A heteromeric snake toxin and the molecular details of pain perception
Research output: Contribution to journal › Journal article › Research › peer-review
Gaining on pain: Two snake protein toxins combine to form a heteromeric complex, MitTx, which activates acid-sensing ion channels (ASICs) and elicits pain. MitTx is used to explore the roles of specific ASIC subtypes in pain pathways. These insights may provide new pharmacological tools ultimately leading to new treatments for pain.
| Original language | English |
|---|---|
| Journal | Angewandte Chemie International Edition |
| Volume | 51 |
| Issue number | 17 |
| Pages (from-to) | 4009-4011 |
| ISSN | 1433-7851 |
| DOIs | |
| Publication status | Published - 23 Apr 2012 |
Bibliographical note
Keywords: ion channels; pain; natural products; snake toxins
ID: 37797330