Anders A. Jensen

Anders A. Jensen

Professor


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  1. Published

    Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain

    Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, Tri Hien Viet, Fahlke, C., Bunch, Lennart & Jensen, Anders A., 2013, In: Journal of Neuroscience. 33, 3, p. 1068-1087

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization

    Adelfinger, L., Turecek, R., Ivankova, K., Jensen, Anders A., Moss, S. J., Gassmann, M. & Bettler, B., 2014, In: Biochemical Pharmacology. 91, 3, p. 369-379 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

    Alaux, S., Kusk, M., Sagot, E., Bolte, J., Jensen, Anders A., Bräuner, Hans, Gefflaut, T. & Bunch, Lennart, 2005, In: Journal of Medicinal Chemistry. 48, 25, p. 7980-92 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

    Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Caceres, A. I., Catterall, W. A., Conner, A. C., Davies, P. & 53 others, De Clerq, K., Delling, M., Di Virgilio, F., Falzoni, S., Fenske, S., Fortuny-Gomez, A., Fountain, S., George, C., Goldstein, S. A. N., Grimm, C., Grissmer, S., Ha, K., Hammelmann, V., Hanukoglu, I., Hu, M., Ijzerman, A. P., Jabba, S. V., Jarvis, M., Jensen, Anders A., Jordt, S. E., Kaczmarek, L. K., Kellenberger, S., Kennedy, C., King, B., Kitchen, P., Liu, Q., Lynch, J. W., Meades, J., Mehlfeld, V., Nicke, A., Offermanns, S., Perez-Reyes, E., Plant, L. D., Rash, L., Ren, D., Salman, M. M., Sieghart, W., Sivilotti, L. G., Smart, T. G., Snutch, T. P., Tian, J., Trimmer, J. S., Van den Eynde, C., Vriens, J., Wei, A. D., Winn, B. T., Wulff, H., Xu, H., Yang, F., Fang, W., Yue, L., Zhang, X. & Zhu, M., 2023, In: British Journal of Pharmacology. 180 , Suppl 2, p. S145-S222

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

    CGTP Collaborators, C. C., Dec 2019, In: British Journal of Pharmacology. 176, Suppl 1, p. S142-S228

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The concise guide to pharmacology 2021/22: Ion channels

    Alexander, S. P., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Catterall, W. A., Conner, A. C. & 38 others, Davies, P., Delling, M., Virgilio, F. D., Falzoni, S., Fenske, S., George, C., Goldstein, S. A. N., Grissmer, S., Ha, K., Hammelmann, V., Hanukoglu, I., Jarvis, M., Jensen, Anders A., Kaczmarek, L. K., Kellenberger, S., Kennedy, C., King, B., Kitchen, P., Lynch, J. W., Perez-Reyes, E., Plant, L. D., Rash, L., Ren, D., Salman, M. M., Sivilotti, L. G., Smart, T. G., Snutch, T. P., Tian, J., Trimmer, J. S., Van den Eynde, C., Vriens, J., Wei, A. D., Winn, B. T., Wulff, H., Xu, H., Yue, L., Zhang, X. & Zhu, M., 2021, In: British Journal of Pharmacology. 178 , Suppl. 1, p. S157-S245

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Modulation of thalamo-cortical activity by the NMDA receptor antagonists ketamine and phencyclidine in the awake freely-moving rat

    Amat-Foraster, M., Celada, P., Richter, U., Jensen, Anders A., Plath, N., Artigas, F. & Herrik, K. F., 2019, In: Neuropharmacology. 158, 14 p., 107745.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks

    Amat-Foraster, M., Jensen, Anders A., Plath, N., Herrik, K. F., Celada, P. & Artigas, F., 2018, In: Neuropharmacology. 137, p. 13-23

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives

    Armishaw, C., Jensen, Anders A., Balle, T., Clark, R. J., Harpsøe, Kasper, Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, In: Journal of Biological Chemistry. 284, 14, p. 9498-9512

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Synthesis and biological activity of novel a-conotoxin analogues incorporating substituted proline derivatives

    Armishaw, C., Jensen, Anders A., Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, Peptides for youth: The proceedings of the 20th American peptide symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). Springer, Vol. 611. p. 179-180 (Advances in Experimental Medicine and Biology, Vol. 611).

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  11. Published

    A synthetic combinatorial strategy for developing a-conotoxin analogs as potent a7 nicotinic acetylcholine receptor antagonists

    Armishaw, C. J., Singh, N., Medina-Franco, J. L., Clark, R. J., Scott, K. C. M., Houghten, R. A. & Jensen, Anders A., 2010, In: Journal of Biological Chemistry. 285, 3, p. 1809-1821

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors

    Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

    Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.

