Thomas Kruse
Associate Professor
Nilsson Group
Blegdamsvej 3B
2200 København N
- 2024
- Published
Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19
Padi, S. K. R., Vos, M. R., Godek, R. J., Fuller, J. R., Kruse, Thomas, Hein, J. B., Nilsson, Jakob, Kelker, M. S., Page, R. & Peti, W., 2024, In: Nature. 625, 7993, p. 195-203 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification
Hein, J. B., Nguyen, H. T., Garvanska, Dimitriya Hristoforova, Nasa, I., Kruse, Thomas, Feng, Y., Lopez Mendez, B., Davey, N., Kettenbach, A. N., Fordyce, P. M. & Nilsson, Jakob, 2023, In: Molecular Systems Biology. 19, 17 p., e11782.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatial separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis
Wang, L., Kruse, Thomas, López-Méndez, B., Zhang, Y., Song, C., Zhu, L., Li, B., Fang, J., Lu, Z., Nilsson, Jakob & Zhang, G., 2023, In: Journal of Molecular Cell Biology. 14, 11, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Elmelund, E., Galsgaard, Katrine Douglas, Johansen, C. D., Trammell, Sam, Billeschou, Anna, Winther-Sørensen, Marie, Dal, Jenna Elizabeth Hunt, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Grevengoed, Trisha Jean, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: iScience. 25, 11, 20 p., 105296.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Shearer, Robert Francis, Typas, D., Coscia, F., Schovsbo, Sofie Ulfbeck, Kruse, Thomas, Mund, Andreas & Mailand, Niels, 2022, In: E M B O Journal. 41, 9, 18 p., e110145.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination
Ambjørn, Sara Marie, Duxin, Julien, Hertz, Emil Peter Thrane, Nasa, I., Duro, Joana Maria, Kruse, Thomas, Lopez-Mendez, B., Rymarczyk, B., Cressey, L. E., van Overeem Hansen, T., Kettenbach, A. N., Østergaard, Vibe Hallundbæk, Lisby, Michael & Nilsson, Jakob, 2021, In: Nature Communications. 12, 1, 11 p., 5748.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Kruse, T., Benz, C., Garvanska, D. H., Lindqvist, R., Mihalic, F., Coscia, F., Inturi, R., Sayadi, A., Simonetti, L., Nilsson, E., Ali, M., Kliche, J., Moliner Morro, A., Mund, A., Andersson, E., McInerney, G., Mann, M., Jemth, P., Davey, N. E., Överby, A. K. & 2 others, , 2021, In: Nature Communications. 12, 1, 13 p., 6761.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis
Ueki, Y., Hadders, M. A., Weisser, Melanie, Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, Emil Peter Thrane, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, Jakob, 2021, In: EMBO Reports. 22, 7, 13 p., e52295.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits
Kruse, Thomas, Gnosa, S. P., Nasa, I., Garvanska, Dimitriya Hristoforova, Hein, J. B., Nguyen, H., Samsøe-Petersen, Jacob, Lopez-Mendez, B., Hertz, Emil Peter Thrane, Schwarz, J., Pena, H. S., Nikodemus, D., Kveiborg, Marie, Kettenbach, A. N. & Nilsson, Jakob, 2020, In: EMBO Journal. 39, 18 p., e103695.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry
Nasa, I., Cressey, L. E., Kruse, Thomas, Hertz, Emil Peter Thrane, Gui, J., Graves, L. M., Nilsson, Jakob & Kettenbach, A. N., 2020, In: Science Signaling. 13, 648, 15 p., eaba7823.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
A Consensus Binding Motif for the PP4 Protein Phosphatase
Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In: Molecular Cell. 76, 6, p. 953-964.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex
Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to Raaijmakers & Medema
Zhang, G., Kruse, Thomas, Boldú, C. G., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: The EMBO Journal. 38, 22, 5 p., e103547.Research output: Contribution to journal › Comment/debate › Research
- 2018
- Published
The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30
Kruse, Thomas, Biedenkopf, N., Hertz, Emil Peter Thrane, Dietzel, E., Stalmann, G., López-Méndez, B., Davey, N. E., Nilsson, Jakob & Becker, S., 4 Jan 2018, In: Molecular Cell. 69, 1, p. 136-145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis
Hein, J. B., Hertz, Emil Peter Thrane, Garvanska, Dimitriya Hristoforova, Kruse, Thomas & Nilsson, Jakob, 2017, In: Nature Cell Biology. 19, p. 1433-1440Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
Zhang, G., Kruse, Thomas, López-Méndez, B., Sylvestersen, K. B., Garvanska, Dimitriya Hristoforova, Schopper, S., Nielsen, Michael Lund & Nilsson, Jakob, 12 Jun 2017, In: Nature Communications. 8, 12 p., 15822.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase
Hertz, Emil Peter Thrane, Kruse, Thomas, Davey, N. E., López-Méndez, B., Sigurdsson, J. O., Montoya, Guillermo, Olsen, Jesper Velgaard & Nilsson, Jakob, 2016, In: Molecular Cell. 63, 4, p. 686-695 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth
Jiang, N., Hjorth-Jensen, K., Hekmat, O., Iglesias Gato, Diego, Kruse, Thomas, Wang, C., Wei, W., Ke, B., Yan, B., Niu, Y., Olsen, Jesper Velgaard & Flores Morales, A., 2015, In: Oncogene. 34, p. 2764–2776 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
Pedersen, R. T., Kruse, Thomas, Nilsson, Jakob, Østergaard, Vibe Hallundbæk & Lisby, Michael, 2015, In: Journal of Cell Biology. 210, 4, p. 565-582 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment
Kruse, Thomas, Larsen, Marie Sofie Yoo, Sedgwick, G. G., Sigurdsson, J. O., Streicher, W., Olsen, Jesper Velgaard & Nilsson, Jakob, 29 Jan 2014, In: E M B O Reports. 15, p. 282-290Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression
Kruse, Thomas, Zhang, G., Larsen, Marie Sofie Yoo, Lischetti, T., Streicher, W., Nielsen, T. K., Bjørn, S. P. & Nilsson, Jakob, 23 Jan 2013, In: Journal of Cell Science. 126, p. 1086-1092 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Actin homolog MreB and RNA polymerase interact and are both required for chromosome segregation in Escherichia coli
Kruse, Thomas, Blagoev, B., Løbner-Olesen, Anders, Wachi, M., Sasaki, K., Iwai, N., Mann, Matthias & Gerdes, K., 1 Jan 2006, In: Genes & Development. 20, 1, p. 113-124 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex
Kruse, Thomas, Bork-Jensen, J. & Gerdes, K., Jan 2005, In: Molecular Microbiology. 55, 1, p. 78-89 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Dysfunctional MreB inhibits chromosome segregation in Escherichia coli
Kruse, Thomas, Møller-Jensen, J., Løbner-Olesen, Anders & Gerdes, K., 2003, In: E M B O Journal. 22, 19, p. 5283-5292 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 34503674
Most downloads
-
190
downloads
Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
123
downloads
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
98
downloads
A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis
Research output: Contribution to journal › Journal article › Research › peer-review
Published