Thomas Mandel Clausen

Thomas Mandel Clausen

Guest Researcher

Member of:

  • VAR2CSA team

ORCID: 0000-0001-7543-9622

Publication year:
All
1 - 28 out of 28Page size: 100
  1. 2023
  2. Published

    Identification of global inhibitors of cellular glycosylation

    Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, Clausen, Henrik & Narimatsu, Yoshiki, 2023, In: Nature Communications. 14, 1, 19 p., 948.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Noninvasive detection of any-stage cancer using free glycosaminoglycans

    Bratulic, S., Limeta, A., Dabestani, S., Birgisson, H., Enblad, G., Stålberg, K., Hesselager, G., Häggman, M., Höglund, M., Simonson, O. E., Stålberg, P., Lindman, H., Bång-Rudenstam, A., Ekstrand, M., Kumar, G., Cavarretta, I., Alfano, M., Pellegrino, F., Mandel-Clausen, T., Salanti, A. & 16 others, Maccari, F., Galeotti, F., Volpi, N., Daugaard, M., Belting, M., Lundstam, S., Stierner, U., Nyman, J., Bergman, B., Edqvist, P., Levin, M., Salonia, A., Kjölhede, H., Jonasch, E., Nielsen, J. & Gatto, F., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 50, p. e2115328119

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

    Al Nakouzi, N., Wang, C. K., Oo, H. Z., Nelepcu, I., Lallous, N., Spliid, C. B., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Clausen, T. M., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A. & 6 others, Fazli, L., Esko, J. D., Salanti, Ali, Nelson, P. S., Gleave, M. & Daugaard, M., 2022, In: Nature Communications. 13, 4760.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    Beware, commercial chondroitinases vary in activity and substrate specificity

    Spliid, C. B., Toledo, A. G., Salanti, Ali, Esko, J. D. & Clausen, Thomas Mandel, 2021, In: Glycobiology. 31, 2, p. 103-115 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

    Yuan, S., Yin, X., Meng, X., Chan, J. F. W., Ye, Z. W., Riva, L., Pache, L., Chan, C. C. Y., Lai, P. M., Chan, C. C. S., Poon, V. K. M., Lee, A. C. Y., Matsunaga, N., Pu, Y., Yuen, C. K., Cao, J., Liang, R., Tang, K., Sheng, L., Du, Y. & 25 others, Xu, W., Lau, C. Y., Sit, K. Y., Au, W. K., Wang, R., Zhang, Y. Y., Tang, Y. D., Clausen, Thomas Mandel, Pihl, J., Oh, J., Sze, K. H., Zhang, A. J., Chu, H., Kok, K. H., Wang, D., Cai, X. H., Esko, J. D., Hung, I. F. N., Li, R. A., Chen, H., Sun, H., Jin, D. Y., Sun, R., Chanda, S. K. & Yuen, K. Y., 2021, In: Nature. 593, p. 418–423

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

    Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Development of a bispecific immune engager using a recombinant malaria protein

    Nordmaj, Mie Anemone, Roberts, M. E., Sachse, E. S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare Villum, Erdogan, Sayit Mahmut, Choudhary, Swati, Gustavsson, Tobias, Ørum-madsen, M. S., Moskalev, I., Tian, W., Yang, Zhang, Clausen, Thomas Mandel, Theander, Thor Grundtvig, Daugaard, M., Nielsen, Morten Agertoug & Salanti, Ali, 2021, In: Cell Death & Disease. 12, 4, 11 p., 353.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

    Karlsson, R., Chopra, P., Joshi, A., Yang, Zhang, Vakhrushev, Sergey, Clausen, Thomas Mandel, Painter, C. D., Szekeres, G. P., Chen, Yen-Hsi, Sandoval, D. R., Hansen, Lars, Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, Jeremy Ewan, Clausen, Henrik, Boons, G. J. & Miller, Rebecca Louise, 2021, In: Science Advances. 7, 52, eabl6026.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

