Rasmus Prætorius Clausen

Rasmus Prætorius Clausen

Professor

ORCID: 0000-0001-9466-9431

Publication year:
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1 - 25 out of 136Page size: 25
  1. 2023
  2. Published

    In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

    Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, Lennart, Clausen, Rasmus Prætorius & Wünsch, B., 2023, In: Biological Chemistry. 404, 4, p. 255-265

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

    Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, Lennart, Hansen, K. B. & Clausen, Rasmus Prætorius, 2022, In: Journal of Medicinal Chemistry. 65, 1, p. 734-746

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

    Zhao, F., Mazis, G., Yi, F., Lotti, J. S., Layeux, M. S., Schultz, E. P., Bunch, Lennart, Hansen, K. B. & Clausen, Rasmus Prætorius, 2022, In: Frontiers in Chemistry. 10, 13 p., 1008233.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research

    Qiu, H., Clausen, Rasmus Prætorius, He, Y. & Zhu, H., 2021, In: Current Topics in Medicinal Chemistry. 21, 28, p. 2593-2608

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

    Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model

    Liu, J., Shelkar, G. P., Sarode, L. P., Gawande, D. Y., Zhao, F., Clausen, Rasmus Prætorius, Ugale, R. R. & Dravid, S. M., 2021, In: Neurobiology of Disease. 150, 10 p., 105254.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes

    El-Chami, C., Foster, A. R., Johnson, C., Clausen, Rasmus Prætorius, Cornwell, P., Haslam, I. S., Steward, M. C., Watson, R. E. B., Young, H. S. & O'Neill, C. A., 2021, In: British Journal of Dermatology. 184, 3, p. 482-494

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists

    Maolanon, A., Papangelis, A., Kawiecki, D., Mou, T. C., Syrenne, J. T., Yi, F., Hansen, K. B. & Clausen, Rasmus Prætorius, 2021, In: European Journal of Medicinal Chemistry. 212, 17 p., 113099.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2020
  14. Published

    Improved synthetic route for the GluN2-specific NMDA receptor glycine site agonist AICP

    Zhao, F., Rouzbeh, N., Hansen, K. B. & Clausen, Rasmus Prætorius, 31 Mar 2020, In: Tetrahedron Letters. 61, 12, 4 p., 151653.

    Research output: Contribution to journal › Letter › Research › peer-review

  15. Published

    Compounds for the treatment of acute brain injury

    Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041

    Research output: Patent

  16. Published

    Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

    Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2019
  18. Published

    Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors

    Liu, J., Shelkar, G. P., Zhao, F., Clausen, Rasmus Prætorius & Dravid, S. M., 2019, In: Molecular Pharmacology. 96, p. 193-203

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

    Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2018
  21. Published

    Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius, Jørgensen, E. B., Christoffersen, C. T. & Juhl, K., 2018, In: MedChemComm. 9, 5, p. 893-896 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

    Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2017
  24. Published

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)

    Jørgensen, L., Al-Khawaja, A., Kickinger, S., Vogensen, S. B., Skovgaard-Petersen, J., Rosenthal, E., Borkar, N., Löffler, R., Madsen, K. K., Bräuner, Hans, Schousboe, Arne, Ecker, G. F., Wellendorph, Petrine & Clausen, Rasmus Prætorius, 9 Oct 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8834-8846

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites

    Maolanon, A. R., Risgaard, R., Wang, S. Y., Snoep, Y., Papangelis, A., Yi, F., Holley, D., Barslund, A. F., Svenstrup, N., Hansen, K. B. & Clausen, Rasmus Prætorius, 16 Aug 2017, In: ACS Chemical Neuroscience. 8, 8, p. 1681-1687 7 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  26. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

    Jessen, M., Frederiksen, K., Yi, F., Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Kilburn, J. P. & Damholt, A., Aug 2017, In: Molecular Pharmacology. 92, 2, p. 151-161 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

    Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  28. Published

    Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

    Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  29. Published

    Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements

    Damgaard, M., Haugaard, A. S., Kickinger, S., Al-Khawaja, A., Lie, M. E. K., Ecker, G. F., Clausen, Rasmus Prætorius & Frølund, Bente, 2017, Advances in Neurobiology. Springer, Vol. 16. p. 315-332 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  30. Published

    Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius & Juhl, K., 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 4, p. 425-428 4 p., st-2016-b0535-l.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius & Juhl, K., 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 2, p. 231-234 4 p., st-2016-b0534-l.

    Research output: Contribution to journal › Review › Research › peer-review

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ID: 1302218