Jesper Langgaard Kristensen
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- Published
Synthesis and application of a new fluorous-tagged ammonia equivalent
Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 15, p. 4557-4566Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Animal Behavior in Psychedelic Research
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2022, In: Pharmacological Reviews. 74, 4, p. 1176-1205 30 p.Research output: Contribution to journal › Review › Research › peer-review
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The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation
Odland, Anna Ulstein, Jessen, L., Kristensen, Jesper Langgaard, Fitzpatrick, C. M. & Andreasen T., Jesper, 2021, In: Neuropharmacology. 183, 9 p., 107838.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Brain Research. 401, 5 p., 113093.Research output: Contribution to journal › Journal article › Research › peer-review
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The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Pharmacology. 32, 5, p. 448-452Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Overcoming Energy Transfer for the Metallophotoredox Catalyzed Decarboxylative Alkenylation between Alkylcarboxylic Acids and Enol Triflates
Pedersen, S. K., Clementson, S., Kristensen, Jesper Langgaard, Jessing, M. & El-Chami, K., 2023, In: Chemistry: A European Journal. 29, 35, e202300265.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In: Organic & Biomolecular Chemistry. 15, p. 4351-4358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Pyridoacridines through Anionic Cascade Ring Closure
Petersen, I. N. & Kristensen, Jesper Langgaard, 1 Jan 2014, In: Synthesis. 46, p. 1469-1474 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Petersen, I. N., Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 18 Jan 2017, In: European Journal of Organic Chemistry. 2017, 3, p. 453-458 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide
Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors
Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid
Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Total synthesis of ascididemin via anionic cascade ring closure
Petersen, I. N., Crestey, F. & Kristensen, Jesper Langgaard, 2012, In: Chemical Communications. 48, 72, p. 9092-9094Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists
Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists
Pottie, E., Poulie, Christian Bernard Matthijs, Simon, Ícaro Ariel, Harpsøe, Kasper, D’Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper Langgaard & Stove, C. P., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2727–2742Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
Poulie, Christian Bernard Matthijs, Pottie, E., Simon, I. A., Harpsøe, Kasper, D’andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Stove, C. P. & Kristensen, Jesper Langgaard, 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12031–12043Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dark Classics in Chemical Neuroscience: NBOMes
Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. p. 3860–3869 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and SAR study of a novel series of dopamine receptor agonists
Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936
Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists
Rørsted, E. M., Jensen, Anders A., Smits, G., Frydenvang, Karla Andrea & Kristensen, Jesper Langgaard, 22 Apr 2024, (E-pub ahead of print) In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Snegleprotein øger forståelsen af vigtige receptorer i hjernen
Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.Research output: Contribution to journal › Journal article › Communication
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Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism
Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757Research output: Contribution to journal › Journal article › Research › peer-review
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Convenient access to F-18-labeled amines through the Staudinger reduction
Shalgunov, Vladimir, Steen, J., Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S205-S206 P-050.Research output: Contribution to journal › Conference abstract in journal › Research
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Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites
Sköld, N., Nielsen, Birgitte, Olsen, J., Han, L., Olsen, L., Madsen, Ulf, Kristensen, Jesper Langgaard, Pickering, Darryl S & Johansen, Tommy Nørskov, 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry
Steen, E. J. L., Jørgensen, Jesper Tranekjær, Denk, C., Battisti, Umberto Maria, Norregaard, K., Edem, P. E., Bratteby, K., Shalgunov, Vladimir, Wilkovitsch, M., Svatunek, D., Poulie, Christian Bernard Matthijs, Hvass, Lars, Simon, M., Wanek, T., Rossin, R., Robillard, M., Kristensen, Jesper Langgaard, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: ACS Pharmacology & Translational Science. 4, 2, p. 824-833 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging: [Meeting Abstract]
