Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
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14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
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PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates
Pedersen, Martin Cramer, Wang, Y., Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Combined Simulation and SAXS Study of the Dynamics of Lipid Nanodiscs
Bengtsen, T., Holm-Janas, Viktor, Midtgaard, S. R., Arleth, Lise & Lindorff-Larsen, Kresten, 17 Feb 2018, In: Biophysical Journal. 114, 3, Supp. 1, p. 559A-559A 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Monte Carlo study of the early steps of functional amyloid formation
Tian, P., Lindorff-Larsen, Kresten, Boomsma, Wouter, Jensen, Mogens Høgh & Otzen, D. E., 2016, In: P L o S One. 11, 1, 18 p., e0146096.Research output: Contribution to journal › Journal article › Research › peer-review
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A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases
Wang, Y., Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel
Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956Research output: Contribution to journal › Journal article › Research › peer-review
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A combined computational and structural model of the full-length human prolactin receptor
Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.Research output: Contribution to journal › Journal article › Research › peer-review
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A comprehensive map of human glucokinase variant activity
Andersen, Sarah Gersing, Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
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A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.Research output: Contribution to journal › Journal article › Research › peer-review
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A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
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A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A soluble, folded protein without charged amino acid residues
Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A sticky cage can slow down folding
Boomsma, Wouter & Lindorff-Larsen, Kresten, 2013, In: Biophysical Journal. 104, 5, p. 964-965 2 p.Research output: Contribution to journal › Comment/debate › Research
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A structural biology community assessment of AlphaFold2 applications
Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, , 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast
Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Tesei, Giulio, Schulze, T. K., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2111696118.Research output: Contribution to journal › Journal article › Research › peer-review
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Accurate protein stability predictions from homology models
Valanciute, A., Nygaard, L., Zschach, Henrike, Maglegaard Jepsen, M., Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation and substrate specificity of the human P4-ATPase ATP8B1
Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric modulation of the sarcoplasmic reticulum Ca2+ ATPase by thapsigargin via decoupling of functional motions
Saleh, N., Wang, Y., Nissen, P. & Lindorff-Larsen, Kresten, 2019, In: Physical Chemistry Chemical Physics. 21, 39, p. 21991-21995Research output: Contribution to journal › Journal article › Research › peer-review
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An efficient method for estimating the hydrodynamic radius of disordered protein conformations
Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12
Weinhäupl, K., Wang, Y., Hessel, A., Brennich, M., Lindorff-Larsen, Kresten & Schanda, P., 2021, In: Structure. 29, 9, p. 1065-1073.e4Research output: Contribution to journal › Journal article › Research › peer-review
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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Atomic-level characterization of the structural dynamics of proteins
Shaw, D. E., Maragakis, P., Lindorff-Larsen, Kresten, Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y. & Wriggers, W., 2010, In: Science (New York, N.Y.). 330, 6002, p. 341-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Atomic-level description of ubiquitin folding
Piana, S., Lindorff-Larsen, Kresten & Shaw, D. E., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 5915-5920 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Atomistic description of the folding of a dimeric protein
Piana, S., Lindorff-Larsen, Kresten & Shaw, D. E., 2013, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 117, 42, p. 12935-12942 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Automated Event Detection and Activity Monitoring in Long Molecular Dynamics Simulations
Wriggers, W., Stafford, K. A., Shan, Y., Piana, S., Maragakis, P., Lindorff-Larsen, Kresten, Miller, P. J., Gullingsrud, J., Rendleman, C. A., Eastwood, M. P., Dror, R. O. & Shaw, D. E., 1 Oct 2009, In: Journal of Chemical Theory and Computation. 5, 10, p. 2595-2605 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
BPPred: a Web-based computational tool for predicting biophysical parameters of proteins
Geierhaas, C. D., Nickson, A. A., Lindorff-Larsen, Kresten, Clarke, J. & Vendruscolo, M., 2007, In: Protein Science. 16, 1, p. 125-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Barley lipid transfer protein, LTP1, contains a new type of lipid-like post-translational modification
Lindorff-Larsen, Kresten, Lerche, M. H., Poulsen, F. M., Roepstorff, P. & Winther, J. R., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33547-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Barnaba: software for analysis of nucleic acid structures and trajectories
Bottaro, S., Bussi, G., Pinamonti, G., Reisser, S., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2019, In: RNA. 25, 2, p. 219-231Research output: Contribution to journal › Journal article › Research › peer-review
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Bayesian-Maximum-Entropy Reweighting of IDP Ensembles Based on NMR Chemical Shifts
Crehuet, R., Buigues, P. J., Salvatella, X. & Lindorff-Larsen, Kresten, 2019, In: Entropy. 21, 9, 17 p., 898.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases
Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.Research output: Contribution to journal › Journal article › Research › peer-review
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Biomolecular conformational changes and ligand binding: from kinetics to thermodynamics
Wang, Y., Martins, J. & Lindorff-Larsen, Kresten, Sep 2017, In: Chemical Science. 8, 9, p. 6466-6473 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysical and Mechanistic Models for Disease-Causing Protein Variants
Stein, Amelie, Fowler, D. M., Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2019, In: Trends in Biochemical Sciences. 44, 7, p. 575-588Research output: Contribution to journal › Review › Research › peer-review
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Biophysical experiments and biomolecular simulations: a perfect match?
