Hans Bräuner

Hans Bräuner

Prodekan for forskning

ORCID: 0000-0001-9495-7388

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  1. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139

    Ísberg, V., Andersen, K. B., Bisig, C., Dietz, G. P., Bräuner, Hans & Gloriam, David E., 14 May 2014, In: Journal of Chemical Information and Modeling. 54, 6, p. 1553-1557 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization

    van Senten, Jeffrey Roy, Møller, T. C., Moo, Ee Von, Seiersen, S. D. & Bräuner, Hans, 2022, In: Journal of Biological Chemistry. 298, 10, 16 p., 102466.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

    Zimmermann, D., Janin, Y. L., Brehm, L., Bräuner, Hans, Ebert, B., Johansen, Tommy Nørskov, Madsen, Ulf & Krogsgaard-Larsen, Povl, 1 Nov 1999, In: European Journal of Medicinal Chemistry. 34, 11, p. 967-976

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

    Zhou, Y., Daver, H., Trapkov, B., Wu, L., Wu, M., Harpsøe, Kasper, Gentry, P. R., Liu, K., Larionova, M., Liu, J., Chen, N., Bräuner, Hans, Gloriam, David E., Hua, T. & Liu, Z. J., 2022, In: Cell Research. 32, 2, p. 210-213

    Research output: Contribution to journal › Letter › Research › peer-review

  6. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein

    Zhang, H., Xiong, X., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, 7 Jun 2017, In: ChemMedChem. 12, 11, p. 830-834 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

    Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, Kasper, Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner, Hans, Gloriam, David E. & Strømgaard, Kristian, 2018, In: European Journal of Medicinal Chemistry. 156, p. 847-860

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

    Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner, Hans & Strømgaard, Kristian, 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890

    Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, Apr 2019, In: ChemMedChem. 14, 8, p. 865-870

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The rat GPRC6A: cloning and characterization

    Wellendorph, Petrine, Burhenne, N., Christiansen, B., Walter, B., Schmale, H. & Bräuner, Hans, 15 Jul 2007, In: Gene. 396, 2, p. 257-267 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain

    Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The emerging role of promiscuous 7TM receptors as chemosensors for food intake

    Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 1 Jan 2010, Incretins and insulin secretion. Litwack, G. (ed.). Amsterdam: Elsevier Editora, Vol. 84. p. 151-184 (Vitamins & hormones, Vol. 84).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  13. Published

    Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids

    Wellendorph, Petrine, Hansen, K. B., Balsgaard, A., Greenwood, J. R., Egebjerg, J. & Bräuner, Hans, Mar 2005, In: Molecular Pharmacology. 67, 3, p. 589-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations

    Wellendorph, Petrine, Hansen, K. B., Christiansen, B., Burhenne, N., Balsgaard, A., Greenwood, J. R., Walter, B., Schmale, H., Egebjerg, J. & Bräuner, Hans, 2008, In: Fundamental and Clinical Pharmacology. Suppl. 2, p. 19

    Research output: Contribution to journal › Conference abstract in journal › Research

  15. Published

    Molecular basis for amino acid sensing by family C G-protein-coupled receptors

    Wellendorph, Petrine & Bräuner, Hans, 2009, In: British Journal of Pharmacology. 156, 6, p. 869-884

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain

    Wellendorph, Petrine, Høg, S., Skonberg, C. & Bräuner, Hans, 2009, In: Fundamental and Clinical Pharmacology. 23, 2, p. 207-213 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients

    Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 2009, In: Molecular Pharmacology. 76, 3, p. 453-465

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor

    Wellendorph, Petrine & Bräuner, Hans, 23 Jun 2004, In: Gene. 335, p. 37-46

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

    Wellendorph, Petrine, Johansen, L. D., Jensen, Anders A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B. & Bräuner, Hans, 2009, In: Journal of Molecular Endocrinology. 42, 3, p. 215-223

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites

    Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Ligand-directed bias of G protein signaling at the dopamine D2 receptor

    Moo, Ee Von, Harpsøe, Kasper, Hauser, Alexander Sebastian, Masuho, I., Bräuner, Hans, Gloriam, David E. & Martemyanov, K. A., 2022, In: Cell Chemical Biology. 29, 2, p. 226-238

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Differential compartmentalization and distinct functions of GABAB receptor variants

