Nicole Schmitt

Nicole Schmitt

Professor with special responsibilities


  1. Published

    Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

    Adinolfi, B., Carpi, S., Romanini, A., Da Pozzo, E., Castagna, M., Costa, B., Martini, C., Olesen, S., Schmitt, Nicole, Breschi, M. C., Nieri, P. & Fogli, S., Jul 2015, In: Anticancer Research. 35, 7, p. 3781-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking

    Andersen, M. N., Hefting, L. L., Steffensen, Annette Buur, Schmitt, Nicole, Olesen, S., Olsen, Jesper Velgaard, Lundby, Alicia & Rasmussen, Hanne Borger, 15 Nov 2015, In: American Journal of Physiology: Cell Physiology. 309, 10, p. C693-C706 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Genetic Modifier of the QTc Interval Associated With Early-Onset Atrial Fibrillation

    Andreasen, Laura Korsholm, Nielsen, J. B., Christophersen, I. E., Holst, A. G., Sajadieh, Ahmad, Tveit, A., Haunsø, Stig, Svendsen, Jesper Hastrup, Schmitt, Nicole & Olesen, Morten Steen Salling, Oct 2013, In: Canadian Journal of Cardiology. 29, 10, p. 1234-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Brugada syndrome risk loci seem protective against atrial fibrillation

    Andreasen, Laura Korsholm, Nielsen, J. B., Darkner, S., Christophersen, I. E., Jabbari, J., Refsgaard, L., Thiis, J. J., Sajadieh, Ahmad, Tveit, A., Haunsø, Stig, Svendsen, Jesper Hastrup, Schmitt, Nicole & Olesen, Morten Steen Salling, 26 Mar 2014, In: European Journal of Human Genetics. 22, p. 1357-1361 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

    Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, M. & Olesen, S., 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes

    Blom, S. M., Schmitt, Nicole & Jensen, H. S., 2009, In: PLoS ONE. 4, 12, p. e8251

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group

    Blom, S. M., Rottländer, M., Kehler, J., Bundgaard, C., Schmitt, Nicole & Jensen, H. S., Jun 2014, In: PloS one. 9, 6, 9 p., e100209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Differential effects of ICA-27243 on cloned K(V)7 channels

    Blom, S. M., Schmitt, Nicole & Jensen, H. S., Jan 2010, In: Pharmacology. 86, 3, p. 174-81 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

    Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, M., Svendsen, J. H. & Olesen, S., 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A

    Calloe, K., Schmitt, Nicole, Grubb, Søren, Pfeiffer, R., David, J., Kanter, R., Cordeiro, J. M., Antzelevitch, C. & Callø, Kirstine, 2011, In: Canadian Journal of Physiology and Pharmacology. 89, 10, p. 723-36 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

    Callø, Kirstine, Nielsen, Morten Schak, Grunnet, M., Schmitt, Nicole & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome

    Callø, Kirstine, Refaat, M. M., Grubb, Søren, Wojciak, J., Campagna, J., Thomsen, N. M., Nussbaum, R. L., Scheinman, M. M. & Schmitt, Nicole, 2013, In: Circulation. Arrhythmia and Electrophysiology (Online). 6, 1, p. 177-184 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

    Christensen, A. H., Chatelain, F. C., Huttner, I. G., Olesen, Morten Steen Salling, Soka, M., Feliciangeli, S., Horvat, C., Santiago, C. F., Vandenberg, J. I., Schmitt, Nicole, Olesen, S., Lesage, F. & Fatkin, D., Aug 2016, In: Journal of Molecular and Cellular Cardiology. 97, p. 24-35 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Fast detection of extrasynaptic GABA with a whole-cell sniffer

    Christensen, R. K., Petersen, A. V., Schmitt, Nicole & Perrier, Jean-Francois Marie, 2014, In: Frontiers in Cellular Neuroscience. 8, p. 1-9 9 p., 00133.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Cellular mechanisms for presynaptic inhibition of sensory afferents

    Christensen, R. K., Delgado-Lezama, R., russo, R., lind, B., Schmitt, Nicole, LOEZA-ALCOCER, M., Lauritzen, Martin & Perrier, Jean-Francois Marie, 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  16. Published

    Spinal dorsal horn astrocytes release GABA in response to synaptic activation

    Christensen, R. K., Delgado-Lezama, R., Russo, R. E., Lind, Barbara Lykke, Alcocer, E. L., Rath, Martin Fredensborg, Fabbiani, G., Schmitt, Nicole, Lauritzen, Martin, Petersen, A. V., Carlsen, E. M. & Perrier, Jean-Francois Marie, 2018, In: The Journal of Physiology. 596, 20, p. 4983-4994 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

    Christophersen, I. E., Olesen, M. S., Liang, Bo, Andersen, M. N., Larsen, A. P., Nielsen, J. B., Haunsø, Stig, Olesen, S., Tveit, A., Svendsen, Jesper Hastrup & Schmitt, Nicole, 21 Dec 2012, In: European Heart Journal.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

    Colman, M. A., Ni, H., Liang, Bo, Schmitt, Nicole & Zhang, H., Jun 2017, In: PLoS Computational Biology. 13, 6, 21 p., e1005587.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2

    Cordeiro, J. M., Perez, G. J., Schmitt, Nicole, Pfeiffer, R., Nesterenko, V. V., Burashnikov, E., Veltmann, C., Borggrefe, M., Wolpert, C., Schimpf, R. & Antzelevitch, C., Dec 2010, In: Canadian Journal of Physiology and Pharmacology. 88, 12, p. 1181-90 10 p.

