Cord Herbert Brakebusch

Cord Herbert Brakebusch

ORCID: 0000-0002-9342-1634

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  1. Published

    Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.

    van Hengel, J., D'Hooge, P., Hooghe, B., Wu, X., Libbrecht, L., De Vos, R., Quondamatteo, F., Klempt, M., Brakebusch, Cord Herbert & van Roy, F., 2008, In: Gastroenterology. 134, 3, p. 781-92 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

    Zu, T., Wen, J., Xu, L., Li, H., Mi, J., Brakebusch, Cord Herbert, Fisher, D. E. & Wu, X., 2020, In: Frontiers in Oncology. 10, 15 p., 624.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Neurocan is dispensable for brain development.

    Zhou, X. H., Brakebusch, Cord Herbert, Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., Buettner, R., Gundelfinger, E. D. & Fässler, R., 2001, In: Molecular and Cellular Biology. 21, 17, p. 5970-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice

    Yuan, H., Zhang, H., Wu, X., Zhang, Z., Du, D., Zhou, W., Zhou, S., Brakebusch, Cord Herbert & Chen, Z., 2009, In: Hepatology. 49, 1, p. 240-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth

    Ye, Z., Kilic, G., Dabelsteen, Sally, Marinova, I. N., Thøfner, J. F. B., Song, Ming, Levann, Asha Maria Rudjord, Bagdonaite, Ieva , Vakhrushev, Sergey, Brakebusch, Cord Herbert, Olsen, Jesper Velgaard & Wandall, Hans H., 2022, In: Science Signaling. 15, 761, eabo2206.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells

    Xu, L., Zu, T., Li, T., Li, M., Mi, J., Bai, F., Liu, G., Wen, J., Li, H., Brakebusch, Cord Herbert, Wang, X. & Wu, X., 2021, In: PLOS Genetics. 17, 2, p. 1-25 e1009283.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

    Xia, J., Swiercz, J. M., Bañón-Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, Cord Herbert, Kumanogoh, A., Friedel, R. H., Martín-Belmonte, F., Gröne, H., Offermanns, S. & Worzfeld, T., May 2015, In: Developmental Cell. 33, 3, p. 299-313 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.

    Xanthoulea, S., Pasparakis, M., Kousteni, S., Brakebusch, Cord Herbert, Wallach, D., Bauer, J., Lassmann, H. & Kollias, G., 2004, In: Journal of Experimental Medicine. 200, 3, p. 367-76 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.

    Wu, X., Li, S., Chrostek-Grashoff, A., Czuchra, A., Meyer, H., Yurchenco, P. D. & Brakebusch, Cord Herbert, 2007, In: Developmental Dynamics. 236, 10, p. 2767-78 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.

    Wu, X., Quondamatteo, F., Lefever, T., Czuchra, A., Meyer, H., Chrostek, A., Paus, R., Langbein, L. & Brakebusch, Cord Herbert, 2006, In: Genes & Development. 20, 5, p. 571-85 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.

    Wu, X., Quondamatteo, F. & Brakebusch, Cord Herbert, 2006, In: Matrix Biology. 25, 8, p. 466-74 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

    Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W. G., Larue, L., Brakebusch, Cord Herbert, Insall, R. H. & Machesky, L. M., 6 Mar 2017, In: Current biology : CB. 27, 5, p. 624-637 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells.

    Winzen, R., Wallach, D., Engelmann, H., Nophar, Y., Brakebusch, Cord Herbert, Kemper, O., Resch, K. & Holtmann, H., 1992, In: Journal of Immunology. 148, 11, p. 3454-60 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    p21-activated Kinase1(PAK1) can promote ERK activation in a kinase independent manner

    Wang, Z., Fu, M., Wang, L., Liu, J., Li, Y., Brakebusch, Cord Herbert & Mei, Q., 7 May 2013, In: Journal of Biological Chemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes

    Wang, Z., Jiang, Z., Zhang, Q., Hu, M., Huang, L., Ou, X., Guo, L., Ouyang, Y., Hou, Y., Brakebusch, Cord Herbert, Schatten, H. & Sun, Q., Dec 2013, In: Molecular Biology of the Cell. 24, 24, p. 3832-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

    Wang, Z., Pedersen, E. D. K., Basse, A., Lefever, T., Peyrollier, K., Kapoor, S., Mei, Q., Karlsson, R., Chrostek-Grashoff, A. & Brakebusch, Cord Herbert, 2010, In: Oncogene. 29, 23, p. 3362-73 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Soluble and cell surface receptors for tumor necrosis factor.

