Arne Schousboe

Arne Schousboe

Professor, emeritus

ORCID: 0000-0001-9600-402X

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  1. Published

    Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells

    Abraham, J. H., Hansen, Gert Helge, Seiler, N. & Schousboe, Arne, 1993, In: Neurochemical Research. 18, 2, p. 153-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Prenatal stress effect on glutamate metabolism, evaluated with mass espectroscopy-liquid cromatography

    Adrover, E., Katunar, M. R., Waagepetersen, Helle S., Schousboe, Arne & Antonelli, M. C., 2009, In: Journal of Neurochemistry. Suppl. 2, p. 172-172

    Research output: Contribution to journal › Conference abstract in journal › Research

  3. Published

    Glutamate neurotransmission is affected in prenatally stressed offspring

    Adrover, E., Pallarés, M. E., Baier, C. J., Monteleone, M. C., Giuliani, F. A., Waagepetersen, Helle S., Brocco, M. A., Cabrera, R., Sonnewald, U., Schousboe, Arne & Antonelli, M. C., Sep 2015, In: Neurochemistry International. 88, p. 73-87 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Glutamine in the central nervous system: function and dysfunction

    Albrecht, J., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2007, In: Frontiers in Bioscience. 12, p. 332-343

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells

    Aldana, Blanca, Waagepetersen, Helle S., Schousboe, Arne, White, H. S., Bulaj, G. & Walls, Anne Byriel, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2286-2296 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

    Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

    Andersen, Jens Velde, Christensen, S. K., Westi, Emil Winther, Diaz-delcastillo, M., Tanila, H., Schousboe, Arne, Aldana, Blanca & Waagepetersen, Helle S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes

    Andersen, Jens Velde & Schousboe, Arne, 2023, In: Journal of Neurochemistry. 166, 2, p. 109-137

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

    Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle

    Andersen, Jens Velde, Schousboe, Arne & Verkhratsky, A., 2022, In: Progress in Neurobiology. 217, 24 p., 102331.

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling

    Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Accepted/In press

    Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex

    Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

    Andersen, Jens Velde, McNair, Laura M., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Glial Glutamine Homeostasis in Health and Disease

    Andersen, J. V. & Schousboe, Arne, 2023, In: Neurochemical Research. 48, p. 1100–1128

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of .....

    Bacon, C. L., Berezin, V., Bode, G., Bock, E., Bojic, U., Doherty, P., Edvardsen, K., Ehlers, K., Ellerbeck, U., Julien, P., Kawa, A., Maar, T., Nau, H., Pirovano, R., Regan, C., Schousboe, Arne, Spezia, F., Walsh, F. S. & Williams, E. J., 1998, In: Toxicology in Vitro. 12, p. 101-109

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?

    Bak, Lasse Kristoffer, Mueller, M. S., Fox, R., Pedersen, Sofie E., Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Jakobsen, E., Schousboe, Arne & Waagepetersen, Helle S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  18. Published

    Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Astrocytic glycogen metabolism in the healthy and diseased brain

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

    Bak, Lasse Kristoffer, Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Oct 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 10, p. 1285-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures

    Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

    Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, Jan 2004, In: Neurochemical Research. 29, 1, p. 257-65 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

    Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

    Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  30. Published

    Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

    Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Glutamate and glutamine in brain disorders

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  32. Published

    Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  34. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Comparison of the agonist binding site of homomeric, heteromeric, and chimeric GluR1(o) and GluR3(o) AMPA receptors

    Banke, T. G., Schousboe, Arne, Pickering, D. S. & Pickering, D., 1997, In: Journal of Neuroscience Research. 49, 2, p. 176-85 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Identification of amino acid residues in GluR1 responsible for ligand binding and desensitization

    Banke, T. G., Greenwood, J. R., Christensen, J. K., Liljefors, T., Traynelis, S. F., Schousboe, Arne, Pickering, D. S. & Pickering, D., 2001, In: Journal of Neuroscience. 21, 9, p. 3052-62 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The 13th International Conference on Brain Energy Metabolism: "How Metabolism Dictates Neurotransmission, Function and Behavior"

    Barros, L. F., Schousboe, Arne & McKenna, M. C., 2019, In: Journal of Neuroscience Research. 97, 8, p. 849-853 5 p.