Bottaro, S. & Lindorff-Larsen, Kresten, 2018, In: Science. 361, 6400, p. 355-360 6 p.Research output: Contribution to journal › Review › Research › peer-review
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Blocking protein quality control to counter hereditary cancers
Kampmeyer, Caroline, Nielsen, S. V., Bjørnkjær, Lene, Stein, Amelie, Gerdes, Anne-Marie Axø, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, Dec 2017, In: Genes, Chromosomes & Cancer. 56, 12, p. 823-831 9 p.Research output: Contribution to journal › Review › Research › peer-review
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CECAM workshop on intrinsically disordered proteins
Rösner, Heike Ilona, Papaleo, E., Haxholm, G. W., Best, R. B., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2014, In: Intrinsically Disordered Proteins. 2, 1, p. 1-5 5 p.Research output: Contribution to journal › Conference abstract in journal › Research
Calculation of mutational free energy changes in transition states for protein folding
Lindorff-Larsen, Kresten, Paci, E., Serrano, L., Dobson, C. M. & Vendruscolo, M., 2003, In: Biophysical Journal. 85, 2, p. 1207-14 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Bouchard, J. J., Otero, J. H., Scott, D. C., Szulc, E., Martin, E. W., Sabri, N., Granata, D., Marzahn, M. R., Lindorff-Larsen, Kresten, Salvatella, X., Schulman, B. A. & Mittag, T., 2018, In: Molecular Cell. 72, 1, p. 19-36, e1-e8Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the residual structure in the unfolded state of the Delta 131 Delta fragment of staphylococcal nuclease
Francis, C. J., Lindorff-Larsen, Kresten, Best, R. B. & Bendruscolo, M., 2006, In: Proteins - Structure Function and Bioinformatics. 65, 1, p. 145-52Research output: Contribution to journal › Journal article › Research › peer-review
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Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Gersing, S., Schulze, Thea Klarsø, Cagiada, Matteo, Stein, Amelie, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Genome Biology. 25, 1, 22 p., 98.Research output: Contribution to journal › Journal article › Research › peer-review
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Charge Interactions in a Highly Charge-Depleted Protein
Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Class I Cytokine Receptors: Towards the Inside
Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Classifying disease-associated variants using measures of protein activity and stability
Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Abildgaard, A. B., Andersen, Sarah Gersing, Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.Research output: Contribution to journal › Review › Research › peer-review
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Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system
Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501Research output: Contribution to journal › Journal article › Research › peer-review
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Combining Experiments and Simulations to Examine the Temperature-Dependent Behavior of a Disordered Protein
Pesce, Francesco & Lindorff-Larsen, Kresten, 2023, In: Journal of Physical Chemistry B. 127, 28, p. 6277-6286 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining experiments and simulations using the maximum entropy principle
Boomsma, Wouter, Ferkinghoff-Borg, J. & Lindorff-Larsen, Kresten, 2014, In: PLoS Computational Biology. 10, 2, 9 p., e1003406.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution
Nørgrd Larsen, Andreas, Wang, Y., Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.Research output: Contribution to journal › Journal article › Research › peer-review
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Communication routes in ARID domains between distal residues in Helix 5 and the DNA-binding loops
Invernizzi, G., Tiberti, M., Lambrughi, M., Lindorff-Larsen, Kresten & Papaleo, E., 2014, In: P L o S Computational Biology (Online). 10, 9, 13 p., e1003744.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing molecular dynamics force fields in the essential subspace
Martin-García, F., Papaleo, E., Gomez-Puertas, P., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2015, In: PLoS ONE. 10, 3, 16 p., e0121114.Research output: Contribution to journal › Journal article › Research › peer-review
Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints
Paci, E., Friel, C. T., Lindorff-Larsen, Kresten, Radford, S. E., Karplus, M. & Vendruscolo, M., 2004, In: Proteins: Structure, Function, and Bioinformatics. 54, 3, p. 513-25 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold
Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149Research output: Contribution to journal › Journal article › Research › peer-review
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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
Abildgaard, A. B., Stein, Amelie, Nielsen, S. V., Schultz-Knudsen, Katrine, Papaleo, E., Shrikhande, A., Hoffmann, Eva, Bernstein, I., Gerdes, Anne-Marie Axø, Takahashi, M., Ishioka, C., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2019, In: eLife. 8, 28 p., e49138 .Research output: Contribution to journal › Journal article › Research › peer-review
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Computational design and experimental testing of the fastest-folding ß-sheet protein
Piana, S., Sarkar, K., Lindorff-Larsen, Kresten, Guo, M., Gruebele, M. & Shaw, D. E., 7 Jan 2011, In: Journal of Molecular Biology. 405, 1, p. 43-48 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins
Ahmed, M. C., Crehuet, R. & Lindorff-Larsen, Kresten, 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 429-445 17 p. (Methods in Molecular Biology, Vol. 2141).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations
Bottaro, S., Bussi, G. & Lindorff-Larsen, Kresten, 2021, In: Journal of the American Chemical Society. 143, 22, p. 8333-8343Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
Thomasen, Emil, Cuneo, M. J., Mittag, T. & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 23 p., e84147.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational changes and free energies in a Proline isomerase
Papaleo, E., Sutto, L., Gervasio, F. L. & Lindorff-Larsen, Kresten, 2014, In: Journal of Chemical Theory and Computation. 10, 9, p. 4169-4174 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations
Bottaro, S., Bussi, G., Kennedy, S. D., Turner, D. H. & Lindorff-Larsen, Kresten, 18 May 2018, In: Science Advances. 4, 5, 8 p., eaar8521.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
Thomasen, Emil & Lindorff-Larsen, Kresten, 2022, In: Biochemical Society Transactions. 50, 1, p. 541-554 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Conformational ensembles of the human intrinsically disordered proteome
Tesei, Giulio, Trolle, A. I., Jonsson, Nicolas, Betz, J., Knudsen, F. E., Pesce, Francesco, Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2024, In: Nature. 626, p. 897-904 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational fluctuations affect protein alignment in dilute liquid crystal media.
Louhivuori, M., Otten, R., Lindorff-Larsen, Kresten & Annila, A., 2006, In: Journal of the American Chemical Society. 128, 13, p. 4371-4376 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery
Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 16 Feb 2017, In: Molecular Cell. 65, 4, p. 644-658 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conserved conformational dynamics determine enzyme activity
Torgeson, K. R., Clarkson, M. W., Granata, D., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 2022, In: Science Advances. 8, 31, 10 p., eabo5546.Research output: Contribution to journal › Journal article › Research › peer-review
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Conserved degronome features governing quality control associated proteolysis
Mashahreh, B., Armony, S., Johansson, Kristoffer Enøe, Chappleboim, A., Friedman, N., Gardner, R. G., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Ravid, T., 2022, In: Nature Communications. 13, 1, 13 p., 7588.Research output: Contribution to journal › Journal article › Research › peer-review
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
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Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
Neumann, C., Rosenbæk, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Y., Lindorff-Larsen, Kresten, Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P., 2022, In: EMBO Journal. 41, 23, 15 p., e110169.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DEER-PREdict: Software for efficient calculation of spin-labeling EPR and NMR data from conformational ensembles
Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Wang, Y., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: PLOS Computational Biology. 17, 1, 18 p., e1008551.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions
Lambrughi, M., De Gioia, L., Gervasio, F. L., Lindorff-Larsen, Kresten, Nussinov, R., Urani, C., Bruschi, M. & Papaleo, E., 2016, In: Nucleic Acids Research. 44, 19, p. 9096-9109 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties
Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of initiation sites in protein folding of the four helix bundle ACBP by chemical shift analysis.
