Leila Lo Leggio
Professor
Department of Chemistry
Universitetsparken 5
2100 København Ø
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Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 a-galactosidases
Abou Hachem, M., Fredslund, F., Andersen, J. M., Larsen, R. J., Majumder, A., Hansen, M. E., van Zanten, G. C., Lahtinen, S. J., Barrangou, R., Klaenhammer, T., Jacobsen, S., Coutinho, P. M., Lo Leggio, Leila & Svensson, B., 2012, In: Biocatalysis and Biotransformation. 30, 3, p. 316-325 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria
Abou Hachem, M., Andersen, J. M., Barrangou, R., Møller, M. S., Fredslund, F., Majumder, A., Hansen, M. E., Lahtinen, S. J., Jacobsen, S., Lo Leggio, Leila, Goh, Y. J., Klaenhammer, T. R. & Svensson, B., 2013, In: Biocatalysis and Biotransformation. 31, 4, p. 226-235 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A snapshot into the metabolism of isomalto-oligosaccharides in probiotic bacteria
Abou Hachem, M., Møller, M. S., Andersen, J. M., Fredslund, F., Majumder, A., Nakai, H., Lo Leggio, Leila, Goh, Y., Barrangou, R., Klaenhammer, T. R. & Svensson, B., 2013, In: Journal of Applied Glycoscience. 60, 2, p. 95-100 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of dimeric, recombinant Sulfolobus solfataricus phosphoribosyl diphosphate synthase: a bent dimer defining the adenine specificity of the substrate ATP
Andersen, R. W., Lo Leggio, Leila, Hove-Jensen, B. & Kadziola, Anders, 2015, In: Extremophiles. 19, 2, p. 407-415 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An 1,4-α-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus
Andersen, S., Møller, M. S., Poulsen, Jens-Christian Navarro, Pichler, M. J., Svensson, B., Lo Leggio, Leila, Goh, Y. J. & Abou Hachem, M., 22 May 2020, In: Applied and Environmental Microbiology. 86, 15, 14 p., e00661-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Kinetics and stereochemistry of the Cellulomonas fimi ß-mannanase studied using 1H-NMR
Anderson, L., Hägglund, P., Stoll, D., Lo Leggio, Leila, Drakenberg, T. & Stålbrand, H., 2008, In: Biocatalysis and Biotransformation. 26, p. 86-95Research output: Contribution to journal › Journal article › Research › peer-review
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Kinetics and stereochemistry of the Cellulomonas fimi β-mannanase studied using 1 H-NMR
Anderson, L., Hägglund, Per Mårten, Stoll, D., Lo Leggio, Leila, Drakenberg, T. & Stålbrand, H., 1 Jan 2008, In: Biocatalysis and Biotransformation. 26, 1-2, p. 86-95Research output: Contribution to journal › Journal article › Research › peer-review
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Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds
Arnling Bååth, J., Mazurkewich, S., Poulsen, Jens-Christian Navarro, Olsson, L., Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 16, p. 6635-6644 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion
Baath, J. A., Mazurkewich, S., Knudsen, R. M., Poulsen, Jens-Christian Navarro, Olsson, L., Lo Leggio, Leila & Larsbrink, J., 2018, In: Biotechnology for Biofuels. 11, 14 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
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Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases
Banerjee, S., Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Singh, R. K., Ipsen, J. O., Hernandez Rollan, Cristina, Nørholm, M. H. H., Bjerrum, Morten Jannik, Johansen, Katja Salomon & Lo Leggio, Leila, 2022, In: Biomolecules. 12, 2, 15 p., 194.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemoenzymatic indican for light-driven denim dyeing
Bidart, G. N., Teze, D., Jansen, C. U., Pasutto, E., Putkaradze, N., Sesay, A. M., Fredslund, F., Lo Leggio, Leila, Ögmundarson, O., Sukumara, S., Qvortrup, K. & Welner, D. H., 2024, In: Nature Communications. 15, 1, 11 p., 1489.Research output: Contribution to journal › Journal article › Research › peer-review
