Leila Lo Leggio

Leila Lo Leggio

Professor

ORCID: 0000-0002-5135-0882

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  1. Published

    Xylanase-oligosaccharide interactions studied by a competitive enzyme assay

    Lo Leggio, Leila & Pickersgill, R. W., 1999, In: Enzyme and Microbial Technology. 25, p. 701-709

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    X-Ray Crystallographic Study of Xylopentaose Binding to Pseudomonas fluorescens Xylanase A.

    Lo Leggio, Leila, Jenkins, J., Harris, G. W. & Pickersgill, R. W., 2000, In: Proteins - Structure Function and Bioinformatics. 41, p. 362-373

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase LsAA9A at low pH

    Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tandrup, T. & Lo Leggio, Leila, 2017, In: Carbohydrate Research. 448, p. 187-190 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases

    Frandsen, K. E. H., Simmons, T. J., Dupree, P., Poulsen, J-C. N., Hemsworth, G. R., Ciano, L., Johnston, E. M., Tovborg, M., Johansen, K. S., von Freiesleben, P., Marmuse, L., Fort, S., Cottaz, S., Driguez, H., Henrissat, B., Lenfant, N., Tuna, F., Baldansuren, A., Davies, G. J., Lo Leggio, L. & 1 others, Walton, P. H., 2016, In: Nature Chemical Biology. 12, 4, p. 298-303 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The Structure of Endo-ß-1,4-galactanase from Bacillius licheniformis in Complex with Two Oligosaccharide Products

    Ryttersgaard, C., Le Nours, J., Lo Leggio, Leila, Thea Jørgensen, C., Lehmann Hylling Christensen, L., Bjørnvad, M. & Larsen, Sine, 2004, In: Journal of Molecular Biology. 341, p. 107-117

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The Structure and Specificity of Escherichia coli Maltose Acetyltransferase Give New Insight into the LacA Family of Acyltransferases

    Lo Leggio, Leila, Dal Degan, F., Poulsen, P., Møller Andersen, S. & Larsen, Sine, 2003, In: Biochemistry. 42, p. 5225-5235

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The Structure and Characterization of a Modular Endo-ß-1,4-mannanase from Cellulomonas fimi

    Le Nours, J., Anderson, L., Stoll, D., Stålbrand, H. & Lo Leggio, Leila, 2005, In: Biochemistry. 44, p. 12700-12708

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The 1.62 Å structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5

    Lo Leggio, Leila & Larsen, Sine, 2002, In: FEBS Letters. 523, p. 103-108

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)

    Kryshtafovych, A., Albrecht, R., Basle, A., Bule, P., Caputo, A. T., Carvalho, A. L., Chao, K. L., Diskin, R., Fidelis, K., Fontes, C. M. G. A., Fredslund, F., Gilbert, H. J., Goulding, C. W., Hartmann, M. D., Hayes, C. S., Herzberg, O., Hill, J. C., Joachimiak, A., Kohring, G-W., Koning, R. I. & 19 others, Lo Leggio, Leila, Mangiagalli, M., Michalska, K., Moult, J., Najmudin, S., Nardini, M., Nardone, V., Ndeh, D., Nguyen, T., Pintacuda, G., Postel, S., van Raaij, M. J., Roversi, P., Shimon, A., Singh, A. K., Sundberg, E. J., Tars, K., Zitzmann, N. & Schwede, T., 2018, In: Proteins: Structure, Function, and Bioinformatics. 86, S1, p. 27-50 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A

    Lo Leggio, Leila, Kalogiannis, S., Eckert, K., Teixeira, S. C. M., Mahalingeswara, K. B., Andrei, C., Pickersgill, R. W. & Larsen, Sine, 2001, In: FEBS Letters. 509, p. 303-308

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis

    Theilmann, M. C., Fredslund, F., Svensson, B., Lo Leggio, Leila & Abou Hachem, M., 2019, In: Journal of Biological Chemistry. 294, 31, p. 11701-11711 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds

    Arnling Bååth, J., Mazurkewich, S., Poulsen, Jens-Christian Navarro, Olsson, L., Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 16, p. 6635-6644 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Structures of two fungal ß-galactanases: Searching for the basis for temperature and pH optimum

