TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis

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T helper (TH) 17 cells are believed to play a pivotal role in development of inflammatory bowel disease, and their contribution to intestinal inflammation has been studied in various models of colitis. TH17 cells produce a range of cytokines, some of which are potential targets for immunotherapy. However, blockade of IL-17A alone with secukinumab was not effective in Crohn's disease. In this regard, the pathogenic impact of IL-17A versus IL-17F during intestinal inflammation is still unresolved.
Original languageEnglish
JournalInflammatory Bowel Diseases
Issue number8
Pages (from-to)1567-1576
Number of pages10
Publication statusPublished - 2013

ID: 47486081