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Scission of Glucosidic Bonds by a Lentinus similis Lytic Polysaccharide Monooxygenases Is Strictly Dependent on H2O2while the Oxidation of Saccharide Products Depends on O2
Brander, Søren, Tokin, Radina, Ipsen, J., Jensen, Poul Erik, Hernández-Rollán, C., Nørholm, M. H. H., Lo Leggio, Leila, Dupree, P. & Johansen, Katja Salomon, 2021, In: ACS Catalysis. 11, 22, p. 13848-13859Research output: Contribution to journal › Journal article › Research › peer-review
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Biochemical evidence of both copper chelation and oxygenase activity at the histidine brace
Brander, Søren, Horvath, I., Ipsen, J. Ø., Peciulyte, A., Olsson, L., Hernández-rollán, C., Nørholm, M. H. H., Mossin, S., Lo Leggio, Leila, Probst, C., Thiele, D. J. & Johansen, Katja Salomon, 1 Dec 2020, In: Scientific Reports. 10, 1, 11 p., 16369.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a fungal dimeric a-type carbonic anhydrase
Cuesta Seijo, J. A., Borchert, M. S., Poulsen, Jens-Christian Navarro, Schnorr, K. M., Mortensen, S. B. & Lo Leggio, Leila, 2011, In: F E B S Letters. 585, p. 1042-1048Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7
Czene, A., Toth, E., Gyurcsik, B., Otten, H., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Larsen, Sine, Christensen, H. E. M. & Nagata, K., 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, p. 551-554 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009
Eckert, K., Zielinski, F., Lo Leggio, Leila & Schneider, E., 2002, In: Applied Microbiology and Biotechnology. 60, p. 428-436Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary X-ray analysis of Alicyclobacillus acidocaldarius endoglucanase CelA
Eckert, K., Ernst, H. A., Schneider, E., Larsen, Sine & Lo Leggio, Leila, 2003, In: Acta Crystallographica. Section D: Biological Crystallography. 51, p. 139-141Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of A. acidocaldarius Endoglucanase Cel9A in complex with cello-oligosaccharides: strong -1 and -2 subsites mimic cellobiohydrolase activity
Eckert, K., Vigouroux, A., Lo Leggio, Leila & Morera, S., 2009, In: Journal of Molecular Biology. 394, 1, p. 61-70Research output: Contribution to journal › Journal article › Research › peer-review
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Probing the structure of glucan lyases by sequence analysis, circular dichroism and proteolysis
Ernst, H. A., Lo Leggio, Leila, Yu, S., Finnie, C., Svensson, B. & Larsen, Sine, 2005, In: Biologia. 60, Suppl. 16, p. 149-159Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus
Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 12, p. 1039-42 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the conserved domain of ANAC, a member of the NAC family of transcription factors
Ernst, H. A., Olsen, A. N., Skriver, Karen, Larsen, Sine & Lo Leggio, Leila, 2004, In: EMBO Reports. 5, p. 297-303Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31
Ernst, H. A., Lo Leggio, Leila, Willemoës, Martin, Leonard, G. A., Blum, P. & Larsen, Sine, 2006, In: Journal of Molecular Biology. 358, 4, p. 1106-24Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of different crystal forms of the a-glucosidase MalA from Sulfolobus solfataricus
Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica Section F. 61, p. 1039-1042Research output: Contribution to journal › Journal article › Research › peer-review
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Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases
Frandsen, Kristian Erik Høpfner, Tovborg, M., Jørgensen, C. I., Spodsberg, N., Rosso, M., Hemsworth, G. R., Garman, E. F., Grime, G. W., Poulsen, Jens-Christian Navarro, Batth, T. S., Miyauchi, S., Lipzen, A., Daum, C., Grigoriev, I. V., Johansen, Katja Salomon, Henrissat, B., Berrin, J. & Lo Leggio, Leila, 2019, In: The Journal of Biological Chemistry. 294, p. 17117-17130 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)