    Research output: Contribution to journalJournal articleResearch

  20. Published

    Gliadin Fragments and a Specific Gliadin 33-mer Peptide Close KATP Channels and Induce Insulin Secretion in INS-1E Cells and Rat Islets of Langerhans

    Dall, M., Callø, Kirstine, Haupt-Jorgensen, M., Larsen, J., Schmitt, Nicole, Josefsen, K. & Buschard, K., 2013, In: PLOS ONE. 8, 6, p. 1-10 10 p., e66474.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia

    David, J., Lisewski, U., Crump, S. M., Jepps, Thomas Andrew Qvistgaard, Bocksteins, E., Wilck, N., Lossie, J., Roepke, T. K., Schmitt, Nicole & Abbott, G. W., Feb 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 2537-2552 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Trafficking of the IKs -Complex in MDCK Cells: Site of Subunit Assembly and Determinants of Polarized Localization

    David, J., Andersen, M. N., Olesen, S., Rasmussen, Hanne Borger & Schmitt, Nicole, Apr 2013, In: Traffic. 14, 4, p. 399-411 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels

    David, J., Stas, J. I., Schmitt, Nicole & Bocksteins, E., 5 Aug 2015, In: Scientific Reports. 5, p. 1-14 14 p., 12813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

    Denti, F., Paludan-Müller, Christian, Olesen, S., Haunsø, Stig, Svendsen, Jesper Hastrup, Olesen, Morten Steen Salling, Bentzen, Bo Hjorth & Schmitt, Nicole, Mar 2018, In: Personalized Medicine. 15, 2, p. 93-102 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome

    Denti, F., Bentzen, Bo Hjorth, Wojciak, J., Thomsen, N. M., Scheinman, M. & Schmitt, Nicole, 2018, In: Pacing and Clinical Electrophysiology. 41, 6, p. 620-626

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning

    Eckey, K., Wrobel, E., Strutz-Seebohm, N., Pott, L., Schmitt, Nicole & Seebohm, G., 15 Aug 2014, In: The Journal of Biological Chemistry. 289, 33, p. 22749-58 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Functional properties of human neuronal Kv11 channels

    Einarsen, K., Callø, Kirstine, Grunnet, M., Olesen, S. & Schmitt, Nicole, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Modulation of ERG channels by XE991.

    Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, M. & Olesen, S., 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants

    Gregers, E., Ahlberg, G., Christensen, T., Jabbari, J., Larsen, K. O., Herfelt, C. B., Henningsen, K. M., Andreasen, Laura Korsholm, Thiis, J. J., Lund, J., Holme, S., Haunsø, Stig, Bentzen, Bo Hjorth, Schmitt, Nicole, Svendsen, Jesper Hastrup & Olesen, Morten Steen Salling, Oct 2017, In: Heart Rhythm. 14, 10, p. 1531-1538

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.

    Grunnet, M., Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, S. & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    KCNQ1 channels sense small changes in cell volume.

    Grunnet, M., Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, S. & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Functional phenotype variations of two novel Kv 7.1 mutations identified in patients with Long QT syndrome

    Hammami Bomholtz, S., Refaat, M., Steffensen, Annette Buur, David, J., Espinosa, K., Nussbaum, R., Wojciak, J., Bentzen, Bo Hjorth, Scheinman, M. & Schmitt, Nicole, 2020, In: Pacing and Clinical Electrophysiology. 43, 2, p. 210-216 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

    Hansen, T. H., Yan, Yannan, Ahlberg, G., Vad, O. B., Refsgaard, L., Dos Santos, J. L., Mutsaers, N., Svendsen, Jesper Hastrup, Olesen, Morten Steen Salling, Bentzen, Bo Hjorth & Schmitt, Nicole, 29 Jan 2020, In: Scientific Reports. 10, 1, 10 p., 1453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway

    Jensen, C. S., Watanabe, S., Stas, J. I., Klaphaak, J., Yamane, A., Schmitt, Nicole, Olesen, S., Trimmer, J. S., Rasmussen, Hanne Borger & Misonou, H., 29 Nov 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 48, p. 11523-11536 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Specific Sorting and Post-Golgi trafficking of Dendritic Potassium Channels in Living Neurons

    Jensen, C. S., Watanabe, S., Rasmussen, Hanne Borger, Schmitt, Nicole, Olesen, S., Frost, N. A., Blanpied, T. A. & Misonou, H., 25 Feb 2014, In: The Journal of Biological Chemistry. 289, p. 10566-10581 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia

