Pontus Emanuel Gourdon
Associate Professor
- 2024
- Published
Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases
Guo, Zongxin, Orädd, F., Bågenholm, Viktoria, Grønberg, C., Ma, J. F., Ott, P., Wang, Y., Andersson, M., Pedersen, Per Amstrup, Wang, Kaituo & Gourdon, Pontus Emanuel, 2024, In: Nature Communications. 15, 1, 16 p., 2690.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of phosphorylation in calmodulin-mediated gating of human AQP0
Kreida, S., Roche, J. V., Missel, Julie Winkel, Al-Jubair, T., Hagströmer, C. J., Wittenbecher, V., Linse, S., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., 2024, In: The Biochemical journal. 481, 1, p. 17-32 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs
Couston, J., Guo, Zongxin, Wang, Kaituo, Gourdon, Pontus Emanuel & Blaise, M., 2023, In: Current Research in Structural Biology. 6, 100109.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus
Hagströmer, C. J., Steffen, Jonas Hyld, Kreida, S., Al-Jubair, T., Frick, A., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., Dec 2023, In: Scientific Reports. 13, 1, 15 p., 14674.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FK506-Binding Protein 2 Participates in Proinsulin Folding
Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, , 2023, In: Biomolecules. 13, 1, 20 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structure supports a role of AQP7 as a junction protein
Huang, P., Venskutonytė, R., Prasad, R. B., Ardalani, H., de Maré, S. W., Fan, X., Li, P., Spégel, P., Yan, N., Gourdon, Pontus Emanuel, Artner, I. & Lindkvist-Petersson, K., 2023, In: Nature Communications. 14, 1, 12 p., 600.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Principles to recover copper-conducting CTR proteins for the purpose of structural and functional studies
Nayeri, N., Li, P., Górecki, K., Lindkvist-Petersson, K. & Gourdon, Pontus Emanuel, 2023, In: Protein Expression and Purification. 203, 8 p., 106213.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1
Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of a Mycobacterium tuberculosis Active Peptide
Rao, K. U., Li, P., Welinder, C., Tenland, E., Gourdon, Pontus Emanuel, Sturegård, E., Ho, J. C. S. & Godaly, G., 2023, In: Pharmaceutics. 15, 2, 16 p., 540.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids
Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Characterization of human aquaporin protein-protein interactions using microscale thermophoresis (MST)
Al-Jubair, T., Steffen, Jonas Hyld, Missel, Julie Winkel, Kitchen, P., Salman, M. M., Bill, R. M., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., 2022, In: STAR Protocols. 3, 2, 8 p., 101316.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-yield overproduction and purification of human aquaporins from Pichia pastoris
Al-Jubair, T., Steffen, Jonas Hyld, Missel, Julie Winkel, Kitchen, P., Salman, M. M., Bill, R. M., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., 2022, In: STAR Protocols. 3, 2, 19 p., 101298.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microfluidic-Derived Detection of Protein-Facilitated Copper Flux Across Lipid Membranes
Gorecki, K., Hansen, J. S., Li, P., Nayeri, N., Lindkvist-Petersson, K. & Gourdon, Pontus Emanuel, 2022, In: Analytical Chemistry. 94, 34, p. 11831-11837Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
He, Jianfei, Steffen, Jonas Hyld, Thulstrup, Peter Waaben, Pedersen, J. N., Sauerland, Max Benjamin, Otzen, D. E., Hawkins, Clare Louise, Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2022, In: Scientific Reports. 12, 1, 15 p., 22051.Research output: Contribution to journal › Journal article › Research › peer-review
Aquaglyceroporins and orthodox aquaporins in human adipocytes
Huang, P., Hansen, J. S., Saba, K. H., Bergman, A., Negoita, F., Gourdon, Pontus Emanuel, Hagström-Andersson, A. & Lindkvist-Petersson, K., 1 Feb 2022, In: B B A - Biomembranes. 1864, 1, 183795.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