    Wallach, D., Engelmann, H., Nophar, Y., Aderka, D., Kemper, O., Hornik, V., Holtmann, H. & Brakebusch, Cord Herbert, 1991, In: Agents and actions. Supplements. 35, p. 51-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

    Wahlestedt, M., Erlandsson, E., Kristiansen, T., Lu, R., Brakebusch, Cord Herbert, Weissman, I. L., Yuan, J., Martin Gonzalez, Javier & Bryder, D., 22 Feb 2017, In: Nature Communications. 8, 8 p., 14533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues

    Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Discoidin domain receptor 1 is activated independently of beta(1) integrin.

    Vogel, W., Brakebusch, Cord Herbert, Fässler, R., Alves, F., Ruggiero, F. & Pawson, T., 2000, In: Journal of Biological Chemistry. 275, 8, p. 5779-84 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse

    Vasyutina, E., Martarelli, B., Brakebusch, Cord Herbert, Wende, H. & Birchmeier, C., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 22, p. 8935-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis

    Vadodaria, K. C., Brakebusch, Cord Herbert, Suter, U. & Jessberger, S., 16 Jan 2013, In: Journal of Neuroscience. 33, 3, p. 1179-89 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells

    Vadakumchery, A., Faraidun, H., Ayoubi, O. E., Outaleb, I., Schmid, V., Abdelrasoul, H., Amendt, T., Khadour, A., Setz, C., Göhring, K., Lodd, K., Hitzing, C., Alkhatib, A., Bilal, M., Benckendorff, J., Al Shugri, A. K., Brakebusch, C. H., Engels, N., Datta, M., Hobeika, E. & 2 others, Alsadeq, A. & Jumaa, H., 2022, In: Frontiers in Immunology. 13, 19 p., 842340.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.

    Tscharntke, M., Pofahl, R., Chrostek-Grashoff, A., Smyth, N., Niessen, C., Niemann, C., Hartwig, B., Herzog, V., Klein, H. W., Krieg, T., Brakebusch, Cord Herbert & Haase, I., 2007, In: Journal of Cell Science. 120, Pt 8, p. 1480-90 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.

    Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K., Franklin, R. J. M., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2006, In: Journal of Neuroscience. 26, 40, p. 10110-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Integrin gene targeting.

    Talts, J. F., Brakebusch, Cord Herbert & Fässler, R., 1999, In: Methods in Molecular Biology. 129, p. 153-87 34 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Rac1 regulates neuronal polarization through the WAVE complex

    Tahirovic, S., Hellal, F., Neukirchen, D., Hindges, R., Garvalov, B. K., Flynn, K. C., Stradal, T. E., Chrostek-Grashoff, A., Brakebusch, Cord Herbert & Bradke, F., 2010, In: Journal of Neuroscience. 30, 20, p. 6930-43 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Rho GTPases in cancer: friend or foe?

    Svensmark, J. H. & Brakebusch, Cord Herbert, 2019, In: Oncogene. 38, p. 7448-7456

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury

    Stern, S., Hilton, B. J., Burnside, E. R., Dupraz, S., Handley, E. E., Gonyer, J. M., Brakebusch, Cord Herbert & Bradke, F., 2021, In: Neuron. 109, 21, p. 3436-3455 30 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

    Steffen, A., Ladwein, M., Dimchev, G. A., Hein, A., Schwenkmezger, L., Arens, S., Ladwein, K. I., Margit Holleboom, J., Schur, F., Victor Small, J., Schwarz, J., Gerhard, R., Faix, J., Stradal, T. E. B., Brakebusch, Cord Herbert & Rottner, K., 15 Oct 2013, In: Journal of Cell Science. 126, Pt 20, p. 4572-88 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and rho GTPases in cell migration

    Stanley, A., Thompson, K., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., 1 May 2014, In: Antioxidants & Redox Signaling. 20, 13, p. 2026-42 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Rho GTPases and Nox dependent ROS production in skin. Is there a connection?