Frandsen, Kristian Erik Høpfner, Haon, M., Grisel, S., Henrissat, B., Lo Leggio, Leila & Berrin, J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 11 p., 100086.Research output: Contribution to journal › Journal article › Research › peer-review
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Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder
Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tovborg, M., Johansen, Katja Salomon & Lo Leggio, Leila, 2017, In: Acta crystallographica Section D: Structural biology . 73, p. 64-76 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding of the N-terminal domain of the lactococcal bacteriophage TP901-1 CI repressor to its target DNA: a crystallography, small angle scattering, and nuclear magnetic resonance study
Frandsen, Kristian Erik Høpfner, Rasmussen, K. K., Jensen, M. R., Hammer, K., Pedersen, M., Poulsen, Jens-Christian Navarro, Arleth, Lise & Lo Leggio, Leila, 2013, In: Biochemistry. 52, 39, p. 6892-6904 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
Frandsen, K. E. H., Simmons, T. J., Dupree, P., Poulsen, J-C. N., Hemsworth, G. R., Ciano, L., Johnston, E. M., Tovborg, M., Johansen, K. S., von Freiesleben, P., Marmuse, L., Fort, S., Cottaz, S., Driguez, H., Henrissat, B., Lenfant, N., Tuna, F., Baldansuren, A., Davies, G. J., Lo Leggio, L. & 1 others, , 2016, In: Nature Chemical Biology. 12, 4, p. 298-303 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase LsAA9A at low pH
Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tandrup, T. & Lo Leggio, Leila, 2017, In: Carbohydrate Research. 448, p. 187-190 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes
Frandsen, Kristian Erik Høpfner & Lo Leggio, Leila, 2016, In: IUCrJ. 3, Part 6, p. 448-467 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney
Fredslund, F., Borchert, M. S., Poulsen, Jens-Christian Navarro, Mortensen, S. B., Perner, M., Streit, W. R. & Lo Leggio, Leila, 2018, In: Enzyme and Microbial Technology. 114, p. 48-54 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural characterization of the thermostable Bradyrhizobium japonicum D-sorbitol dehydrogenase
Fredslund, F., Otten, H., Gemperlein, S., Poulsen, Jens-Christian Navarro, Carius, Y., Kohring, G. & Lo Leggio, Leila, 2016, In: Acta Crystallographica Section F. 72, 11, p. 846-852 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of a-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding
Fredslund, F., Abou Hachem, M., Larsen, R. J., Sørensen, P. G., Pedro, C., Lo Leggio, Leila & Svensson, B., 2011, In: Journal of Molecular Biology. 412, 466-480, p. 466–480Research output: Contribution to journal › Journal article › Research › peer-review
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A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis
Garcia-Santamarina, S., Probst, C., Festa, R. A., Ding, C., Smith, A. D., Conklin, S. E., Brander, Søren, Kinch, L. N., Grishin, N. V., Franz, K. J., Riggs-Gelasco, P., Lo Leggio, Leila, Johansen, Katja Salomon & Thiele, D. J., 2020, In: Nature Chemical Biology. 16, p. 337-344 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An L-glucitol oxidizing dehydrogenase from Bradyrhizobium japonicum USDA 110 for production of D-sorbose with enzymatic or electrochemical cofactor regeneration
Gauer, S., Wang, Z., Otten, H., Etienne, M., Bjerrum, Morten Jannik, Lo Leggio, Leila, Walcarius, A., Giffhorn, F. & Kohring, G., 2014, In: Applied Microbiology and Biotechnology. 98, 7, p. 3023-3032 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family
Harris, P. V., Welner, D. H., McFarland, K., Re, E., Poulsen, Jens-Christian Navarro, Brown, K., Salbo, R., Ding, H., Vlasenko, E., Marino, S., Xu, F., Cherry, J., Larsen, Sine & Lo Leggio, Leila, 2010, In: Biochemistry. 49, p. 3305-3316Research output: Contribution to journal › Journal article › Research › peer-review
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Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-β-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3
