Helle S. Waagepetersen

Helle S. Waagepetersen

Guest Researcher

ORCID: 0000-0003-4583-8379

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  1. Published

    Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

    Parpura, V., Fisher, E. S., Lechleiter, J. D., Schousboe, Arne, Waagepetersen, Helle S., Brunet, S., Baltan, S. & Verkhratsky, A., 2017, In: Neurochemical Research. 42, 1, p. 19-34 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Glutamate and glutamine in brain disorders

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  3. Published

    Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 26 Apr 2013, In: Neurochemical Research. 39, 3, p. 487-499

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation

    Hohnholt, M. C., Andersen, V. H., Andersen, Jens Velde, Christensen, S. K., Karaca, M., Maechler, P. & Waagepetersen, Helle S., Oct 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 10, p. 1754–1768

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  7. Published

    Glutamate homeostasis revisited - neuronal transport and metabolism

    Waagepetersen, Helle S., McNair, Laura M., Christensen, S. K., Andersen, Jens Velde & Aldana, Blanca, 2019, p. 19-19.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  8. Published

    Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

    Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Glutamate metabolism in the brain focusing on astrocytes

    Schousboe, Arne, Scafidi, S., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Glutamate neurotransmission is affected in prenatally stressed offspring

    Adrover, E., Pallarés, M. E., Baier, C. J., Monteleone, M. C., Giuliani, F. A., Waagepetersen, Helle S., Brocco, M. A., Cabrera, R., Sonnewald, U., Schousboe, Arne & Antonelli, M. C., Sep 2015, In: Neurochemistry International. 88, p. 73-87 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

    McKenna, M. C., Stridh, M. H., McNair, Laura M., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 15 Sep 2016, In: Journal of Neuroscience Research. 94, 12, p. 1561-1571 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

    Aldana, Blanca, Zhang, Y., Jensen, P., Chandrasekaran, Abinaya, Christensen, S. K., Nielsen, T. T., Nielsen, Jørgen Erik, Hyttel, P., Larsen, M. R., Waagepetersen, Helle S. & Freude, Kristine, 2020, In: Molecular Brain. 13, 1, 7 p., 125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Glutamine and ammonia in hepatic encephalopathy

    Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  14. Published

    Glutamine in the central nervous system: function and dysfunction

    Albrecht, J., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2007, In: Frontiers in Bioscience. 12, p. 332-343

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Glutamine, glutamate and GABA: metabolic aspects

    Waagepetersen, Helle S., Sonnerwald, U. & Schousboe, Arne, 2007, Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. Lajtha, A., Oja, S. S., Schousboe, A. & Saransaari, P. (eds.). 3rd. ed. Berlin: Springer, p. 1-21

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  16. Published

    Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

    Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto-Kakizaki rats

    Soares, A. F., Nissen, J. D., Garcia-Serrano, A. M., Nussbaum, S. S., Waagepetersen, Helle S. & Duarte, J. M. N., 1 Jan 2019, In: Journal of Neuroscience Research. 97, p. 1004-1017

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Hjernens forsvarsmur kortlagt og kopieret

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010, In: Lægemiddelforskning. 2010, p. 22-24

    Research output: Contribution to journal › Journal article › Communication

  21. Published

    Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice

    Arildsen, L., Andersen, Jens Velde, Waagepetersen, Helle S., Nissen, J. B. D. & Sheykhzade, Majid, 2019, In: Diabetes and Vascular Disease Research. 16, 6, p. 539 548 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Impact of the malate-aspartate shuttle in glutamate neurotransmission

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9

    Research output: Contribution to journal › Conference abstract in journal › Research

  23. Published

    Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus

    Andersen, Jens Velde, Nissen, J. D., Christensen, S. K., Markussen, K. H. & Waagepetersen, Helle S., 2017, In: Neural Plasticity. 2017, p. 2107084 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

    Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Keiding, S., Schousboe, Arne & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Importance of glutamate dehydrogenase, GDH, in astrocyte metabolism for maintenance of glutamate and energy homeostasis

    Waagepetersen, Helle S., 29 Jun 2012, København. 66 p.

    Research output: Book/Report › Ph.D. thesis › Research

  26. Published

    Improved cerebral energetics and ketone body metabolism in db/db mice

    Andersen, Jens Velde, Christensen, S. K., Nissen, J. D. & Waagepetersen, Helle S., Mar 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 1137–1147 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    In vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 18 Jul 2009.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  28. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  30. Published

    In-vitro models of the blood brain barrier

    Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  31. E-pub ahead of print

    Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease

    Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, Aisha, Gegelashvili, G., Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

    Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana, Blanca, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In: Cell Reports. 23, 7, p. 2211-2224 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

    Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Is neuronal utilization of glucose and lactate linked to Ca2+-dependent modulation of malate-aspartate shuttle activity?

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Walls, Anne Byriel & Schousboe, Arne, 2008.