    Weiss, R. J., Spahn, P. N., Chiang, A. W. T., Liu, Q., Li, J., Hamill, K. M., Rother, S., Clausen, Thomas Mandel, Hoeksema, M. A., Timm, B. M., Godula, K., Glass, C. K., Tor, Y., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2021, In: Nature Chemical Biology. 17, p. 684–692

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Oncofetal chondroitin sulfate is a highly expressed therapeutic target in non-small cell lung cancer

    Oo, H. Z., Lohinai, Z., Khazamipour, N., Lo, J., Kumar, G., Pihl, J., Adomat, H., Nabavi, N., Behmanesh, H., Zhai, B., Dagil, R., Choudhary, S., Gustavsson, T., Clausen, T. M., Esko, J. D., Allen, J. W., Thompson, M. A., Tran, N. L., Moldvay, J., Dome, B. & 4 others, Salanti, Ali, Al-Nakouzi, N., Weiss, G. J. & Daugaard, M., 2021, In: Cancers. 13, 17, 16 p., 4489.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

    Spliid, C. B., Toledo, A. G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, Tobias, Choudhary, Swati, Saldanha, A. L., Vogelsang, R. P., Gögenur, Ismail, Theander, Thor Grundtvig, Leach, F. E., Amster, I. J., Esko, J. D., Salanti, Ali & Clausen, Thomas Mandel, 2021, In: The Journal of Biological Chemistry. 297, 6, 15 p., 101391.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2020
  16. Published

    A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

    Clausen, Thomas Mandel, Kumar, G., Ibsen, E. K., Ørum-Madsen, M. S., Hurtado-Coll, A., Gustavsson, Tobias, Agerbæk, Mette Ørskov, Gatto, F., Todenhöfer, T., Basso, U., Knowles, M. A., Sanchez-Carbayo, M., Salanti, Ali, Black, P. C. & Daugaard, M., 2020, In: Cell Death Discovery. 6, 65.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer

    Toledo, A. G., Pihl, J., Spliid, C. B., Persson, A., Nilsson, J., Pereira, M. A., Gustavsson, Tobias, Choudhary, Swati, Zarni Oo, H., Black, P. C., Daugaard, M., Esko, J. D., Larson, G., Salanti, Ali & Clausen, Thomas Mandel, 2020, In: Glycobiology. 30, 12, p. 989-1002 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

    Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., Yang, Z., Torres, J. L., Golden, G. J., Bartels, P. L., Porell, R. N., Garretson, A. F., Laubach, L., Feldman, J. & 16 others, Yin, X., Pu, Y., Hauser, B. M., Caradonna, T. M., Kellman, B. P., Martino, C., Gordts, P. L. S. M., Chanda, S. K., Schmidt, A. G., Godula, K., Leibel, S. L., Jose, J., Corbett, K. D., Ward, A. B., Carlin, A. F. & Esko, J. D., 2020, In: Cell. 183, 4, p. 1043-1057.e15

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The role of proteoglycans in cancer metastasis and circulating tumor cell analysis

    Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, Caroline Bang, Spliid, C. B., Sand, Nicolai Tue, Clausen, Thomas Mandel, Salanti, Ali & Agerbæk, Mette Ørskov, 2020, In: Frontiers in Cell and Developmental Biology. 8, 27 p., 749.