Hekmat, O., Lo Leggio, Leila, Rosengren, A., Kamarauskaite, J., Kolenova, K. & Stålbrand, H., 2010, In: Biochemistry. 49, 23, p. 4884-4896 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-ß-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3
Hekmat, O., Lo Leggio, Leila, Rosengren, A., Kamarauskaite, J., Kolenova, K. & Stålbrand, H., 2010, In: Biochemistry. 49Research output: Contribution to journal › Journal article › Research › peer-review
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Characterisation and Crystallisation of an Active N-terminally Truncated Form of the Escherichia coli Glycogen Branching Enzyme
Hilden, I., Lo Leggio, Leila, Larsen, Sine & Poulsen, P., 2000, In: European Journal of Biochemistry. 267, p. 2150-2155Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-based engineering of glucose specificity in a family 10 xylanase from Streptomyces olivaceoviridis E-86
Ichinose, H., Diertavitian, S. W. S., Fujimoto, Z., Kuno, A., Lo Leggio, Leila & Kaneko, S., 2012, In: Process Biochemistry. 47, 3, p. 358-365 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications
Ipsen, J., Hallas-Møller, Magnus, Brander, Søren, Lo Leggio, Leila & Johansen, Katja Salomon, 2021, In: Biochemical Society Transactions. 49, 1, p. 531-540 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC
Ipsen, J. Ø., Hernández‐Rollán, C., Muderspach, Sebastian Jannick, Brander, Søren, Bertelsen, A. B., Jensen, Poul Erik, Nørholm, M. H. H., Lo Leggio, Leila, Johansen, Katja Salomon & Ferguson, S. (ed.), 2021, In: FEBS Letters. 595, 12, p. 1708-1720 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus
Jensen, M. H., Otten, H., Christensen, U., Borchert, T. V., Christensen, L. L. H., Larsen, Sine & Lo Leggio, Leila, 2010, In: Journal of Molecular Biology. 404, p. 100-111Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity
Jensen, P. F., Kadziola, Anders, Comamala, G., Segura, D. R., Anderson, L., Poulsen, Jens-Christian Navarro, Rasmussen, K. K., Agarwal, S., Sainathan, R. K., Monrad, R. N., Svendsen, A., Nielsen, J. E., Lo Leggio, Leila & Rand, Kasper Dyrberg, 2019, In: Cell Chemical Biology. 26, 2, p. 191-202.e1-e6 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans
Kristensen, C. S., Varming, A. K., Leinweber, H. A. K., Hammer, K., Lo Leggio, Leila, Ingmer, Hanne & Kilstrup, M., 1 Oct 2021, In: MicrobiologyOpen. 10, 5, 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii
Krska, D., Mazurkewich, S., Brown, H. A., Theibich, Yusuf, Poulsen, Jens-Christian Navarro, Morris, A. L., Koropatkin, N. M., Lo Leggio, Leila & Larsbrink, J., 13 Jul 2021, In: Biochemistry. 60, 27, p. 2206-2220 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)
Kryshtafovych, A., Albrecht, R., Basle, A., Bule, P., Caputo, A. T., Carvalho, A. L., Chao, K. L., Diskin, R., Fidelis, K., Fontes, C. M. G. A., Fredslund, F., Gilbert, H. J., Goulding, C. W., Hartmann, M. D., Hayes, C. S., Herzberg, O., Hill, J. C., Joachimiak, A., Kohring, G-W., Koning, R. I. & 19 others, , 2018, In: Proteins: Structure, Function, and Bioinformatics. 86, S1, p. 27-50 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A fungal family of lytic polysaccharide monooxygenase-like copper proteins
Labourel, A., Frandsen, Kristian Erik Høpfner, Zhang, F., Brouilly, N., Grisel, S., Haon, M., Ciano, L., Ropartz, D., Fanuel, M., Martin, F., Navarro, D., Rosso, M., Tandrup, T., Bissaro, B., Johansen, Katja Salomon, Zerva, A., Walton, P. H., Henrissat, B., Lo Leggio, Leila & Berrin, J., 2020, In: Nature Chemical Biology. 16, p. 345-350 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863Research output: Contribution to journal › Journal article › Research › peer-review
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Glucuronoyl esterases – enzymes to decouple lignin and carbohydrates and enable better utilization of renewable plant biomass