Modig, K., Jürgensen, V. W., Lindorff-Larsen, Kresten, Fieber, W., Bohr, H. G. & Poulsen, F. M., 2007, In: FEBS Letters. 581, 25, p. 4965-4971 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein
Lindorff-Larsen, Kresten, Kristjansdottir, S., Teilum, K., Fieber, W., Dobson, C. M., Poulsen, F. M. & Vendruscolo, M., 2004, In: Journal of the American Chemical Society. 126, 10, p. 3291-3219 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovering functionally important sites in proteins
Cagiada, Matteo, Bottaro, S., Lindemose, Søren, Schenstrøm, S. M., Stein, Amelie, Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2023, In: Nature Communications. 14, 1, 13 p., 4175.Research output: Contribution to journal › Journal article › Research › peer-review
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Disease-linked mutations cause exposure of a protein quality control degron
Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5Research output: Contribution to journal › Journal article › Research › peer-review
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Dissecting the statistical properties of the linear extrapolation method of determining protein stability
Lindorff-Larsen, Kresten, 2019, In: Protein engineering, design & selection : PEDS. 32, 10, p. 471-479 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diversity-oriented peptide stapling: a third generation copper-catalysed azide–alkyne cycloaddition stapling and functionalisation strategy
Tran, T. P., Larsen, C. Ø., Røndbjerg, T., de Foresta, M., Kunze, M. B. A., Marek, A., Hartvig Løper, J., Boyhus, L., Knuhtsen, A., Lindorff-Larsen, Kresten & Pedersen, D. S., 8 Mar 2017, In: Chemistry: A European Journal. 23, 14, p. 3490-3495 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy
Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic activation and regulation of the mitogen-activated protein kinase p38
Kumar, G. S., Clarkson, M. W., Kunze, M. B. A., Granata, D., Wand, A. J., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 1 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4655-4660 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ENCORE: Software for Quantitative Ensemble Comparison
Tiberti, M., Papaleo, E., Bengtsen, T., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2015, In: PLoS Computational Biology. 11, 10, 16 p., e1004415.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial overview: Theory and simulation: Interpreting experimental data at the molecular level
Best, R. B. & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 49, p. iv-v 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Pacheco-Garcia, J. L., Cagiada, Matteo, Tienne-Matos, K., Salido, E., Lindorff-Larsen, Kresten & L. Pey, A., 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 1063620.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
Kassem, M. M., Christoffersen, L. B., Cavalli, A. & Lindorff-Larsen, Kresten, 2018, In: Scientific Reports. 8, 11112.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
Koehler Leman, J., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., Kuenze, G., Krys, J. D., Ljubetič, A., Loshbaugh, A. L., Maguire, J., Moretti, R., Mulligan, V. K., Nance, M. L. & 30 others, , 2021, In: Nature Communications. 12, 15 p., 6947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts
Boomsma, Wouter, Tian, P., Frellsen, J., Ferkinghoff-Borg, J., Hamelryck, Thomas Wim, Lindorff-Larsen, Kresten & Vendruscolo, M., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13852-13857 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
Piana, S., Lindorff-Larsen, Kresten, Dirks, R. M., Salmon, J. K., Dror, R. O. & Shaw, D. E., 2012, In: P L o S One. 7, 6, 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolution i overhalingsbanen
Abildgaard, A. B., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Winther, Jakob R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
Experimental parameterization of an energy function for the simulation of unfolded proteins
Nørgaard, A. B., Ferkinghoff-Borg, J. & Lindorff-Larsen, Kresten, 2008, In: Biophysical Journal. 94, 1, p. 182-192Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy
Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FRETpredict: a Python package for FRET efficiency predictions using rotamer libraries
Montepietra, D., Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Best, R. B. & Lindorff-Larsen, Kresten, 2024, In: Communications Biology . 7, 1, 10 p., 298.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Corrections to an RNA Force Field Using Experimental Data
Cesari, A., Bottaro, S., Lindorff-Larsen, Kresten, Banás, P., Sponer, J. & Bussi, G., 2019, In: Journal of Chemical Theory and Computation. 15, 6, p. 3425-3431Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Force Field Parameters to NMR Relaxation Data
Kümmerer, Felix, Orioli, S. & Lindorff-Larsen, Kresten, 5 Jun 2023, In: Journal of Chemical Theory and Computation. 19, 12, p. 3741-3751 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations
Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Folding of heterologous proteins in bacterial cell factories: Cellular mechanisms and engineering strategies
Rong, Y., Jensen, S. I., Lindorff-Larsen, Kresten & Nielsen, A. T., 2023, In: Biotechnology Advances. 63, 21 p., 108079.Research output: Contribution to journal › Review › Research › peer-review
- Published
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation
Bjørnkjær, Lene, Stein, Amelie, Grønbæk-Thygesen, Martin, Nygaard, L., Søltoft, C. L., Nielsen, S. V., Lisby, Michael, Ravid, T., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: PLOS Genetics. 16, 11, 28 p., e1009187.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity
Jephthah, S., Pesce, Francesco, Lindorff-Larsen, Kresten & Skepö, M., 2021, In: Journal of Chemical Theory and Computation. 17, 10, p. 6634-6646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of Native and Non-native Interactions in Ensembles of Denatured ACBP Molecules from Paramagnetic Relaxation Enhancement Studies
Kristjansdottir, S., Lindorff-Larsen, Kresten, Fieber, W., Dobson, C. M., Vendruscolo, M. & Poulsen, F. M., 2005, In: Journal of Molecular Biology. 347, 5, p. 1053-1062Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency adaptive metadynamics for the calculation of rare-event kinetics
Wang, Y., Valsson, O., Tiwary, P., Parrinello, M. & Lindorff-Larsen, Kresten, 2018, In: Journal of Chemical Physics. 149, 7, p. 1-7 072309.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
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Similarity measures for protein ensembles
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Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
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