TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis
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T helper (TH) 17 cells are believed to play a pivotal role in development of inflammatory bowel disease, and their contribution to intestinal inflammation has been studied in various models of colitis. TH17 cells produce a range of cytokines, some of which are potential targets for immunotherapy. However, blockade of IL-17A alone with secukinumab was not effective in Crohn's disease. In this regard, the pathogenic impact of IL-17A versus IL-17F during intestinal inflammation is still unresolved.
|Journal||Inflammatory Bowel Diseases|
|Number of pages||10|
|Publication status||Published - 2013|