Kristian Strømgaard
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
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Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein
Zhang, H., Xiong, X., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, 7 Jun 2017, In: ChemMedChem. 12, 11, p. 830-834 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359
Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, Kasper, Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner, Hans, Gloriam, David E. & Strømgaard, Kristian, 2018, In: European Journal of Medicinal Chemistry. 156, p. 847-860Research output: Contribution to journal › Journal article › Research › peer-review
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Recent achievements in developing selective Gq inhibitors
Zhang, H., Nielsen, A. L. & Strømgaard, Kristian, 2020, In: Medicinal Research Reviews. 40, 1, p. 135-157Research output: Contribution to journal › Review › Research › peer-review
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Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors
Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner, Hans & Strømgaard, Kristian, 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors
Xiong, X., Poulsen, Mette Homann, Hussein, R. A., Nørager, N. G. & Strømgaard, Kristian, Dec 2014, In: ChemMedChem. 9, 12, p. 2661-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polyamine toxins from spiders and wasps: Polyamine toxins from spiders and wasps
Xiong, X. & Strømgaard, Kristian, 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, p. 201-214 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890
Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, Apr 2019, In: ChemMedChem. 14, 8, p. 865-870Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1
Wilbek, T. S., Skovgaard, T., Sorrell, F. J., Knapp, S., Berthelsen, J. & Strømgaard, Kristian, 2 Jan 2015, In: ChemBioChem. 16, 1, p. 59-63 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
Voss, J. H., Crüsemann, M., Bartling, Christian Reinhard Otto, Kehraus, S., Inoue, A., König, G. M., Strømgaard, Kristian & Müller, C. E., 2023, In: iScience. 26, 4, 19 p., 106492.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists
Vogensen, S. B., Strømgaard, Kristian, Shindou, H., Jaracz, S., Suehiro, M., Ishii, S., Shimizu, T. & Nakanishi, K., 13 Feb 2003, In: Journal of Medicinal Chemistry. 46, 4, p. 601-608 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport
Vistrup-Parry, M., Sneddon, W. B., Bach, S., Strømgaard, Kristian, Friedman, P. A. & Mamonova, T., 2021, In: Journal of Biological Chemistry. 296, 12 p., 100473.Research output: Contribution to journal › Journal article › Research › peer-review
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Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation
Vistrup-Parry, M., Chen, X., Johansen, T. L., Bach, S., Buch-Larsen, Sara Charlotte, Bartling, Christian Reinhard Otto, Ma, C., Clemmensen, L. S., Nielsen, Michael Lund, Zhang, M. & Strømgaard, Kristian, 2021, In: iScience. 24, 11, 103268.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein
Toto, A., Ma, S., Malagrinò, F., Visconti, L., Pagano, L., Strømgaard, Kristian & Gianni, S., 2020, In: Protein Science. 29, 10, p. 2038-2042 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand binding to the PDZ domains of postsynaptic density protein 95
Toto, A., Pedersen, S. W., Karlsson, O. A., Moran, G. E., Andersson, E., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., May 2016, In: Protein Engineering Design and Selection (Print). 29, 5, p. 169-75 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites
Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation
Sønderby, T. V., Louros, N. N., Khodaparast, L., Khodaparast, L., Madsen, D. J., Olsen, W. P., Moonen, N., Nagaraj, M., Sereikaité, Vita, Strømgaard, Kristian, Rousseau, F., Schymkowitz, J. & Otzen, D. E., 2023, In: Journal of Molecular Biology. 435, 11, 168039.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthetic and mechanistic insight into nosylation of glycine residues
Stuhr-Hansen, N., Sølling, Theis Ivan & Strømgaard, Kristian, 14 Apr 2013, In: Organic & Biomolecular Chemistry. 11, 14, p. 2288-2293 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids
Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines
Stuhr-Hansen, N., Bork, N. & Strømgaard, Kristian, 14 Aug 2014, In: Organic & Biomolecular Chemistry. 12, 30, p. 5745-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of symmetrical and non-symmetrical bivalent neurotransmitter ligands
Stuhr-Hansen, N., Andersen, J., Thygesen, Mikkel Boas & Strømgaard, Kristian, 2016, In: ChemistrySelect. 1, 3, p. 407-413 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters
Stuhr-Hansen, N., Wilbek, T. S. & Strømgaard, Kristian, 1 Aug 2013, In: European Journal of Organic Chemistry. 2013, 24, p. 5290-5294 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling
Strømgaard, Kristian, 2008, In: Carlsbergfondet. Aarsskrift. p. 42-47Research output: Contribution to journal › Journal article › Communication
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Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist
Strømgaard, Kristian, Mellor, I. R., Andersen, K., Neagoe, I., Pluteanu, F., Usherwood, P. N. R., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 22 Apr 2002, In: Bioorganic & Medicinal Chemistry Letters. 12, 8, p. 1159-1162 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins
Strømgaard, Kristian & Mellor, I., Sep 2004, In: Medicinal Research Reviews. 24, 5, p. 589-620 32 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation
Strømgaard, Kristian, Saito, D. R., Shindou, H., Ishii, S., Shimizu, T. & Nakanishi, K., 29 Aug 2002, In: Journal of Medicinal Chemistry. 45, 18, p. 4038-4046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polyamine toxins: development of selective ligands for ionotropic receptors
Strømgaard, Kristian, Jensen, L. S. & Vogensen, S. B., 1 Mar 2005, In: Toxicon. 45, 3, p. 249-254 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemistry and biology of terpene trilactones from Ginkgo biloba
Strømgaard, Kristian & Nakanishi, K., 19 Mar 2004, In: Angewandte Chemie International Edition. 43, 13, p. 1640-1658 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparation of a tritiated ginkgolide
Strømgaard, Kristian, Suehiro, M. & Nakanishi, K., 15 Nov 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 22, p. 5673-5675 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A heteromeric snake toxin and the molecular details of pain perception
Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of polyamines and polyamine toxins. An improved alkylation procedure
Strømgaard, Kristian & Andersen, T., 2004, In: Tetrahedron Letters. 45, p. 7929-7933Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical biology
Strømgaard, Kristian, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 59-74Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Fatty acid derivatives of dimeric inhibitors of PSD-95
Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735Research output: Patent
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Natural products as tools for studies of ligand-gated ion channels
Strømgaard, Kristian, 2005, In: Chemical Record. 5, 4, p. 229-239 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy
Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example
Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In: Synthesis. 6, p. 877-884 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Skræddersyede proteiner: uden naturens begrænsninger
Strømgaard, Kristian, Jensen, M. S. & Kristensen, Anders Skov, 2009, In: Lægemiddelforskning. p. 10-12Research output: Contribution to journal › Journal article › Communication
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Recent advances in the medicinal chemistry of polyamine toxins
Strømgaard, Kristian, Andersen, K., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Nov 2001, In: Mini - Reviews in Medicinal Chemistry. 1, 4, p. 317-338 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues
Strømgaard, Kristian, Brier, T. J., Andersen, K., Mellor, I. R., Saghyan, A., Tikhonov, D., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Nov 2000, In: Journal of Medicinal Chemistry. 43, 23, p. 4526-4533 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12
Strømgaard, Kristian, Bjørnsdottir, I., Andersen, K., Brierley, M. J., Rizoli, S., Eldursi, N., Mellor, I. R., Usherwood, P. N., Hansen, S. H., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Feb 2000, In: Chirality. 12, 2, p. 93-102 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Site-specific incorporation of unnatural amino acids into proteins
Strømgaard, A., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: ChemBioChem. 5, 7, p. 909-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor
Strømgaard, Kristian, Brierley, M. J., Andersen, K., Sløk, F. A., Mellor, I. R., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Dec 1999, In: Journal of Medicinal Chemistry. 42, 25, p. 5224-5234 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 20 Jan 2017, In: European Journal of Neuroscience. 45, 2, p. 238-248 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations
Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145Research output: Contribution to journal › Review › Research › peer-review
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Targeting the gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABA(B) Receptor Protein-Protein Interaction
Sereikaité, Vita, Fritzius, T., Kasaragod, V. B., Bader, N., Maric, H. M., Schindelin, H., Bettler, B. & Strømgaard, Kristian, 2019, In: Journal of Medicinal Chemistry. 62, 19, p. 8819-8830Research output: Contribution to journal › Journal article › Research › peer-review
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
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