Lykke Sylow

Lykke Sylow

Associate Professor - Promotion Programme


  1. 2023
  2. Published

    Universiteterne har brug for en reformpause

    Kropp, K., Vallgårda, Karen Asta Arnfred, Hougaard Laustsen-Kiel, A., Albrechtsen, Nicolai Jacob Wewer, Sylow, Lykke, Damgaard, R. B., Kristensen, Line Burholt, Hansen, N. C., Uusimäki, E., Jønsson, A. B., Høyland-Kroghsbo, Nina Molin, Eriksen, J. J., Rasmussen, Laura Vang, Andersen, P. E., Jensen, Louise Kruse, Lomborg, Stine, Morueta-Holme, Naia, Simonsen, K. B., Zetterberg-Nielsen, S. & Autzen, A., 29 Jan 2023, In: Berlingske Tidende.

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  3. Published

    Adenosine monophosphate-activated protein kinase is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice

    Raun, Steffen Henning, Ali, Mona Sadek, Han, X., Henriquez-Olguín, Carlos, Pham, Tang Cam Phung, Meneses Valdés, Roberto Andrés, Knudsen, Jonas Roland, Willemsen, A. C. H., Larsen, Steen, Jensen, Thomas Elbenhardt, Langen, R. & Sylow, Lykke, 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, 4, p. 1631-1647

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

    Irazoki, Andrea, Gordaliza-Alaguero, I., Frank, E., Giakoumakis, N. N., Seco, J., Palacín, M., Gumà, A., Sylow, Lykke, Sebastián, D. & Zorzano, A., 2023, In: Nature Communications. 14, 1, 19 p., 108.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Insulin resistance in patients with cancer: a systematic review and meta-analysis

    Màrmol, J. M., Carlsson, Michala, Raun, Steffen Henning, Grand, Mia Klinten, Sørensen, Jonas, Lang Lehrskov, L., Richter, Erik A., Norgaard, O. & Sylow, Lykke, 2023, In: Acta Oncologica. 62, 4, p. 364-371

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    NOX2 deficiency exacerbates diet-induced obesity and impairs molecular training adaptations in skeletal muscle

    Henriquez-Olguín, Carlos, Meneses Valdés, Roberto Andrés, Raun, Steffen Henning, Gallero, S., Knudsen, Jonas Roland, Li, Z., Li, J., Sylow, Lykke, Jaimovich, E. & Jensen, Thomas Elbenhardt, 2023, In: Redox Biology. 65, 12 p., 102842.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    TNIK is a conserved regulator of glucose and lipid metabolism in obesity

    Pham, Tang Cam Phung, Dollet, L., Ali, Mona Sadek, Raun, Steffen Henning, Møller, Lisbeth L V, Jafari Kermani, Abbas, Ditzel, N., Andersen, Nicoline Resen, Fritzen, Andreas Mæchel, Gerhart-Hines, Zach, Kiens, Bente, Suomalainen, A., Simpson, S. J., Salling Olsen, M., Kieser, A., Schjerling, Peter, Nieminen, A. I., Richter, Erik A., Havula, E. & Sylow, Lykke, 2023, In: Science Advances. 9, 32, 18 p., eadf7119.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action

    Møller, Lisbeth L V, Ali, Mona Sadek, Davey, J., Raun, Steffen Henning, Andersen, Nicoline Resen, Long, J. Z., Qian, H., Jeppesen, J. F., Henriquez-Olguín, Carlos, Frank, E., Jensen, Thomas Elbenhardt, Højlund, K., Wojtaszewski, Jørgen F P, Nielsen, J., Chiu, T. T., Jedrychowski, M. P., Gregorevic, P., Klip, A., Richter, Erik A. & Sylow, Lykke, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 27, 12 p., e2211041120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2022
  10. Published

    Medlemmer af Det Unge Akademi: Øget fokus på diversitet vil føre til bedre forskning

    Houman Ellersgaard, C., Vallgårda, Karen Asta Arnfred, Kropp, K., Sylow, Lykke & Eriksen, J. J., 14 Oct 2022, Altinget.dk.

