Agnete Kirkeby
Guest Researcher, Associate professor, group leader, Associate Professor
Developmental Neuroscience
Blegdamsvej 3B
2200 København N
Kirkeby Lab
Blegdamsvej 3
2200 København N
Member of:
- 2007
- Published
Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor
Kirkeby, Agnete, van Beek, J., Nielsen, J., Leist, M. & Helboe, L., 15 Aug 2007, In: Journal of Neuroscience Methods. 164, 1, p. 50-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures
Montero, M., Poulsen, F. R., Noraberg, J., Kirkeby, Agnete, van Beek, J., Leist, M. & Zimmer, J., 1 Mar 2007, In: Experimental Neurology. 204, 1, p. 106-117 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).
Kirkeby, Agnete, Torup, L., Bochsen, L., Kjalke, M., Abel, K., Theilgaard-Mønch, Kim, Johansson, P. I., Bjørn, S. E., Gerwien, J. & Leist, M., 2008, In: Thrombosis and Haemostasis. 99, 4, p. 720-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits
Lapchak, P. A., Kirkeby, Agnete, Zivin, J. A. & Sager, T. N., 31 Oct 2008, In: Brain Research. 1238, p. 208-214 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy
Leist, M., Bremer, S., Brundin, P., Hescheler, J., Kirkeby, Agnete, Krause, K. H., Pörzgen, P., Pucéat, M., Schmidt, M., Schrattenholz, A., Zak, N. B. & Hentze, H., 1 Dec 2008, In: Altex. 25, 3, p. 163-190 28 p.Research output: Contribution to journal › Review › Research › peer-review
- 2010
- Published
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
Sachdeva, R., Jönsson, M. E., Nelander, J., Kirkeby, Agnete, Guibentif, C., Gentner, B., Naldini, L., Björklund, A., Parmar, M. & Jakobsson, J., 22 Jun 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11602-11607 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Direct conversion of human fibroblasts to dopaminergic neurons
Pfisterer, U., Kirkeby, Agnete, Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J. & Parmar, M., 21 Jun 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10343-10348 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development
Kirkeby, Agnete & Parmar, M., 1 Dec 2012, In: Translational Neuroscience. 3, 4, p. 314-319 6 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
Kirkeby, Agnete, Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O. & Parmar, M., 28 Jun 2012, In: Cell Reports. 1, 6, p. 703-714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Generating regionalized neuronal cells from pluripotency, a step-by-stepprotocol
Kirkeby, Agnete, Nelander, J. & Parmar, M., 3 Jan 2013, In: Frontiers in Cellular Neuroscience. JANUARY 2013Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease
Grealish, S., Diguet, E., Kirkeby, Agnete, Mattsson, B., Heuer, A., Bramoulle, Y., Van Camp, N., Perrier, A. L., Hantraye, P., Björklund, A. & Parmar, M., 1 Jan 2014, In: Cell Stem Cell. 15, 5, p. 653-665 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons
Grealish, S., Heuer, A., Cardoso, T., Kirkeby, Agnete, Jönsson, M., Johansson, J., Björklund, A., Jakobsson, J. & Parmar, M., 9 Jun 2015, In: Stem Cell Reports. 4, 6, p. 975-983 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive analysis of microrna expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor
Jönsson, M. E., Wahlestedt, J. N., Åkerblom, M., Kirkeby, Agnete, Malmevik, J., Brattaas, P. L., Jakobsson, J. & Parmar, M., 23 Sep 2015, In: Development (Cambridge). 142, 18, p. 3166-3177 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?
Barker, R. A., Parmar, M., Kirkeby, Agnete, Björklund, A., Thompson, L. & Brundin, P., 30 Mar 2016, In: Journal of Parkinson's Disease. 6, 1, p. 57-63 7 p.Research output: Contribution to journal › Review › Research › peer-review
HESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation
Heuer, A., Jönsson, M. E., Pfisterer, U., Kirkeby, Agnete & Parmar, M., 1 Aug 2016, In: Experimental Neurology. 282, p. 78-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The stem cell niche finds its true north
Kirkeby, Agnete, Perlmann, T. & Pereira, C. F., 15 Aug 2016, In: Development (Cambridge). 143, 16, p. 2877-2881 5 p.Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.
Kee, N., Volakakis, N., Kirkeby, Agnete, Dahl, L., Storvall, H., Nolbrant, S., Lahti, L., Bjoerklund, A. K., Gillberg, L., Joodmardi, E., Sandberg, R., Parmar, M. & Perlmann, T., 5 Jan 2017, In: Cell Stem Cell. 20, 1, p. 29-40 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.
