Birthe Brandt Kragelund

Birthe Brandt Kragelund

Professor

ORCID: 0000-0002-7454-1761

Publication year:
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1 - 100 out of 179Page size: 100
  1. 2024
  2. Published

    Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs

    Olsen, Johan Gotthardt, Prestel, Andreas, Kassem, N., Broendum, S. S., Hossain, Mohammad Shamim, Simonsen, Signe, Grysbæk, M., Mortensen, J., Rytkjær, L. L., Haxholm, G. W., Marabini, R., Holmberg, Christian, Carr, A. M., Crehuet, R., Nielsen, Olaf & Kragelund, Birthe Brandt, 2024, In: Nucleic acids symposium series. 52, 4, p. 2030–2044 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

    Bjarnason, S., McIvor, J. A. P., Prestel, Andreas, Demény, K. S., Bullerjahn, J. T., Kragelund, Birthe Brandt, Mercadante, D. & Heidarsson, P. O., 2024, In: Nature Communications. 15, 1, 16 p., 1445.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

    Theisen, Frederik Friis, Prestel, Andreas, Elkjær, Steffie Martina H, Leurs, Y. H. A., Morffy, N., Strader, L. C., O'Shea, Charlotte, Teilum, Kaare, Kragelund, Birthe Brandt & Skriver, Karen, 2024, In: Nature Communications. 15, 1, 13 p., 592.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction

    Weidner, P., Saar, D., Söhn, M., Schroeder, T., Yu, Y., Zöllner, F. G., Ponelies, N., Zhou, X., Zwicky, A., Rohrbacher, F. N., Pattabiraman, V. R., Tanriver, M., Bauer, A., Ahmed, H., Ametamey, S. M., Riffel, P., Seger, R., Bode, J. W., Wade, R. C., Ebert, M. P. A. & 2 others, Kragelund, Birthe Brandt & Burgermeister, E., 2024, In: Cancer Letters. 588, 19 p., 216783.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    PPARγ antagonists induce aromatase transcription in adipose tissue cultures

    Ardenkjær-Skinnerup, J., Saar, Daniel, Petersen, Patricia Stephanie S, Pedersen, M., Svingen, T., Kragelund, Birthe Brandt, Hadrup, N., Ravn-Haren, G., Emanuelli, Brice, Brown, K. A. & Vogel, U., 2024, In: Biochemical Pharmacology. 222, 13 p., 116095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The molecular basis for cellular function of intrinsically disordered protein regions

    Holehouse, A. S. & Kragelund, Birthe Brandt, 2024, In: Nature Reviews Molecular Cell Biology. 25, p. 187–211 25 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. 2023
  9. Published

    Modeling of flexible membrane-bound biomolecular complexes for solution small-angle scattering

    Barclay, A., Kragelund, Birthe Brandt, Arleth, Lise & Pedersen, Martin Cramer, Apr 2023, In: Journal of Colloid and Interface Science. 635, p. 611-621 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

    Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Comment on “Intrinsic protein disorder uncouples affinity from binding specificity”

    Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 4, 2 p., e4602.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  12. Published

    Conformational entropy in molecular recognition of intrinsically disordered proteins

    Skriver, Karen, Theisen, Frederik Friis & Kragelund, Birthe Brandt, 2023, In: Current Opinion in Structural Biology. 83, 8 p., 102697.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

    Elkjær, Steffie Martina H, Due, Amanda Duncan, Christensen, L. F., Theisen, Frederik Friis, Staby, L., Kragelund, Birthe Brandt & Skriver, Karen, 2023, In: Communications Biology . 6, 11 p., 63.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

    Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, Saar, Daniel, Blæsild, H., Stahlhut, M., Andersen, K. V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L. & Kragelund, Birthe Brandt, 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Molecular insights into alginate beta-lactoglobulin A multivalencies: The foundation for their amorphous aggregates and coacervation