Larsbrink, J. & Lo Leggio, Leila, 2023, In: Essays in Biochemistry. 67, 3, p. 493-503 11 p.Research output: Contribution to journal › Review › Research › peer-review
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The Structure and Characterization of a Modular Endo-ß-1,4-mannanase from Cellulomonas fimi
Le Nours, J., Anderson, L., Stoll, D., Stålbrand, H. & Lo Leggio, Leila, 2005, In: Biochemistry. 44, p. 12700-12708Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling
Le Nours, J., De Maria, L., Welner, D. H., Jørgensen, C. T., Borchert, T. V., Christensen, L. L., Larsen, Sine & Lo Leggio, Leila, 2009, In: Proteins - Structure Function and Bioinformatics. 75, p. 977-989Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of two fungal ß-galactanases: Searching for the basis for temperature and pH optimum
Le Nours, J., Ryttersgaard, C., Lo Leggio, Leila, Østergaard, P. R., Vedel Borchert, T., Lehmann Hylling Christensen, L. & Larsen, Sine, 2003, In: Protein Science. 12, p. 1195-1204Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A
Lo Leggio, Leila, Kalogiannis, S., Eckert, K., Teixeira, S. C. M., Mahalingeswara, K. B., Andrei, C., Pickersgill, R. W. & Larsen, Sine, 2001, In: FEBS Letters. 509, p. 303-308Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary X-ray analysis of maltose O-acetyltransferase
Lo Leggio, Leila, Dal Degan, F., Poulsen, P., Oxenbøll Sørensen, S., Harlow, K. W., Harris, P. H. & Larsen, Sine, 2001, In: Acta Cryst.. D57, p. 1915-1918Research output: Contribution to journal › Journal article › Research › peer-review
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The 1.62 Å structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5
Lo Leggio, Leila & Larsen, Sine, 2002, In: FEBS Letters. 523, p. 103-108Research output: Contribution to journal › Journal article › Research › peer-review
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Polysaccharide lyase family 4
Lo Leggio, Leila & Larsen, Sine, 2014, Cazypedia.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research
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Xylanase-oligosaccharide interactions studied by a competitive enzyme assay
Lo Leggio, Leila & Pickersgill, R. W., 1999, In: Enzyme and Microbial Technology. 25, p. 701-709Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase
Lo Leggio, Leila, Simmons, T. J., Poulsen, Jens-Christian Navarro, Frandsen, Kristian Erik Høpfner, Hemsworth, G. R., Stringer, M. A., von Freiesleben, P., Tovborg, M., Johansen, Katja Salomon, De Maria, L., Harris, P. V., Soong, C., Dupree, P., Tryfona, T., Lenfant, N., Henrissat, B., Davies, G. J. & Walton, P. H., 2015, In: Nature Communications. 6, 9 p., 5961.Research output: Contribution to journal › Journal article › Research › peer-review
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High Resolution Structure and Sequence of T. aurantiacus Xylanase I: Implications for the Evolution of Thermostability in Family 10 Xylanases and Enzymes With ßa-Barrel Architecture
Lo Leggio, Leila, Kalogiannis, S., Bhat, M. K. & Pickersgill, R. W., 1999, In: Proteins: Structure, Functions, and Genetics. 36, p. 295-306Research output: Contribution to journal › Journal article › Research › peer-review
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Glycoside hydrolase family 53 - CAZYpedia entry
Lo Leggio, Leila, 2012Research output: Other contribution › Net publication - Internet publication › Communication
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The Structure and Specificity of Escherichia coli Maltose Acetyltransferase Give New Insight into the LacA Family of Acyltransferases
Lo Leggio, Leila, Dal Degan, F., Poulsen, P., Møller Andersen, S. & Larsen, Sine, 2003, In: Biochemistry. 42, p. 5225-5235Research output: Contribution to journal › Journal article › Research › peer-review
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X-Ray Crystallographic Study of Xylopentaose Binding to Pseudomonas fluorescens Xylanase A.