Kirkeby, Agnete, Nolbrant, S., Tiklova, K., Heuer, A., Kee, N., Cardoso, T., Ottosson, D. R., Lelos, M. J., Rifes, P., Dunnett, S. B., Grealish, S., Perlmann, T. & Parmar, M., 2017, In: Cell Stem Cell. 20, 1, p. 135-148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)
Kirkeby, Agnete, Parmar, M. & Barker, R. A., 2017, Functional Neural Transplantation IV: Translation to Clinical Application, Part A. Vol. 230. p. 165-190 26 p. (Progress in Brain Research).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.
Lehnen, D., Barral, S., Cardoso, T., Grealish, S., Heuer, A., Smiyakin, A., Kirkeby, Agnete, Kollet, J., Cremer, H., Parmar, M., Bosio, A. & Knoebel, S., Oct 2017, In: Stem Cell Reports. 9, 4, p. 1207-1220 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anatomical and Molecular insight into the developing entorhinal cortex in a large mammalian species, the pig.
Liu, Y., Peralvo Vidal, Juan Miguel, Thomsen, Preben Dybdahl, Møllgård, Kjeld, Kirkeby, Agnete & Hall, Vanessa Jane, 2017.Research output: Contribution to conference › Conference abstract for conference › Research
Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.
Moraghebi, R., Kirkeby, Agnete, Chaves, P., Roenn, R. E., Sitnicka, E., Parmar, M., Larsson, M., Herbst, A. & Woods, N., 25 Aug 2017, In: Stem Cell Research & Therapy. 8, 12 p., 190.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation
Nolbrant, S., Heuer, A., Parmar, M. & Kirkeby, Agnete, 2017, In: Nature Protocols. 12, 9, p. 1962-1979Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Report of the international conference on manufacturing and testing of pluripotent stem cells
Abbot, S., Agbanyo, F., Ahlfors, J-E., Baghbaderani, B. A., Bartido, S., Bharti, K., Burke, C., Carlsson, B., Cavagnaro, J., Creasey, A., Lin, S., DiGiusto, D., Francissen, K., Gaffney, A., Goldring, C., Gorba, T., Griffiths, E., Lubiniecki, A., Vandeputte, J., Hanatani, T. & 23 others, , Nov 2018, In: Biologicals. 63, p. 67-83Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats
Cardoso, T., Adler, A. F., Mattsson, B., Hoban, D. B., Nolbrant, S., Wahlestedt, J. N., Kirkeby, Agnete, Grealish, S., Björklund, A. & Parmar, M., 1 Sep 2018, In: The Journal of Comparative Neurology. 526, 13, p. 2133-2146Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
Mondal, T., Juvvuna, P. K., Kirkeby, A., Mitra, S., Kosalai, S. T., Traxler, L., Hertwig, F., Wernig-Zorc, S., Miranda, C., Deland, L., Volland, R., Bartenhagen, C., Bartsch, D., Bandaru, S., Engesser, A., Subhash, S., Martinsson, T., Carén, H., Akyürek, L. M., Kurian, L. & 5 others, , 12 Mar 2018, In: Cancer Cell. 33, 3, p. 417-434.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A symphony of stem cells in Vienna - looking to the future
Porrello, E. R. & Kirkeby, Agnete, 8 Jun 2018, In: Development (Cambridge, England). 145, 11, 6 p., 163501.Research output: Contribution to journal › Conference article › Research › peer-review
- 2019
- Published
Parkinson disease and growth factors — is GDNF good enough?
