Joshua Mark Brickman
Professor
Brickman Lab
Blegdamsvej 3B, 2200 København N
Member of:
- 2024
- Published
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation
Redó-Riveiro, A., Al-Mousawi, J., Linneberg-Agerholm, Madeleine, Proks, Martin, Perera Pérez, Marta, Salehin, S M Nazmus & Brickman, Joshua Mark, 2024, In: Stem Cell Reports. 19, 2, p. 174-186 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
In vitro models of human hypoblast and mouse primitive endoderm
Perera Pérez, Marta & Brickman, Joshua Mark, 2023, In: Current Opinion in Genetics and Development. 83, 11 p., 102115.Research output: Contribution to journal › Review › Research › peer-review
- Published
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
Knudsen, Teresa Emmilie Toudal, Hamilton, W. B., Proks, Martin, Lykkegaard, M., Linneberg-Agerholm, Madeleine, Nielsen, Alexander Valentin, Perera Pérez, Marta, Malzard, L. L., Trusina, Ala & Brickman, Joshua Mark, 2023, In: Cell Systems. 14, 9, p. 788-805.e8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
Wong, Yan Fung, Kumar, Y., Proks, Martin, Herrera, J. A. R., Rothová, M. M., S. Monteiro, Rita, Pozzi, S., Jennings, R. E., Hanley, N. A., Bickmore, W. A. & Brickman, Joshua Mark, 2023, In: Nature Cell Biology. 25, p. 481-492Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development
Kim, Junil, Rothová, M. M., Madan, E., Rhee, S., Weng, Guangzheng, Palma, A. M., Liao, Linbu, David, E., Amit, I., Hajkarim, M. C., Vudatha, V., Gutiérrez-García, A., Moreno, E., Winn, R., Trevino, J., Fisher, P. B., Brickman, Joshua Mark, Gogna, R. & Won, K. J., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 2, 10 p., e2205371120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Wenger, Alice, Biran, Alva Ada, Alcaraz, N., Redó-Riveiro, A., Sell, Annika Charlotte, Krautz, Robert, Flury, Valentin, Reveron-Gomez, Nazaret, Solis-Mezarino, V., Völker-Albert, M., Imhof, A., Andersson, Robin, Brickman, Joshua Mark & Groth, Anja, 2023, In: Nature Genetics. 55, 9, p. 1567-1578 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming
Perera Pérez, Marta, Nissen, Silas Boye, Proks, Martin, Pozzi, S., S. Monteiro, Rita, Trusina, Ala & Brickman, Joshua Mark, 15 Aug 2022, In: eLife. 11, 23 p., e78967.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids
Hashmi, A., Tlili, S., Perrin, P., Lowndes, Molly, Peradziryi, H., Brickman, Joshua Mark, Martínez Arias, A. & Lenne, P. F., 2022, In: eLife. 11Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differentiation and Expansion of Human Extra-Embryonic Endoderm Cell Lines from Naïve Pluripotent Stem Cells
Linneberg-Agerholm, Madeleine & Brickman, Joshua Mark, 2022, Methods in Molecular Biology. Humana Press, p. 105-116 12 p. (Methods in Molecular Biology, Vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
Sukparangsi, W., Morganti, E., Lowndes, Molly, Mayeur, H., Weisser, Melanie, Hammachi, F., Peradziryi, H., Roske, F., Hölzenspies, J., Livigni, A., Godard, B. G., Sugahara, F., Kuratani, S., Montoya, Guillermo, Frankenberg, S. R., Mazan, S. & Brickman, Joshua Mark, 2022, In: Nature Communications. 13, 1, 21 p., 5537.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the central intermediate in the extra-embryonic to embryonic endoderm transition through single-cell transcriptomics
Rothová, M. M., Nielsen, Alexander Valentin, Proks, Martin, Wong, Yan Fung, Riveiro, A. R., Linneberg-Agerholm, Madeleine, David, E., Amit, I., Trusina, Ala & Brickman, Joshua Mark, 2022, In: Nature Cell Biology. 24, 6, p. 833-844 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β cell differentiation
Nakamura, A., Wong, Yan Fung, Venturato, A., Michaut, Magali, Venkateswaran, S., Santra, M., Gonçalves, C., Larsen, M., Leuschner, M., Kim, Y. H., Brickman, Joshua Mark, Bradley, M. & Grapin-Botton, A., 2022, In: Stem Cell Reports. 17, 5, p. 1215-1228 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development
Kim, Junil, Rothová, M. M., Liao, Linbu, Rhee, S., Weng, Guangzheng, David, E., Amit, I., Hajkarim, M. C., Brickman, Joshua Mark & Won, K. J., 2022, Cold Spring Harbor Laboratory, 26 p. (bioRxiv).Research output: Working paper › Preprint › Research
- 2021
- Published
Changes in Cell Morphology and Actin Organization in Embryonic Stem Cells Cultured under Different Conditions
Farhangibarooji, Younes, Hvid, K. G., Petitjean, I. I., Brickman, Joshua Mark, Oddershede, L. B. & Bendix, Poul Martin, 2021, In: Cells. 10, 11, 16 p., 2859.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
Narita, Takeo, Ito, S., Higashijima, Y., Chu, W. K., Neumann, K., Walter, Jonas, Satpathy, S., Liebner, Tim, Hamilton, W. B., Maskey, E., Prus, G., Shibata, M., Iesmantavicius, V., Brickman, Joshua Mark, Anastassiadis, K., Koseki, H. & Choudhary, Chunaram, 2021, In: Molecular Cell. 81, 10, p. 2166-2182.e6Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
From pluripotency to totipotency: an experimentalist's guide to cellular potency
Riveiro, A. R. & Brickman, Joshua Mark, Aug 2020, In: Development. 147, 16, 11 p., 189845.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Can a Cell Put Its Arms around a Memory?