Lo Leggio, Leila, Jenkins, J., Harris, G. W. & Pickersgill, R. W., 2000, In: Proteins - Structure Function and Bioinformatics. 41, p. 362-373Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant
Lo Leggio, Leila, Weihe, C. D., Poulsen, Jens-Christian Navarro, Sweeney, M., Rasmussen, F., Lin, J., De Maria, L. & Wogulis, M., 2018, In: Carbohydrate Research. 469, p. 55-59 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural diversity of lytic polysaccharide monooxygenases
Lo Leggio, Leila, Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tovborg, M., De Maria, L. & Johansen, K. S., 2015, Proceedings of "Mie Bioforum 2014 - Lignocellulose Degradation and Biorefinery". Sakka, K., Kimura, T., Tamaru, Y., Karita, S. & Sakka, M. (eds.). UNI Publishers Co., Ltd, p. 148-156 9 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Structure and specificity of polysaccharidases belonging to clan GH-A
Lo Leggio, Leila, Le Nours, J., Ryttersgaard, C., Kaneko, S., Fujimoto, Z., Kuno, A., Diertavitian, S. & Larsen, Sine, 2004, Biotechnology of Lignocellulose Degradation and Biomass Utilization. Ohmiya, K., Sakka, K., Karita, S., Kimura, T., Sakka, M. & Onishi, Y. (eds.). UNI Publishers Co., Ltd, p. 27-33Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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A structural overview of GH61proteins – fungal cellulose degrading polysaccharide monooxygenases
Lo Leggio, Leila, Welner, D. H. & De Maria, L., 2012, In: Computational and Structural Biotechnology Journal. 2, 3, p. 1-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A structural model for the N-terminal N1 module of E. coli glycogen branching enzyme
Lo Leggio, Leila, Ernst, H. A., Hilden, I. & Larsen, Sine, 2002, In: Biologia. 57, Suppl. 11, p. 109-118Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enzymatisk nedbrydning af polysaccharider
Lo Leggio, Leila, Tovborg, M. & Johansen, K. S., 2016, In: Dansk Kemi. 97, 4, p. 23-25 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components
Mazurkewich, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 52, p. 19978-19987Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans
Mazurkewich, S., Scholzen, K. C., Brusch, R. H., Poulsen, Jens-Christian Navarro, Theibich, Yusuf, Hüttner, S., Olsson, L., Larsbrink, J. & Lo Leggio, Leila, 2023, In: Acta crystallographica. Section D, Structural biology. 79, 6, p. 545-555 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima
Mc Donough, M. A., Ryttersgaard, C., Eskelund Bjørnvad, M., Lo Leggio, Leila, Schülein, M., Schrøder Glad, S. O. & Larsen, Sine, 2002, In: Acta Crystallographica. Section D: Biological Crystallography. 58, p. 709-711Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects
Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure, function, and protein engineering of GH53 β-1,4-galactanases
Muderspach, Sebastian Jannick, Jensen, K., Krogh, K. B. R. M. & Lo Leggio, Leila, 2023, Glycoside Hydrolases: Biochemistry, Biophysics, and Biotechnology. Elsevier, p. 295-322 28 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans
Muderspach, Sebastian Jannick, Fredslund, F., Volf, V., Poulsen, Jens-Christian Navarro, Blicher, T. H., Clausen, M. H., Rasmussen, K. K., Krogh, K. B. R. M., Jensen, K. & Lo Leggio, Leila, 1 Dec 2021, In: Biotechnology for Biofuels. 14, 1, 16 p., 183.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Further structural studies of the lytic polysaccharide monooxygenase AoAA13 belonging to the starch-active AA13 family
Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Santoni, G., Poulsen, Jens-Christian Navarro & Lo Leggio, Leila, 2019, In: Amylase. 3, 1, p. 41-54 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enzymology and structure of the GH13_31 glucan 1,6-a-glucosidase that confers isomaltooligosaccharide utilization in the probiotic Lactobacillus acidophilus NCFM