    Vigot, R., Barbieri, S., Bräuner, Hans, Turecek, R., Shigemoto, R., Zhang, Y., Luján, R., Jacobson, L. H., Biermann, B., Fritschy, J., Vacher, C., Müller, M., Sansig, G., Guetg, N., Cryan, J. F., Kaupmann, K., Gassmann, M., Oertner, T. G. & Bettler, B., 18 May 2006, In: Neuron. 50, 4, p. 589-601

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Pharmacology and function of the orphan GPR139 G protein-coupled receptor

    Vedel, L., Nøhr, A. C., Gloriam, David E. & Bräuner, Hans, 27 May 2019, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 35-46

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

    Vedel, L., Bräuner, Hans & Mathiesen, Jesper M., 2015, In: Journal of Biomolecular Screening. 20, p. 849-857 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

    Valgeirsson, J., Christensen, J. K., Kristensen, Anders Skov, Pickering, Darryl S, Nielsen, Birgitte, Fischer, C., Bräuner, Hans, Nielsen, E. Ø., Krogsgaard-Larsen, Povl & Madsen, U., 2003, In: Bioorganic & Medicinal Chemistry. 11, 20, p. 4341-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Transmembrane a-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor

    Underwood, C. R., Knudsen, S. M., Wulff, B. S., Bräuner, Hans, Lau, J., Knudsen, L. B., Peters, G. H. J. & Reedtz-Runge, S., 2011, In: Pharmacology. 88, 5-6, p. 340-348 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Regulation of GABAB receptors by extracellular proteins and phosphorylation

    Tiao, J. Y., Bradaia, A., Jensen, A. A., Biermann, B., Bräuner, Hans, Müller, M., Kaupmann, K., Gassmann, M. & Bettler, B., 2008, In: Neuropharmacology. 4, p. 626

    Research output: Contribution to journal › Conference abstract in journal › Research

  28. Published

    Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling

    Thomsen, A. R. B., Smajilovic, S. & Bräuner, Hans, 1 Sep 2012, In: Current Drug Targets. 13, 10, p. 1324-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells

    Thomsen, A. R. B., Worm, J., Jacobsen, S. E., Stahlhut, M., Latta, M. & Bräuner, Hans, Dec 2012, In: Journal of Pharmacology and Experimental Therapeutics. 343, 3, p. 638-49 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Biased agonism of the calcium-sensing receptor

    Thomsen, A. R. B., Hvidtfeldt, M. & Bräuner, Hans, Feb 2012, In: Cell Calcium. 51, 2, p. 107-116

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay

    Strange, M., Bräuner, Hans & Jensen, Anders A., 2006, In: Combinatorial Chemistry & High Throughput Screening. 9, 2, p. 147-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology

    Stensbøl, T. B., Uhlmann, P., Morel, S., Eriksen, B. L., Felding, J., Kromann, H., Hermit, M. B., Greenwood, J. R., Braüner-Osborne, H., Madsen, Ulf, Junager, F., Krogsgaard-Larsen, Povl, Begtrup, M., Vedsø, P. & Bräuner, Hans, 3 Jan 2002, In: Journal of Medicinal Chemistry. 45, 1, p. 19-31

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    1,2,3-triazolyl amino acids as AMPA receptor ligands

    Stanley, N. J., Pedersen, D. S., Nielsen, Birgitte, Kvist, T., Mathiesen, Jesper M., Bräuner, Hans, Taylor, D. K. & Abell, A. D., 15 Dec 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 24, p. 7512-7515

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

    Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, Birgitte, Mathiesen, Jesper M., Bräuner, Hans, Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D. & Taylor, D. K., 2010, In: Bioorganic & Medicinal Chemistry. 18, 16, p. 6089-6098

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis

    Spalding, T. A., Burstein, E. S., Bräuner, Hans, Hill-Eubanks, D. & Brann, M. R., Dec 1995, In: Journal of Pharmacology and Experimental Therapeutics. 275, 3, p. 1274-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

    Smajilovic, S., Wellendorph, Petrine & Bräuner, Hans, 2014, In: Current Pharmaceutical Design. 20, p. 2693-702 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

    Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner, Hans, 2013, In: Amino Acids. 44, 2, p. 383-390 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

    Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  39. Published

    Homology modelling of the GABA transporter and analysis of tiagabine binding

    Skovstrup, S., Taboureau, O., Bräuner, Hans & Jørgensen, Flemming Steen, 2010, In: ChemMedChem. 5, 7, p. 986-1000

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

    Shehata, M. A., Christensen, H. B., Isberg, V., Pedersen, D. S., Bender, A., Bräuner, Hans & Gloriam, David E., 2015, In: RSC Advances. 5, p. 48551-48557 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

