Lene Juel Rasmussen
Professor
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From powerhouse to perpetrator—mitochondria in health and disease
Fakouri, N. B., Hansen, T. L., Desler, Claus, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In: Biology. 8, 2, 15 p., 35.Research output: Contribution to journal › Review › Research › peer-review
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EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration
Durhuus, J. A., Rozing, Maarten Pieter, Nielsen, M. K., Molbech, C. R., Keijzers, G., Scheibye-Knudsen, Morten, Rasmussen, Lene Juel, Westendorp, Rudi GJ & Sørensen, Torben Lykke, 2021, In: Scientific Reports. 11, 1, 8226.Research output: Contribution to journal › Journal article › Research › peer-review
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Simvastatin improves mitochondrial respiration in peripheral blood cells
Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India
Durhuus, J. A., Desler, Claus & Rasmussen, Lene Juel, Jan 2015, In: Mitochondrion. 20, p. 7-12 6 p.Research output: Contribution to journal › Conference article › Research › peer-review
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Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546Research output: Contribution to journal › Journal article › Research › peer-review
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MRE11A: a novel negative regulator of human DNA mismatch repair
Du, D., Yang, Y., Wang, G., Chen, L., Guan, X., Rasmussen, Lene Juel & Liu, D., 2023, bioRxiv, 34 p.Research output: Working paper › Preprint › Research
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A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome
Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, G., Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, L. J., Greenblatt, M. S. & 2 others, , 2019, In: Genetics in Medicine. 21, p. 1486–1496Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome
Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In: Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants
Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In: Human Mutation. 33, 3, p. 488-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome
Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, In: Genetics in Medicine. 22, p. 847–856Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome
Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein
Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In: Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In: Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of mitochondrial dysfunction in the progression of Alzheimer’s disease
Desler, Claus, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In: Current Medicinal Chemistry. 25, 40, p. 5578 - 5587Research output: Contribution to journal › Review › Research › peer-review
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Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation
Desler, Claus, Durhuus, J. A., Hansen, T. L. L., Anugula, Sharath, Zelander, N. T., Bøggild, S. & Rasmussen, Lene Juel, 2022, In: Mitochondrion. 64, p. 73-81 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Silico screening for functional candidates amongst hypothetical proteins
Desler, Claus, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In: BMC Bioinformatics. 10, p. 289Research output: Contribution to journal › Journal article › Research › peer-review
Mitochondria as determinant of nucleotide pools and chromosomal stability
Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
The role of mitochondrial dNTP levels in cells with reduced TK2 activity
Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In: Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Christensen, Christa Lykke, Helge, Jørn Wulff, Krasnik, Allan, Kriegbaum, Margit, Rasmussen, Lene Juel, Hickson, Ian David, Liisberg, Kasper Bering, Oxlund, Bjarke, Bruun, B., Lau, Sofie Rosenlund, Olsen, M. N. A., Andersen, John Sahl, Heltberg, Andreas Søndergaard, Kuhlman, A. C. B., Morville, T. H., Dohlmann, T. L., Larsen, Steen & Dela, Flemming, 2016, In: Scandinavian Journal of Public Health. 44, 5, p. 534-539 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Societal need for interdisciplinary ageing research
Cherbuin, N., Lijima, K., Kalula, S., Malhotrad, R., Rasmussen, Lene Juel, Chan, A., Lafortune, L., Harper, S., Zheng, X., Lindeman, D., Walsh, E., Hussain, R., Burns, R., Kristiansen, Maria, Sugawara, I., Son, B., Tanaka, T., Buckner, S., Hoffman, J. & Combrinck, M., 25 Feb 2021, In: Biomedicine Hub. 6, 1, p. 42-47 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms
Cherbuin, N., Patel, H., Walsh, E. I., Ambikairajah, A., Burns, R., Brüstle, A. & Rasmussen, Lene Juel, 2024, In: Genes. 15, 2, 15 p., 153.Research output: Contribution to journal › Journal article › Research › peer-review
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Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, L. H., Jun 2012, In: Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia
Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In: Journal of Experimental Biology. 222, 11, 9 p., jeb200410.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste
Bouchami, O., Sghaier, H., Desler, Claus, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In: Annals of Microbiology.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions
Bjerregaard, Victoria Alexandra, Schönewolf-Greulich, B., Rasmussen, Lene Juel, Desler, Claus & Tümer, Asuman Zeynep, 2020, In: Frontiers in Neurology. 11, 9 p., 163.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor
Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor
Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516Research output: Contribution to journal › Journal article › Research › peer-review
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Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside
Anugula, Sharath, Li, Zhiquan, Li, Yuan, Hendriksen, A., Christensen, P. B., Wang, L., Monk, J. M., de Wind, N., Bohr, Vilhelm, Desler, Claus, Naviaux, R. K. & Rasmussen, Lene Juel, 2023, In: Heliyon. 9, 6, e17392.Research output: Contribution to journal › Journal article › Research › peer-review
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RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma
Andreassen, C. H., Lorenzen, M., Nielsen, J. E., Kafai Yahyavi, S., Toft, Birgitte Grønkær, Ingerslev, L. R., Clemmensen, Christoffer, Rasmussen, Lene Juel, Bokemeyer, C., Juul, Anders, Jørgensen, A. & Jensen, M. B., 2022, In: British Journal of Cancer. 127, p. 408-421Research output: Contribution to journal › Journal article › Research › peer-review
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14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients
Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, Mef Christina, Dominguez, M., Nyström, M., Hansen, Thomas van Overeem, Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In: Human Mutation. 33, 12, p. 1647-1655 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In: Mechanisms of Ageing and Development. 185, 111194.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytosolic self-DNA—A potential source of chronic inflammation in aging
Akbari, M., Shanley, D. P., Bohr, Vilhelm & Rasmussen, Lene Juel, 2021, In: Cells. 10, 12, 3544.Research output: Contribution to journal › Review › Research › peer-review
ID: 13558388
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Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Research output: Contribution to journal › Journal article › Research › peer-review
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984
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Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells
Research output: Contribution to journal › Journal article › Research › peer-review
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572
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Research output: Contribution to journal › Journal article › Research › peer-review
Published