    Research output: Contribution to conference › Poster › Research

  36. Published

    Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

    Müller, M. S., Pedersen, Sofie E., Walls, Anne Byriel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Jan 2015, In: Glia. 63, 1, p. 154-62 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Knockdown of GDH indicates its potential impact in sustaining glutamate homeostasis and neurotransmission

    Klawonn, A. M., Bolanos, J. P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s2, p. 105

    Research output: Contribution to journal › Conference abstract in journal › Research

  38. Published

    Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

    Walls, Anne Byriel, Eyjolfsson, E. M., Smeland, O. B., Nilsen, L. H., Schousboe, I., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 494-503 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Lactate: More than merely a metabolic waste product

    Vohra, Rupali, Aldana, Blanca, Skytt, D. M., Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 2018, In: Acta Ophthalmologica. 96, Supplement 261, p. 137 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  40. Published

    Lactate-Mediated Protection of Retinal Ganglion Cells

    Vohra, Rupali, Aldana, Blanca, Bulli, G., Jensen, Dorte Skytt, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1878-1888 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Limited energy supply in Müller cells alters glutamate uptake

    Toft-Kehler, A. K., Jensen, Dorte Skytt, Poulsen, K. A., Brændstrup, C. T., Gegelashvili, G., Waagepetersen, Helle S. & Kolko, M., May 2014, In: Neurochemical Research. 39, 5, p. 941-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

    Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-(13)C]Glucose and [1,2-(13)C]Acetate as Substrates

    McNair, Laura M., Kornfelt, R., Walls, Anne Byriel, Andersen, Jens Velde, Aldana, B. I., Nissen, J. D., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 3, p. 810-826 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

    Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Metabolic impairments in neurons and astrocytes derived from human induced pluripotent stem cells of Alzheimer's disease patients

    Garcia, B. A., Salcedo, C., Hyttel, P., Waagepetersen, Helle S. & Freude, Kristine, 2019, p. 111-111.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  46. Published

    Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)

    Walls, Anne Byriel, Bak, Lasse Kristoffer, Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Metabolic profiles of the brains of Zucker Diabetic Fatty, Zucker Obese and Sprague-Dawley rats and the involvement of glycogen metabolism

    Sickmann, H. M., Bouman, S. D., Schousboe, Arne, Tracey, W. R. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 293-293

    Research output: Contribution to journal › Conference abstract in journal › Research

  48. Published

    Metabolism of [1,6-13C]glucose and [U-13C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices

    Waagepetersen, Helle S., Døring, S. & Schousboe, Arne, 2008, In: Neurochemical Research. 33, 8, p. 1610-1617

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

    Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Mitochondrial function in Müller cells - Does it matter?

    Toft-Kehler, A. K., Jensen, Dorte Skytt, Svare, A., Lefevere, E., Van Hove, I., Moons, L., Waagepetersen, Helle S. & Kolko, Miriam, 2017, In: Mitochondrion. 36, p. 43-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  52. Published

    Muller cell survival and function is maintained by the presence of lactate

    Vohra, Rupali, Skytt, D. M., Aldana, Blanca, Freude, Kristine, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, Jul 2018, p. 1480. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  53. Published

    Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

    Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Neuronal metabolism in GAD65 knockout mice is compromised and not susceptible to kainic acid

    Walls, A. B., Eyjolfsson, E. M., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. Suppl. 2, p. 123

    Research output: Contribution to journal › Conference abstract in journal › Research

  57. Published

    Novel culturing platform for brain slices and neuronal cells

    Svendsen, W. E., Al Atraktchi, F. A. Z., Bakmand, T., Waagepetersen, Helle S. & Dimaki, M., 4 Nov 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., p. 346-349 4 p. 7318370. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Vol. 2015-November).

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  58. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis

    Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1527-37 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    One third of glycolytic activity in astrocytes depends on the operation of the glycogen shunt

    Walls, Anne Byriel, Heimbürger, C. M., Sickmann, H. M., Bouman, S. D., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neurochemistry. 102, s1, p. 119

    Research output: Contribution to journal › Conference abstract in journal › Research

  61. Published

    Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

    Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

    Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Azevedo, C., Roybon, L., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 297.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.

    Research output: Contribution to conference › Conference abstract for conference › Research

  65. Published

    Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.

    Research output: Contribution to conference › Poster › Communication

  66. Published

    Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

    Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, Kristine, 2017, In: Stem Cell Reports. 8, 3, p. 648-658

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen

    Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

    Huyghe, D., Denninger, A. R., Voss, C. M., Frank, P., Gao, N., Brandon, N., Waagepetersen, Helle S., Ferguson, A. D., Pangalos, M., Doig, P. & Moss, S. J., 21 May 2019, In: Frontiers in Molecular Neuroscience. 12, 14 p., 120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Prenatal stress effect on glutamate metabolism, evaluated with mass espectroscopy-liquid cromatography

    Adrover, E., Katunar, M. R., Waagepetersen, Helle S., Schousboe, Arne & Antonelli, M. C., 2009, In: Journal of Neurochemistry. Suppl. 2, p. 172-172

    Research output: Contribution to journal › Conference abstract in journal › Research

  70. Published

    Primary cultures of astrocytes: their value in understanding astrocytes in health and disease