    Shehata, M. A., Jensen, A. C. N., Jespers, W., Floryan, L., Isberg, V., Andersen, K. B., Åqvist, J., Gutiérrez-de-Terán, H., Bräuner, Hans & Gloriam, David E., 25 Apr 2017, In: Scientific Reports. 7, 9 p., 1128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

    Shehata, M. A., Jensen, A. C. N., Lissa, D., Bisig, C., Isberg, V., Andersen, K. B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner, Hans & Gloriam, David E., 10 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 36681.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

    Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus

    Runge, S., Gram, C., Bräuner, Hans, Madsen, K., Knudsen, L. B. & Wulff, B. S., 25 Jul 2003, In: Journal of Biological Chemistry. 278, 30, p. 28005-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity

    Runge, S., Wulff, B. S., Madsen, K., Bräuner, Hans & Knudsen, L. B., Mar 2003, In: British Journal of Pharmacology. 138, 5, p. 787-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

    Roszko, K. L., Bi, R., Gorvin, C. M., Bräuner, Hans, Xiong, X., Inoue, A., Thakker, R. V., Strømgaard, Kristian, Gardella, T. & Mannstadt, M., 9 Feb 2017, In: JCI insight. 2, 3, 15 p., e91079.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

    Rossol, M., Pierer, M., Raulien, N., Quandt, D., Meusch, U., Rothe, K., Schubert, K., Schöneberg, T., Schaefer, M., Krügel, U., Smajilovic, S., Bräuner, Hans, Baerwald, C. & Wagner, U., 2012, In: Nature Communications. 3, p. 1329

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

    Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

    Roed, S. N., Wismann, P., Underwood, C. R., Kulahin, N., Iversen, H., Cappelen, K. A., Schäffer, L., Lehtonen, J., Hecksher-Soerensen, J., Secher, A., Mathiesen, Jesper M., Bräuner, Hans, Whistler, J. L., Knudsen, S. M. & Waldhoer, M., Feb 2014, In: Molecular and Cellular Endocrinology. 382, 2, p. 938-949 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking

    Roed, S. N., Nøhr, A. C., Wismann, P., Iversen, H., Bräuner, Hans, Knudsen, S. M. & Waldhoer, M., 9 Jan 2015, In: The Journal of Biological Chemistry. 290, 2, p. 1233-1243 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Accepted/In press

    Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

    Reiner-Link, David, Madsen, Jakob Sture, Gloriam, David E., Bräuner, Hans & Hauser, Alexander Sebastian, 2024, (Accepted/In press) In: British Journal of Pharmacology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

    Ramiro, Iris Bea L. , Bjørn-Yoshimoto, Walden, Imperial, J. S., Gajewiak, J., Salcedo, P. F., Watkins, M., Taylor, D., Resager, W., Ueberheide, B., Bräuner, Hans, Whitby, F. G., Hill, C. P., Martin, L. F., Patwardhan, A., Concepcion, G. P., Olivera, B. M. & Safavi-Hemami, H., 2022, In: Science Advances. 8, 12, 16 p., eabk1410.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo

    Quinn, S. J., Thomsen, A. R. B., Pang, J. L., Kantham, L., Brown, E. M., Bräuner, Hans, Pollak, M. & Goltzman, D., 1 Feb 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 304, 3, p. E310-320

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

    Pinto, A., Conti, P., De Amici, M., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Christesen, T., Bräuner, Hans & De Micheli, C., 2008, In: Journal of Medicinal Chemistry. 51, 7, p. 2311-2315

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

    Pedersen, M. F., Wrobel, T. M., Marcher, Emil, Pedersen, D. S., Møller, T. C., Gabriele, F., Pedersen, H., Matosiuk, D., Foster, S. R., Bouvier, M. & Bräuner, Hans, 2020, In: Neuropharmacology. 166, 13 p., 107718.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline

    Pedersen, H., Bräuner, Hans, Ball, R. G., Frydenvang, Karla Andrea, Meier, E., Bøgesø, K. P. & Krogsgaard-Larsen, Povl, 1999, In: Bioorganic & Medicinal Chemistry. 7, 5, p. 795-809 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA

    Palmelund, L. B., van Woerden, G. M., Bräuner, Hans & Wellendorph, Petrine, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 8 p., 107226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139

    Pallareti, L., Rath, T. F., Trapkov, Boris, Tsonkov, T., Nielsen, A. T., Harpsøe, Kasper, Gentry, P. R., Bräuner, Hans, Gloriam, David E. & Foster, S. R., 2023, In: European Journal of Pharmacology. 943, 175553.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology.