    Le Nours, J., Ryttersgaard, C., Lo Leggio, Leila, Østergaard, P. R., Vedel Borchert, T., Lehmann Hylling Christensen, L. & Larsen, Sine, 2003, In: Protein Science. 12, p. 1195-1204

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Structure-based engineering of glucose specificity in a family 10 xylanase from Streptomyces olivaceoviridis E-86

    Ichinose, H., Diertavitian, S. W. S., Fujimoto, Z., Kuno, A., Lo Leggio, Leila & Kaneko, S., 2012, In: Process Biochemistry. 47, 3, p. 358-365 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Structure, function, and protein engineering of GH53 β-1,4-galactanases

    Muderspach, Sebastian Jannick, Jensen, K., Krogh, K. B. R. M. & Lo Leggio, Leila, 2023, Glycoside Hydrolases: Biochemistry, Biophysics, and Biotechnology. Elsevier, p. 295-322 28 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  16. Published

    Structure of the conserved domain of ANAC, a member of the NAC family of transcription factors

    Ernst, H. A., Olsen, A. N., Skriver, Karen, Larsen, Sine & Lo Leggio, Leila, 2004, In: EMBO Reports. 5, p. 297-303

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31

    Ernst, H. A., Lo Leggio, Leila, Willemoës, Martin, Leonard, G. A., Blum, P. & Larsen, Sine, 2006, In: Journal of Molecular Biology. 358, 4, p. 1106-24

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Structure of dimeric, recombinant Sulfolobus solfataricus phosphoribosyl diphosphate synthase: a bent dimer defining the adenine specificity of the substrate ATP

    Andersen, R. W., Lo Leggio, Leila, Hove-Jensen, B. & Kadziola, Anders, 2015, In: Extremophiles. 19, 2, p. 407-415 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant

    Lo Leggio, Leila, Weihe, C. D., Poulsen, Jens-Christian Navarro, Sweeney, M., Rasmussen, F., Lin, J., De Maria, L. & Wogulis, M., 2018, In: Carbohydrate Research. 469, p. 55-59 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney

    Fredslund, F., Borchert, M. S., Poulsen, Jens-Christian Navarro, Mortensen, S. B., Perner, M., Streit, W. R. & Lo Leggio, Leila, 2018, In: Enzyme and Microbial Technology. 114, p. 48-54 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Structure of a fungal dimeric a-type carbonic anhydrase

    Cuesta Seijo, J. A., Borchert, M. S., Poulsen, Jens-Christian Navarro, Schnorr, K. M., Mortensen, S. B. & Lo Leggio, Leila, 2011, In: F E B S Letters. 585, p. 1042-1048

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Structure of Aspergillus aculeatus β-1,4-galactanase in complex with galactobiose

    Torpenholt, S., Poulsen, Jens-Christian Navarro, Muderspach, Sebastian Jannick, De Maria, L. & Lo Leggio, Leila, 2019, In: Acta Crystallographica Section F: Structural Biology Communications. 75, 6, p. 399-404 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Structure and specificity of polysaccharidases belonging to clan GH-A

    Lo Leggio, Leila, Le Nours, J., Ryttersgaard, C., Kaneko, S., Fujimoto, Z., Kuno, A., Diertavitian, S. & Larsen, Sine, 2004, Biotechnology of Lignocellulose Degradation and Biomass Utilization. Ohmiya, K., Sakka, K., Karita, S., Kimura, T., Sakka, M. & Onishi, Y. (eds.). UNI Publishers Co., Ltd, p. 27-33

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

  24. Published

    Structure and function of enzymes in biomass degradation

    Welner, D. H., Jensen, M. H., McFarland, K. C., Poulsen, Jens-Christian Navarro, Otten, H., Salbo, R., Christensen, U., Harris, P., Larsen, Sine, Borchert, T., Christensen, L. L. H., Friis, E. P. & Lo Leggio, Leila, 2008, Biotechnology of lignocellulose degradation and Biomass Utilization - Mie Bioforum 2008. p. 349-355

