Analyzing skin tumor development in mice by the DMBA/TPA model
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Mice are the most important animals to model tumor formation and malignant progression in humans. Chemical induction of skin tumors in mice by treatment with DMBA and TPA is a well-studied tumor induction model that is easy to use and directly applicable to genetically modified mice without any mandatory crossing with mice carrying mutations in oncogenes and tumorsuppressors. This article describes the basic protocol for DMBA/TPA induced skin tumor formation and discusses the advantages and limitations of this model, in particular the translatability of results obtained in this system to human cancer patients.
Original language | English |
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Title of host publication | Carcinogen-driven mouse models of oncogenesis |
Editors | Lorenzo Galluzzi, Aitziber Buqué |
Number of pages | 9 |
Volume | 163 |
Publisher | Elsevier |
Publication date | 2021 |
Pages | 113-121 |
Chapter | 7 |
DOIs | |
Publication status | Published - 2021 |
Series | Methods in Cell Biology |
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ISSN | 0091-679X |
Bibliographical note
Copyright © 2021 Elsevier Inc. All rights reserved.
ID: 274873491