    Nørskov-Lauritsen, L., Thomsen, A. R. B. & Bräuner, Hans, 2014, In: International Journal of Molecular Sciences (Online). 15, 2, p. 2554-2572

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

    Nørskov-Lauritsen, L. & Bräuner, Hans, 2015, In: European Journal of Pharmacology. 763, p. 233-240 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

    Nørskov-Lauritsen, L., Jørgensen, S. & Bräuner, Hans, 21 Jan 2015, In: FEBS Letters. 589, p. 588–597 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist

    Nøhr, A. C., Shehata, M. A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, P. R., Gloriam, David E. & Bräuner, Hans, 7 Mar 2019, In: Scientific Reports. 9, 1, 10 p., 3802.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2

    Nielsen, S. D., Fulco, M., Serpi, M., Nielsen, Birgitte, Hansen, M. B., Hansen, K. L., Thomsen, C., Brodbeck, R., Bräuner, Hans, Pellicciari, R., Norrby, P., Greenwood, J. R. & Clausen, Rasmus Prætorius, 23 Sep 2011, In: MedChemComm. 2, 11, p. 1120-1124

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

    Møller, T. C., Moo, Ee Von, Inoue, A., Pedersen, M. F. & Bräuner, Hans, 2024, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1871, 1, 12 p., 119584.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

    Møller, T. C., Pedersen, M. F., van Senten, Jeffrey Roy, Seiersen, S. D., Mathiesen, Jesper M., Bouvier, M. & Bräuner, Hans, 2020, In: Scientific Reports. 10, 1, 13 p., 17395.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Mathiesen, Jesper M., Nielsen, S. M. & Bräuner, Hans, Oct 2014, In: Neurochemical Research. 39, 10, p. 1862-1875 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

    Mosley, C. A., Acker, T. M., Hansen, K. B., Mullasseril, P., Andersen, K. T., Le, P., Vellano, K. M., Bräuner, Hans, Liotta, D. C. & Traynelis, S. F., 2010, In: Journal of Medicinal Chemistry. 53, 15, p. 5476-5490

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Calcium-Sensing Receptor Internalization Is β-Arrestin-Dependent and Modulated by Allosteric Ligands

    Mos, I., Jacobsen, S. E., Foster, S. R. & Bräuner, Hans, Oct 2019, In: Molecular Pharmacology. 96, 4, p. 463-474 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Arrestin-Dependent and -Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling

    Moo, Ee Von, van Senten, Jeffrey Roy, Bräuner, Hans & Møller, T. C., 2021, In: Molecular Pharmacology. 99, 4, p. 242-255

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

    Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43

    Research output: Contribution to journal › Conference abstract in journal › Research

  73. Published

    Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids

    Meyer, U., Bisel, P., Bräuner, Hans, Madsen, Ulf, Höfner, G., Wanner, K. T. & Frahm, A. W., Feb 2005, In: Chirality. 17, 2, p. 99-107

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells

    Messier, T. L., Dorman, C. M., Bräuner, Hans, Eubanks, D. & Brann, M. R., May 1995, In: Basic & Clinical Pharmacology & Toxicology. 76, 5, p. 308-11

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors

    Mathiesen, Jesper M., Vedel, L. & Bräuner, Hans, 2013, In: Methods in Enzymology. 522, p. 191-207 17 p.

    Research output: Contribution to journal › Journal article › Research

  76. Published

    Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

    Mathiesen, Jesper M., Svendsen, N., Bräuner, Hans, Thomsen, C. & Ramirez, M. T., Mar 2003, In: British Journal of Pharmacology. 138, 6, p. 1026-30

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

    Malfacini, D., Patt, J., Annala, S., Harpsøe, Kasper, Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, David E., Bräuner, Hans, Strømgaard, Kristian, König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In: The Journal of Biological Chemistry. 294, 15, p. 5747-5758

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes

    Madsen, Ulf, Pickering, Darryl S, Nielsen, Birgitte & Bräuner, Hans, 2005, In: Neuropharmacology. 49 Suppl 1, p. 114-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders

    Madsen, Ulf, Bräuner, Hans, Greenwood, J. R., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  80. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

    Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist

    Madsen, Ulf, Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Lützhøft, H. H., Poulsen, M. V., Eriksen, L. & Krogsgaard-Larsen, Povl, Jan 2000, In: European Journal of Medicinal Chemistry. 35, 1, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid

    Madsen, Ulf, Dumpis, M. A., Bräuner, Hans & Piotrovsky, L. B., 16 Jun 1998, In: Bioorganic & Medicinal Chemistry Letters. 8, 12, p. 1563-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Mutational Landscape of the Proglucagon-Derived Peptides

    Lindquist, Peter, Madsen, Jakob Sture, Bräuner, Hans, Rosenkilde, Mette & Hauser, Alexander Sebastian, 2021, In: Frontiers in Endocrinology. 12, 14 p., 698511.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action

    Lehmann, A., Antonsson, M., Holmberg, A. A., Blackshaw, L. A., Brändén, L., Bräuner, Hans, Christiansen, B., Dent, J., Elebring, T., Jacobson, B., Jensen, J., Mattsson, J. P., Nilsson, K., Oja, S. S., Page, A. J., Saransaari, P. & von Unge, S., 2009, In: Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 504-512

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

    Leach, K., Hannan, F. M., Josephs, T. M., Keller, A. N., Møller, T. C., Ward, D. T., Kallay, E., Mason, R. S., Thakker, R. V., Riccardi, D., Conigrave, A. D. & Bräuner, Hans, Jul 2020, In: Pharmacological Reviews. 72, 3, p. 558-604 47 p.

    Research output: Contribution to journal › Review › Research › peer-review

  86. Published

    The use of Xenopus oocytes in drug screening

    Kvist, T., Hansen, K. B. & Bräuner, Hans, 2011, In: Expert Opinion on Drug Discovery. 6, 2, p. 141-153

    Research output: Contribution to journal › Review › Research › peer-review

  87. Published

    Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors

    Kvist, T., Greenwood, J. R., Hansen, K. B., Traynelis, S. F. & Bräuner, Hans, 22 Aug 2013, In: Neuropharmacology. 75, p. 324-336 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    The four human ¿-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay

    Kvist, T., Christiansen, B., Jensen, Anders A. & Bräuner, Hans, 2009, In: Combinatorial Chemistry & High Throughput Screening. 12, 3, p. 241-249

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand

    Kuhne, S., Nøhr, A. C., Marek, A., Elbert, T., Klein, A. B., Bräuner, Hans, Wellendorph, Petrine & Pedersen, D. S., 2016, In: RSC Advances. 6, 2, p. 947-952 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor

    Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Bräuner, Hans & Jensen, Anders A., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 2, p. 722-727

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    En genetisk variation i en serotonin-receptor: et muligt link til depression?

    Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Jensen, Anders A. & Bräuner, Hans, 2007, In: Lægemiddelforskning. p. 30-31

    Research output: Contribution to journal › Journal article › Communication

  93. Published

    Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling

    Krzywkowski, K. M., Davies, P. A., Irving, A. J., Bräuner, Hans & Jensen, Anders A., 2008, In: Pharmacogenetics and Genomics (Print Edition). 18, 12, p. 1027-1040

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    En genetisk variation i en serotonin–receptor – et muligt link til depression?

    Krzywkowski, K. M., Feinberg-Zadek, P., Davies, P. A., Jensen, Anders A. & Bräuner, Hans, 2008, In: Dansk Kemi 83. 89, 6/7

    Research output: Contribution to journal › Journal article › Communication

  95. Published

    Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

    Krzywkowski, K. M., Jensen, Anders A., Connolly, C. N. & Bräuner, Hans, 2007, In: Pharmacogenetics and Genomics (Print Edition). 17, 4, p. 255-266

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids

    Kromann, H., Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 14 Feb 2002, In: Journal of Medicinal Chemistry. 45, 4, p. 988-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile

    Kragholm, B., Kvist, T., Madsen, K. K., Jørgensen, L., Vogensen, S. B., Schousboe, Arne, Clausen, Rasmus Prætorius, Jensen, Anders A. & Bräuner, Hans, 2013, In: Biochemical Pharmacology. 86, p. 521-528

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA-B1-deficient mice

    Kaupmann, K., Cryan, J. F., Wellendorph, Petrine, Mombereau, C., Sansig, G., Klebs, K., Schmutz, M., Froestl, W., van der Putten, H., Mosbacher, J., Bräuner, Hans, Waldmeier, P. & Bettler, B., Nov 2003, In: European Journal of Neuroscience. 18, 10, p. 2722-30

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators

    Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

    Research output: Contribution to journal › Journal article › Research › peer-review

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