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

  25. Published

    Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

    Lo Leggio, Leila, Simmons, T. J., Poulsen, Jens-Christian Navarro, Frandsen, Kristian Erik Høpfner, Hemsworth, G. R., Stringer, M. A., von Freiesleben, P., Tovborg, M., Johansen, Katja Salomon, De Maria, L., Harris, P. V., Soong, C., Dupree, P., Tryfona, T., Lenfant, N., Henrissat, B., Davies, G. J. & Walton, P. H., 2015, In: Nature Communications. 6, 9 p., 5961.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity

    Jensen, P. F., Kadziola, Anders, Comamala, G., Segura, D. R., Anderson, L., Poulsen, Jens-Christian Navarro, Rasmussen, K. K., Agarwal, S., Sainathan, R. K., Monrad, R. N., Svendsen, A., Nielsen, J. E., Lo Leggio, Leila & Rand, Kasper Dyrberg, 2019, In: Cell Chemical Biology. 26, 2, p. 191-202.e1-e6 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Structural studies of temperate phage genetic switches

    Varming, A., Rasmussen, K. K., Kilstrup, M., Hammer, K., Ringkjøbing Jensen, M., Ingmer, Hanne & Lo Leggio, Leila, 18 Aug 2019, p. e105-e105. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research

  28. Published

    Structural diversity of lytic polysaccharide monooxygenases

    Lo Leggio, Leila, Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tovborg, M., De Maria, L. & Johansen, K. S., 2015, Proceedings of "Mie Bioforum 2014 - Lignocellulose Degradation and Biorefinery". Sakka, K., Kimura, T., Tamaru, Y., Karita, S. & Sakka, M. (eds.). UNI Publishers Co., Ltd, p. 148-156 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  29. Published

    Structural characterization of the thermostable Bradyrhizobium japonicum D-sorbitol dehydrogenase

    Fredslund, F., Otten, H., Gemperlein, S., Poulsen, Jens-Christian Navarro, Carius, Y., Kohring, G. & Lo Leggio, Leila, 2016, In: Acta Crystallographica Section F. 72, 11, p. 846-852 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Structural basis of the bacteriophage TP901‐1 CI repressor dimerization and interaction with DNA

    Rasmussen, K. K., Varming, A. K., Schmidt, S. N., Frandsen, Kristian Erik Høpfner, Thulstrup, Peter Waaben, Jensen, M. R. & Lo Leggio, Leila, 2018, In: F E B S Letters. 592, 10, p. 1738-1750 13 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  31. Published

    Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans

    Mazurkewich, S., Scholzen, K. C., Brusch, R. H., Poulsen, Jens-Christian Navarro, Theibich, Yusuf, Hüttner, S., Olsson, L., Larsbrink, J. & Lo Leggio, Leila, 2023, In: Acta crystallographica. Section D, Structural biology. 79, 6, p. 545-555 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates

    Simmons, T. J., Frandsen, Kristian Erik Høpfner, Ciano, L., Tryfona, T., Lenfant, N., Poulsen, Jens-Christian Navarro, Wilson, L. F. L., Tandrup, T., Tovborg, M., Schnorr, K., Johansen, Katja Salomon, Henrissat, B., Walton, P. H., Lo Leggio, Leila & Dupree, P., 2017, In: Nature Communications. 8, 12 p., 1064.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1

    Rasmussen, K. K., Frandsen, Kristian Erik Høpfner, Boeri Erba, E., Pedersen, M., Varming, A. K., Hammer, K., Kilstrup, M., Thulstrup, Peter Waaben, Blackledge, M., Jensen, M. R. & Lo Leggio, Leila, 2016, In: Scientific Reports. 6, 12 p., 29574.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components

    Mazurkewich, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 52, p. 19978-19987

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus

    Jensen, M. H., Otten, H., Christensen, U., Borchert, T. V., Christensen, L. L. H., Larsen, Sine & Lo Leggio, Leila, 2010, In: Journal of Molecular Biology. 404, p. 100-111

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii

    Krska, D., Mazurkewich, S., Brown, H. A., Theibich, Yusuf, Poulsen, Jens-Christian Navarro, Morris, A. L., Koropatkin, N. M., Lo Leggio, Leila & Larsbrink, J., 13 Jul 2021, In: Biochemistry. 60, 27, p. 2206-2220 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family