    Research output: Contribution to journal › Review › Research › peer-review

  20. 2019
  21. Published

    Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

    Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, Hamerlik, P., Salanti, Ali & Agerbæk, Mette Ørskov, 2019, In: Cells. 8, 9, 21 p., 998.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2018
  23. Published

    The GAGOme: a cell-based library of displayed glycosaminoglycans

    Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas Mandel, Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, Tobias, Salanti, Ali, Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, Eric Paul, Mao, Y., Clausen, Henrik & Yang, Zhang, 2018, In: Nature Methods. 15, 11, p. 881-888

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

    Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Virus-like particle display of HER2 induces potent anti-cancer responses

    Palladini, A., Thrane, Susan, Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, Thomas Mandel, Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Lollini, P., Nanni, P. & Sander, Adam F. , 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2017
  27. Published

    An oncofetal glycosaminoglycan modification provides therapeutic access to Cisplatin-resistant bladder cancer

    Seiler, R., Oo, H. Z., Tortora, D., Clausen, T. M., Wang, C. K., Kumar, G., Ayres Pereira, M., Ørum-Madsen, M. S., Agerbæk, M. Ø., Gustavsson, T., Nordmaj, M. A., Rich, J. R., Lallous, N., Fazli, L., Lee, S., Douglas, J., Todenhöfer, T., Esfandnia, S., Battsogt, D., Babcook, J. S. & 10 others, Al Nakouzi, N., Crabb, S. J., Moskalev, I., Kiss, B., Davicioni, E., Thalmann, G. N., Rennie, P. S., Black, P. C., Salanti, Ali & Daugaard, M., 2017, In: European Urology Supplements. 72, 1, p. 142-150 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

    Agerbaek, M. Ø., Bento Ayres Pereira, M. M., Clausen, T. M., Pehrson, C., Oo, H. Z., Spliid, C., Rich, J. R., Fung, V., Nkrumah, F., Neequaye, J., Biggar, R. J., Reynolds, S. J., Tosato, G., Pullarkat, S. T., Ayers, L. W., Theander, T. G., Daugaard, M., Bhatia, K., Nielsen, M. A., Mbulaiteye, S. M. & 1 others, Salanti, Ali, 2017, In: International Journal of Cancer. 140, 7, p. 1597–1608 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2016
  30. Published

    Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library

    Sugiura, N., Clausen, Thomas Mandel, Shioiri, T., Gustavsson, Tobias, Watanabe, H. & Salanti, Ali, Dec 2016, In: Glycoconjugate Journal. 33, 6, p. 985-994 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

    Clausen, Thomas Mandel, Bento Ayres Pereira, M. M., Al Nakouzi, N., Oo, H. Z., Agerbæk, Mette Ørskov, Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, Peter Johannes, Theander, Thor Grundtvig, Sorensen, P. H., Daugaard, M. & Salanti, Ali, Dec 2016, In: Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1

    Ayres Pereira, M., Clausen, Thomas Mandel, Pehrson, Caroline, Mao, Y., Resende, M., Daugaard, M., Riis Kristensen, A., Spliid, C. B., Mathiesen, Line, Knudsen, Lisbeth E., Damm, Peter, Theander, Thor Grundtvig, R Hansson, S., Nielsen, Morten Agertoug & Salanti, Ali, Aug 2016, In: P L o S Pathogens. 12, 8, 26 p., e1005831.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting

    Clausen, Thomas Mandel, Ayres Pereira, M., Oo, H. Z., Resende, M., Gustavsson, Tobias, Mao, Y., Sugiura, N., Liew, J., Fazli, L., Theander, Thor Grundtvig, Daugaard, M. & Salanti, Ali, Jul 2016, In: Sensing and Bio-Sensing Research. 9, p. 23-30 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2015
  35. Published

    Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

    Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, Thrane, Susan, Holst, Peter Johannes, Meng, L., Favero, F., Weiss, G. J., Nielsen, Morten Agertoug, Freeth, J., Nielsen, T. O., Zaia, J., Tran, N. L., Trent, J., Babcook, J. S., Theander, Thor Grundtvig, Sorensen, P. H. & Daugaard, M., 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2014
  37. Published

    Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes

    Beaudet, J. M., Mansur, L., Joo, E. J., Kamhi, E., Yang, B., Clausen, Thomas Mandel, Salanti, Ali, Zhang, F. & Linhardt, R. J., Feb 2014, In: Glycoconjugate Journal. 31, 2, p. 109-16 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2012
  39. Published

    Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

    Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 35054027