    Bach, T. B., Jensen, Anders A., Petersen, J. G., Sørensen, T. E., Volpe, S. D., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 425-444 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings

    Bader, B. M., Steder, A., Klein, A. B., Frølund, Bente, Schroeder, O. H. U. & Jensen, Anders A., 2017, In: PloS One. 12, 10, 32 p., e0186147.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Synthesis and nicotinic receptor activity of a hydroxylated tropane

    Bremner, J. B., Godfrey, C. A., Jensen, Anders A. & Smith, R. J., 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 1, p. 271-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

    Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

    Bräuner, Hans, Wellendorph, Petrine & Jensen, Anders A., 2007, In: Current Drug Targets. 8, 1, p. 169-184

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters

    Bräuner, Hans, Bunch, Lennart, Chopin, N., Couty, F., Evano, G., Jensen, Anders A., Kusk, M. L., Nielsen, Birgitte & Rabasso, N., 2005, In: Organic & Biomolecular Chemistry. 3, 21, p. 3926-36 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

    Bunch, Lennart, Pickering, Darryl S, Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., Nielsen, Birgitte & Jensen, Anders A., 2009, In: ChemMedChem. 4, 11, p. 1925-1929

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Excitatory amino acid transporters as potential drug targets

    Bunch, Lennart, Erichsen, M. N. & Jensen, Anders A., 2009, In: Expert Opinion On Therapeutic Targets. 13, 6, p. 719-731

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Selective inhibitors of the excitatory amino acid transporter subtype 1 (EAAT1/GLAST)

    Bunch, Lennart & Jensen, Anders A., 2010, Patent No. WO/2010/066253

    Research output: Patent

  25. Published

    Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3

    Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A. & Bräuner, Hans, 2006, In: Journal of Medicinal Chemistry. 49, 1, p. 172-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

    Chałupnik, P., Vialko, A., Pickering, Darryl S, Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, Anders A., Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders Skov, Johansen, Tommy Nørskov, Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The human GABA transporter GAT-2: From cloning to high throughput screening

    Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative drug development for headache disorders. Olesen, J. & Ramadan, N. (eds.). Oxford, Storbritannien: Oxford University Press, Vol. 16. p. 3-15 (Frontiers in headache research series, Vol. 16).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  28. Published

    Cloning and characterization of a functional human ¿-aminobutyric acid (GABA) transporter, human GAT-2

    Christiansen, B., Meinild, A., Jensen, Anders A. & Bräuner, Hans, 2007, In: Journal of Biological Chemistry. 282, 27, p. 19331-19341 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Ny human GABA-transportør: et muligt mål for behandling af epilepsi

    Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, In: Lægemiddelforskning. p. 25-27

    Research output: Contribution to journal › Journal article › Communication

  30. Published

    The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening

    Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative Drug Development for Headache Disorders. Frontiers in Headache Research. Olesen, J. & Ramadan, N. (eds.). Oxford, UK: Oxford University Press, Vol. 16. p. 3-15

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  31. Published

    Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism

    Chua, H. C., Christensen, E. H. T., Hoestgaard-Jensen, K., Hartiadi, L. Y., Ramzan, I., Jensen, Anders A., Absalom, N. L. & Chebib, M., 23 Jun 2016, In: P L o S One. 11, 6, p. 1-17 17 p., e0157700.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

    Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

    Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

    Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake

    Colleoni, S., Jensen, Anders A., Landucci, E., Fumagalli, E., Conti, P., Pinto, A., De Amici, M., Pellegrini-Giampietro, D. E., De Micheli, C., Mennini, T. & Gobbi, M., 2008, In: Journal of Pharmacology and Experimental Therapeutics. 326, 2, p. 646-656 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In: Journal of Medicinal Chemistry. 61, p. 1719-1729

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

    Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

    Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Identification of the first highly selective inhibitor of human GABA transporter GAT3

    Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Functional characterization of alpha7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

    Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2018, In: European Journal of Pharmacology. 826, p. 106-113

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue

    Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2017, In: PLOS ONE. 12, 21 p., e0189513.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

    Erichsen, M. N., Hansen, J., Artacho Ruiz, J., Demmer, C. S., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Jensen, Anders A. & Bunch, Lennart, 2014, In: Neurochemical Research. 39, 10, p. 1964-1979 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

    Erichsen, M. N., Huynh, Tri Hien Viet, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Monrad, O., Bekker-Jensen, A., Nielsen, C. W., Frydenvang, Karla Andrea, Jensen, Anders A. & Bunch, Lennart, 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7180–7191

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3

    Faure, S., Jensen, Anders A., Maurat, V., Gu, X., Sagot, E., Aitken, D. J., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2006, In: Journal of Medicinal Chemistry. 49, 22, p. 6532-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Effekt og bivirkninger: GABA fra A til C.

    Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journal › Journal article › Communication

  46. Published

    Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors

    Fu, H., Zhang, J., Tepper, P. G., Bunch, Lennart, Jensen, Anders A. & Poelarends, G. J., 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 7741-7753

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay

    Gadgaard, C. & Jensen, Anders A., 2020, In: Biochemical Pharmacology. 175, 13 p., 113870.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors

    Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Targeting α4β2 nAChRs in CNS disorders: Perspectives on positive allosteric modulation as a therapeutic approach

    Grupe, M., Grunnet, M., Bastlund, J. F. & Jensen, Anders A., 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 187-200 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal nicotine-evoked glutamatergic transients in rats

    Grupe, M., Paolone, G., Jensen, Anders A., Sandager-Nielsen, K., Sarter, M. & Grunnet, M., 2013, In: Biochemical Pharmacology. 86, 10, p. 1487-1496

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Unraveling the mechanism of action of NS9283, a positive allosteric modulator of (a4)3(ß2)2 nicotinic ACh receptors

    Grupe, M., Jensen, Anders A., Ahring, P. K., Christensen, J. K. & Grunnet, M., 2013, In: British Journal of Pharmacology. 168, 8, p. 2000-2010

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABAA receptors expressed in Xenopus laevis oocytes

    Hammer, H., Ebert, B., Jensen, H. S. & Jensen, Anders A., 2015, In: P L o S One. 10, p. 1-21 21 p., e0120239.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)

    Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, Lennart, Hoestgaard-Jensen, K., Schroeder, O. H., Bastlund, J. F., Gramowski-Voß, A. & Jensen, Anders A., 2015, In: Molecular Pharmacology. 88, 2, p. 401-420 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective a4ß2 nicotinic acetylcholine receptor agonist

    Hansen, C. P., Jensen, Anders A., Christensen, J. K., Balle, T., Liljefors, T. & Frølund, Bente, 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7380-7395

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)

    Hansen, C. P., Jensen, Anders A., Balle, T., Bitsch-Jensen, K., Hassan, M. M., Liljefors, T. & Frølund, Bente, 2009, In: Bioorganic & Medicinal Chemistry Letters. 19, 1, p. 87-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences

    Hansen, J. C., Bjørn-Yoshimoto, Walden, Bisballe, N., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102

    Hansen, S. W., Erichsen, M. N., Huynh, Tri Hien Viet, Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, Jeanette Venla, Storgaard, M., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 382-402 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study

    Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, J. C., Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8757-8770 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)

    Haym, I., Huynh, Tri Hien Viet, Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 403-419 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

    Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain

    Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio hartree-fock calculations

    Huynh, Tri Hien Viet, Shim, I., Bohr, H., Abrahamsen, B., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5403-12 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the excitatory amino acid transporters (EAATs): Improving the potency of a micromolar screening hit is not truism

    Huynh, Tri Hien Viet, Demmer, C. S., Abrahamsen, B., Marcher, Emil, Frykman, M., Jensen, Anders A. & Bunch, Lennart, 2013, In: SpringerPlus. 2, p. 112

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102

    Huynh, Tri Hien Viet, Abrahamsen, B., Madsen, K. K., Gonzalez-Franquesa, A., Jensen, Anders A. & Bunch, Lennart, 2012, In: Bioorganic & Medicinal Chemistry. 20, 23, p. 6831-6839

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Ginkgolides and glycine receptors: a structure-activity relationship study

    Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

    Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

    Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

    Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors

    Jensen, Anders A., 2023, In: Frontiers in Molecular Biosciences. 10, 11 p., 1265429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors

    Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor

    Jensen, Anders A., Sheppard, P. O., Jensen, L. B., O'Hara, P. J. & Bräuner, Hans, 2001, In: Journal of Biological Chemistry. 276, 13, p. 10110-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors

    Jensen, Anders A., Gharagozloo, P., Birdsall, N. J. M. & Zlotos, D. P., 2006, In: European Journal of Pharmacology. 539, 1-2, p. 27-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Functional importance of the carboxyl tail cysteine residues in the human D1 dopamine receptor

