Thomas Mandel Clausen

Thomas Mandel Clausen

    Member of:

    • VAR2CSA team

    ORCID: 0000-0001-7543-9622

    Publication year:
    All
    1 - 28 out of 28Page size: 100
    1. 2023
    2. Published

      Identification of global inhibitors of cellular glycosylation

      Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, Clausen, Henrik & Narimatsu, Yoshiki, 2023, In: Nature Communications. 14, 1, 19 p., 948.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2022
    4. Published

      Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

      Al Nakouzi, N., Wang, C. K., Oo, H. Z., Nelepcu, I., Lallous, N., Spliid, C. B., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Clausen, T. M., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A. & 6 others, Fazli, L., Esko, J. D., Salanti, Ali, Nelson, P. S., Gleave, M. & Daugaard, M., 2022, In: Nature Communications. 13, 4760.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Noninvasive detection of any-stage cancer using free glycosaminoglycans

      Bratulic, S., Limeta, A., Dabestani, S., Birgisson, H., Enblad, G., Stålberg, K., Hesselager, G., Häggman, M., Höglund, M., Simonson, O. E., Stålberg, P., Lindman, H., Bång-Rudenstam, A., Ekstrand, M., Kumar, G., Cavarretta, I., Alfano, M., Pellegrino, F., Mandel-Clausen, T., Salanti, A. & 16 others, Maccari, F., Galeotti, F., Volpi, N., Daugaard, M., Belting, M., Lundstam, S., Stierner, U., Nyman, J., Bergman, B., Edqvist, P., Levin, M., Salonia, A., Kjölhede, H., Jonasch, E., Nielsen, J. & Gatto, F., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 50, p. e2115328119

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2021
    7. Published

      Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

      Karlsson, R., Chopra, P., Joshi, A., Yang, Zhang, Vakhrushev, Sergey, Clausen, Thomas Mandel, Painter, C. D., Szekeres, G. P., Chen, Yen-Hsi, Sandoval, D. R., Hansen, Lars, Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, Jeremy Ewan, Clausen, Henrik, Boons, G. J. & Miller, Rebecca Louise, 2021, In: Science Advances. 7, 52, eabl6026.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Development of a bispecific immune engager using a recombinant malaria protein

      Nordmaj, Mie Anemone, Roberts, M. E., Sachse, E. S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare Villum, Erdogan, Sayit Mahmut, Choudhary, Swati, Gustavsson, Tobias, Ørum-madsen, M. S., Moskalev, I., Tian, W., Yang, Zhang, Clausen, Thomas Mandel, Theander, Thor Grundtvig, Daugaard, M., Nielsen, Morten Agertoug & Salanti, Ali, 2021, In: Cell Death & Disease. 12, 4, 11 p., 353.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Oncofetal chondroitin sulfate is a highly expressed therapeutic target in non-small cell lung cancer

      Oo, H. Z., Lohinai, Z., Khazamipour, N., Lo, J., Kumar, G., Pihl, J., Adomat, H., Nabavi, N., Behmanesh, H., Zhai, B., Dagil, R., Choudhary, S., Gustavsson, T., Clausen, T. M., Esko, J. D., Allen, J. W., Thompson, M. A., Tran, N. L., Moldvay, J., Dome, B. & 4 others, Salanti, Ali, Al-Nakouzi, N., Weiss, G. J. & Daugaard, M., 2021, In: Cancers. 13, 17, 16 p., 4489.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Beware, commercial chondroitinases vary in activity and substrate specificity

      Spliid, C. B., Toledo, A. G., Salanti, Ali, Esko, J. D. & Clausen, Thomas Mandel, 2021, In: Glycobiology. 31, 2, p. 103-115 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

      Spliid, C. B., Toledo, A. G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, Tobias, Choudhary, Swati, Saldanha, A. L., Vogelsang, R. P., Gögenur, Ismail, Theander, Thor Grundtvig, Leach, F. E., Amster, I. J., Esko, J. D., Salanti, Ali & Clausen, Thomas Mandel, 2021, In: The Journal of Biological Chemistry. 297, 6, 15 p., 101391.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

      Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

      Weiss, R. J., Spahn, P. N., Chiang, A. W. T., Liu, Q., Li, J., Hamill, K. M., Rother, S., Clausen, Thomas Mandel, Hoeksema, M. A., Timm, B. M., Godula, K., Glass, C. K., Tor, Y., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2021, In: Nature Chemical Biology. 17, p. 684–692

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

      Yuan, S., Yin, X., Meng, X., Chan, J. F. W., Ye, Z. W., Riva, L., Pache, L., Chan, C. C. Y., Lai, P. M., Chan, C. C. S., Poon, V. K. M., Lee, A. C. Y., Matsunaga, N., Pu, Y., Yuen, C. K., Cao, J., Liang, R., Tang, K., Sheng, L., Du, Y. & 25 others, Xu, W., Lau, C. Y., Sit, K. Y., Au, W. K., Wang, R., Zhang, Y. Y., Tang, Y. D., Clausen, Thomas Mandel, Pihl, J., Oh, J., Sze, K. H., Zhang, A. J., Chu, H., Kok, K. H., Wang, D., Cai, X. H., Esko, J. D., Hung, I. F. N., Li, R. A., Chen, H., Sun, H., Jin, D. Y., Sun, R., Chanda, S. K. & Yuen, K. Y., 2021, In: Nature. 593, p. 418–423

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2020
    16. Published

      The role of proteoglycans in cancer metastasis and circulating tumor cell analysis

      Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, Caroline Bang, Spliid, C. B., Sand, Nicolai Tue, Clausen, Thomas Mandel, Salanti, Ali & Agerbæk, Mette Ørskov, 2020, In: Frontiers in Cell and Developmental Biology. 8, 27 p., 749.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

      Clausen, Thomas Mandel, Kumar, G., Ibsen, E. K., Ørum-Madsen, M. S., Hurtado-Coll, A., Gustavsson, Tobias, Agerbæk, Mette Ørskov, Gatto, F., Todenhöfer, T., Basso, U., Knowles, M. A., Sanchez-Carbayo, M., Salanti, Ali, Black, P. C. & Daugaard, M., 2020, In: Cell Death Discovery. 6, 65.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

      Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., Yang, Z., Torres, J. L., Golden, G. J., Bartels, P. L., Porell, R. N., Garretson, A. F., Laubach, L., Feldman, J. & 16 others, Yin, X., Pu, Y., Hauser, B. M., Caradonna, T. M., Kellman, B. P., Martino, C., Gordts, P. L. S. M., Chanda, S. K., Schmidt, A. G., Godula, K., Leibel, S. L., Jose, J., Corbett, K. D., Ward, A. B., Carlin, A. F. & Esko, J. D., 2020, In: Cell. 183, 4, p. 1043-1057.e15

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer

      Toledo, A. G., Pihl, J., Spliid, C. B., Persson, A., Nilsson, J., Pereira, M. A., Gustavsson, Tobias, Choudhary, Swati, Zarni Oo, H., Black, P. C., Daugaard, M., Esko, J. D., Larson, G., Salanti, Ali & Clausen, Thomas Mandel, 2020, In: Glycobiology. 30, 12, p. 989-1002 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2019
    21. Published

      Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

      Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, Hamerlik, P., Salanti, Ali & Agerbæk, Mette Ørskov, 2019, In: Cells. 8, 9, 21 p., 998.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2018
    23. Published

      The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

      Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The GAGOme: a cell-based library of displayed glycosaminoglycans

      Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas Mandel, Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, Tobias, Salanti, Ali, Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, Eric Paul, Mao, Y., Clausen, Henrik & Yang, Zhang, 2018, In: Nature Methods. 15, 11, p. 881-888

