Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
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[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Zn2+ modulation of neurotransmitter transporters
Nørgaard-Nielsen, K. & Gether, Ulrik, 2006, In: Handbook of Experimental Pharmacology. 175, p. 1-22 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Zn(2+) site engineering oat the oligomeric interface of the dopamine transporter
Nørgaard-Nielsen, K., Norregaard, L., Hastrup-Nielsen, H., Javitch, J. A. & Gether, Ulrik, 2002, In: FEBS Letters. vol. 524(1-3), p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
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Zn(2+) site engineering at the oligomeric interface of the dopamine transporter
Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A. & Gether, Ulrik, 31 Jul 2002, In: FEBS Letters. 524, 1-3, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter
Meinild, A., Sitte, H. H. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. 279, 48, p. 49671-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
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Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response
Ejdrup, Aske Lykke, Wellbourne-Wood, J., Dreyer, J. K., Guldhammer, N., Lycas, M. D., Gether, Ulrik, Hall, B. J. & Sørensen, G., 2023, In: ACS Chemical Neuroscience. 14, 9, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In: Journal of Physiology. 530 (Pt 3), p. 367-378Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Validity of the diagnosis of a single depressive episode in a case register
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In: Clinical Practice and Epidemiology in Mental Health. 5, p. 4Research output: Contribution to journal › Journal article › Research › peer-review
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Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor
Kobilka, B. K. & Gether, Ulrik, 2002, In: Methods in Enzymology. 343, 343, p. 170-182 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding G-protein coupled receptors and their role in the CNS
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
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Uncovering molecular mechanism involved in activation of G protein-coupled receptors
Gether, Ulrik, 2000, In: Endocrine Reviews. 21(1), p. 90-113Research output: Contribution to journal › Journal article › Research › peer-review
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Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.Research output: Contribution to journal › Journal article › Research › peer-review
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Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task: differential effects of dopaminergic and noradrenergic manipulations
Hervig, M. E. S., Toschi, C., Petersen, Anders, Vangkilde, Signe, Gether, Ulrik & Robbins, T. W., 2023, In: Psychopharmacology. 240, p. 41-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task
Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, Ulrik, Habekost, Thomas, Bundesen, C., Vangkilde, Signe, Woldbye, David Paul Drucker, Andreasen T., Jesper & Petersen, Anders, 2017, In: Psychopharmacology. 234, 5, p. 845-855Research output: Contribution to journal › Journal article › Research › peer-review
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The solute carrier 6 family of transporters
Bröer, S. & Gether, Ulrik, 22 Aug 2012, In: British Journal of Pharmacology. 167, 2, p. 256-78 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation
Rahbek-Clemmensen, T., Bay, T., Eriksen, J., Gether, Ulrik & Jørgensen, T. N., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, p. 23004-23019 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The second sodium site in the dopamine transporter controls cation permeability and is regulated by chloride
Borre, L., Andreassen, T. F., Shi, L., Weinstein, H. & Gether, Ulrik, 25 Jul 2014, In: The Journal of Biological Chemistry. 289, p. 25764-25773 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of zine ions in reverse transport mediated by monoamine transporters
Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In: Journal of Biological Chemistry. 277, p. 21505-21513Research output: Contribution to journal › Journal article › Research › peer-review
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The role of zinc ions in reverse transport mediated by monoamine transporters
Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In: Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.Research output: Contribution to journal › Journal article › Research › peer-review
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The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. O. D., Vinberg, Maj, Kessing, Lars Vedel & Gether, U., 1 Jan 2010, In: Psychopathology. 43, 3, p. 197-204 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of pH on ß2 adrenoceptor function
Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Gether, Ulrik, Winkel, P., Gluud, C., Wetterslev, J. & Kessing, Lars Vedel, 30 Dec 2012, In: Psychiatry Research Review. 200, 2-3, p. 354-60 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The binding sites for benztropines and dopamine in the dopamine transporter overlap
Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The N terminus of monoamine transporters is a lever required for the action of amphetamines
Sucic, S., Dallinger, S., Zdrazil, B., Weissensteiner, R., Jørgensen, T. N., Holy, M., Kudlacek, O., Seidel, S., Cha, J. H., Gether, Ulrik, Newman, A. H., Ecker, G. F., Freissmuth, M. & Sitte, H. H., 2010, In: Journal of Biological Chemistry. 285, 14, p. 10924-38 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway
Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926Research output: Contribution to journal › Journal article › Research › peer-review
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The Environment Shapes the Inner Vestibule of LeuT
Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.Research output: Contribution to journal › Journal article › Research › peer-review
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The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells
da Silva Pinheiro, P. C., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, Kenneth Lindegaard, Verhage, M., Gether, Ulrik & Sørensen, Jakob Balslev, 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32, p. 10688-700 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tandem Facial Amphiphiles for Membrane Protein Stabilization
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, Ulrik, Javitch, J. A., Erreger, K. & Galli, A., 2008, In: Molecular Pharmacology. 74, 4, p. 1101-1108 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions
Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions
Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36Research output: Contribution to journal › Journal article › Research › peer-review
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Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Rahbek-Clemmensen, T., Lycas, M. D., qrc243, qrc243, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter
Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm
Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering
Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846Research output: Contribution to journal › Journal article › Research › peer-review
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Structural biology: Antidepressants at work
Caron, M. G. & Gether, Ulrik, 21 Apr 2016, In: Nature. 532, p. 320-321 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Structural basis of organic cation transporter-3 inhibition
Khanppnavar, B., Maier, J., Herborg, Freja, Gradisch, R., Lazzarin, E., Luethi, D., Yang, J. W., Qi, C., Holy, M., Jäntsch, K., Kudlacek, O., Schicker, K., Werge, Thomas, Gether, Ulrik, Stockner, T., Korkhov, V. M. & Sitte, H. H., 2022, In: Nature Communications. 13, 1, 13 p., 6714.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
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