    Stanley, A., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., Nov 2012, In: Histology and Histopathology. 27, 11, p. 1395-406 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    Changes in dermal matrix in the absence of Rac1 in keratinocytes

    Stanley, A., Pedersen, E. D. K., Brakebusch, Cord Herbert & Quondamatteo, F., May 2016, In: Journal of Anatomy. 228, 5, p. 826-37 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

    Socodato, R., Almeida, T. O., Portugal, C. C., Santos, E. C. S., Tedim-Moreira, J., Galvão-Ferreira, J., Canedo, T., Baptista, F. I., Magalhães, A., Ambrósio, A. F., Brakebusch, Cord Herbert, Rubinstein, B., Moreira, I. S., Summavielle, T., Pinto, I. M. & Relvas, J. B., 2023, In: Cell Reports. 42, 12, 28 p., 113447.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

    Socodato, R., Portugal, C. C., Canedo, T., Rodrigues, A., Almeida, T. O., Henriques, J. F., Vaz, S. H., Magalhães, J., Silva, C. M., Baptista, F. I., Alves, R. L., Coelho-Santos, V., Silva, A. P., Paes-de-Carvalho, R., Magalhães, A., Brakebusch, Cord Herbert, Sebastião, A. M., Summavielle, T., Ambrósio, A. F. & Relvas, J. B., 2020, In: Cell Reports. 31, 12, p. 1-29 107796.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

    Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.

    Research output: Contribution to journal › Conference article › Research › peer-review

  37. Published

    Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

    Sitnicka, E., Brakebusch, Cord Herbert, Martensson, I., Svensson, M., Agace, W. W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C. M., Ahlenius, H., Maraskovsky, E., Peschon, J. J. & Jacobsen, S. E. W., 2003, In: Journal of Experimental Medicine. 198, 10, p. 1495-506 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Differential effect on TCR:CD3 stimulation of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger receptor cysteine-rich domain protein family.

    Silvestri, B., Calderazzo, F., Coppola, V., Rosato, A., Iacobelli, S., Natoli, C., Ullrich, A., Sures, I., Azam, M., Brakebusch, Cord Herbert, Chieco-Bianchi, L. & Amadori, A., 1998, In: Clinical and Experimental Immunology. 113, 3, p. 394-400 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination

    Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2022, Cold Spring Harbor Laboratory, 15 p. (bioRxiv).

    Research output: Working paper › Preprint › Research

  40. Published

    A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination

    Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2023, In: Progress in Neurobiology. 227, 13 p., 102481.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The small GTPase RhoA regulates the onset of myelination and myelin production during PNS development: [Meeting Abstract}

    Seixas, A., Morais, M., Pereira, J. A., Krause, S., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2019, In: Glia. 67, S1, p. E473-E474 T12-052B.

    Research output: Contribution to journal › Conference abstract in journal › Research

  42. Published

    Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.

    Seidler, J., Durzok, R., Brakebusch, Cord Herbert & Cordes, N., 2005, In: Radiotherapy & Oncology. 76, 2, p. 129-34 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Podocyte-specific loss of cdc42 leads to congenital nephropathy

    Scott, R. P., Hawley, S. P., Ruston, J., Du, J., Brakebusch, Cord Herbert, Jones, N. & Pawson, T., 19 Apr 2012, In: Journal of the American Society of Nephrology. 23, 7, p. 1149-54 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

    Schulz, A. M., Stutte, S., Hogl, S., Luckashenak, N., Dudziak, D., Leroy, C., Forné, I., Imhof, A., Müller, S. A., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 9 Nov 2015, In: Journal of Cell Biology. 211, 3, p. 553-67 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions.

    Schuchmann, M., Hess, S., Bufler, P., Brakebusch, Cord Herbert, Wallach, D., Porter, A., Riethmüller, G. & Engelmann, H., 1995, In: European Journal of Immunology. 25, 8, p. 2183-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.