Møller, M. S., Fredslund, F., Majumder, A., Nakai, H., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Svensson, B. & Abou Hachem, M., 2012, In: Journal of Bacteriology. 194, 16, p. 4249-4259 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA-binding specificity and molecular functions of NAC transcription factors
Olsen, A. N., Ernst, H. A., Lo Leggio, Leila & Skriver, Karen, 2005, In: Plant Science. 169, 4, p. 785-797Research output: Contribution to journal › Journal article › Research › peer-review
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NAC transcription factors: structurally distinct, functionally diverse
Olsen, A. N., Ernst, H. A., Lo Leggio, Leila & Skriver, Karen, 2005, In: Trends in Plant Science. 10, 2, p. 79-87 8 p.Research output: Contribution to journal › Review › Research
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Preliminary crystallographic analysis of the NAC domain of ANAC, a member of the plant-specific NAC transcription factor family
Olsen, A. N., Ernst, H. A., Lo Leggio, Leila, Johansson, E. H., Larsen, Sine & Skriver, Karen, 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, p. 112-115Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of Quaternary Structure and functional domains of the CI repressor from Bacteriophage TP901-1
Pedersen, M., Lo Leggio, Leila, Grossmann, J. G., Larsen, Sine & Hammer, K., 2008, In: Journal of Molecular Biology. 373, p. 983-996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator
Pedersen, M., Neergaard, J. T., Cassias, J., Rasmussen, K. K., Lo Leggio, Leila, Sneppen, Kim, Hammer, K. & Kilstrup, M., 26 May 2020, In: Scientific Reports. 10, 1, 13 p., 8659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping of an Internal Protease Cleavage Site in the Ssy5p Component of the Amino Acid Sensor of Saccharomyces cerevisiae and Functional Characterization of the Resulting Pro- and Protease Domains by Gain-of-Function Genetics
Poulsen, P., Lo Leggio, Leila & Kielland-Brandt, M. C., 2006, In: Eukaryotic Cell. 5, p. 601-608Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components to cleave cellulose
Quinlan, R. J., Sweeney, M. D., Lo Leggio, Leila, Otten, H., Poulsen, Jens-Christian Navarro, Johansen, K. S., Krogh, K. B. R. M., Jørgensen, C. I., Tovborg, M., Anthonsen, A., Tryfona, T., Tryfona, T., Walter, C. P., Dupree, P., Xu, F., Davies, G. J. & Walton, P. H., 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, p. 15079-15084Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis of the bacteriophage TP901‐1 CI repressor dimerization and interaction with DNA
Rasmussen, K. K., Varming, A. K., Schmidt, S. N., Frandsen, Kristian Erik Høpfner, Thulstrup, Peter Waaben, Jensen, M. R. & Lo Leggio, Leila, 2018, In: F E B S Letters. 592, 10, p. 1738-1750 13 p.Research output: Contribution to journal › Letter › Research › peer-review
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Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1
Rasmussen, K. K., Frandsen, Kristian Erik Høpfner, Boeri Erba, E., Pedersen, M., Varming, A. K., Hammer, K., Kilstrup, M., Thulstrup, Peter Waaben, Blackledge, M., Jensen, M. R. & Lo Leggio, Leila, 2016, In: Scientific Reports. 6, 12 p., 29574.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor
Rasmussen, K. K., Falkesgaard, M. H., Winther, M., Roed, N. K., Quistgaard, C. L. A., Teisen, M. N., Edslev, S. M., Petersen, D. L., Aljubouri, A., Christensen, C., Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare & Walmod, P. S., 2018, In: Scientific Reports. 8, 13 p., 8957 .Research output: Contribution to journal › Journal article › Research › peer-review
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Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage
Rasmussen, K. K., Palencia, A., Varming, A. K., El-Wali, H., Erba, E. B., Blackledge, M., Hammer, K., Herrmann, T., Kilstrup, M., Lo Leggio, Leila & Jensen, M. R., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20576-20585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Structure of Endo-ß-1,4-galactanase from Bacillius licheniformis in Complex with Two Oligosaccharide Products