    Research output: Contribution to journal › Journal article › Research

  38. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

    Beich-Frandsen, M., Pickering, Darryl S, Mirza, Osman Asghar, Johansen, Tommy Nørskov, Greenwood, J., Vestergaard, Bente, Schousboe, Arne, Gajhede, Michael, Liljefors, T. & Kastrup, Jette Sandholm Jensen, 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    GABA agonist induced changes in ultrastructure and GABA receptor expression in cerebellar granule cells is linked to hyperpolarization of the neurons

    Belhage, B., Hansen, Gert Helge & Schousboe, Arne, 1990, In: International Journal of Developmental Neuroscience. 8, 4, p. 473-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA

    Belhage, B., Hansen, Gert Helge & Schousboe, Arne, 1993, In: Neuroscience. 54, 4, p. 1019-34 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development

    Belhage, B., Hansen, Gert Helge, Schousboe, Arne & Meier, E., 1988, In: International Journal of Developmental Neuroscience. 6, 2, p. 125-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    3H-D-aspartate release from cerebellar granule neurons is differentially regulated by glutamate- and K(+)-stimulation

    Belhage, B., Rehder, V., Hansen, Gert Helge, Kater, S. B. & Schousboe, Arne, 1992, In: Journal of Neuroscience Research. 33, 3, p. 436-44 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells

    Belhage, B., Hansen, Gert Helge, Meier, E. & Schousboe, Arne, 1990, In: Journal of Neurochemistry. 55, 4, p. 1107-13 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Effects of gamma-aminobutyric acid (GABA) on synaptogenesis and synaptic function

    Belhage, B., Hansen, Gert Helge, Elster, L. & Schousboe, Arne, 1998, In: Perspectives of Developmental Neurobiology. 5, 2-3, p. 235-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

    Bjerrum, E. J., Kristensen, Anders Skov, Pickering, D. S., Greenwood, J. R., Nielsen, Birgitte, Liljefors, T., Schousboe, Arne, Bräuner, Hans, Madsen, Ulf & Pickering, Darryl S, 2003, In: Journal of Medicinal Chemistry. 46, 11, p. 2246-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

    Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In: European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

    Brekke, E., Morken, T. S., Walls, Anne Byriel, Waagepetersen, Helle S., Schousboe, Arne & Sonnewald, U., 2016, The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Springer, Vol. 13. p. 43-58 16 p. (Advances in Neurobiology, Vol. 13).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  48. Published

    Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

    Brekke, E., Walls, Anne Byriel, Nørfeldt, L., Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Glia. 60, 1, p. 147-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

    Brekke, E. M., Walls, Anne Byriel, Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1788-1799 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter

    Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, Trine Meldgaard, Schousboe, Arne, Waagepetersen, Helle S. & Ransom, B. R., 2005, In: Journal of Neuroscience Research. 79, 1-2, p. 74-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Introduction to special issue in honor of Professor Povl Krogsgaard-Larsen

    Bräuner, Hans & Schousboe, Arne, Oct 2014, In: Neurochemical Research. 39, 10, p. 1845-6 2 p.

    Research output: Contribution to journal › Journal article › Research

  52. Published

    1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators

    Butini, S., Pickering, Darryl S, Morelli, E., Coccone, S. S., Trotta, F., De Angelis, M., Guarino, E., Fiorini, I., Campiani, G., Novellino, E., Schousboe, Arne, Christensen, J. K. & Gemma, S., 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6614-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties

    Campiani, G., Morelli, E., Nacci, V., Fattorusso, C., Ramunno, A., Novellino, E., Greenwood, J., Liljefors, T., Griffiths, R., Sinclair, C., Reavy, H., Kristensen, A. S., Pickering, Darryl S, Schousboe, Arne, Cagnotto, A., Fumagalli, E., Mennini, T. & Pickering, Darryl S, 2001, In: Journal of Medicinal Chemistry. 44, 26, p. 4501-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Expression of the GABA(A) receptor alpha6 subunit in cultured cerebellar granule cells is developmentally regulated by activation of GABA(A) receptors