Li, P., Nayeri, N., Górecki, K., Becares, E. R., Wang, Kaituo, Mahato, D. R., Andersson, M., Abeyrathna, S. S., Lindkvist-Petersson, K., Meloni, G., Missel, Julie Winkel & Gourdon, Pontus Emanuel, 2022, In: Protein Science. 31, 7, p. 1-16 e4364.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria
Li, P., Hendricks, A. L., Wang, Yong, Villones, R. L. E., Lindkvist-Petersson, K., Meloni, G., Cowan, J. A., Wang, Kaituo & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 12 p., 4339.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B
Orädd, F., Steffen, Jonas Hyld, Gourdon, Pontus Emanuel & Andersson, M., 2022, In: PLOS Computational Biology. 18, 9 September, 21 p., e1010074.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Yong, Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis of ion uptake in copper-transporting P1B-type ATPases
Salustros, N., Gronberg, C., Abeyrathna, N. S., Lyu, Pin, Oradd, F., Wang, Kaituo, Andersson, M., Meloni, G. & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 11 p., 5121.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation
Song, Y., Dai, B., Wang, Yong, Wang, Y., Liu, C., Gourdon, Pontus Emanuel, Liu, L., Wang, Kaituo & Dong, M., 2022, In: Nano Letters. 22, 9, p. 3707–3712Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup
Steffen, Jonas Hyld, Missel, Julie Winkel, Al-Jubair, T., Kitchen, P., Salman, M. M., Bill, R. M., Törnroth-Horsefield, S. & Gourdon, Pontus Emanuel, 2022, In: STAR Protocols. 3, 2, 11 p., 101312.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
Wiuf, A., Steffen, Jonas Hyld, Becares, E. R., Gronberg, C., Mahato, D. R., Rasmussen, Søren Gøgsig Faarup, Andersson, M., Croll, T., Gotfryd, K. & Gourdon, Pontus Emanuel, 2022, In: Science Advances. 8, 28, 13 p., 4331.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Zhang, L., Simonsen, C., Zimova, L., Wang, Kaituo, Moparthi, L., Gaudet, R., Ekoff, M., Nilsson, G., Hellmich, U. A., Vlachova, V., Gourdon, Pontus Emanuel & Zygmunt, P. M., 2022, In: Nature Communications. 13, 1, 18 p., 7483.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and Crystallization of the D156C Form of Optogenetic ChR2
Zhang, L., Wang, Kaituo, Ning, S., Pedersen, Per Amstrup, Duelli, A. S. & Gourdon, Pontus Emanuel, 2022, In: Cells. 11, 5, 11 p., 895.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization
Becares, E. R., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Cells. 10, 2, 21 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and ion-release mechanism of PIB-4-type ATPases
Grønberg, C., Hu, Q., Mahato, D. R., Longhin, E., Salustros, N., Duelli, A., Lyu, P., Bågenholm, Viktoria, Eriksson, J., Rao, K. U., Henderson, D. I., Meloni, G., Andersson, M., Croll, T., Godaly, G., Wang, Kaituo & Gourdon, Pontus Emanuel, Dec 2021, In: eLife. 10, e73124.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and transport mechanism of P5B-ATPases
Li, P., Wang, Kaituo, Salustros, N., Grønberg, C. & Gourdon, Pontus Emanuel, 2021, In: Nature Communications. 12, 1, 8 p., 3973.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclohexyl-alpha maltoside as a highly efficient tool for membrane protein studies
Missel, Julie Winkel, Salustros, N., Becares, E. R., Steffen, Jonas Hyld, Laursen, A. G., Garcia, A. S., Garcia-Alai, M. M., Kolar, C., Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Current Research in Structural Biology. 3, p. 85-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins
Preisler, Sarah Spruce, Wiuf, A. D., Friis, M., Kjaergaard, L., Hurd, M., Becares, E. R., Nurup, C. N., Bjoerkskov, F. B., Szathmáry, Z., Gourdon, Pontus Emanuel, Callø, Kirstine, Klærke, Dan Arne, Gotfryd, K. & Pedersen, Per Amstrup, 2021, In: Current research in structural biology. 3, p. 51-71 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynein regulates Kv7.4 channel trafficking from the cell membrane
van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin
He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rapid “teabag” method for high-end purification of membrane proteins
Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema
Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., Al-Jubair, T., Missel, Julie Winkel, Gourdon, Pontus Emanuel, Törnroth-Horsefield, S., Conner, M. T., Ahmed, Z., Conner, A. C. & Bill, R. M., 2020, In: Cell. 181, 4, p. 784-799Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- 2019
- Published
Structure of the human ClC-1 chloride channel
Wang, Kaituo, Preisler, Sarah Spruce, Zhang, L., Cui, Y., Missel, Julie Winkel, Grønberg, C., Gotfryd, K., Lindahl, E., Andersson, M., Callø, Kirstine, Egea, P. F., Klærke, Dan Arne, Pusch, M., Pedersen, Per Amstrup, Zhou, Z. H. & Gourdon, Pontus Emanuel, 2019, In: PLOS Biology. 17, 4, p. 1-20 e3000218.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification of Functional Human TRP Channels Recombinantly Produced in Yeast
Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment
Autzen, Henriette Elisabeth, Koldso, H., Stansfeld, P. J., Gourdon, Pontus Emanuel, Sansom, M. S. P. & Nissen, P., 2018, In: Biochemistry. 57, 28, p. 4063-4073Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human adipose glycerol flux is regulated by a pH gate in AQP10
Gotfryd, K., Mósca, A. F., Missel, Julie Winkel, Truelsen, S. F., Wang, Kaituo, Spulber, M., Krabbe, S., Hélix-nielsen, C., Laforenza, U., Soveral, G., Pedersen, Per Amstrup & Gourdon, Pontus Emanuel, 2018, In: Nature Communications. 9, p. 1-11 4749.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function
Lindahl, V., Gourdon, Pontus Emanuel, Andersson, M. & Hess, B., 2018, In: Scientific Reports. 8, 13 p., 2995 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase
Longhin, E., Gronberg, C., Hu, Q., Duelli, A. S., Andersen, K. R., Laursen, N. S. & Gourdon, Pontus Emanuel, 2018, In: Antibodies. 7, 4, 15 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization
Bjørkskov, F. B., Krabbe, S., Nurup, C. N., Missel, Julie Winkel, Spulber, M., Bomholt, J., Molbaek, K., Helix-Nielsen, C., Gotfryd, K., Gourdon, Pontus Emanuel & Pedersen, Per Amstrup, 4 Dec 2017, In: Scientific Reports. 7, 21 p., 16899.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phospholipid flipping involves a central cavity in P4 ATPases
Jensen, M. S., Costa, S., Duelli, A. S., Andersen, P. A., Poulsen, L. R., Stanchev, L. D., Gourdon, Pontus Emanuel, Palmgren, Michael, Pomorski, Thomas Guenther & Lopez Marques, Rosa Laura, 2017, In: Scientific Reports. 7, 13 p., 17621.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease
Skjørringe, T., Pedersen, Per Amstrup, Thorborg, S. S., Nissen, P., Gourdon, Pontus Emanuel & Møller, L. B., 7 Apr 2017, In: Scientific Reports. 7, 18 p., 757.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport
Grønberg, C., Sitsel, O., Lindahl, E., Gourdon, Pontus Emanuel & Andersson, M., 6 Dec 2016, In: Biophysical Journal. 111, 11, p. 2417-2429 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Crystal Structure of an Ammonia-Permeable Aquaporin
Kirscht, A., Kaptan, S. S., Bienert, G. P., Chaumont, F., Nissen, P., de Groot, B. L., Kjellbom, P., Gourdon, Pontus Emanuel & Johanson, U., Mar 2016, In: PLoS Biology. 14, 3, 19 p., e1002411.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overproduction of PIB-Type ATPases
Liu, X., Sitsel, O., Wang, Kaituo & Gourdon, Pontus Emanuel, 2016, P-Type ATPases: Methods and Protocols. Bublitz, M. (ed.). Springer, Vol. 1377. p. 29-36 8 p. (Methods in Molecular Biology, Vol. 1377).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 108586181
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A high-yield co-expression system for the purification of an intact drs2p-cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate
Research output: Contribution to journal › Journal article › Research › peer-review
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534
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Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
186
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Structure of the human ClC-1 chloride channel
Research output: Contribution to journal › Journal article › Research › peer-review
Published