Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
- 2015
- Published
Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation
Rajamanickam, J., Annamalai, B., Rahbek-Clemmensen, T., Sundaramurthy, S., Gether, Ulrik, Jayanthi, L. D. & Ramamoorthy, S., 15 May 2015, In: Biochemical Journal. 468, 1, p. 177-190 14 p., BJ20140826.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering
Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional regulation of amphetamine-induced efflux by CaMKII
Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Pollak, D. D., Aug 2015, In: Amino Acids. 47, 8, p. 1659-1659 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform
Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter
Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial
Knorr, Ulla Benedichte Søsted, Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, Ulrik, Vinberg, Maj & Kessing, Lars Vedel, 11 Jan 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini
Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial
Knorr, Ulla Benedichte Søsted, Koefoed, P., Soendergaard, M. H. G., Vinberg, Maj, Gether, Ulrik, Gluud, C., Wetterslev, J., Winkel, P. & Kessing, Lars Vedel, Apr 2016, In: Acta Neuropsychiatrica. 28, 2, p. 101-109 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: Antidepressants at work
Caron, M. G. & Gether, Ulrik, 21 Apr 2016, In: Nature. 532, p. 320-321 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function
Vuorenpää, A. E., Ammendrup-Johnsen, I., Jorgensen, T. N. & Gether, Ulrik, Sep 2016, In: Neurochemistry International. 98, p. 103-114Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Environment Shapes the Inner Vestibule of LeuT
Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer
Jacobsen, S. E., Gether, Ulrik & Bräuner, Hans, 2017, In: Scientific Reports. 7, 14 p., 46355.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter Transporters: Structure, Function, and Drug Binding
Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm
Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Rahbek-Clemmensen, T., Lycas, M. D., qrc243, qrc243, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway
Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task
Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, Ulrik, Habekost, Thomas, Bundesen, C., Vangkilde, Signe, Woldbye, David Paul Drucker, Andreasen T., Jesper & Petersen, Anders, 2017, In: Psychopharmacology. 234, 5, p. 845-855Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice
Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017Research output: Other contribution › Research
- Published
Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
Jensen, Kathrine Louise, Runegaard, A. H., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Sep 2017, In: Journal of Visualized Experiments. 127, 10 p., e56093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1
Jensen, Rasmus Herlo Beenfeldt, Lund, Viktor Karlovich, Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., qrc243, qrc243, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An unsuspected role for organic cation transporter 3 in the actions of amphetamine
Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, Mia, Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H., Gether, Ulrik, Koek, W., Daws, L. C. & Sitte, H. H., 2018, In: Neuropsychopharmacology. 43, p. 2408-2417 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obituary
Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In: Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.Research output: Contribution to journal › Comment/debate › Communication
- Published
PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors
DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, Freja, Rickhag, M., Chen, H., Gether, Ulrik, Wallace, M. T. & Galli, A., 2019, In: Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice
Kønig, A. B., Ciriachi, C., Gether, Ulrik & Rickhag, Karl Mattias, 2019, In: Neuroscience. 401, p. 106-116Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task
Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, A., Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization
Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.Research output: Contribution to journal › Review › Research › peer-review
- Published
Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout
Giguère, N., Delignat-Lavaud, B., Herborg, Freja, Voisin, A., Li, Yuan, Jacquemet, V., Anand-Srivastava, M., Gether, Ulrik, Giros, B. & Trudeau, L., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol
Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets
qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges
Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, , 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor pharmacology-The next generation
Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.Research output: Contribution to journal › Editorial › Research
- Published
Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent
Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In: Neurochemistry International. 138, 9 p., 104772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter
Guthrie, D. A., Klein Herenbrink, Carmen, Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, Signe, Javitch, J. A., Grimm, J. B., Lavis, L., Gether, Ulrik & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD
Toschi, C., Hervig, M. E., Moazen, P., Parker, M. G., Dalley, J. W., Gether, Ulrik & Robbins, T. W., 2021, In: Psychopharmacology. 238, p. 2601–2615 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior
Christensen, M., Nørr, Søren Emil, Gether, Ulrik & Rickhag, Karl Mattias, 2021, In: Neuroscience. 453, p. 32-42 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation
Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
Research output: Contribution to journal › Journal article › Research › peer-review
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