    Madsen, M., Prestel, Andreas, Madland, E., Westh, P., Tondervik, A., Sletta, H., Peters, G. H. J., Aachmann, F. L. L., Kragelund, Birthe Brandt & Svensson, B., 2023, In: Protein Science. 32, 2, 15 p., 4556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Monomeric α-synuclein activates the plasma membrane calcium pump

    Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro

    Jacobsen, Nina Louise, Bloch, Magnus Borup, Millard, P. S., Ruidiaz, Sarah Frederiksen, Elsborg, Jonas Damgaard, Boomsma, Wouter, Hendus-Altenburger, R., Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 9, 16 p., e4733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand

    Vedel, I. M., Prestel, Andreas, Zhang, Z., Skawinska, N. T., Stark, H., Harris, Pernille, Kragelund, Birthe Brandt & Peters, G. H. J., 2023, In: Structure (London, England : 1993). 31, 6, p. 689-699e6 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Targeted imaging of uPAR expression in vivo with cyclic AE105 variants

    Leth, Julie Maja, Newcombe, Estella Anne, Grønnemose, A. L., Jørgensen, Jesper Tranekjær, Qvist, K., Clausen, Anne Skovsbo, Knudsen, Line Bruhn Schneider, Kjær, Andreas, Kragelund, Birthe Brandt, Jørgensen, Thomas Jørgen Dyreborg & Ploug, Michael, 2023, In: Scientific Reports. 13, 17 p., 17248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

    Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

    Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2022
  24. Published

    A context-dependent and disordered ubiquitin-binding motif

    Dreier, Jesper Elmsted, Prestel, Andreas, Martins, J. M., Brøndum, S. S., Nielsen, Olaf, Garbers, Anna Engstrøm, Suga, H., Boomsma, Wouter, Rogers, Joseph Matthew, Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2022, In: Cellular and molecular life sciences : CMLS. 79, 9, 21 p., 484.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    A glutamine-based single α-helix scaffold to target globular proteins

    Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Mateos, B., Garcia-Cabau, C., Sanchez-Navarro, M., Topal, B., Biesaga, M., Staby, L., Kragelund, Birthe Brandt, Garcia, J., Millet, O., Orozco, M., Coles, M., Crehuet, R. & Salvatella, X., 2022, In: Nature Communications. 13, 18 p., 7073.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties

    Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    How phosphorylation impacts intrinsically disordered proteins and their function

    Newcombe, Estella Anne, Delaforge, Elise, Hartmann-Petersen, Rasmus, Skriver, Karen & Kragelund, Birthe Brandt, 2022, In: Essays in Biochemistry. 66, 7, p. 901-913 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

    Madsen, M. S., Broekema, M. F., Madsen, M. R., Koppen, A., Borgman, A., Grawe, C., Thomsen, E. G. K., Westland, D., Kranendonk, M. E. G., Koerkamp, M. G., Hamers, N., Bonvin, A. M. J. J., Pittol, J. M. R., Natarajan, K. N., Kersten, S., Holstege, F. C. P., Monajemi, H., van Mil, S. W. C., Vermeulen, M., Kragelund, B. B. & 3 others, Cassiman, D., Mandrup, S. & Kalkhoven, E., 2022, In: Nature Communications. 13, 19 p., 7090.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges

    Martinsen, J. H., Saar, Daniel, Fernandes, Catarina, Schuler, B., Bugge, K. & Kragelund, Birthe Brandt, 2022, In: Protein Science. 31, 4, p. 918-932 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The denatured state of HIV-1 protease under native conditions

    Rösner, Heike Ilona, Caldarini, M., Potel, G., Malmodin, D., Vanoni, M. A., Aliverti, A., Broglia, R. A., Kragelund, Birthe Brandt & Tiana, G., 2022, In: Proteins: Structure, Function, and Bioinformatics. 90, 1, p. 96-109

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    αα-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes

    Theisen, Frederik Friis, Salladini, Edoardo, Davidsen, R., Rasmussen, C. J., Staby, L., Kragelund, Birthe Brandt & Skriver, Karen, 2022, In: Journal of Biological Chemistry. 298, 6, 16 p., 101963.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2021
  33. Published