    Research output: Other contributionNet publication - Internet publicationCommunication

  11. Published
  12. Published

    Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type-specific manner

    Raun, Steffen Henning, Knudsen, Jonas Roland, Han, X., Jensen, Thomas Elbenhardt & Sylow, Lykke, 2022, In: F A S E B Journal. 36, 3, 16 p., e22211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle

    Knudsen, Jonas Roland, Persson, Kaspar Wredstrøm, Meister, J., Carl, Christian Strini, Raun, Steffen Henning, Andersen, Nicoline Resen, Sylow, Lykke, Kiens, Bente, Jensen, Thomas Elbenhardt, Richter, Erik A. & Kleinert, Maximilian, 2022, In: American Journal of Physiology: Endocrinology and Metabolism. 322, 1, p. E63-E73 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Genetic variation of macronutrient tolerance in Drosophila melanogaster

    Havula, E., Ghazanfar, S., Lamichane, N., Francis, D., Hasygar, K., Liu, Y., Alton, L. A., Johnstone, J., Needham, E. J., Pulpitel, T., Clark, T., Niranjan, H. N., Shang, V., Tong, V., Jiwnani, N., Audia, G., Alves, A. N., Sylow, L., Mirth, C., Neely, G. G. & 4 others, Yang, Jingxian, Hietakangas, V., Simpson, S. J. & Senior, A. M., 2022, In: Nature Communications. 13, 16 p., 1637.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Incidence of new-onset type 2 diabetes after cancer: A Danish cohort study

    Sylow, Lykke, Grand, Mia Klinten, von Heymann, A., Persson, F., Siersma, Volkert Dirk, Kriegbaum, Margit, Andersen, Christen Bertel L & Johansen, Christoffer, 2022, In: Diabetes Care. 45, 6, p. e105-e106 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  16. Published

    Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake

    Draicchio, F., Behrends, V., Tillin, N. A., Hurren, N. M., Sylow, Lykke & Mackenzie, R., 2022, In: Journal of Physiology. 600, 20, p. 4393-4408 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Kroppen og kræften

    Sylow, Lykke, 2022, In: Det Unge Akademi. Årsskrift. 2022, p. 16-19

    Research output: Contribution to journalJournal articleCommunication

  18. Published

    Measurement of skeletal muscle glucose uptake in mice in response to acute treadmill running

    Møller, Lisbeth L V, Raun, Steffen Henning, Fritzen, Andreas Mæchel & Sylow, Lykke, 2022, In: Journal of Biological Methods. 9, 3, 13 p., e162.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2021
  20. Published

    Forskningsfriheden i Danmark er under pres

    Albrechtsen, N. J. W., Andersen, P. E., Autzen, A., Bjørn, A., Damgaard, R. B., Burholt, L., Danbolt, M., Ellersgaard, C., Hansen, N. C., Jensen, L. K., Jensen, K. M. Ø., Jønsson, K., Kristensen, P. M., Kropp, K., Levisen, C., Møller, N. M., Nielsen, T. K., Laustsen, A. H., Nielsen, M. W., Simonsen, K. B. & 4 others, Sylow, Lykke, Vallgårda, Karen Asta Arnfred, Zetterberg-Nielsen, S. & Det Unge Akademi, D. U. A., 30 Oct 2021, In: Politiken. p. 5-6 2 p.

    Research output: Contribution to journalContribution to newspaper - Feature articleCommunication

  21. Published

    Editorial: Skeletal muscle immunometabolism

    Trollet, C., Cheng, A. J., Sylow, Lykke, Batista, M. L. & Pillon, N. J., 2021, In: Frontiers in Physiology. 12, 3 p., 683088.

