Jens Bukh
Professor
Virology
Blegdamsvej 3B, 2200 København N, 07 Bygning 7, Building: 07-13-84
Member of:
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In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms
Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, A. & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus
Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.Research output: Contribution to journal › Journal article › Research › peer-review
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A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.
Kuiken, C., Combet, C., Bukh, Jens, Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J., Simmonds, P. & Los Alamos HIV Database Group, L. A. H. D. G., 2006, In: Hepatology. 44, 5, p. 1355-61 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients
Fahnøe, Ulrik, Ronit, A., Berg, Ronan Martin Griffin, Jørgensen, S. E., Mogensen, T. H., Underwood, Alexander Paul James, Scheel, Troels Kasper Høyer, Bukh, Jens & Plovsing, R. R., 2022, In: The Journal of Infectious Diseases. 226, 12, p. 2137–2141Research output: Contribution to journal › Journal article › Research › peer-review
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A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans
Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.Research output: Contribution to journal › Journal article › Research › peer-review
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A milestone for hepatitis C virus research: a virus generated in cell culture is fully viable in vivo.
Bukh, Jens & Purcell, R. H., 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3500-1 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus
Pedersen, M. S., Fahnøe, Ulrik, Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2018, In: Journal of Clinical Virology. 105, p. 49-56 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor
Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974
Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085Research output: Patent
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Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.Research output: Contribution to journal › Journal article › Research › peer-review
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An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Feng, S., Marichal-Gallardo, P., Holmbeck, Kenn, Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, Katrine Top, Pham, Long, Zhou, Y., Gammeltoft, Karen Anbro, Fahnøe, Ulrik, Schneider, Uffe Vest, Pedersen, Gabriel Kristian, Jensen, Henrik Elvang, Christensen, Jan Pravsgaard, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: iScience. 26, 2, 105949.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines
Sølund, C., Underwood, Alexander Paul James, Fernandez-Antunez, C., Bollerup, S., Mikkelsen, L. S., Villadsen, S. L., Fahnøe, Ulrik, Winckelmann, Anni Assing, Feng, S., Nørløv Vinten, C. A., Dalegaard, M. I., Vizgirda, G., Sørensen, A. L., Ramirez Almeida, Santseharay, Bukh, Jens & Weis, Nina, 2022, In: Vaccines. 10, 1, 75.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7
Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants
Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Animal models for the study of hepatitis C virus infection and related liver disease
Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development
Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6Research output: Contribution to journal › Journal article › Research › peer-review
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Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model
Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.Research output: Contribution to journal › Journal article › Research › peer-review
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Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A
Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.Research output: Contribution to journal › Journal article › Research › peer-review
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At the Core of Depression: A Diagnostic Interview of the Core Features of Depression
Bukh, Jens, Fabrazzo, M., Christensen, E. M., Mikkelsen, R. L., Larsen, J. K., Hageman, I., Bendsen, B. B., Bolwig, T., Vinberg, Maj, Bech, P., Dam, O. H., Maj, M. & Kessing, Lars Vedel, 11 Mar 2022, In: Psychopathology. 55, 3-4, p. 219–225 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a
Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes
Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentø, Jannick, Velázquez-Moctezuma, R., Walker, Melanie Rose, Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, Jens, Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2C
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y. P. & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584
Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083Research output: Patent
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Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Liang, T. J., Law, J. L. M., Pietschmann, T., Ray, S. C., Bukh, Jens, Bull, R., Chung, R. T., Tyrrell, D. L., Houghton, M. & Rice, C. M., 2023, In: Clinical Infectious Diseases. 77, p. S257-S261Research output: Contribution to journal › Journal article › Research › peer-review
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Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models
Bukh, Jens, Meuleman, P., Tellier, R., Engle, R. E., Feinstone, S. M., Eder, G., Satterfield, W. C., Govindarajan, S., Krawczynski, K., Miller, R. H., Leroux-Roels, G. & Purcell, R. H., 1 May 2010, In: Journal of Infectious Diseases. 201, 9, p. 1381-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease
Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of a novel hepatitis C virus genotype 1 subtype from a patient failing 4 weeks of glecaprevir-pibrentasvir treatment
Pedersen, M. S., Fahnøe, Ulrik, Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, Jens, 2021, In: Microbiology resource announcements. 10, 41, e00755.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry
Carlsen, T. H. R., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Foung, S. K. H. & Bukh, Jens, 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system
Fernandez-Antunez, C., Wang, K., Fahnøe, Ulrik, Mikkelsen, L. S., Gottwein, Judith Margarete, Bukh, Jens & Ramirez Almeida, Santseharay, 2023, In: Hepatology. 78, 2, p. 621-636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses
Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus
Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein
Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort
Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Bartenschlager, R., Baumert, T. F., Bukh, Jens, Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., 2018, In: Virus Research. 248, p. 53-62 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies
Ramirez Almeida, Santseharay & Bukh, Jens, 2018, In: Antiviral Research. 158, p. 264-287 24 p.Research output: Contribution to journal › Review › Research › peer-review
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Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead
Mikkelsen, M. & Bukh, Jens, 2007, In: Current Infectious Disease Reports. 9, 2, p. 94-101 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.
Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34Research output: Contribution to journal › Journal article › Research › peer-review
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Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization
Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a TaqMan assay for the six major genotypes of hepatitis C virus: Comparison with commercial assays
Engle, R. E., Russell, R. S., Purcell, R. H. & Bukh, Jens, 2008, In: Journal of Medical Virology. 80, 1, p. 72-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine
Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential activity of nucleotide analogs against tick-borne encephalitis and yellow fever viruses in human cell lines
Binderup, A., Galli, Andrea, Fossat, Nicolas Julien, Fernandez-Antunez, C., Mikkelsen, L. S., Rivera, Lizandro, Scheel, Troels Kasper Høyer, Fahnøe, Ulrik, Bukh, Jens & Ramirez, S., 2023, In: Virology. 585, p. 179-185 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors
Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation
Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, Ulrik, Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Bélard, E., Madsen, Lone Galmstrup, Schønning, Kristian, Pedersen, A. G., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2018, In: Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Durability and breadth of neutralisation following multiple antigen exposures to SARS-CoV-2 infection and/or COVID-19 vaccination
Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Mikkelsen, L. S., Fahnøe, Ulrik, Bollerup, S., Winckelmann, Anni Assing, Schneider, Uffe Vest, Binderup, A., Vizgirda, G., Sørensen, A. L., Vinten, C. N., Dalegaard, M. I., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2023, In: EBioMedicine. 89, 104475.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles
Czarnota, A., Offersgaard, Anna Falden, Owsianka, A., Alzua, G. P., Bukh, Jens, Gottwein, Judith Margarete, Patel, A. H., Bienkowska-Szewczyk, K. & Grzyb, K., 2023, In: Microbiology Spectrum. 11, 2, 17 p., e0024523.Research output: Contribution to journal › Journal article › Research › peer-review
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Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study
Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants
Gottwein, Judith Margarete, Pham, Long, Mikkelsen, L. S., Ghanem, L., Ramirez Almeida, Santseharay, Scheel, Troels Kasper Høyer, Carlsen, T. H. R. & Bukh, Jens, Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro
Zhou, Y., Gammeltoft, Karen Anbro, Galli, Andrea, Offersgaard, Anna Falden, Fahnøe, Ulrik, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Viruses. 13, 10, 2082.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations
Scheel, Troels Kasper Høyer, Gottwein, J. M., Carlsen, T. H. R., Li, Y., Jensen, T. B., Spengler, U., Weis, Nina & Bukh, Jens, Mar 2011, In: Journal of Virology. 85, 6, p. 2891-2906 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706
Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333Research output: Patent
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Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653
Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189Research output: Patent
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Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275
Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113Research output: Patent
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Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472
Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332Research output: Patent
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Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969
Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 13 Aug 2013, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patent No. WO2010/017819, 18 Feb 2010, Priority date 31 Jul 2009, Priority No. PCT/DK2009/050193Research output: Patent
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Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2020, bioRxiv.Research output: Working paper › Preprint › Research
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Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors
Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77
Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells
Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elimination af hepatitis C-virus i Danmark
Døssing, A., Røge, B. T., Madsen, Lone Galmstrup, Laursen, A. L., Hansen, J. B., Bukh, Jens & Weis, Nina, 2020, In: Ugeskrift for Laeger. 182, 9Research output: Contribution to journal › Journal article › Research › peer-review
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Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain
Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis
Tomlinson, J. E., Wolfisberg, R., Fahnøe, Ulrik, Sharma, H., Renshaw, R. W., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, Jens, Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2020, In: P L o S Pathogens. 16, 7, 23 p., e1008677.Research output: Contribution to journal › Journal article › Research › peer-review
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Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals
Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P., Ramirez Almeida, S. & 4 others, , 6 Jul 2022.Research output: Contribution to conference › Poster › Communication
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Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants
Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, , 2019, In: Hepatology. 70, 3, p. 771-787 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary selection of pestivirus variants with altered or no microRNA dependency
Kokkonos, K. G., Fossat, Nicolas Julien, Nielsen, L., Holm, C., Hepkema, W. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource
Smith, D. B., Bukh, Jens, Kuiken, C., Muerhoff, A. S., Rice, C. M., Stapleton, J. T. & Simmonds, P., Jan 2014, In: Hepatology. 59, 1, p. 318-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FLAVIVIRDAE
Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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First-in-human use of a modular capsid virus-like vaccine platform: An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2