    Sasaki, T., Göhring, W., Mann, K., Brakebusch, Cord Herbert, Yamada, Y., Fässler, R. & Timpl, R., 2001, In: Journal of Molecular Biology. 314, 4, p. 751-63 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

    Sasaki, T., Brakebusch, Cord Herbert, Engel, J. & Timpl, R., 1998, In: EMBO Journal. 17, 6, p. 1606-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

    Sakamori, R., Das, S., Yu, S., Feng, S., Stypulkowski, E., Guan, Y., Douard, V., Tang, W., Ferraris, R. P., Harada, A., Brakebusch, Cord Herbert, Guo, W. & Gao, N., 1 Mar 2012, In: Journal of Clinical Investigation. 122, 3, p. 1052-65 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    PATHBIO: an international training program for precision mouse phenotyping

    Ruberte, J., Schofield, P. N., Brakebusch, Cord Herbert, Vogel, P., Herault, Y., Gracia, G., McKerlie, C., Hrabĕ de Angelis, M., Hagn, M. & Sundberg, J. P., 2020, In: Mammalian Genome. 31, p. 49-53

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo

    Robel, S., Bardehle, S., Lepier, A., Brakebusch, Cord Herbert & Götz, M., 31 Aug 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 35, p. 12471-82 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Sequence and chromosomal localization of the mouse brevican gene.

    Rauch, U., Meyer, H., Brakebusch, Cord Herbert, Seidenbecher, C., Gundelfinger, E. D., Beier, D. R. & Fässler, R., 1997, In: Genomics. 44, 1, p. 15-21 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    The small GTPase Rac1 is required for smooth muscle contraction

    Rahman, A., Davis, B., Lövdahl, C., Hanumaiah, V. T., Feil, R., Brakebusch, Cord Herbert & Arner, A., 1 Mar 2014, In: The Journal of Physiology. 592, 5, p. 915-26 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Cdc42 Controls Vascular Network Assembly Through Protein Kinase C{iota} During Embryonic Vasculogenesis

    Qi, Y., Liu, J., Wu, X., Brakebusch, Cord Herbert, Leitges, M., Han, Y., Corbett, S. A., Lowry, S. F., Graham, A. M. & Li, S., 1 Aug 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 8, p. 1861-70 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow.

    Potocnik, A. J., Brakebusch, Cord Herbert & Fässler, R., 2000, In: Immunity. 12, 6, p. 653-63 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection

    Porubsky, S., Wang, S., Kiss, E., Dehmel, S., Bonrouhi, M., Dorn, T., Luckow, B., Brakebusch, Cord Herbert & Gröne, H., 1 Jan 2011, In: European Journal of Immunology. 41, 1, p. 76-88 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

    Pleines, I., Hagedorn, I., Gupta, S., May, F., Chakarova, L., van Hengel, J., Offermanns, S., Krohne, G., Kleinschnitz, C., Brakebusch, Cord Herbert & Nieswandt, B., 1 Nov 2011, In: Blood. 119, 4, p. 1054-63 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

    Pleines, I., Eckly, A., Elvers, M., Hagedorn, I., Eliautou, S., Bender, M., Wu, X., Lanza, F., Gachet, C., Brakebusch, Cord Herbert & Nieswandt, B., 2010, In: Blood. 115, 16, p. 3364-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

    Pleines, I., Dütting, S., Cherpokova, D., Eckly, A., Meyer, I., Morowski, M., Krohne, G., Schulze, H., Gachet, C., Debili, N., Brakebusch, Cord Herbert & Nieswandt, B., 31 Oct 2013, In: Blood. 122, 18, p. 3178-87 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Rac1 is essential for phospholipase C-gamma2 activation in platelets.

    Pleines, I., Elvers, M., Strehl, A., Pozgajova, M., Varga-Szabo, D., May, F., Chrostek-Grashoff, A., Brakebusch, Cord Herbert & Nieswandt, B., 2008, In: Pflügers Archiv: European Journal of Physiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion

    Piwko-Czuchra, A., Koegel, H., Meyer, H., Bauer, M., Werner, S., Brakebusch, Cord Herbert & Fässler, R., 2009, In: PLoS ONE. 4, 5, p. e5488

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.