    Carlson, B. X., Belhage, B., Hansen, Gert Helge, Elster, L., Olsen, R. W. & Schousboe, Arne, 1997, In: Journal of Neuroscience Research. 50, 6, p. 1053-62 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    A single glycine residue at the entrance to the first membrane-spanning domain of the γ-aminobutyric acid type a receptor β2 subunit affects allosteric sensitivity to GABA and anesthetics

    Carlson, B. X., Engblom, A. C., Kristiansen, Uffe, Schousboe, Arne & Olsen, R. W., 2000, In: Molecular Pharmacology. 57, 3, p. 474-484 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Preface: Special issue on neurotransmitter transporters

    Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.

    Research output: Contribution to journal › Editorial › Research › peer-review

  57. Published

    Special Issue in Honor of Dr. Elias K. Michaelis

    Choi, I. & Schousboe, Arne, 2019, In: Neurochemical Research. 44, 1, p. 1-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Effect of phenylsuccinate on potassium- and ischemia-induced release of glutamate in rat hippocampus monitored by microdialysis

    Christensen, T., Bruhn, T., Diemer, N. H. & Schousboe, Arne, 16 Dec 1991, In: Neuroscience Letters. 134, 1, p. 71-74 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Point mutation in the first transmembrane region of the β2 subunit of the γ-aminobutyric acid type A receptor alters desensitization kinetics of γ-aminobutyric acid- and anesthetic-induced channel gating

    Christine Engblom, A., Carlson, B. X., Olsen, R. W., Schousboe, Arne & Kristiansen, Uffe, 17 May 2002, In: Journal of Biological Chemistry. 277, 20, p. 17438-17447 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Design, synthesis, and characterisation of selective GABA transport inhibitors

    Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150

    Research output: Contribution to journal › Conference abstract in journal › Research

  61. Published

    Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  62. Published

    Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues

    Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  64. Published

    Agonist discrimination between AMPA receptor subtypes

    Coquelle, T., Christensen, J. K., Banke, T. G., Madsen, U., Schousboe, Arne & Pickering, Darryl S, 2000, In: NeuroReport. 11, 12, p. 2643-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Glutamine and ammonia in hepatic encephalopathy

    Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  66. Published

    Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

    Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

    Dadsetan, S., Kukolj, E., Bak, Lasse Kristoffer, Sørensen, M., Ott, P., Vilstrup, H., Schousboe, Arne, Keiding, S. & Waagepetersen, Helle S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Lipid raft localization of GABA A receptor and Na+, K+-ATPase in discrete microdomain clusters in rat cerebellar granule cells

    Dalskov, S., Immerdal, L., Niels-Christiansen, L. W., Hansen, Gert Helge, Schousboe, Arne & Danielsen, E. M., 2005, In: Neurochemistry International. 46, 6, p. 489-99 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  72. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    State-Dependent Changes in Brain Glycogen Metabolism

    DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  74. Accepted/In press

    A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies

    Dienel, G. A., Schousboe, Arne, McKenna, M. C. & Rothman, D. L., 2023, (Accepted/In press) In: Journal of Neurochemistry.

    Research output: Contribution to journal › Review › Research › peer-review

  75. Published

    Parallel expression of synaptophysin and evoked neurotransmitter release during development of cultured neurons

    Ehrhart-Bornstein, M., Treiman, M., Hansen, Gert Helge, Schousboe, Arne, Thorn, N. A. & Frandsen, A., 1991, In: International Journal of Developmental Neuroscience. 9, 5, p. 463-71 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2

    Elster, L., Kristiansen, Uffe, Pickering, Darryl S, Olsen, R. W. & Schousboe, Arne, 2001, In: Neurochemistry International. 38, 7, p. 581-92 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Differential distribution of GABAA receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist

    Elster, L., Hansen, Gert Helge, Belhage, B., Fritschy, J. M., Möhler, H. & Schousboe, Arne, 1995, In: International Journal of Developmental Neuroscience. 13, 5, p. 417-28 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells

    Elster, L., Banke, T., Kristiansen, Uffe, Schousboe, Arne & Wahl, P., May 1998, In: Neuroscience. 84, 2, p. 519-28 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues

    Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2

    Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: Molecular Pharmacology. 67, 3, p. 703-13 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

    Fries, A. W., Dadsetan, S., Keiding, S., Bak, Lasse Kristoffer, Schousboe, Arne, Waagepetersen, Helle S., Simonsen, M., Ott, P., Vilstrup, H. & Sørensen, M., Mar 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 460-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS

    Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Characterization of NCAM diversity in cultured neurons

    Gegelashvili, G., Andersson, A., Schousboe, Arne & Bock, E., 1993, In: FEBS Letters. 324, p. 337-340

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Cyclic AMP regulates NCAM expression and phosphorylation in cultures mouse astrocytes

    Gegelashvili, G., Andersson, A., Schousboe, Arne & Bock, E., 1993, In: European Journal of Cell Biology. 62, p. 343-351

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Neurotransmitter transporters: molecular function of important drug targets

    Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Light and electron microscopic localization of GABAA-receptors on cultured cerebellar granule cells and astrocytes using immunohistochemical techniques

    Hansen, Gert Helge, Hösli, E., Belhage, B., Schousboe, Arne & Hösli, L., 1991, In: Neurochemical Research. 16, 3, p. 341-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Effect of a GABA agonist on the expression and distribution of GABAA receptors in the plasma membrane of cultured cerebellar granule cells: an immunocytochemical study

    Hansen, Gert Helge, Belhage, B. & Schousboe, Arne, 1991, In: Neuroscience Letters. 124, 2, p. 162-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells

    Hansen, Gert Helge, Belhage, B., Schousboe, Arne & Meier, E., 1987, In: International Journal of Developmental Neuroscience. 5, 3, p. 263-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development

    Hansen, Gert Helge, Belhage, B., Schousboe, Arne & Meier, E., 1988, In: Journal of Neurochemistry. 51, 1, p. 243-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    First direct electron microscopic visualization of a tight spatial coupling between GABAA-receptors and voltage-sensitive calcium channels

    Hansen, Gert Helge, Belhage, B. & Schousboe, Arne, 1992, In: Neuroscience Letters. 137, 1, p. 14-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    GABA INFLUENCES THE ULTRASTRUCTURE COMPOSITION OF CEREBELLAR GRANULE CELLS DURING DEVELOPMENT IN CULTURE

    Hansen, Gert Helge, Meier, E. & Schousboe, Arne, 1984, In: International Journal of Developmental Neuroscience. 2, 3, p. 247-257 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Determination of the phospholipid precursor of anandamide and other N- acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons

    Hansen, H. H., Schousboe, Arne, Hansen, Harald S. & Hansen, S. H., 1 Jan 2000, In: Journal of Neurochemistry. 75, 2, p. 861-871 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity

    Hansen, Harald S., Moesgaard, B., Hansen, H. H., Schousboe, Arne & Petersen, G., 1 Jan 1999, In: Lipids. 34, 6 SUPPL.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Characterization of glutamate-induced formation of N- acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons

    Hansen, Harald S., Lauritzen, Lotte, Strand, A. M., Vinggaard, A. M., Frandsen, Aase & Schousboe, Arne, 1 Aug 1997, In: Journal of Neurochemistry. 69, 2, p. 753-761 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Glutamate uptake triggers transporter-mediated GABA release from astrocytes

    Héja, L., Barabás, P., Nyitrai, G., Kékesi, K. A., Lasztóczi, B., Toke, O., Tárkányi, G., Madsen, K. K., Schousboe, Arne, Dobolyi, Á., Palkovits, M. & Kardos, J., 2009, In: PLoS ONE. 4, 9, p. e7153-e7153

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Structure-Activity Relationships of Selective GABA Uptake Inhibitors

    Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

    Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

    Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

    Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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