    Research output: Contribution to journalEditorialResearch

  22. Published

    Effect of hypoxic exercise on glucose tolerance in healthy and pre-diabetic adults

    De Groote, E., Britto, F. A., Balan, E., Warnier, G., Thissen, J., Nielens, H., Sylow, Lykke & Deldicque, L., 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, 1, p. E43-E54 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes

    Pham, Tang Cam Phung, Bojsen-Møller, K. N., Madsbad, Sten, Wojtaszewski, Jørgen F P, Richter, Erik A. & Sylow, Lykke, 2021, In: International Journal of Obesity. 45, p. 316-325 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Exercise - a panacea of metabolic dysregulation in cancer: Physiological and molecular insights

    Raun, Steffen Henning, Buch-Larsen, K., Schwarz, Peter & Sylow, Lykke, 2021, In: International Journal of Molecular Sciences. 22, 7, 23 p., 3469.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Interactions between insulin and exercise

    Richter, Erik A., Sylow, Lykke & Hargreaves, M., 2021, In: Biochemical Journal. 478, 21, p. 3827-3846 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

    Sylow, Lykke, Tokarz, V. L., Richter, Erik A. & Klip, A., 2021, In: Cell Metabolism. 33, 4, p. 758-780 23 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Three challenges of being a scientist in an age of misinformation

    Sylow, Lykke, 2021, In: Journal of Physiology. 599, 7, p. 1937-1938 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  28. 2020
  29. Published

    Conditioned media from MCF7 and BT474 breast cancer cells induce insulin resistance in skeletal muscle myotubes

    Ali, Mona Sadek, Han, X., Li, J., Jäättelä, M. & Sylow, Lykke, 28 Jan 2020, bioRxiv.

    Research output: Working paperPreprintResearch

  30. Published
  31. Published

    Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes

    Sylow, Lykke, Vind, B. F., Kruse, R., Møller, P. M., Wojtaszewski, Jørgen F P, Richter, Erik A. & Højlund, K., 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 5, p. 1343-1354 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Housing temperature influences exercise training adaptations in mice

    Raun, Steffen Henning, Henriquez-Olguín, Carlos, Karavaeva, Iuliia, Ali, Mona Sadek, Møller, Lisbeth L V, Kot, Witold, Castro-Mejía, J. L., Nielsen, Dennis Sandris, Gerhart-Hines, Zach, Richter, Erik A. & Sylow, Lykke, 2020, In: Nature Communications. 11, 16 p., 1560.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle

    Møller, Lisbeth L V, Jaurji, M., Kjøbsted, Rasmus, Joseph, G. A., Madsen, A. B., Knudsen, Jonas Roland, Lundsgaard, Anne-Marie, Andersen, Nicoline Resen, Schjerling, P., Jensen, Thomas Elbenhardt, Krauss, R. S., Richter, Erik A. & Sylow, Lykke, 2020, In: Journal of Physiology. 598, 23, p. 5351-5377 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients

    Draicchio, F., van Vliet, S., Ancu, O., Paluska, S. A., Wilund, K. R., Mickute, M., Sathyapalan, T., Renshaw, D., Watt, P., Sylow, Lykke, Burd, N. A. & Mackenzie, R., 2020, In: Journal of Physiology. 598, 24, p. 5701-5716 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Klyngevejledning til ph.d.- studerendes artikelskrivning

    Sylow, Lykke, 2020, Improving University Science Teaching and Learning - Pedagogical Projects 2020. Christiansen, F. V. & Arias, A. A. (eds.). Copenhagen: Department of Science Education, University of Copenhagen, p. 109-119 11 p. (Improving University Science Teaching and Learning - Pedagogical Projects, Vol. 15).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  36. Published

    The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport

    Møller, Lisbeth L V, Nielsen, I. L., Knudsen, Jonas Roland, Andersen, Nicoline Resen, Jensen, Thomas Elbenhardt, Sylow, Lykke & Richter, Erik A., 2020, In: Physiological Reports. 8, 12, 13 p., e14460.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2019
  38. Published

    Current advances in our understanding of exercise as medicine in metabolic disease

    Sylow, Lykke & Richter, Erik A., 2019, In: Current Opinion in Physiology. 12, p. 12-19 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

    Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Raun, Steffen Henning, Li, Z., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Sylow, Lykke, Holmdahl, R., Richter, Erik A., Jaimovich, E. & Jensen, Thomas Elbenhardt, 2019, In: Nature Communications. 10, 11 p., 4623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

    Han, X., Møller, Lisbeth L V, De Groote, E., Bojsen-Møller, K. N., Davey, J., Henriquez-Olguín, Carlos, Li, Z., Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Madsbad, Sten, Gregorevic, P., Richter, Erik A. & Sylow, Lykke, 2019, In: Journal of Cachexia, Sarcopenia and Muscle. 10, 6, p. 1241-1257 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