    Binding Sites for Oligosaccharide Repeats from Lactic Acid Bacteria Exopolysaccharides on Bovine β-Lactoglobulin Identified by NMR Spectroscopy

    Birch, J., Khan, S., Madsen, M., Kjeldsen, C., Møller, M. S., Stender, E. G. P., Peters, G. H. J., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2021, In: ACS Omega. 6, 13, p. 9039-9052 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Connecting the αα-hubs: same fold, disordered ligands, new functions

    Staby, L., Bugge, K., Falbe-Hansen, R. G., Salladini, Edoardo, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Cell Communication and Signaling. 19, 5 p., 2.

    Research output: Contribution to journal › Letter › Research › peer-review

  35. Published

    Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

    Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

    Sjøgaard-Frich, Lise Margrethe, Prestel, Andreas, Pedersen, E. S., Severin, M., Kristensen, Kristian Kølby, Olsen, Johan Gotthardt, Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2021, In: eLife. 10, 29 p., e60889.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Evolution of A bHLH Interaction Motif

    Millard, P. S., Kragelund, Birthe Brandt & Burow, Meike, 2021, In: International Journal of Molecular Sciences. 22, 1, 18 p., 447.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution: Flanking disorder tunes the RCD1-RST ensemble

    Staby, L., Due, Amanda Duncan, Kunze, M. B. A., Jørgensen, M. L. M., Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 24, 15 p., 167320.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

    Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins

    Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    On the specificity of protein-protein interactions in the context of disorder

    Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2021, In: Biochemical Journal. 478, 11, p. 2035-2050 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  42. Published

    Order and disorder - An integrative structure of the full-length human growth hormone receptor

    Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Yong, Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Quantification of Conformational Entropy Unravels Effect of Disordered Flanking Region in Coupled Folding and Binding

    Theisen, Frederik Friis, Staby, L., Tidemand, Frederik Grønbæk, O'Shea, Charlotte, Prestel, Andreas, Willemoës, Martin, Kragelund, Birthe Brandt & Skriver, Karen, 2021, In: Journal of the American Chemical Society. 143, 36, p. 14540-14550 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

    Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function

    Ruidiaz, Sarah Frederiksen, Dreier, Jesper Elmsted, Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2021, In: Protein Science. 30, 10, p. 2069-2082 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

    Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    αα-Hub domains and intrinsically disordered proteins: a decisive combo

    Bugge, K., Staby, L., Salladini, Edoardo, Falbe-Hansen, R. G., Kragelund, Birthe Brandt & Skriver, Karen, 2021, In: Journal of Biological Chemistry. 296, 18 p., 100226.

    Research output: Contribution to journal › Review › Research › peer-review

  48. 2020
  49. Published

    The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity

    Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, Andreas, Cardenas, M., Pedraz-Cuesta, E., Arleth, Lise, Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Orchestration of signaling by structural disorder in class 1 cytokine receptors

    Seiffert, P., Bugge, K., Nygaard, M., Haxholm, G. W., Martinsen, J. H., Pedersen, M. N., Arleth, Lise, Boomsma, Wouter & Kragelund, Birthe Brandt, 24 Aug 2020, In: Cell Communication and Signaling. 18, 1, 30 p., 132.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Exploring the Protein-Membrane Interactions on the Intracellular Side of PRLR

    Araya-Secchi, R., Bugge, K., Kragelund, Birthe Brandt & Arleth, Lise, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl.1, p. 57A-57A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  52. Published

    Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

    Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Context Matters in Disorder Based Protein Communication

    Kragelund, Birthe Brandt, Prestel, Andreas, Wickmann, N., Martins, J., Boomsma, Wouter, Staby, L., Hendus-Altenburger, R. & Skriver, Karen, 2020, In: Biophysical Journal. 118, 3, suppl. 1, p. 491A 2407-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  54. Published

    Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding Protein

    Sonar, P., Bellucci, L., Mossa, A., Heidarsson, P. O., Kragelund, Birthe Brandt & Cecconi, C., 2020, In: Biophysical Journal. 119, 9, p. 1821-1832 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer

    Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions—Insights from transcription factors

    Millard, P. S., Bugge, K., Marabini, R., Boomsma, Wouter, Burow, Meike & Kragelund, Birthe Brandt, 2020, In: Protein Science. 29, 1, p. 169-183 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Interactions by Disorder - A Matter of Context

    Bugge, K., Brakti, Inna, Fernandes, Catarina, Dreier, J. E., Lundsgaard, J. E., Olsen, Johan Gotthardt, Skriver, Karen & Kragelund, Birthe Brandt, 2020, In: Frontiers in Molecular Biosciences. 7, 16 p., 110.

    Research output: Contribution to journal › Review › Research › peer-review

  58. Published

    Intrinsically Disordered Proteins: Methods and Protocols

    Skriver, Karen (ed.) & Kragelund, Birthe Brandt (ed.), 2020, New York: Humana Press. 777 p. (Methods in Molecular Biology, Vol. 2141).

    Research output: Book/Report › Book › Research › peer-review

  59. Published

    Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water

    Kampmeyer, Caroline, Johansen, Jens Vilstrup, Holmberg, Christian, Karlson, M., Andersen, Sarah Gersing, Nunes Bordallo, Heloisa, Kragelund, Birthe Brandt, Lerche, M. H., Jourdain, I., Winther, Jakob R. & Hartmann-Petersen, Rasmus, 2020, In: A C S Synthetic Biology. 9, 4, p. 733-748 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

    Nedal, A., Ræder, S. B., Dalhus, B., Helgesen, E., Forstrøm, R. J., Lindland, K., Sumabe, B. K., Martinsen, J. H., Kragelund, Birthe Brandt, Skarstad, K., Bjørås, M. & Otterlei, M., 2020, In: Nucleic Acids Research. 48, 10, p. 5540-5554 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

    Sottini, A., Borgia, A., Borgia, M. B., Bugge, K., Nettels, D., Chowdhury, A., Heidarsson, P. O., Zosel, F., Best, R. B., Kragelund, Birthe Brandt & Schuler, B., 2020, In: Nature Communications. 11, 14 p., 5736.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

    Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, Bente, Bugge, K., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: Biomolecules. 10, 8, 23 p., 1192.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies

    Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. 2019
  65. Published

    Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

    Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Alginate Trisaccharide Binding Sites on the Surface of β-Lactoglobulin Identified by NMR Spectroscopy: Implications for Molecular Network Formation

    Stender, E. G. P., Birch, J., Kjeldsen, C., Nielsen, L. D., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2019, In: ACS Omega. 4, 4, p. 6165-6174 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions

    Cragnell, C., Staby, L., Lenton, S., Kragelund, Birthe Brandt & Skepö, M., 2019, In: Biomolecules. 9, 5, 20 p., 168.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome

    Christensen, L. F., Staby, L., Bugge, K., O'Shea, Charlotte, Kragelund, Birthe Brandt & Skriver, Karen, 2019, In: Scientific Reports. 9, 15 p., 18927.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

    Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

    Millard, P. S., Kragelund, Birthe Brandt & Burow, Meike, 2019, In: Trends in Plant Science. 24, 10, p. 934-946

    Research output: Contribution to journal › Review › Research › peer-review

  71. Published

    Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

    Hendus-Altenburger, R., Fernandes, Catarina, Bugge, K., Kunze, M. B. A., Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Journal of Biomolecular NMR. 73, 12, p. 713–725 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Specificity of MYB interactions relies on motifs in ordered and disordered contexts

    Millard, P. S., Weber, K., Kragelund, Birthe Brandt & Burow, Meike, 2019, In: Nucleic Acids Research. 47, 18, p. 9592-9608 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Temperature Dependence of Intrinsically Disordered Proteins in Simulations: What are We Missing?