    Pietri, T., Eder, O., Breau, M. A., Topilko, P., Blanche, M., Brakebusch, Cord Herbert, Fässler, R., Thiery, J. & Dufour, S., 2004, In: Development. 131, 16, p. 3871-83 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition

    Petersen, L., Stroh, S., Schöttelndreier, D., Grassl, G. A., Rottner, K., Brakebusch, Cord Herbert, Fahrer, J. & Genth, H., 2022, In: Frontiers in Microbiology. 13, 11 p., 846215.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Rho GTPase function in cell morphogenesis

    Pedersen, E. D. K. & Brakebusch, Cord Herbert, 2010, ENCYCLOPEDIA OF LIFE SCIENCES. Wiley

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  64. Accepted/In press

    Rho GTPase knockout induction in primary keratinocytes from adult mice

    Pedersen, E. D. K., Basse, A. L., Lefever, T., Peyrollier, K. C. & Brakebusch, Cord Herbert, 2011, (Accepted/In press) Methods in Rho GTPases. Rivero, F. (ed.). New York: Humana Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  65. Published

    RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

    Pedersen, E. D. K., Wang, Z., Stanley, A., Peyrollier, K., Rösner, L. M., Werfel, T., Quondamatteo, F. & Brakebusch, Cord Herbert, 15 Nov 2012, In: Journal of Cell Science. 125, Pt 22, p. 5379-90 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Rho GTPase function in development: How in vivo models change our view

    Pedersen, E. & Brakebusch, Cord Herbert, 29 May 2012, In: Experimental Cell Research. 318, 14, p. 1779-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

    Papareddy, P., Rossnagel, M., Doreen Hollwedel, F., Kilic, G., Veerla, S., Naudin, C., Smeds, E., Westman, J., Martinez-Martinez, I., Egesten, A., de la Morena-Barrio, M. E., Corral, J., Linder, A., Artoni, A., Abbattista, M., Novembrino, C., Brakebusch, Cord Herbert, Martinelli, I., Kasetty, G. & Herwald, H., 2019, In: Nature Microbiology. 4, 12, p. 2442-2455 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

    Nophar, Y., Kemper, O., Brakebusch, Cord Herbert, Englemann, H., Zwang, R., Aderka, D., Holtmann, H. & Wallach, D., 1990, In: EMBO Journal. 9, 10, p. 3269-78 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Threonine 788 in integrin subunit beta1 regulates integrin activation.

    Nilsson, S., Kaniowska, D., Brakebusch, Cord Herbert, Fässler, R. & Johansson, S., 2006, In: Experimental Cell Research. 312, 6, p. 844-53 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

    Nieswandt, B., Brakebusch, Cord Herbert, Bergmeier, W., Schulte, V., Bouvard, D., Mokhtari-Nejad, R., Lindhout, T., Heemskerk, J. W., Zirngibl, H. & Fässler, R., 2001, In: EMBO Journal. 20, 9, p. 2120-30 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Adgrf5 contributes to patterning of the endothelial deep layer in retina

    Niaudet, C., Petkova, M., Jung, B., Lu, S., Laviña, B., Offermanns, S., Brakebusch, Cord Herbert & Betsholtz, C., 2019, In: Angiogenesis. 22, 4, p. 491-505 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Two Transient Receptor Potential Channels at Focal Adhesions

    Mitsou, I., Carlson, C. R., Multhaupt, Hinke Arnolda B V H, Brakebusch, Cord Herbert & Couchman, John Robert, 2023, In: Journal of Histochemistry and Cytochemistry. 71, 9, p. 495-508 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

    Meehan, T. F., Chen, C. K., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Bottomley, J., Ramirez-Solis, R., Smedley, D., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., De Angelis, M. H., Ball, S., Blake, A., Fray, M., Kenyon, J. & 23 others, Mallon, A. M., Brown, S., Massimi, M., Matteoni, R., Tocchini-Valentini, G., Herault, Y., Kollias, G., Ulfhake, B., Demengeot, J., Fremond, C., Bosch, F., Montoliu, L., Soininen, R., Schughart, K., Brakebusch, Cord Herbert, Sedlacek, R., Rülicke, T., McKerlie, C., Malissen, B., Iraqi, F., Jonkers, J., Russig, H. & Huylebroeck, D., 28 Jan 2015, In: Nucleic Acids Research. 43, D1, p. D1171-D1175

