Dorte Frees

Dorte Frees

Associate Professor

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    1. Published

      β-lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease

      Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W. E. A. & Frees, Dorte, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4593-4603 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus

      Feng, J., Michalik, S., Varming, A. N., Andersen, J. H., Albrecht, D., Jelsbak, L., Krieger, S., Ohlsen, K., Hecker, M., Gerth, U., Ingmer, Hanne & Frees, Dorte, 2013, In: Journal of Proteome Research. 12, 2, p. 547-558 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Therapy of haematogenous osteomyelitis: a comparative study in a porcine model and Angolan children

      Jensen, Louise Kruse, Koch, J., Kirketerp-Møller, K., Wamsler, O. J., Nielsen, O. L., Leifsson, Páll S., Frees, Dorte, Aalbæk, Bent & Jensen, Henrik Elvang, 2013, In: In Vivo. 27, 3, p. 305-312 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      The sle1 cell wall amidase is essential for β-lactam resistance in community-acquired methicillin-resistant staphylococcus aureus USA300

      Thalsø-Madsen, I., Torrubia, F. R., Xu, Lijuan, Petersen, A., Jensen, C. & Frees, Dorte, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 1, 15 p., e01931-19.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The role of Spi-6 and a putative type six secretion system in Salmonella serotype Gallinarum virulence

      Olsen, John Elmerdahl, Kristensen, B. M. & Frees, Dorte, 2009, ASM conference on Salmonella: Biology, Pathogenesis & Prevention. p. 50 1 p.

      Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research

    6. Published

      The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice

      Harslund, J. L. F., Frees, Dorte, Leifsson, Páll S., Offenberg, H. K., Rømer, M. U. K., Brünner, N. & Olsen, John Elmerdahl, 2013, In: Pathogens and Disease. 68, 3, p. 96-104 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The role of ClpX in Staphylococcus aureus stress response and virulence

      Rasmussen, T., Frees, Dorte & Thomsen, Line Elnif, 2007. 1 p.

      Research output: Contribution to conference › Poster › Research

    8. Published

      The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by rot dependent and independent pathways

      Jelsbak, L., Ingmer, Hanne, Valihrach, L., Cohn, M. T., Christiansen, M. H. G., Kallipolitis, B. H. & Frees, Dorte, 2010, In: PLoS ONE. 5, 9, 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus

      Engman, J., Rogstam, A. H., Frees, Dorte, Ingmer, Hanne & Wachenfeldt, C. V., 2012, In: Journal of Bacteriology. 194, 5, p. 1186-1194 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus

      Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, Dorte, 2017, In: Scientific Reports. 7, 14 p., 11739.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

      Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, Lijuan, Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, Dorte, 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division

      Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, Dorte, 2024, In: Molecular Microbiology. 121, 1, p. 98-115

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

      Baek, K. T., Bowman, L., Millership, C., Sogaard, M. D., Kaever, V., Siljamaki, P., Savijoki, K., Varmanen, P., Nyman, T. A., Grundling, A. & Frees, Dorte, 2016, In: mBio (Print). 7, 4, 11 p., 01228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Stress toelrance mechanisms influencing virulence and survival of food borne pathogens

      Frees, Dorte, Varmanen, P. ;., SavijokiK.;, Andersen, M. T., Brønsted, L. & Ingmer, Hanne, 2003. 1 p.

      Research output: Contribution to conference › Paper › Research

    15. Published

      Stress Responses in Staphylococcus aureus

      Frees, Dorte & Ingmer, Hanne, Oct 2016, Staphylococcus: Genetics and Physiology. Somerville, G. A. (ed.). Caister Academic Press, p. 221-248

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    16. Published

      Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene

      Bæk, K. T., Thøgersen, L., Mogensen, R. G., Pedersen, M. M., Thomsen, Line Elnif, Petersen, A., Skov, Søren, Cameron, D. R., Peleg, A. Y. & Frees, Dorte, Nov 2015, In: Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983-6991 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Staphylococcus aureus ClpYQ plays a minor role in stress survival

      Frees, Dorte, Thomsen, Line Elnif & Ingmer, Hanne, 2005, In: Archives of Microbiology. 183, 4, p. 286-291 6 p.

      Research output: Contribution to journal › Journal article › Research

    18. Published

      Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase

      Alqarzaee, A. A., Chaudhari, S. S., Islam, M. M., Kumar, V., Zimmerman, M. C., Saha, R., Bayles, K. W., Frees, Dorte & Thomas, V. C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2109671118.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis

      Veiga, P., Bulbarela-Sampieri, C., Furlan, S., Maisons, A., Chapot-Chartier, M., Erkelenz, M., Mervelet, P., Noirot, P., Frees, Dorte, Kuipers, O. P., Kok, J., Gruss, A., Buist, G. & Kulakauskas, S., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19342-19354 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus

      Pamp, S. J., Frees, Dorte, Engelmann, S., Hecker, M. & Ingmer, Hanne, 2006, In: Journal of Bacteriology. 188, 13, p. 4861-4870 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      SosA inhibits cell division in Staphylococcus aureus in response to DNA damage

      Bojer, Martin Saxtorph, Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, Dorte, Veening, J. W., Foster, S. J. & Ingmer, Hanne, 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      SosA in Staphylococci: an addition to the paradigm of membrane-localized, SOS-induced cell division inhibition in bacteria

      Bojer, Martin Saxtorph, Frees, Dorte & Ingmer, Hanne, 2020, In: Current Genetics. 66, p. 495-499

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils

      Nielsen, A., Månsson, M., Bojer, Martin Saxtorph, Gram, L., Larsen, T. O., Novick, R. P., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, 2014, In: P L o S One. 9, 1, p. e84992 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Solonamide B Inhibits Quorum Sensing and reduces Staphylococcus aureus mediated killing of Human Neutrophils

      Nielsen, A., Månsson, M., Gram, L., Larsen, T. O., Phipps, R. K., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, Aug 2012.

