, Thue W., 2001, In: Journal of Leukocyte Biology. 70, 2, p. 277-82 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

      Lückmann, Michael, Holst, Birgitte, Schwartz, Thue W. & Frimurer, Thomas Michael, 2016, In: Molecular Informatics. 35, p. 19-24 6 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    30. Published

      Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

      Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

      Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Structure-based discovery of novel US28 small molecule ligands with different modes of action

      Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

      Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

      Lund, M. L., Sorrentino, G., Egerod, Kristoffer Lihme, Kroone, C., Mortensen, B., Knop, Filip Krag, Reimann, F., Gribble, F. M., Drucker, D. J., De Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, Thue W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites

      Lund, M. L., Egerod, Kristoffer Lihme, Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A. & Schwartz, Thue W., 2018, In: Molecular Metabolism. 11, p. 70-83 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Outrunning obesity with Lac-Phe?

      Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    37. Published

      Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands

      Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48

      Research output: Contribution to journal › Review › Research › peer-review

    38. Published

      The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation

      Lindow, M., Nansen, A., Bartholdy, C., Stryhn, A., Hansen, N. J. V., Boesen, T. P., Wells, T. N. C., Schwartz, Thue W. & Thomsen, Allan Randrup, 2003, In: Journal of Virology. 77, 13, p. 7393-400 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Viral leads for chemokine-modulatory drugs

      Lindow, M., Lüttichau, H. R. & Schwartz, Thue W., 2003, In: TIPS - Trends in Pharmacological Sciences. 24, 3, p. 126-30 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

      Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T. S., Grarup, N., Guo, Y., Hellman, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H. & 18 others, Wu, R., Yu, C., Zheng, H., Astrup, A., Bolund, L., Holmkvist, J., Jørgensen, T., Kristiansen, Karsten, Schmitz, O., Schwartz, Thue W., Zhang, X., Li, R., Yang, H., Wang, J., Hansen, Torben, Pedersen, Oluf Borbye, Nielsen, Rasmus & Wang, J., 2010, In: Nature Genetics. 42, 11, p. 969-72 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists

      Larson, D. L., Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 2000, In: Journal of Medicinal Chemistry. 43, no. 8, p. 1573-6

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Regional distribution of putative NPY Y*U1 receptors and neurons expressing Y*U1 mRNA in forebrain areas of the rat central nervous system

      Larsen, P. J., Sheikh, S. P., Jakobsen, C. R., Schwartz, Thue W. & Mikkelsen, J. D., 1993, In: European Journal of Neuroscience. Vol 5, p. 1622-37

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Why Warburg Works: Lactate Controls Immune Evasion through GPR81

      Jørgensen, Kathrine Lundø, Trauelsen, Mette, Pedersen, Stine Helene Falsig & Schwartz, Thue W., 2020, In: Cell Metabolism. 31, 4, p. 666–668 3 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    44. Published

      Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery

      Lappa, D., Meijnikman, A. S., Krautkramer, K. A., Olsson, L. M., Aydin, Ö., Van Rijswijk, A. S., Acherman, Y. I. Z., De Brauw, M. L., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Hjorth, Siv Annegrethe, Ji, B., Gerdes, V. E. A., Groen, A. K., Schwartz, Thue W., Nieuwdorp, M., Bäckhed, F. & Nielsen, J., 2023, In: PLoS ONE. 18, 3, 26 p., e0279335.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Receptorji s sedmimi transmembranskimi območji (7TM) v luči dimerizacije ter eksperimentalni pristopi za proučevanje njihove dimerizacije in medsebojnih vplivov

      Kubale, V., Pogačnik, A., Schwartz, Thue W. & Vrecl, M., 2008, In: Slovenian Veterinary Research. 45, 3, p. 89-102 14 p.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Published

      The MicroRNA Repertoire in Enteroendocrine Cells: Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage

      Knudsen, L. A., Petersen, N., Schwartz, Thue W. & Egerod, Kristoffer Lihme, Nov 2015, In: Endocrinology. 156, 11, p. 3971-83 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28

      Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. 19, 3, p. 812-23 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s)