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Rac1-dependent recruitment of PAK2 to G 2 phase centrosomes and their roles in the regulation of mitotic entry

    May, M., Schelle, I., Brakebusch, Cord Herbert, Rottner, K. & Genth, H., 19 May 2014, In: Cell Cycle. 13, 14, p. 2211-21 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation

    Martínez-Sánchez, L. D. C., Ngo, P. A., Pradhan, R., Becker, L-S., Boehringer, D., Soteriou, D., Kubankova, M., Schweitzer, C., Koch, T., Thonn, V., Erkert, L., Stolzer, I., Günther, C., Becker, C., Weigmann, B., Klewer, M., Daniel, C., Amann, K., Tenzer, S., Atreya, R. & 8 others, Bergo, M., Brakebusch, Cord Herbert, Watson, A. J. M., Guck, J., Fabry, B., Atreya, I., Neurath, M. F. & López-Posadas, R., 2023, In: Gut. 72, 2, p. 275-294 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

    Martin Gonzalez, Javier, Morgani, S. M., Bone, Robert Alexander, Bonderup, K., Abelechian, Sahar, Brakebusch, Cord Herbert & Brickman, Joshua Mark, 9 Aug 2016, In: Stem Cell Reports. 7, 2, p. 177-91 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.

    Marsal, J., Brakebusch, Cord Herbert, Bungartz, G., Fässler, R. & Agace, W. W., 2005, In: European Journal of Immunology. 35, 6, p. 1805-11 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis

    Manresa-Arraut, A., Johansen, F. F., Brakebusch, Cord Herbert, Issazadeh-Navikas, Shohreh & Hasseldam, Henrik, 2018, In: Frontiers in Immunology. 9, p. 1-14 14 p., 1235.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

    López-Posadas, R., Becker, C., Günther, C., Tenzer, S., Amann, K., Billmeier, U., Atreya, R., Fiorino, G., Vetrano, S., Danese, S., Ekici, A. B., Wirtz, S., Thonn, V., Watson, A. J. M., Brakebusch, Cord Herbert, Bergö, M., Neurath, M. F. & Atreya, I., Feb 2016, In: The Journal of Clinical Investigation. 126, 2, p. 611-26 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice

    López-Posadas, R., Fastancz, P., Martínez-Sánchez, L. D. C., Panteleev-Ivlev, J., Thonn, V., Kisseleva, T., Becker, L. S., Schulz-Kuhnt, A., Zundler, S., Wirtz, S., Atreya, R., Carlé, B., Friedrich, O., Schürmann, S., Waldner, M. J., Neufert, C., Brakebusch, Cord Herbert, Bergö, M. O., Neurath, M. F. & Atreya, I., Nov 2019, In: Gastroenterology. 157, 5, p. 1293-1309 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo

    Luckashenak, N., Wähe, A., Breit, K., Brakebusch, Cord Herbert & Brocker, T., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 27-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion

    Liu, L., Li, J., Zhang, L., Zhang, F., Zhang, R., Chen, X., Brakebusch, Cord Herbert, Wang, Z. & Liu, X., 27 Oct 2015, In: BioFactors (Oxford, England). 41, 5, p. 352-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA

    Li, S., Dislich, B., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 1 Nov 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 9, p. 4244-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Negative regulation of p53-induced senescence by N-WASP is crucial for DMBA/TPA-induced skin tumor formation

    Li, H., Petersen, S., Garcia Mariscal, A. & Brakebusch, Cord Herbert, 1 May 2019, In: Cancer Research. 79, 9, p. 2167-2181 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Rho GTPases and cancer

    Li, H., Peyrollier, K., Kilic, G. & Brakebusch, Cord Herbert, Mar 2014, In: BioFactors (Oxford, England). 40, 2, p. 226-35 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  86. Published

    Senescence regulation by nuclear N-WASP: a role in cancer?