    Lange, S. C., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Progressive Mitochondrial Dysfunction of Striatal Synapses in R6/2 Mouse Model of Huntington's Disease

    Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Madsen, M., Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, 2022, In: Journal of Huntington's disease. 11, 2, p. 121-140

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes

    Ilieva, M., Aldana, Blanca, Vinten, K. T., Hohmann, S., Woofenden, T. W., Lukjanska, R., Waagepetersen, Helle S. & Michel, T. M., 2022, In: Molecular Psychiatry. 27, p. 3749–3759

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Purinergic Signaling in Pericytes of the Blood-Brain Barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jul 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  74. Published

    Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

    Brekke, E. M., Walls, Anne Byriel, Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1788-1799 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo

    McNair, Laura M., Mason, G. F., Chowdhury, G. M. I., Jiang, L., Ma, X., Rothman, D. L., Waagepetersen, Helle S. & Behar, K. L., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 8, p. 1507–1523

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy

    Keiding, S., Iversen, P., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Gjedde, A., Schousboe, Arne & Vilstrup, H., 2009, In: Journal of Neurochemistry. s1, p. 269-270

    Research output: Contribution to journal › Conference abstract in journal › Research

  77. Published

    Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  78. Published

    Rises in intracellular calcium in primary brain pericytes are caused by ATP

    Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  79. Published

    Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents

    Walls, Anne Byriel, Heimbürger, C., Bouman, S., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Neuroscience. 158, 1, p. 284-292

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, Jan 2004, In: Neurochemical Research. 29, 1, p. 257-65 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

    Schousboe, Arne, Sarup, A., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Larsson, O. M., Sep 2004, In: Neurochemistry International. 45, 4, p. 521-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

    Andersen, Jens Velde, McNair, Laura M., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice

    McNair, Laura M., Andersen, Jens Velde & Waagepetersen, Helle S., 2023, In: Neurochemistry International. 171, 10 p., 105626.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    State-Dependent Changes in Brain Glycogen Metabolism

    DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  85. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    The 11th International Conference on Brain Energy Metabolism "how energy metabolism shapes brain function". Preface: Preface

    Waagepetersen, Helle S., Schousboe, Arne & McKenna, M. C., Jul 2015, In: Journal of Neuroscience Research. 93, 7, p. 985-6 2 p.

    Research output: Contribution to journal › Journal article › Research

  87. Published

    The Glutamine-Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

    Walls, Anne Byriel, Waagepetersen, Helle S., Bak, Lasse Kristoffer, Schousboe, Arne & Sonnewald, U., Feb 2015, In: Neurochemical Research. 40, 2, p. 402-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

    Hohnholt, M. C., Blumrich, E., Waagepetersen, Helle S. & Dringen, R., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2307-2320 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases

    Zaganas, I., Pajecka, K., Nielsen, C. W., Schousboe, Arne, Waagepetersen, Helle S. & Plaitakis, A., Jun 2013, In: Metabolic Brain Disease. 28, 2, p. 127-131 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  91. Published

    The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

    Johansen, M. L., Bak, Lasse Kristoffer, Schousboe, Arne, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Gjedde, A., Ott, P. & Waagepetersen, Helle S., 2007, In: Neurochemistry International. 50, p. 1042-1051

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    The micro-architecture of the cerebral cortex: Functional neuroimaging models and metabolism

    Riera, J. J., Schousboe, Arne, Waagepetersen, Helle S., Howarth, C. & Hyder, F., 2008, In: NeuroImage. 40, 4, p. 1436-1459

    Research output: Contribution to journal › Review › Research

  95. Published

    The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells

    Aldana, Blanca, Waagepetersen, Helle S., Schousboe, Arne, White, H. S., Bulaj, G. & Walls, Anne Byriel, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2286-2296 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    The role of astrocytes in seizure generation: Insights from a novel in vitro seizure model based on mitochondrial dysfunction

    Chan, F., Lax, N. Z., Voss, C. M., Aldana, B. I., Whyte, S., Jenkins, A., Nicholson, C., Nichols, S., Tilley, E., Powell, Z., Waagepetersen, Helle S., Davies, C. H., Turnbull, D. M. & Cunningham, M. O., 1 Feb 2019, In: Brain. 142, 2, p. 391-411 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

    Lovatt, D., Sonnewald, U., Waagepetersen, Helle S., Schousboe, Arne, He, W., Lin, J. H., Han, X., Takano, T., Wang, S., Sim, F. J., Goldman, S. A. & Nedergaard, M., 2007, In: Journal of Neuroscience. 27, 45, p. 12255-12266

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23

    Hohnholt, M. C., Blumrich, E., Waagepetersen, Helle S. & Dringen, R., Jan 2017, In: Neurochemistry International. 102, p. 13-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Transport pathways mediating blood-to-brain L-glutamate efflux

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  100. Published

    Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes

    Montana, V., Flint, D., Waagepetersen, Helle S., Schousboe, Arne & Parpura, V., 2021, In: Neurochemical Research. 46, p. 2551–2579

    Research output: Contribution to journal › Journal article › Research › peer-review

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