Knudsen, Teresa Emmilie Toudal & Brickman, Joshua Mark, 7 May 2020, In: Cell Stem Cell. 26, 5, p. 609-610 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2019
- Published
Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm
Linneberg-Agerholm, Madeleine, Wong, Yan Fung, Romero Herrera, J. A., S. Monteiro, Rita, Anderson, K. G. V. & Brickman, Joshua Mark, 16 Dec 2019, In: Development (Cambridge, England). 146, 24, 15 p., 180620.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause
Pozzi, S., Bowling, S., Apps, J., Brickman, Joshua Mark, Rodriguez, T. A. & Martinez-Barbera, J. P., 10 Dec 2019, In: Stem Cell Reports. 13, 6, p. 970-979 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An automated microfluidic device for time-lapse imaging of mouse embryonic stem cells
Laing, A. F., Tirumala, V., Hegarty, E., Mondal, S., Zhao, P., Hamilton, W. B., Brickman, Joshua Mark & Ben-Yakar, A., Sep 2019, In: Biomicrofluidics. 13, 5, 054102.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic lineage priming is driven via direct enhancer regulation by ERK
Hamilton, W. B., Mosesson, Y., S. Monteiro, Rita, Emdal, Kristina Bennet, Knudsen, Teresa Emmilie Toudal, Francavilla, C., Barkai, N., Olsen, Jesper Velgaard & Brickman, Joshua Mark, 2019, In: Nature. 575, p. 355-360Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M. M., Marin-Juez, R., Guenther, S., Maischein, H., Fukuda, N., Canham, M. A., Brickman, Joshua Mark, Bogue, C. W., Jayaraman, P. & Stainier, D. Y. R., 2018, In: Nature Communications. 9, 1, 14 p., 2704.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Weinert, B. T., Narita, Takeo, Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chunaram, 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Four simple rules that are sufficient to generate the mammalian blastocyst
Nissen, Silas Boye, Perera Pérez, Marta, Martin Gonzalez, Javier, Morgani, S. M. C., Jensen, Mogens Høgh, Sneppen, Kim, Brickman, Joshua Mark & Trusina, Ala, 12 Jul 2017, In: PLOS Biology. 15, 7, p. 1-30 e2000737.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional Regulation of Hhex in Hematopoiesis and Hematopoietic Stem Cell Ontogeny
Portero Migueles, R., Shaw, L., Rodrigues, N. P., May, G., Henseleit, K., Anderson, K. G. V., Goker, H., Jones, C. M., de Bruijn, M. F. T. R., Brickman, Joshua Mark & Enver, T., 9 Feb 2017, In: Developmental Biology. 424, 2, p. 236-245 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Properties of embryoid bodies
Brickman, Joshua Mark & Serup, Palle, Feb 2017, In: Developmental Biology. 6, 2, 11 p., e259.Research output: Contribution to journal › Review › Research › peer-review
- Published
Surveillance for Secure Differentiation
Hamilton, W. B. & Brickman, Joshua Mark, 5 Jan 2017, In: Cell Stem Cell. 20, 1, p. 3-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm
Anderson, K. G. V., Hamilton, W. B., Roske, F. V., Azad, A., Knudsen, Teresa Emmilie Toudal, Canham, M., Forrester, L. M. & Brickman, Joshua Mark, 2017, In: Nature Cell Biology. 19, 10, p. 1164-1177Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Polycomb enables primitive endoderm lineage priming in embryonic stem cells
Illingworth, R. S., Hölzenspies, J. J., Roske, F. V., Bickmore, W. A. & Brickman, Joshua Mark, 10 Oct 2016, In: eLife. 5, 28 p., e14926.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
Martin Gonzalez, Javier, Morgani, S. M., Bone, Robert Alexander, Bonderup, K., Abelechian, Sahar, Brakebusch, Cord Herbert & Brickman, Joshua Mark, 9 Aug 2016, In: Stem Cell Reports. 7, 2, p. 177-91 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optical quantification of forces at play during stem cell differentiation
Ritter, C., Brickman, Joshua Mark & Oddershede, L. B., 4 Mar 2016, In: Proceedings of S P I E - International Society for Optical Engineering. 9764, UNSP 97640J.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Differentiation of Mouse Embryonic Stem Cells into Ventral Foregut Precursors
Rothová, M., Hölzenspies, J. J., Livigni, A., Villegas, S. N. & Brickman, Joshua Mark, 3 Feb 2016, In: Current Protocols in Stem Cell Biology. 36, p. 1G.3.1-12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum to: Resolving Heterogeneity: Fluorescence-Activated Cell Sorting of Dynamic Cell Populations from Feeder-Free Mouse Embryonic Stem Cell Culture
Holzenspies, J., dela Cruz, Gelo & Brickman, Joshua Mark, 2016, In: Methods in Molecular Biology. 1341, p. 445 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Resolving Heterogeneity: Fluorescence-Activated Cell Sorting of Dynamic Cell Populations from Feeder-Free Mouse Embryonic Stem Cell Culture