Ryttersgaard, C., Le Nours, J., Lo Leggio, Leila, Thea Jørgensen, C., Lehmann Hylling Christensen, L., Bjørnvad, M. & Larsen, Sine, 2004, In: Journal of Molecular Biology. 341, p. 107-117Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aspergillus aculeatus ß-1,4-Galactanase: Substrate Recognition and Relations to Other Glycoside Hydrolases in Clan GH-A
Ryttersgaard, C., Lo Leggio, Leila, Coutinho, P. M., Henrissat, B. & Larsen, Sine, 2002, In: Biochemistry. 41, p. 15135-15143Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis
Sakanaka, M., Hansen, M. E., Gotoh, A., Katoh, T., Yoshida, K., Odamaki, T., Yachi, H., Sugiyama, Y., Kurihara, S., Hirose, J., Urashima, T., Xiao, J., Kitaoka, M., Fukiya, S., Yokota, A., Lo Leggio, Leila, Abou Hachem, M. & Katayama, T., 2019, In: Science Advances. 5, 8, p. 1-15 15 p., eaaw7696.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
Seveso, A., Mazurkewich, S., Banerjee, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2024, In: Applied and Environmental Microbiology. 90, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
Simmons, T. J., Frandsen, Kristian Erik Høpfner, Ciano, L., Tryfona, T., Lenfant, N., Poulsen, Jens-Christian Navarro, Wilson, L. F. L., Tandrup, T., Tovborg, M., Schnorr, K., Johansen, Katja Salomon, Henrissat, B., Walton, P. H., Lo Leggio, Leila & Dupree, P., 2017, In: Nature Communications. 8, 12 p., 1064.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan
Sprenger, J., Lawson, C. L., Von Wachenfeldt, C., Lo Leggio, Leila & Carey, J., 1 Jul 2021, In: Acta Crystallographica Section F: Structural Biology Communications. 77, 7, p. 215-225 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guest-protein incorporation into solvent channels of a protein host crystal (hostal)
Sprenger, J., Carey, J., Schulz, Alexander, Drouard, F., Lawson, C. L., Von Wachenfeldt, C., Linse, S. & Lo Leggio, Leila, 2021, In: Acta crystallographica Section D: Structural biology . 77, p. 471-485 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calmodulin complexes with brain and muscle creatine kinase peptides
Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., Rowlett, R., Lo Leggio, Leila, Åkerfeldt, K. S. & Linse, S., 2021, In: Current Research in Structural Biology. 3, p. 121-132 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila
Sun, P., Huang, Zhiyu, Banerjee, S., Kadowaki, M. A. S., Veersma, R. J., Magri, S., Hilgers, R., Muderspach, Sebastian Jannick, Laurent, C. V. F. P., Ludwig, R., Cannella, D., Lo Leggio, Leila, van Berkel, W. J. H. & Kabel, M. A., 2023, In: ACS Catalysis. 13, 7, p. 4454-4467 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature
Tandrup, T., Lo Leggio, Leila & Meilleur, F., 2023, In: Acta crystallographica. Section F, Structural biology communications. 79, 1, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding
Tandrup, T., Muderspach, Sebastian Jannick, Banerjee, S., Santoni, G., Ipsen, J. O., Hernandez Rollan, Cristina, Norholm, M. H. H., Johansen, Katja Salomon, Meilleur, F. & Lo Leggio, Leila, Sep 2022, In: IUCrJ. 9, 5, p. 666-681 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases
Tandrup, T., Tryfona, T., Frandsen, Kristian Erik Høpfner, Johansen, Katja Salomon, Dupree, P. & Lo Leggio, Leila, 2020, In: Biochemistry. 59, 36, p. 3347-3358 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13810
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Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus
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A structural overview of GH61proteins – fungal cellulose degrading polysaccharide monooxygenases
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Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder
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