    Jephthah, S., Staby, L., Kragelund, Birthe Brandt & Skepö, M., 2019, In: Journal of Chemical Theory and Computation. 15, 4, p. 2672-2683

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    The PCNA interaction motifs revisited: thinking outside the PIP-box

    Prestel, Andreas, Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, Olaf, Willemoës, Martin, Ploug, Michael, Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

    Sjøgaard, Ida Marie Zobbe, Bressendorff, Simon, Prestel, Andreas, Kausika, S., Oksbjerg, Emilie Duus, Kragelund, Birthe Brandt & Brodersen, Peter, 2019, In: Biochemical Journal. 476, 3, p. 449-465 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit

    He, L., Cohen, E. B., Edwards, A. P. B., Xavier-Ferrucio, J., Bugge, K., Federman, R. S., Absher, D., Myers, R. M., Kragelund, Birthe Brandt, Krause, D. S. & DiMaio, D., 2019, In: iScience. 17, p. 167-181 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. 2018
  78. Published

    Expanded Interactome of the Intrinsically Disordered Protein Dss1

    Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, Birthe Brandt & Hartmann-Petersen, Rasmus, 23 Oct 2018, In: Cell Reports. 25, 4, p. 862-870

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Extreme disorder in an ultrahigh-affinity protein complex

    Borgia, A., Borgia, M. B., Bugge, K. Ø., Kissling, V. M., Heidarsson, P. O., Fernandes, Catarina, Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., Kragelund, Birthe Brandt, Best, R. B. & Schuler, B., 1 Mar 2018, In: Nature. 555, p. 61-66 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

    Kristensen, Kristian Kølby, Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, Nicholas, Beigneux, A. P., Kragelund, Birthe Brandt, Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, Michael, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

    Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, Birthe Brandt, Brooks, A. J. & Waters, M. J., 2018, In: Oncogene. 37, p. 489-501 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Characterization of Dynamic IDP Complexes by NMR Spectroscopy

    Prestel, Andreas, Bugge, K., Staby, L., Hendus-Altenburger, R. & Kragelund, Birthe Brandt, 2018, Intrinsically Disordered Proteins. Rhoades, E. (ed.). Academic Press, p. 193-226 34 p. (Methods in Enzymology, Vol. 611).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  83. Published

    Role of protein dynamics in transmembrane receptor signalling

    Wang, Yong, Bugge, K. Ø., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 48, p. 74-82 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  84. Published

    Structure of radical-induced cell death1 hub domain reveals a common αα-scaffold for disorder in transcriptional networks

    Bugge, K. Ø., Staby, L., Kemplen, K. R., O'Shea, Charlotte, Bendsen, S. K., Jensen, M. K., Olsen, Johan Gotthardt, Skriver, Karen & Kragelund, Birthe Brandt, 2018, In: Structure. 26, 5, p. 734-746 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective

    Choudhary, D., Kragelund, Birthe Brandt, Heidarsson, P. O. & Cecconi, C., 2018, In: Frontiers in Molecular Neuroscience. 11, p. 1-8 468.

    Research output: Contribution to journal › Review › Research › peer-review

  86. 2017
  87. Published

    SLiMming the fuzz in gene-regulating interactomes

    Staby, L., O'Shea, Charlotte, Kragelund, Birthe Brandt & Skriver, Karen, 7 Nov 2017, 1 p.

    Research output: Other contribution › Net publication - Internet publication › Research

  88. Published

    Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions

    He, L., Steinocher, H., Shelar, A., Cohen, E. B., Heim, E. N., Kragelund, Birthe Brandt, Grigoryan, G. & DiMaio, D., 4 Sep 2017, In: eLife. 6, 28 p., e27701.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)

    Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

    Olsen, Johan Gotthardt, Teilum, Kaare & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  91. Published

    Functions of intrinsic disorder in transmembrane proteins

    Kjærgaard, M. & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.