      Jorgensen, R., Kubale, V., Vrecl, M., Schwartz, Thue W. & Elling, C. E., 2007, In: Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 148-54 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

      Jorgensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Schwartz, Thue W. & Elling, C. E., 2007, In: Molecular Pharmacology. 73, 2, p. 349-58 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. Vol. 19, no.3, p. 812-23

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors

      Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 1998, In: Journal of Medicinal Chemistry. 41, p. 4911-4914

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      C-terminal KDEL-modified cystatin C is retained in transfected CHO cells

      Johansen, T. E., Vogel, Lotte & Schwartz, Thue W., 1990, In: Biochemical and Biophysical Research Communications. 172, 3, p. 1384-91 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors

      Johansen, T. E., Schifter, S., Vogel, Lotte, Tolstoy, S. & Schwartz, Thue W., 1991, In: Molecular and Cellular Endocrinology. 82, 1, p. 51-60 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET

      Joergensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Elling, C. E. & Schwartz, Thue W., 2008, In: Molecular Pharmaceutics. 73, 2, p. 349-358 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

      Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

      Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma

      Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. Vol. 174, no. 6, p. 3686-94

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering

      Jensen, K. K., Martini, L. & Schwartz, Thue W., 2001, In: Biochemistry. 40 (4), p. 938-945

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma

      Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. 174, 6, p. 3686-94 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.

      Jensen, K., Manfra, D., Grisotto, M., Martin, A., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S., Mar 2005, In: Journal of immunology (Baltimore, Md. : 1950).

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Molecular mechanism of ligand binding pathways and activation of the succinate receptor

      Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.

      Research output: Contribution to journal › Conference abstract in journal › Research

    67. Published

      Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

      Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      GPCR-Mediated Signaling of Metabolites

      Husted, Anna Sofie, Trauelsen, Mette, Rudenko, Olga, Hjorth, Siv Annegrethe & Schwartz, Thue W., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 777-796 20 p.

      Research output: Contribution to journal › Review › Research › peer-review

    69. Published

      Virally encoded chemokines and chemokine receptors in the role of viral infections

      Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

      Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

      Holst, Jens Juul, Ørskov, Cathrine, Nielsen, Olaf & Schwartz, Thue W., 1987, In: F E B S Letters. 211, 2, p. 169-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor

      Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

      Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

      Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

      Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Common structural basis for constitutive activity of the ghrelin receptor family

      Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

      Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

      Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Ghrelin receptor mutations--too little height and too much hunger

      Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Clinical Investigation. 116, 3, p. 637-41 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

      Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

      Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

      Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism

      Holst, Birgitte, Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T. M., Beck-Sickinger, A. G. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 21, p. 15799-811 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

      Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      GPR39 signaling is stimulated by zinc ions but not by obestatin

      Holst, Birgitte, Egerod, Kristoffer Lihme, Schild, E., Vickers, S. P., Cheetham, S., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Endocrinology. 148, 1, p. 13-20 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis

      Holst, Birgitte, Hastrup, H., Raffetseder, U., Martini, L. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276, 23, p. 19793-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

      Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 58, 2, p. 263-70 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2

      Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor

      Holliday, N. D., Holst, Birgitte, Rodionova, E. A., Schwartz, Thue W. & Cox, H. M., 2007, In: Molecular Endocrinology. 21, 12, p. 3100-12 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Constitutive activity of glucagon receptor mutants

      Hjorth, S. A., Ørskov, Cathrine & Schwartz, Thue W., 1998, In: Molecular Endocrinology. 12, no. 1, p. 78-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)

      Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting

      Heydorn, A., Søndergaard, B. P., Hadrup, N., Holst, Birgitte, Haft, C. R. & Schwartz, Thue W., 2004, In: FEBS Letters. 556, 1-3, p. 276-80 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor

      Heding, A., Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Receptors and Signal Transduction. 22, 1-4, p. 241-52 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

      Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

      Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100

      Hatse, S., Princen, K., Gerlach, L., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60 (1), p. 164-173

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100

      Hatse, S., Princen, K., Gerlach, L. O., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60, 1, p. 164-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

      Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

      Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673

      Research output: Contribution to journal › Journal article › Research › peer-review

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