    Harris, P. V., Welner, D. H., McFarland, K., Re, E., Poulsen, Jens-Christian Navarro, Brown, K., Salbo, R., Ding, H., Vlasenko, E., Marino, S., Xu, F., Cherry, J., Larsen, Sine & Lo Leggio, Leila, 2010, In: Biochemistry. 49, p. 3305-3316

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

    Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Scission of Glucosidic Bonds by a Lentinus similis Lytic Polysaccharide Monooxygenases Is Strictly Dependent on H2O2while the Oxidation of Saccharide Products Depends on O2

    Brander, Søren, Tokin, Radina, Ipsen, J., Jensen, Poul Erik, Hernández-Rollán, C., Nørholm, M. H. H., Lo Leggio, Leila, Dupree, P. & Johansen, Katja Salomon, 2021, In: ACS Catalysis. 11, 22, p. 13848-13859

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage

    Rasmussen, K. K., Palencia, A., Varming, A. K., El-Wali, H., Erba, E. B., Blackledge, M., Hammer, K., Herrmann, T., Kilstrup, M., Lo Leggio, Leila & Jensen, M. R., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20576-20585 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator

    Pedersen, M., Neergaard, J. T., Cassias, J., Rasmussen, K. K., Lo Leggio, Leila, Sneppen, Kim, Hammer, K. & Kilstrup, M., 26 May 2020, In: Scientific Reports. 10, 1, 13 p., 8659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Recent insights into lytic polysaccharide monooxygenases (LPMOs)

    Tandrup, T., Frandsen, Kristian Erik Høpfner, Johansen, Katja Salomon, Berrin, J. & Lo Leggio, Leila, 2018, In: Biochemical Society Transactions. 46, 6, p. 1431-1447 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria

    Abou Hachem, M., Andersen, J. M., Barrangou, R., Møller, M. S., Fredslund, F., Majumder, A., Hansen, M. E., Lahtinen, S. J., Jacobsen, S., Lo Leggio, Leila, Goh, Y. J., Klaenhammer, T. R. & Svensson, B., 2013, In: Biocatalysis and Biotransformation. 31, 4, p. 226-235 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-β-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3

    Hekmat, O., Lo Leggio, Leila, Rosengren, A., Kamarauskaite, J., Kolenova, K. & Stålbrand, H., 2010, In: Biochemistry. 49, 23, p. 4884-4896 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-ß-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3

    Hekmat, O., Lo Leggio, Leila, Rosengren, A., Kamarauskaite, J., Kolenova, K. & Stålbrand, H., 2010, In: Biochemistry. 49

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 a-galactosidases

    Abou Hachem, M., Fredslund, F., Andersen, J. M., Larsen, R. J., Majumder, A., Hansen, M. E., van Zanten, G. C., Lahtinen, S. J., Barrangou, R., Klaenhammer, T., Jacobsen, S., Coutinho, P. M., Lo Leggio, Leila & Svensson, B., 2012, In: Biocatalysis and Biotransformation. 30, 3, p. 316-325 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus

    Wilkens, C., Poulsen, Jens-Christian Navarro, Ramløv, H. & Lo Leggio, Leila, 2014, In: Cryobiology. 69, 1, p. 163-168 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases

    Banerjee, S., Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Singh, R. K., Ipsen, J. O., Hernandez Rollan, Cristina, Nørholm, M. H. H., Bjerrum, Morten Jannik, Johansen, Katja Salomon & Lo Leggio, Leila, 2022, In: Biomolecules. 12, 2, 15 p., 194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Probing the structure of glucan lyases by sequence analysis, circular dichroism and proteolysis

    Ernst, H. A., Lo Leggio, Leila, Yu, S., Finnie, C., Svensson, B. & Larsen, Sine, 2005, In: Biologia. 60, Suppl. 16, p. 149-159

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Probing the determinants of the transglycosylation/hydrolysis partition in a retaining α-L-arabinofuranosidase

    Zhao, J., Tandrup, T., Bissaro, B., Barbe, S., Poulsen, Jens-Christian Navarro, André, I., Dumon, C., Lo Leggio, Leila, O'Donohue, M. J. & Fauré, R., 25 May 2021, In: New Biotechnology. 62, p. 68-78 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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