      Research output: Contribution to conference › Poster › Research

    25. Published

      Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus

      Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008. 1 p.

      Research output: Contribution to conference › Paper › Research › peer-review

    26. Published

      Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus

      Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008.

      Research output: Contribution to conference › Poster › Research

    27. Published

      Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus

      Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008.

      Research output: Contribution to conference › Poster › Research

    28. Published

      Searching for small sB-regulated genes in Staphylococcus aureus

      Nielsen, J. S., Christiansen, M. H. G., Bonde, M., Gottschalk, S., Frees, Dorte, Thomsen, Line Elnif & Kallipolitis, B. H., 2011, In: Archives of Microbiology. 193, 1, p. 23-34 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus

      Villanueva, M., Jousselin, A., Baek, K. T., Prados, J., Andrey, D. O., Renzoni, A., Ingmer, Hanne, Frees, Dorte & Kelley, W. L., 1 Oct 2016, In: Journal of Bacteriology. 198, 19, p. 2719-2731 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis

      Breüner, A., Frees, Dorte, Varmanen, P., Boguta, A. M., Hammer, K., Martinussen, J. & Kilstrup, M., Oct 2016, In: Microbiology. 162, 10, p. 1829-1839 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system

      Farrand, A. J., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., 2013, In: Journal of Bacteriology. 195, 22, p. 5041-5050 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Rapid in vivo development of resistance to daptomycin in vancomycin-resistant Enterococcus faecium due to genomic alterations

      Mollerup, S., Elmeskov, C., Pinholt, M., Sejersen, T. S., Pedersen, M. S., Worning, P., Frees, Dorte & Westh, Henrik T., 2022, In: FEMS Microbiology Letters. 369, 1, 6 p., 063.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus

      Farrand, A. J., Friedman, D. B., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., Apr 2015, In: Pathogens and Disease. 73, 3, 6 p., ftv004.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Planktonic aggregates of Staphylococcus aureus protect against common antibiotics

      Haaber, J. K., Cohn, M. T., Frees, Dorte, Andersen, Thorbjørn Joest & Ingmer, Hanne, 2012, In: P L o S One. 7, 7, 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      PhD course "Infection Microbiology": time schedule for module A, 2010

      Frees, Dorte, Nielsen, M. & Thomsen, Line Elnif, 2010, Department of Veterinary Disease Biology, University of Copenhagen. 72 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    36. Published

      Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis

      Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Norlichexanthone modulate Staphylococcus aureus virulence gene expression possibly via agr and sae

      Nielsen, A., Ifrah, D., Friberg, C., Larsen, T. O., Novick, R. P., Frøkiær, Hanne, Frees, Dorte, Hede, N. G. & Ingmer, Hanne, 2012.

      Research output: Contribution to conference › Poster › Research

    38. Published

      Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

      Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus

      Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564

      Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Method for screening compounds that influence virulence gene expression in Staphylococcus aureus

      Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2010, In: Antimicrobial Agents and Chemotherapy. 54, 1, p. 509-512 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis

      Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool

      Olsen, John Elmerdahl, Frees, Dorte, Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Investigation of correlation between gene expressions of 162 selected genes and survival and colonization abilities of Salmonella strains in the food chain

      Olsen, John Elmerdahl, Gram, L., Frees, Dorte & Holmstrøm, K., 2008, The 21st International ICFMH Symposium "Evolving Microbial Food Quality and Safety": Programme and Abstract Book. p. 164 1 p.

      Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research

    45. Published

      Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis

      Frees, Dorte, Varmanen, P. & Ingmer, Hanne, 2001, In: Molecular Microbiology. 41, 1, p. 93-103 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Identification of the ClpX Regulon in Staphylococcus aureus

      Jelsbak, L., Thomsen, Line Elnif, Ingmer, Hanne, Donat, S., Ohlsen, K. & Frees, Dorte, 2006. 1 p.

      Research output: Contribution to conference › Poster › Research

    47. Published

      Identification of proteins induced at low pH in Lactococcus lactis

      Frees, Dorte, Vogensen, Finn Kvist & Ingmer, Hanne, 2003, In: International Journal of Food Microbiology. 87, 87, p. 293-300 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP

      Savijoki, K., Ingmer, Hanne, Frees, Dorte, Vogensen, Finn Kvist, Palva, A. & Varmanen, P., 2003, In: Molecular Microbiology. 50, 2, p. s.609-621 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation

      Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2010, In: Veterinary Research. 41, 25, 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus

      Jelsbak, L., Hemmingsen, L., Donat, S., Ohlsen, K., Boye, K., Westh, H., Ingmer, Hanne & Frees, Dorte, 2010, In: International Journal of Medical Microbiology. 300, 4, p. 229-236 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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