    Li, H. & Brakebusch, Cord Herbert, Jul 2019, In: Oncoscience. 6, 7-8, p. 354-356 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Analyzing skin tumor development in mice by the DMBA/TPA model

    Li, H. & Brakebusch, Cord Herbert, 2021, Carcinogen-driven mouse models of oncogenesis. Galluzzi, L. & Buqué, A. (eds.). Elsevier, Vol. 163. p. 113-121 9 p. (Methods in Cell Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  88. Published

    Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

    Li, H., Yao, Q., Mariscal, A. G., Wu, X., Hülse, J., Pedersen, E., Helin, K., Waisman, A., Vinkel, C., Thomsen, Simon Francis, Avgustinova, A., Benitah, S. A., Lovato, P., Norsgaard, H., Mortensen, M. S., Veng, L., Rozell, B. & Brakebusch, Cord Herbert, 2018, In: Nature Communications. 9, 1, p. 1-18 18 p., 1420.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain

    Leone, D. P., Srinivasan, K., Brakebusch, Cord Herbert & McConnell, S. K., 2010, In: Developmental Neurobiology. 70, 9, p. 659-78 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Regulation of neural progenitor proliferation and survival by beta1 integrins.

    Leone, D. P., Relvas, J. B., Campos, L. S., Hemmi, S., Brakebusch, Cord Herbert, Fässler, R., Ffrench-Constant, C. & Suter, U., 2005, In: Journal of Cell Science. 118, Pt 12, p. 2589-99 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways

    Lefever, T., Pedersen, E., Basse, A., Paus, R., Quondamatteo, F., Stanley, A. C., Langbein, L., Wu, X., Wehland, J., Lommel, S. & Brakebusch, Cord Herbert, 2010, In: Journal of Cell Science. 123, Pt 1, p. 128-40 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Cdc42 promotes host defenses against fatal infection

    Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Baldwin, H. S., Brakebusch, Cord Herbert, Skaar, E. P., Boothby, M. & Zent, R., 20 May 2013, In: Infection and Immunity. 81, 8, p. 2714-2723 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

    Laviña, B., Castro, M., Niaudet, C., Cruys, B., Álvarez-Aznar, A., Carmeliet, P., Bentley, K., Brakebusch, Cord Herbert, Betsholtz, C. & Gaengel, K., 2 Jul 2018, In: Development (Cambridge, England). 145, 13, 20 p., dev161182.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration

    Lammermann, T., Renkawitz, J., Wu, X., Hirsch, K., Brakebusch, Cord Herbert & Sixt, M., 2009, In: Blood.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Cancer-associated fibroblasts: how do they contribute to metastasis?

    Kwa, M. Q., Herum, K. M. & Brakebusch, Cord Herbert, 2019, In: Clinical and Experimental Metastasis. 36, 2, p. 71-86

    Research output: Contribution to journal › Review › Research › peer-review

  96. Published

    MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model

    Kwa, M. Q., Brandao, R., Phung, T. H., Ge, J., Scieri, G. & Brakebusch, Cord Herbert, 2021, In: Cells. 10, 4, 942.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.

    Kuijpers, M. J. E., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, Cord Herbert, Offermanns, S., Fässler, R., Heemskerk, J. W. M. & Nieswandt, B., 2003, In: The FASEB Journal. 17, 6, p. 685-7 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Mouse macrophages completely lacking Rho (RhoA, RhoB and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and increased motility

    Koenigs, V., Jennings, R., Vogl, T., Horsthemke, M., Bachg, A. C., Xu, Y., Grobe, K., Brakebusch, Cord Herbert, Schwab, A., Baehler, M., Knaus, U. G. & Hanley, P. J., 31 Oct 2014, In: The Journal of Biological Chemistry. 289, 44, p. 30772-30784 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    RhoB promotesSalmonellasurvival by regulating autophagy

    Kirchenwitz, M., Halfen, J., Peinen, K. V., Prettin, S., Kollasser, J., Brakebusch, Cord Herbert, Rottner, K., Steffen, A. & Stradal, T. E. B., 2023, bioRxiv, 52 p.

    Research output: Working paper › Preprint › Research

  100. Published

    RhoB promotes Salmonella survival by regulating autophagy

    Kirchenwitz, M., Halfen, J., von Peinen, K., Prettin, S., Kollasser, J., zur Lage, S., Blankenfeldt, W., Brakebusch, Cord Herbert, Rottner, K., Steffen, A. & Stradal, T. E. B., 2023, In: European Journal of Cell Biology. 102, 4, 17 p., 151358.

    Research output: Contribution to journal › Journal article › Research › peer-review

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