    Research output: Contribution to journal › Review › Research › peer-review

  92. Published

    An efficient method for estimating the hydrodynamic radius of disordered protein conformations

    Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Eukaryotic transcription factors: paradigms of protein intrinsic disorder

    Staby, L., O'Shea, Charlotte, Willemoës, Martin, Theisen, F., Kragelund, Birthe Brandt & Skriver, Karen, 12 Jul 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  94. Published

    Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication

    Fleck, O., Fahnøe, Ulrik, Løvschal, K. V., Gasasira, M. U., Marinova, I. N., Kragelund, Birthe Brandt, Carr, A. M., Hartsuiker, E., Holmberg, Christian & Nielsen, Olaf, 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    (S)Pinning down protein interactions by NMR

    Teilum, Kaare, Kunze, M. B. A., qrc243, qrc243 & Kragelund, Birthe Brandt, Mar 2017, In: Protein Science. 26, 3, p. 436-451 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  96. Published

    Cold denaturation of the HIV-1 protease monomer

    Rösner, Heike Ilona, Caldarini, M., Prestel, Andreas, Vanoni, M. A., Broglia, R. A., Aliverti, A., Tiana, G. & Kragelund, Birthe Brandt, 7 Feb 2017, In: Biochemistry. 56, 8, p. 1029-1032 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

    O'Shea, Charlotte, Staby, L., Bendsen, S. K., Tidemand, Frederik Grønbæk, Redsted, A., Willemoës, Martin, Kragelund, Birthe Brandt & Skriver, Karen, 13 Jan 2017, In: Journal of Biological Chemistry. 292, 2, p. 512-527 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Choreography by Structural Disorder in Membrane Proteins

    Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, suppl. 1, p. 12A 1 p., 65-Subg.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  99. Published

    Class I Cytokine Receptors: Towards the Inside

    Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  100. 2016
  101. Published

    Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing?

    Bugge, K. Ø., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Dec 2016, In: The FEBS Journal. 283, 24, p. 4424-4451 28 p.

    Research output: Contribution to journal › Review › Research › peer-review

  102. Published

    A combined computational and structural model of the full-length human prolactin receptor

    Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

    Wilkens, C., Andersen, S., Petersen, B. O., Li, A., Busse-Wicher, M., Birch, J., Cockburn, D., Nakai, H., Christensen, H. E. M., Kragelund, Birthe Brandt, Dupree, P., McCleary, B., Hindsgaul, O., Abou Hachem, M. & Svensson, B., 2016, In: Applied Microbiology and Biotechnology. 100, 14, p. 6265-6277 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    DSS1/Sem1, a multifunctional and intrinsically disordered protein

    Kragelund, Birthe Brandt, Schenstrøm, S. M., Rebula, C. A., Panse, V. G. & Hartmann-Petersen, Rasmus, 2016, In: Trends in Biochemical Sciences. 41, 5, p. 446-459 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    Prolactin signaling stimulates invasion via Na+/H+ exchanger NHE1 in T47D human breast cancer cells

    Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. Published

    The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove

    Kragelund, Birthe Brandt, Weterings, E., Hartmann-Petersen, Rasmus & Keijzers, G., 2016, In: Frontiers in Bioscience. 21, 3, p. 514-527 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  107. Published

    The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

    Hendus-Altenburger, R., Pedraz Cuesta, E., Olesen, C. W., Papaleo, E., Schnell, J. A., Hopper, J. T. S., Robinson, C. V., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2016, In: BMC Biology. 14, 17 p., 31.

    Research output: Contribution to journal › Journal article › Research › peer-review

  108. 2015
  109. Published

    A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template

    Malik, L., Nygård, Jesper, Christensen, Niels Johan, Madsen, C. S., Rösner, Heike Ilona, Kragelund, Birthe Brandt, Høiberg-Nielsen, R., Streicher, W., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2015, In: ChemBioChem. 16, 13, p. 1905-1918 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  110. Published

    A residue quartet in the extracellular domain of the prolactin receptor selectively controls mitogen-activated protein kinase signaling

    Zhang, C., Nygaard, M., Haxholm, G. W., Boutillon, F., Bernadet, M., Hoos, S., England, P., Broutin, I., Kragelund, Birthe Brandt & Goffin, V., 2015, In: Journal of Biological Chemistry. 290, 19, p. 11890-11904 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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