    Nelson, M. E., Parker, B. L., Burchfield, J. G., Hoffman, N. J., Needham, E. J., Cooke, K. C., Naim, T., Sylow, Lykke, Ling, N. X. Y., Francis, D., Norris, D. M., Chaudhuri, R., Oakhill, J. S., Richter, Erik A., Lynch, G. S., Stöckli, J. & James, D. E., 2019, In: E M B O Journal. 38, 24, 20 p., e102578.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Rho GTPases-emerging regulators of glucose homeostasis and metabolic health

    Møller, Lisbeth L V, Klip, A. & Sylow, Lykke, 2019, In: Cells. 8, 5, 21 p., 434.

    Research output: Contribution to journalReviewResearchpeer-review

  43. 2018
  44. Published

    Differential effects of high-fat diet and exercise training on bone and energy metabolism

    Picke, A., Sylow, Lykke, Møller, Lisbeth L V, Kjøbsted, Rasmus, Schmidt, F. N., Steejn, M. W., Salbach-Hirsch, J., Hofbauer, C., Blüher, M., Saalbach, A., Busse, B., Rauner, M. & Hofbauer, L. C., 2018, In: Bone. 116, p. 120-134 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

    Kleinert, Maximilian, Parker, B. L., Jensen, Thomas Elbenhardt, Raun, Steffen Henning, Pham, P., Han, X., James, D. E., Richter, Erik A. & Sylow, Lykke, 2018, In: Scientific Reports. 8, 11 p., 10723.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

    Raun, Steffen Henning, Ali, Mona Sadek, Kjøbsted, Rasmus, Møller, Lisbeth L V, Federspiel, M. A., Richter, Erik A., Jensen, Thomas Elbenhardt & Sylow, Lykke, 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

    Madsen, A. L. B., Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Angin, Y., Zaal, K. J., Sylow, Lykke, Schjerling, P., Ralston, E. & Jensen, Thomas Elbenhardt, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2017
  49. Published

    Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects

    Gliemann, Lasse, Rytter, N., Lindskrog, M., Slingsby, M. H. L., Åkerström, T., Sylow, Lykke, Richter, Erik A. & Hellsten, Ylva, 2017, In: Journal of Physiology. 595, 16, p. 5557-5571 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

    Sjøberg, K. A., Frøsig, C., Kjøbsted, Rasmus, Sylow, Lykke, Kleinert, Maximilian, Betik, A. C., Shaw, C. S., Kiens, Bente, Wojtaszewski, Jørgen F P, Rattigan, S., Richter, Erik A. & McConell, G. K., 2017, In: Diabetes. 66, 6, p. 1501-1510 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Exercise-stimulated glucose uptake - regulation and implications for glycaemic control

    Sylow, Lykke, Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  52. Published

    Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

    Kleinert, Maximilian, Parker, B. L., Fritzen, Andreas Mæchel, Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Kjøbsted, Rasmus, Sylow, Lykke, Ruegg, M. A., James, D. E. & Richter, Erik A., 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise

    Sylow, Lykke, Møller, Lisbeth L V, Kleinert, Maximilian, D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, Thomas Elbenhardt & Richter, Erik A., 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2016
  55. Published

    Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism

    Møller, Lisbeth L V, Sylow, Lykke, Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, Pia, Kiens, Bente, Woldbye, David Paul Drucker & Richter, Erik A., 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

    Sylow, Lykke, Laurent, I., Kleinert, Maximilian, Møller, Lisbeth L V, Ploug, Thorkil, Schjerling, Peter, Bilan, P. J., Klip, A., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Rac1 in muscle is dispensable for improved insulin action after exercise in mice

    Sylow, Lykke, Møller, Lisbeth L V, D'Hulst, G., Schjerling, P., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    The cancer drug Dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice

    Sylow, Lykke, Long, J., Lokurkar, I. A., Zeng, X., Richter, Erik A. & Spiegelman, B. M., 2016, In: Endocrinology. 157, 11, p. 4184-4191 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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