    Khanamiri, S., Soltysinska, E., Jepps, Thomas Andrew Qvistgaard, Bentzen, Bo Hjorth, Chadha, P. S., Schmitt, Nicole, Greenwood, Iain Andrew & Olesen, S., 30 Sep 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

    Liang, Bo, Soka, M., Christensen, A. H., Olesen, Morten Steen Salling, Larsen, A. P., Knop, F. K., Wang, F., Nielsen, J. B., Andersen, M. N., Humphreys, D., Mann, S. A., Huttner, I. G., Vandenberg, J. I., Svendsen, Jesper Hastrup, Haunsø, Stig, Preiss, T., Seebohm, G., Olesen, S., Schmitt, Nicole & Fatkin, D., 27 Dec 2013, In: Journal of Molecular and Cellular Cardiology. 67, p. 69-76 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes

    Liin, S. I., Karlsson, U., Bentzen, Bo Hjorth, Schmitt, Nicole & Elinder, F., 23 Feb 2016, In: Acta Physiologica (Print). 218, 1, p. 28-37 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel

    Liin, S. I., Silverå Ejneby, M., Barro-Soria, R., Skarsfeldt, Mark, Larsson, J. E., Starck Härlin, F., Parkkari, T., Bentzen, Bo Hjorth, Schmitt, Nicole, Larsson, H. P. & Elinder, F., 5 May 2015, In: Proceedings of the National Academy of Science of the United States of America. 112, 18, p. 5714–5719 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

    Lundby, Alicia, Tseng, G. & Schmitt, Nicole, 2010, In: Heart Rhythm. 7, 5, p. 708-713

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

    Lundby, Alicia, Jespersen, T., Schmitt, Nicole, Grunnet, M., Olesen, S., Cordeiro, J. M. & Calloe, K., Aug 2010, In: British Journal of Pharmacology. 160, 8, p. 2028-44 17 p.

    Research output: Contribution to journalJournal articleResearch

  42. Published

    KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.

    Lundby, Alicia, Ravn, L. S., Svendsen, J. H., Hauns, S., Olesen, S. & Schmitt, Nicole, 2008, In: Cellular Physiology and Biochemistry. 21, 1-3, p. 47-54 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.

    Lundby, Alicia, Ravn, L. S., Svendsen, Jesper Hastrup, Olesen, S. & Schmitt, Nicole, 2007, In: Heart Rhythm. 4, 12, p. 1532-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling

    Lundby, Alicia, Andersen, M. N., Steffensen, Annette Buur, Horn, H., Kelstrup, C. D., Francavilla, C., Jensen, Lars Juhl, Schmitt, Nicole, Thomsen, Morten Bækgaard & Olsen, Jesper Velgaard, 4 Jun 2013, In: Science Signaling. 6, 278, p. rs11 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation

    Nielsen, J. B., Bentzen, Bo Hjorth, Olesen, Morten Steen Salling, David, J., Olesen, S., Haunsø, Stig, Svendsen, Jesper Hastrup & Schmitt, Nicole, Apr 2014, In: Biomarkers in Medicine. 8, 4, p. 557-570 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Dysfunction of the heteromeric KV7.3/KV7.5 potassium channel is associated with autism spectrum disorders

    Nielsen, M. G., Rasmussen, Hanne Borger, Callø, Kirstine, F. Sequeira, A., Baretto, M., Oliveira, G., Almeida, J., B. Lauritsen, M., Ullmann, R., Boonen, S. E., Brøndum-Nielsen, K., M. Kalscheuer, V., Tümer, Asuman Zeynep, M. Vicente, A., Schmitt, Nicole & Tommerup, Niels, 2013, In: Frontiers in Genetics. 4, 54, p. 1-13 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.

    Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, M., Christiansen, M., Olesen, S. & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

    Olesen, M. S., Bentzen, Bo Hjorth, Nielsen, J. B., Steffensen, Annette Buur, David, J., Jabbari, J., Jensen, H., Haunsø, Stig, Svendsen, Jesper Hastrup & Schmitt, Nicole, 2012, In: B M C Medical Genetics. 13, p. 24

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    High Prevalence of Long QT Syndrome Associated SCN5A Variants in Patients with Early-Onset Lone Atrial Fibrillation

    Olesen, M. S., Yuan, L., Liang, Bo, Holst, A. G., Nielsen, N., Nielsen, J. B., Hedley, P. L., Christiansen, M., Olesen, S., Haunsø, Stig, Schmitt, Nicole, Jespersen, Thomas & Svendsen, Jesper Hastrup, 2012, In: Circulation: Cardiovascular Genetics. 5, 4, p. 450-459 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Letter by Olesen et al regarding article, "MOG1: a new susceptibility gene for Brugada syndrome"

    Olesen, M. S., Holst, A. G. & Schmitt, Nicole, 2011, In: Circulation: Cardiovascular Genetics. 4, 5

    Research output: Contribution to journalJournal articleResearchpeer-review

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