Stephan Pless
Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
Research Focus
Using a combination of electrophysiology, synthetic amino acids, protein engineering and spectroscopic approaches, we focus on the function and pharmacology of a therapeutically relevant class of membrane proteins called ion channels. For further details see www.theplesslab.com
Selected Publications:
Heusser, S.A & Borg, C.B. (...) Pless, S.A.; “Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition”; eLife, 2022
Kschonsak, M, Chua, H.C, (...) Pless, S.A., Payandeh, J.; “Structural architecture of the human NALCN channelosome”;
Khoo, K.K. & Gallenao, I. (...) Pless, S.A.; “Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing”;
Chua, H.C. (...) Pless, S.A.; “The NALCN leak channel complex is modulated by voltage and extracellular calcium”; Science Advances, 2020
Borg, C.B., Braun, N. (...) Pless, S.A.; “Mechanism and site of action of big dynorphin on ASIC1a”; PNAS, 2020
Wulf, M. & Pless, S.A.; "High-sensitivity fluorometry to resolve ion channel conformational dynamics"; Cell Reports, 2018
Selected Grants and Prizes
2023-2027 Lundbeck Foundation Collaborative Project Grant
2020 Paul F Cranefield Award (Society of General Physiologists)
2019-2023 Lundbeck Foundation Ascending Investigator Grant
2018-2021 DFF Sapere Aude Starting Grant
2017-2020 Carlsberg Foundation Distinguished Assoc. Prof. Fellowship
2013-2018 Lundbeck Foundation Fellowship
2011-2013 Michael Smith Foundation Postdoctoral Research Fellowship
2011-2013 Banting Postdoctoral Research Fellowship
2009-2011 Heart & Stroke Foundation Postdoctoral Research Fellowship
2005-2008 University of Queensland Int. Postgraduate Scholarship
2005-2008 University of Queensland Ernest Singer Scholarship
ID: 93715174
Most downloads
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188
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Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel
Research output: Contribution to journal › Journal article › Research › peer-review
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178
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High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
131
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A selectivity filter at the intracellular end of the acid-sensing ion channel pore
Research output: Contribution to journal › Journal article › Research › peer-review
Published