Kirkeby, Agnete & Barker, R. A., 1 Jun 2019, In: Nature Reviews Neurology. 15, 6, p. 312-314 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2020
- Published
Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells
Korshunova, Irina, Rhein, S., vsz834, vsz834, Stölting, I., Pfisterer, U., Barta, A., Dmytriyeva, O., Kirkeby, Agnete, Schwaninger, M. & Khodosevich, Konstantin, 2020, In: JCI insight. 5, 4, p. 1-19 e126268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient
Rifes, P., Isaksson, M., Rathore, Gaurav Singh, Aldrin-Kirk, P., Moller, O. K., Barzaghi, G., Lee, J., Egerod, Kristoffer Lihme, Belmont-Rausch, Dylan Matthew, Parmar, M., Pers, Tune H, Laurell, T. & Kirkeby, Agnete, 2020, In: Nature Biotechnology. 38, p. 1265-1273 9 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
Tiklová, K., Nolbrant, S., Fiorenzano, A., Björklund, Å. K., Sharma, Y., Heuer, A., Gillberg, L., Hoban, D. B., Cardoso, T., Adler, A. F., Birtele, M., Lundén-Miguel, H., Volakakis, N., Kirkeby, Agnete, Perlmann, T. & Parmar, M., 1 Dec 2020, In: Nature Communications. 11, 1, 11 p., 2434.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Preclinical assessment of a pluripotent cell therapy for treatment of Parkinson's Disease
Kirkeby, Agnete, 2021, In: Toxicology Letters. 350, Supplement, p. S37 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Bringing Advanced Therapies for Parkinson's Disease to the Clinic: The Scientist's Perspective
Tomishima, M. & Kirkeby, Agnete, 2021, In: Journal of Parkinson's Disease. 11, p. S135-S140 6 p.Research output: Contribution to journal › Review › Research › peer-review
- 2022
- Published
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells
Dubonyte, Ugne, Asenjo-Martinez, A., Werge, Thomas, Lage, K. & Kirkeby, Agnete, 2022, In: Acta Neuropathologica Communications. 10, 1, 20 p., 183.Research output: Contribution to journal › Review › Research › peer-review
- Published
Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia
Elabi, O. F., Pass, R., Sormonta, I., Nolbrant, S., Drummond, N., Kirkeby, Agnete, Kunath, T., Parmar, M. & Lane, E. L., 2022, In: Journal of Parkinson's Disease. 12, 6, p. 1881-1896 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MSLibrarian: Optimized Predicted Spectral Libraries for Data-Independent Acquisition Proteomics
Isaksson, M., Karlsson, C., Laurell, T., Kirkeby, Agnete & Heusel, M., 2022, In: Journal of Proteome Research. 21, 2, p. 535–546 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia
Garza, R., Sharma, Y., Atacho, D. A. M., Thiruvalluvan, Arun, Abu Hamdeh, S., Jönsson, M. E., Horvath, V., Adami, A., Ingelsson, M., Jern, P., Hammell, M. G., Englund, E., Kirkeby, Agnete, Jakobsson, J. & Marklund, N., 2023, In: Cell Reports. 42, 11, 19 p., 113395.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions
Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H., 2023, In: Developmental Cell. 58, 17, p. 1593-1609.e9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD
Parmar, M., Novo Nordisk Cell Therapy R&D, N. N. C. T. R. & Christiansen, Josefine Rågård, 2023, In: Cell Stem Cell. 30, 10, p. 1299-1314.e9 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease
Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells
Rifes, P., Isaksson, M., Rusimbi, Charlotte Nuru, Ramón Santonja, A., Nelander, J., Laurell, T. & Kirkeby, Agnete, 2023, In: Stem Cell Research and Therapy. 14, 1, 354.Research output: Contribution to journal › Journal article › Research › peer-review
- 2024
- Published
Clinical translation of pluripotent stem cell-based therapies: successes and challenges
Christiansen, Josefine Rågård & Kirkeby, Agnete, 1 Apr 2024, In: Development (Cambridge, England). 151, 7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Good Manufacturing Practice–compliant human induced pluripotent stem cells: from bench to putative clinical products
Novoa, J. J., Westra, I. M., Steeneveld, E., Fonseca Neves, N., Arendzen, C. H., Rajaei, B., Grundeken, E., Yildiz, M., van der Valk, W., Salvador, A., Carlotti, F., Dijkers, P. F., Locher, H., van den Berg, C. W., Raymond, K. I., Kirkeby, A., Mummery, C. L., Rabelink, T. J., Freund, C., Meij, P. & 1 others, , 2024, In: Cytotherapy. 26, 6, p. 556-566Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons
Rifes, P., Kajtez, Janko, Christiansen, Josefine Rågård, Schörling, Alrik, Rathore, Gaurav Singh, Wolf, D. A., Heuer, A. & Kirkeby, Agnete, 16 May 2024, (E-pub ahead of print) In: Stem Cell Reports.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 172979835
Most downloads
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IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
43
downloads
Bringing Advanced Therapies for Parkinson's Disease to the Clinic: The Scientist's Perspective
Research output: Contribution to journal › Review › Research › peer-review
Published -
39
downloads
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
Research output: Contribution to journal › Journal article › Research › peer-review
Published