Steen, J., Norregard, K., Johann, K., Jørgensen, Jesper Tranekjær, Svatunek, D., Birke, A., Edem, P., Rossin, R., Seidl, C., Schmid, F., Robillard, M., Mikula, H., Kristensen, Jesper Langgaard, Barz, M., Kjær, Andreas & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S109-S110Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Towards the Dual Click F-18-labeling of Antibodies
Steen, J., Denk, C., Norregaard, K., Jorgensen, J., Rossin, R., Svatunek, D., Edem, P., Robillard, M., Kjær, Andreas, Kristensen, Jesper Langgaard, Mikula, H. & Herth, Matthias Manfred, 1 May 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Pretargeted PET imaging using a dual click F-18-labeling strategy: [Meeting Abstract]
Steen, J., Denk, C., Jørgensen, Jesper Tranekjær, Norregard, K., Rossin, R., Wilkovitsch, M., Svatunek, D., Edem, P., Kuntner, C., Wanek, T., Robillard, M., Kristensen, Jesper Langgaard, Kjær, Andreas, Mikula, H. & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S22-S23 O-08.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Diclofenac prodrugs for intra-articular depot injectables: In vitro hydrolysis and species variation
Storgaard, Ida Klitzing, Kristensen, Jesper Langgaard, Larsen, C., Mertz, Nina, Østergaard, Jesper & Larsen, Susan Weng, 2020, In: Journal of Pharmaceutical Sciences. 109, 4, p. P1529-1536Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices
Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging
Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Johann, K., Norregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, Vladimir, Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, Jesper Langgaard, Mikula, H., Barz, M., Kjær, Andreas & Herth, Matthias Manfred, 2020, In: ACS Nano. 14, 1, p. 568-584Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2019, In: European Journal of Organic Chemistry. 2019, 8, p. 1722-1725Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cover Feature: Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction (Eur. J. Org. Chem. 8/2019)
Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 28 Feb 2019, In: European Journal of Organic Chemistry. 2019, 8, p. 1686-1686Research output: Contribution to journal › Journal article › Communication
- Published
Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging
Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, Vladimir, Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, Jesper Langgaard, Barz, M., Knudsen, Gitte Moos, Kjær, Andreas & Herth, Matthias Manfred, 1 Jan 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 986-990Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and binding studies of 2-arylapomorphines
Søndergaard, K., Kristensen, Jesper Langgaard, Palner, M., Gillings, N., Knudsen, Gitte Moos, Roth, B. & Begtrup, M., 21 Nov 2005, In: Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations
Søndergaard, K., Kristensen, Jesper Langgaard, Gillings, N. & Begtrup, M., 14 Oct 2005, In: European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection
Thing, M., Agårdh, L., Larsen, Susan Weng, Rasmussen, R., Pallesen, J., Mertz, N., Kristensen, Jesper Langgaard, Hansen, M., Østergaard, Jesper & Larsen, C. S., 2014, In: Journal of Pharmaceutical Sciences. 103, 12, p. 4021–4029 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
Trost, B. M., Schroeder, G. M. & Kristensen, Jesper Langgaard, 16 Sep 2002, In: Angewandte Chemie International Edition. 41, 18, p. 3492-3495 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct Aromatic F-18-labeling of Tetrazines: A Rapid and Convenient Entry to Tetrazines for Pretargeted PET Imaging [Meeting Abstract]
Vazquez, R. G., Battisti, Umberto Maria, Stares, D. L., Petersen, I. N., Crestey, F., Svatunek, D., Mikula, H., Kristensen, Jesper Langgaard, Kjær, Andreas & Herth, Matthias Manfred, 2020, In: Journal of Nuclear Medicine. 61, Supl. 1, 2 p., 134.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Stereoselective synthesis of highly substituted bicyclic γ-lactones using homoaldol addition of 1-(1-cycloalkenyl)methyl carbamates
Özlügedik, M., Kristensen, Jesper Langgaard, Reuber, J., Fröhlich, R. & Hoppe, D., 1 Oct 2004, In: Synthesis. 14, p. 2303-2316 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nonracemic, chiral homoenolate reagents derived from (cycloalk-1-enyl)methyl carbamates and evaluation of their configurational stabilities
Özlügedik, M., Kristensen, Jesper Langgaard, Wibbeling, B., Fröhlich, R. & Hoppe, D., 1 Jan 2002, In: European Journal of Organic Chemistry. 3, p. 414-427 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1305029
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Convenient access to F-18-labeled amines through the Staudinger reduction
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
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