Smit, M. J., Sander, A. F., Ariaans, M. B. P. A., Fougeroux, C., Heinzel, C., Fendel, R., Esen, M., Kremsner, P. G., Ter Heine, R., Wertheim, H. F., Idorn, M., Paludan, S. R., Underwood, A. P., Binderup, A., Ramirez, S., Bukh, J., Soegaard, M., Erdogan, S. M., Gustavsson, T., Clemmensen, S. & 14 others, , 2023, In: The Lancet Microbe. 4, 3, p. e140-e148Research output: Contribution to journal › Journal article › Research › peer-review
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Full-length open reading frame amplification of hepatitis C virus
Fahnøe, Ulrik & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 85-91 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone
Bajpai, P. S., Collignon, Laura Maria F, Sølund, C., Madsen, L. W., Christensen, P. B., Øvrehus, A., Weis, Nina, Holmbeck, Kenn, Fahnøe, Ulrik & Bukh, Jens, 2023, In: Journal of Virology. 97, 12, 23 p., 00925.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional analyses of GB virus B p13 protein: Development of a recombinant GB virus B hepatitis virus with a p7 protein
Takikawa, S., Engle, R. E., Emerson, S. U., Purcell, R. H., St Claire, M. & Bukh, Jens, 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 9, p. 3345-50 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir
Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394Research output: Contribution to journal › Journal article › Research › peer-review
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Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins
Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Tzarum, N., Giang, E., Kong, L., He, L., Prentø, Jannick, Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, Jens, Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study
Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome sequence of an unknown subtype of hepatitis C virus genotype 6: Another piece for the taxonomic puzzle
Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2019, In: Microbiology resource announcements. 8, 42, e01030-19.Research output: Contribution to journal › Journal article › Research › peer-review
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Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, Jens & Prentø, Jannick, 2020, In: Science Advances. 6, 35, 13 p., eabb5938.Research output: Contribution to journal › Journal article › Research › peer-review
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Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome
Fahnøe, Ulrik, Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Thielsen, P., Madsen, Lone Galmstrup, Pedersen, A. G., Schønning, Kristian, Weis, Nina & Bukh, Jens, 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316Research output: Contribution to journal › Journal article › Research › peer-review
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HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models
Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12Research output: Contribution to journal › Journal article › Research › peer-review
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HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4
Pham, Long, Pedersen, M. S., Fahnøe, Ulrik, Fernandez-Antunez, C., Humes, D., Schønning, Kristian, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Gut. 71, p. 627-642 20323585.Research output: Contribution to journal › Journal article › Research › peer-review
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HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape
Pham, Long, Jensen, S. B., Fahnøe, Ulrik, Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez Almeida, Santseharay, Humes, D., Serre, S. B. N., Schønning, Kristian, Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Journal of Hepatology. 70, 3, p. 388-397Research output: Contribution to journal › Journal article › Research › peer-review
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HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen
Filskov, J., Andersen, P., Agger, E. M. & Bukh, Jens, 2019, In: Scientific Reports. 9, 1, 13 p., 14085.Research output: Contribution to journal › Journal article › Research › peer-review
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HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro
Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, Anna Falden, Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, S., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance
Velázquez-moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C homolog in dogs with respiratory illness
Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatitis C hos hiv-inficerede patienter
Bukh, Jens & Nielsen, J. O., 2006, In: Ugeskrift for læger. 168, 42, p. 3599-Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide
Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, , 2023, In: Nature. 619, p. 811-818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus alters the morphology and function of peroxisomes
Martin de Fourchambault, E., Callens, N., Saliou, J. M., Fourcot, M., Delos, O., Barois, N., Thorel, Q., Ramirez Almeida, Santseharay, Bukh, Jens, Cocquerel, L., Bertrand-Michel, J., Marot, G., Sebti, Y., Dubuisson, J. & Rouillé, Y., 2023, In: Frontiers in Microbiology. 14, 1254728.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents
Xiao, F., Fofana, I., Heydmann, L., Barth, H., Soulier, E., Habersetzer, F., Doffoël, M., Bukh, Jens, Patel, A. H., Zeisel, M. B. & Baumert, T. F., May 2014, In: P L o S Pathogens. 10, 5, p. 1-15 16 p., e1004128.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1
Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 12437
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Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Research output: Contribution to journal › Review › Research › peer-review
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382
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Research output: Contribution to journal › Journal article › Research › peer-review
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344
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Research output: Contribution to journal › Review › Research › peer-review
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