Hölzenspies, J., dela Cruz, Gelo & Brickman, Joshua Mark, 2016, Embryonic Stem Cell Protocols. Turksen, K. (ed.). Springer, Vol. 1341. p. 25-40 16 p. (Methods in Molecular Biology, Vol. 134).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2015
- Published
LIF supports primitive endoderm expansion during pre-implantation development
Morgani, S. M. & Brickman, Joshua Mark, 15 Oct 2015, In: Development (Cambridge, England). 142, 20, p. 3488-99 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression
Laing, A. F., Lowell, S. & Brickman, Joshua Mark, 1 Jan 2015, In: Developmental Biology. 397, 1, p. 56-66 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Erk signaling suppresses embryonic stem cell self-renewal to specify endoderm
Hamilton, W. B. & Brickman, Joshua Mark, 24 Dec 2014, In: Cell Reports. 9, 6, p. 2056-70 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The molecular underpinnings of totipotency
Morgani, S. M. C. & Brickman, Joshua Mark, 27 Oct 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1657Research output: Contribution to journal › Review › Research › peer-review
- Published
The POU-er of gene nomenclature
Frankenberg, S. R., Frank, D., Harland, R., Johnson, A. D., Nichols, J., Niwa, H., Schöler, H. R., Tanaka, E., Wylie, C. & Brickman, Joshua Mark, Aug 2014, In: Development (Cambridge, England). 141, 15, p. 2921-3 3 p.Research output: Contribution to journal › Review › Research › peer-review
- 2013
- Published
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix
Villegas, S. N., Rothová, M., Barrios-Llerena, M. E., Pulina, M., Hadjantonakis, A., Le Bihan, T., Astrof, S. & Brickman, Joshua Mark, 24 Dec 2013, In: eLife. 2, 0, p. e00806 eLife 2013;2:e00806.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Survival of the fattest
Morgani, S. M. & Brickman, Joshua Mark, 26 Nov 2013, In: eLife. 2, p. e01760Research output: Contribution to journal › Review › Research › peer-review
- Published
A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance
Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, Joshua Mark, 18 Nov 2013, In: Current biology : CB. 23, 22, p. 2233-44 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oct4: the final frontier, differentiation defining pluripotency
Livigni, A. & Brickman, Joshua Mark, 24 Jun 2013, In: Developmental Cell. 25, 6, p. 547-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions
Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R. P., Ko, M. S. H. & Brickman, Joshua Mark, 4 Jun 2013, In: Cell Reports. p. 1945–1957Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency
Hammachi, F., Morrison, G. M., Sharov, A. A., Livigni, A., Narayan, S., Papapetrou, E. P., O'Malley, J., Kaji, K., Ko, M. S. H., Ptashne, M. & Brickman, Joshua Mark, 23 Feb 2012, In: Cell Biology International Reports. 1, 2, p. 99-109 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the hematopoietic niche
Jackson, M., Axton, R. A., Taylor, A. H., Wilson, J. A., Gordon-Keylock, S. A. M., Kokkaliaris, K. D., Brickman, Joshua Mark, Schulz, H., Hummel, O., Hubner, N. & Forrester, L. M., Feb 2012, In: Stem Cells. 30, 2, p. 150-60 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Gene expression heterogeneities in embryonic stem cell populations: origin and function
Martinez Arias, A. & Brickman, Joshua Mark, Dec 2011, In: Current Opinion in Cell Biology. 23, 6, p. 650-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection
Sousa-Nunes, R., Rana, A. A., Kettleborough, R., Brickman, Joshua Mark, Clements, M., Forrest, A., Grimmond, S., Avner, P., Smith, J. C., Dunwoodie, S. L. & Beddington, R. S. P., Dec 2003, In: Genome Research. 13, 12, p. 2609-20 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction
Carvalho, L. R., Woods, K. S., Mendonca, B. B., Marcal, N., Zamparini, A. L., Stifani, S., Brickman, Joshua Mark, Arnhold, I. J. P. & Dattani, M. T., Oct 2003, In: The Journal of Clinical Investigation. 112, 8, p. 1192-201 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders
Brickman, Joshua Mark, Clements, M., Tyrell, R., McNay, D., Woods, K., Warner, J., Stewart, A., Beddington, R. S. & Dattani, M., Dec 2001, In: Development (Cambridge, England). 128, 24, p. 5189-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 35060713
Most downloads
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245
downloads
Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
240
downloads
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
189
downloads
Four simple rules that are sufficient to generate the mammalian blastocyst
Research output: Contribution to journal › Journal article › Research › peer-review
Published