    Jensen, Anders A., Pedersen, U. B., Kiemer, A., Din, N. & Andersen, P. H., 1995, In: Journal of Neurochemistry. 65, 3, p. 1325-31 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

    Jensen, Anders A., Davies, P. A., Bräuner, Hans & Krzywkowski, K., 2008, In: TIPS - Trends in Pharmacological Sciences. 29, 9, p. 437-444

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    The dopamine D1 receptor family: structural and functional aspects

    Jensen, Anders A., Pedersen, U. B., Din, N. & Andersen, P. H., 1996, In: Biochemical Society Transactions. 24, 1, p. 163-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Øget forståelse af vigtig receptor i hjernen

    Jensen, Anders A. & Bräuner, Hans, 2000, In: Lægemiddelforskning. p. 28-29

    Research output: Contribution to journal › Journal article › Communication

  79. Published

    Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA

    Jensen, Anders A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, Tommy Nørskov, Egebjerg, J., Bräuner, Hans & Clausen, Rasmus Prætorius, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

    Jensen, Anders A., Fahlke, C., Bjørn-Yoshimoto, Walden & Bunch, Lennart, 2015, In: Current Opinion in Pharmacology. 20, p. 116-123 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

    Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

    Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion

    Jensen, Anders A. & Strømgaard, Kristian, 2006, In: Dansk Kemi 83. 87, 1, p. 16-18

    Research output: Contribution to journal › Journal article › Communication

  84. Published

    Fluorescensbaseret farmakologi

    Jensen, Anders A., Strange, M. & Bräuner, Hans, 2004, In: Dansk Kemi 83. p. 29 31 p.

    Research output: Contribution to journal › Journal article › Communication

  85. Published

    Allosteric modulation of G-protein coupled receptors

    Jensen, Anders A. & Spalding, T. A., 2004, In: European Journal of Pharmaceutical Sciences. 21, 4, p. 407-20 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors

    Jensen, Anders A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, Tommy Nørskov, Abrahamsen, B., Mattsson, J., Lehmann, A., Bettler, B. & Bräuner, Hans, 2002, In: Molecular Pharmacology. 61, 6, p. 1377-84 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    The dance of the clams: twists and turns in the family C GPCR homodimer

    Jensen, Anders A., Greenwood, J. R. & Bräuner, Hans, 2002, In: Trends in Pharmacological Sciences. 23, 11, p. 491-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay

    Jensen, Anders A., 2005, In: European Journal of Pharmacology. 521, 1-3, p. 39-42 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

    Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Neurotransmitter transporters

    Jensen, Anders A., 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1799-1800 2 p.

    Research output: Contribution to journal › Journal article › Research

  91. Published

    Molecular pharmacology of the metabotropic glutamate receptors

    Jensen, Anders A., 2004, Molecular Neuropharmacology. Strategies and Methods . Schousboe, A. & Bräuner-Osborne, H. (eds.). Humana Press, p. 47-82

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  92. Published

    The dopamine D1 receptor family: Pharmacology and signal transduction

    Jensen, Anders A., Pedersen, U. B., Din, N. & Andersen, P. H., 1995, Alfred Benzon Symposium. Fog, R., Gerlach, J. & Hemmingsen, R. (eds.). Vol. 38. p. 236-246

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  93. Published

    Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

    Jensen, Anders A., Frølund, Bente, Liljefors, T. & Krogsgaard-Larsen, Povl, 2005, In: Journal of Medicinal Chemistry. 48, 15, p. 4705-45 41 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay

    Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Acetylcholine

    Jensen, Anders A., 2016, Textbook of drug design and discovery. Strømgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Taylor & Francis

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  96. Published

    Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors

    Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)

    Jensen, Anders A., Hansen, J. L., Sheikh, S. P. & Bräuner, Hans, 2002, In: European Journal of Biochemistry. 269, 20, p. 5076-87 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay

    Jensen, Anders A. & Bräuner, Hans, 2004, In: Biochemical Pharmacology. 67, 11, p. 2115-27 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Acetylcholine

    Jensen, Anders A. & Krogsgaard-Larsen, Povl, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 263-281

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  100. Published

    Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1

    Jensen, Anders A., Erichsen, M. N., Nielsen, C. W., Stensbøl, T. B., Kehler, J. & Bunch, Lennart, 2009, In: Journal of Medicinal Chemistry. 52, 4, p. 912-915

    Research output: Contribution to journal › Journal article › Research › peer-review

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