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Virus-like particle display of HER2 induces potent anti-cancer responses

      Palladini, A., Thrane, Susan, Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, Thomas Mandel, Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Lollini, P., Nanni, P. & Sander, Adam F. , 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2017
    27. Published

      Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

      Agerbaek, M. Ø., Bento Ayres Pereira, M. M., Clausen, T. M., Pehrson, C., Oo, H. Z., Spliid, C., Rich, J. R., Fung, V., Nkrumah, F., Neequaye, J., Biggar, R. J., Reynolds, S. J., Tosato, G., Pullarkat, S. T., Ayers, L. W., Theander, T. G., Daugaard, M., Bhatia, K., Nielsen, M. A., Mbulaiteye, S. M. & 1 others, Salanti, Ali, 2017, In: International Journal of Cancer. 140, 7, p. 1597–1608 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      An oncofetal glycosaminoglycan modification provides therapeutic access to Cisplatin-resistant bladder cancer

      Seiler, R., Oo, H. Z., Tortora, D., Clausen, T. M., Wang, C. K., Kumar, G., Ayres Pereira, M., Ørum-Madsen, M. S., Agerbæk, M. Ø., Gustavsson, T., Nordmaj, M. A., Rich, J. R., Lallous, N., Fazli, L., Lee, S., Douglas, J., Todenhöfer, T., Esfandnia, S., Battsogt, D., Babcook, J. S. & 10 others, Al Nakouzi, N., Crabb, S. J., Moskalev, I., Kiss, B., Davicioni, E., Thalmann, G. N., Rennie, P. S., Black, P. C., Salanti, Ali & Daugaard, M., 2017, In: European Urology Supplements. 72, 1, p. 142-150 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2016
    30. Published

      Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1

      Ayres Pereira, M., Clausen, Thomas Mandel, Pehrson, Caroline, Mao, Y., Resende, M., Daugaard, M., Riis Kristensen, A., Spliid, C. B., Mathiesen, Line, Knudsen, Lisbeth E., Damm, Peter, Theander, Thor Grundtvig, R Hansson, S., Nielsen, Morten Agertoug & Salanti, Ali, Aug 2016, In: P L o S Pathogens. 12, 8, 26 p., e1005831.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

      Clausen, Thomas Mandel, Bento Ayres Pereira, M. M., Al Nakouzi, N., Oo, H. Z., Agerbæk, Mette Ørskov, Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, Peter Johannes, Theander, Thor Grundtvig, Sorensen, P. H., Daugaard, M. & Salanti, Ali, Dec 2016, In: Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting

      Clausen, Thomas Mandel, Ayres Pereira, M., Oo, H. Z., Resende, M., Gustavsson, Tobias, Mao, Y., Sugiura, N., Liew, J., Fazli, L., Theander, Thor Grundtvig, Daugaard, M. & Salanti, Ali, Jul 2016, In: Sensing and Bio-Sensing Research. 9, p. 23-30 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library

      Sugiura, N., Clausen, Thomas Mandel, Shioiri, T., Gustavsson, Tobias, Watanabe, H. & Salanti, Ali, Dec 2016, In: Glycoconjugate Journal. 33, 6, p. 985-994 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. 2015
    35. Published

      Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

      Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, Thrane, Susan, Holst, Peter Johannes, Meng, L., Favero, F., Weiss, G. J., Nielsen, Morten Agertoug, Freeth, J., Nielsen, T. O., Zaia, J., Tran, N. L., Trent, J., Babcook, J. S., Theander, Thor Grundtvig, Sorensen, P. H. & Daugaard, M., 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2014
    37. Published

      Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes

      Beaudet, J. M., Mansur, L., Joo, E. J., Kamhi, E., Yang, B., Clausen, Thomas Mandel, Salanti, Ali, Zhang, F. & Linhardt, R. J., Feb 2014, In: Glycoconjugate Journal. 31, 2, p. 109-16 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. 2012
    39. Published

      Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

      Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 35054027