Marco van de Weert
Associate Professor
Drug Delivery and Biophysics of Biopharmaceuticals
Universitetsparken 2
2100 København Ø
Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate
Nijsen, J. F. W., van Steenbergen, M. J., Kooijman, H., Talsma, H., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P., de Witte, A., van het Schip, A. D. & Hennink, W. E., 2001, In: Biomaterials. 22, p. 3073-3081Research output: Contribution to journal › Journal article › Research › peer-review
Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres
Nijsen, J. F., van Het Schip, A. D., van Steenbergen, M. J., Zielhuis, S. W., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P. & Hennink, W. E., Apr 2002, In: Biomaterials. 23, 8, p. 1831-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass
Neergaard, M. S., Nielsen, A. D., Parshad, H. & van de Weert, Marco, Jan 2014, In: Journal of Pharmaceutical Sciences. 103, 1, p. 115-27 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - Prediction of viscosity through protein-protein interaction measurements
Neergaard, M. S., Kalonia, D. S., Parshad, H., Nielsen, A., Møller, E. H., van de Weert, Marco & Nielsen, A. D., 26 Apr 2013, In: European Journal of Pharmaceutical Sciences. 49, 3, p. 400-410 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme
Meng-Lund, H., Friis, N., van de Weert, Marco, Rantanen, Jukka, Poso, A., Grohganz, Holger & Jørgensen, Lene, 15 May 2017, In: International Journal of Pharmaceutics. 523, 1, p. 238-245 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy
Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 2012, In: A A P S PharmSciTech. 13, 3, p. 747-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of insulin allostery in solution and solid state with FTIR
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2009, In: Journal of Pharmaceutical Sciences. 98, 9, p. 3265-3277Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality by design: Spray drying of insulin intended for inhalation
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 70, 3, p. 828-838Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drying methods for protein pharmaceuticals
Maltesen, M. J. & van de Weert, Marco, 2008, In: Drug Discovery Today: Technologies. 5, 2-3, p. 81-88Research output: Contribution to journal › Review › Research › peer-review
- Published
Erratum to: Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy
Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 21 Feb 2013, In: A A P S PharmSciTech. 14, 2, p. 901 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In: A A P S PharmSciTech. 12, 2, p. 627-635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between enzyme activity an stability of a protease, an alpha-amaylase and a lipase in a simplified liquid laundry detergent system, determined by differential scanning calorimetry
Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In: Journal of Surfactants and Detergents. 15, p. 9-21Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protease and amylase stability in the presence of chelators used in laundry detergent applications: correlation between chelator properties and enzyme stability in liquid detergents
Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In: Journal of Surfactants and Detergents. 15, 3, p. 265-276Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation
Lobbens, E. S., Breydo, L., Pedersen, T. S., Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In: B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin
Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In: PloS one. 11, 2, p. 1-16 16 p., e0149148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity
Lobbens, E. S. B., Vissing, K. J., Jørgensen, Lene, van de Weert, Marco & Jäger, A. K., 22 Mar 2017, In: Journal of Ethnopharmacology. 200, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of oxidized methionine in peptides
Lagerwerf, F. M., van de Weert, Marco, Heerma, W. & Haverkamp, J., 1996, In: Rapid Communications in Mass Spectrometry. 10, p. 1905-1910Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Tableting on the Conformation and Thermal Stability of Trypsin as a Model Protein
Klukkert, M., van de Weert, Marco, Fanø, M., Rades, Thomas & Leopold, C. S., 2015, In: Journal of Pharmaceutical Sciences. 104, 12, p. 4314–4321 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces
Kapp, S. J., Larsson, I., van de Weert, Marco, Cardenas Gomez, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 2, p. 593-601 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601
Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems
Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In: Journal of Biomedical Nanotechnology. 5, 4, p. 401-408Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing structural changes of proteins incorporated into water-in-oil emulsions
Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The challenges in and importance of analysing protein structure and physical stability in complex formulations
Jørgensen, Lene, Jensen, M. G., Roest, N., Pinholt, C. & van de Weert, Marco, 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 347-353 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Preparing and evaluating delivery systems for proteins
Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions
Ji, S., Thulstrup, Peter Waaben, Mu, Huiling, Hansen, S. H., van de Weert, Marco, Rantanen, Jukka & Yang, Mingshi, 2017, In: International Journal of Pharmaceutics. 534, 1-2, p. 263-271 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of ethanol as a co-solvent on the aerosol performance and stability of spray-dried lysozyme
Ji, S., Thulstrup, Peter Waaben, Mu, Huiling, Hansen, S. H., van de Weert, Marco, Rantanen, Jukka & Yang, Mingshi, 2016, In: International Journal of Pharmaceutics. 513, 1-2, p. 175-182 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding mode of Thioflavin T in insulin amyloid fibrils
Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In: Journal of Structural Biology. 159, 3, p. 483-497Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities
Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In: Journal of Structural Biology. 158, 3, p. 358-369Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gennembrud i forståelsen af insulinfibrillering
Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11Research output: Contribution to journal › Journal article › Communication
- Published
Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(e)¿-carboxyheptadecanoyl) des(B30)
Jensen, M. H., Wahlund, P., Toft, K. N., Jacobsen, J. K., Steensgaard, D. B., van de Weert, Marco, Havelund, S. & Vestergaard, Bente, 15 Jan 2013, In: Biochemistry. 52, 2, p. 282-94 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering
Jensen, M. H., Wahlund, P., Jacobsen, J. K., Vestergaard, Bente, van de Weert, Marco & Havelund, S., 2011, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 28, p. 2945-2951Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin
Høgstedt, U. B., Østergaard, Jesper, Weiss, T., Sjögren, H. & van de Weert, Marco, Mar 2018, In: Journal of Pharmaceutical Sciences. 107, 3, p. 838-847 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions
Høgstedt, U. B., Schwach, G., van de Weert, Marco & Østergaard, Jesper, 25 Jul 2016, In: European Journal of Pharmaceutical Sciences. 93, p. 21-28 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer
Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In: Pharmaceutical Research. 23, 11, p. 2611-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer
Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In: Biochemistry. 45, 12, p. 4014-4024 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thermal dissociation and unfolding of insulin
Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In: Biochemistry. 44, 33, p. 11171-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of molecular interactions on drug release and antifungal activity in vitro
Huang, Jianfei, Jacobsen, Jette, Larsen, Susan Weng, Genina, Natalja, van de Weert, Marco, Mullertz, Anette , Nielsen, Hanne Mørck & Mu, Huiling, 2020, In: International Journal of Pharmaceutics. 589, p. 1-9 119811.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preferential interactions and the effect of protein PEGylation
Holm, L. S., Thulstrup, Peter Waaben, Kasimova, M. R. & van de Weert, Marco, 2015, In: PLOS ONE. 10, 7, 18 p., e0133584.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Protein PEGylation on Physical Stability in Liquid Formulation
Holm, L. S., Mcumber, A., Rasmussen, J. E., Obiols-Rabasa, M., Thulstrup, Peter Waaben, Kasimova, M. R., Randolph, T. W. & van de Weert, Marco, 21 Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 10, p. 3043-3054 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery
Heller, J., Barr, J., Ng, S., Shen, H., Gurny, R., Schwach-Abdelaoui, K., Rothen-Weinhold, A. & van de Weert, Marco, 17 Jan 2002, In: Journal of controlled release : official journal of the Controlled Release Society. 78, 1-3, p. 133-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin
Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In: Langmuir. 32, 28, p. 7241–7249 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Forced degradation of therapeutic proteins
Hawe, A., Wiggenhorn, M., van de Weert, Marco, Garbe, J. H. O., Mahler, H. & Jiskoot, W., 2012, In: Journal of Pharmaceutical Sciences. 101, 3, p. 895-913Research output: Contribution to journal › Review › Research › peer-review
- Published
Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces
Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2012, In: Langmuir. 28, 3, p. 1804-1815Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interfacial complexes between a protein and lipophilic ions at an oil - water interface
Hartvig, R. A., Méndez, M. A., van de Weert, Marco, Jørgensen, Lene, Østergaard, Jesper, Girault, H. H. & Jensen, H., 2010, In: Analytical Chemistry. 82, 18, p. 7699-7705Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein adsorption at charged surfaces: The role of electrostatic interactions and interacial charge regulation
Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2011, In: Langmuir. 27, p. 2634-2643Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation
Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik Elvang, 15 Mar 2011, In: Langmuir. 27, 6, p. 2634-2643 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formulation, stability and characterization of protein and peptide drugs
Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization
Fonte, P., Araújo, F., Seabra, V., Reis, S., van de Weert, Marco & Sarmento, B., 30 Dec 2015, In: International Journal of Pharmaceutics. 496, 2, p. 850-62 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization
Fonte, P., Andrade, F., Azevedo, C., Pinto, J., Seabra, V., van de Weert, Marco, Reis, S. & Sarmento, B., 2016, In: Pharmaceutical Research. 33, 11, p. 2777–2793Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secondary nucleation and accessible surface in insulin amyloid fibril formation
Foderà, Vito, Librizzi, F., Jensen, M. G., van de Weert, Marco & Leone, M., 2008, In: Journal of Physical Chemistry B. 112, 12, p. 3853-3858Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302800
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Preferential interactions and the effect of protein PEGylation
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On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra
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Rhamnogalacturonan-I based microcapsules for targeted drug release
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