Jette Bornholdt Lange
Computational and RNA Biology
Ole Maaløesvej 5, 2200 København N, 1.3.03
Glycomics Program
Panum Instituttet, Blegdamsvej 3, Building: 6.4.5
2200 2200 København N
Member of:
- 2023
- Published
Detecting host responses to microbial stimulation using primary epithelial organoids
Lange, Jette Bornholdt, Müller, C. V., Nielsen, M. J., Strickertsson, J., Rago, D., Chen, Y., Maciag, Grzegorz Jerzy, Skov, Jonathan, Wellejus, A., Schweiger, P. J., Hansen, Stine Lind, Broholm, C., Gögenur, Ismail, Maimets, Martti, Sloth, S., Hendel, J., Baker, A., Sandelin, Albin Gustav & Jensen, Kim Bak, 2023, In: Gut Microbes. 15, 2, 16 p., 2281012.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation
Pikkupeura, Laura Maarit, Bardini Bressan, Raul, Guiu, J., Chen, Y., Maimets, Martti, Mayer, Daniela, Schweiger, P. J., Hansen, Stine Lind, Maciag, Grzegorz Jerzy, Larsen, Hjalte List, Lõhmussaar, Kadi, Pedersen, M. T., Teves, Joji Marie Yap, Lange, Jette Bornholdt, Benes, V., Sandelin, Albin Gustav & Jensen, Kim Bak, 2023, In: Science Advances. 9, 28, 16 p., eadf9460.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Promoter sequence and architecture determine expression variability and confer robustness to genetic variants
Einarsson, H., Salvatore, Marco, Vaagenso, C., Alcaraz, N., Lange, Jette Bornholdt, Rennie, Sarah & Andersson, Robin, 2022, In: eLife. 2022, 36 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PAMP-triggered genetic reprogramming involves widespread alternative transcription initiation and an immediate transcription factor wave
Thieffry, A., López Márquez, Diego, Lange, Jette Bornholdt, Gholami Malekroudi, M., Bressendorff, Simon, Barghetti, A., Sandelin, Albin Gustav & Brodersen, Peter, 2022, In: The Plant Cell. 34, 7, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M. C., Abugessaisa, I., Aitken, S. & 31 others, , 2021, In: Nature Communications. 12, 18 p., 3297.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial
Lange, Jette Bornholdt, Chen, Y., Rago, Alfredo, Sloth, S., Hendel, J., Melsæther, C., Müller, C. V., Juul Nielsen, M., Strickertsson, J., Engelholm, Lars Henning, Vitting-Seerup, K., Jensen, Kim Bak, Baker, A. & Sandelin, Albin Gustav, 9 Nov 2020, In: Gut Microbes. 12, 1, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sinonasal cancer
Husgafvel-Pursiainen, K., Carton, M., Luce, D., Wolff, H., Holmila, R., Schlünssen, V., Lange, Jette Bornholdt & Hansen, J., 2020, Occupational Cancers. Anttila, S. & Boffetta, P. (eds.). 2. ed. ed. Springer, p. 147-178 32 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Characterization of Arabidopsis thaliana Promoter Bidirectionality and Antisense RNAs by Inactivation of Nuclear RNA Decay Pathways
Thieffry, A., Vigh, Maria Louisa, Lange, Jette Bornholdt, Ivanov, M., Brodersen, Peter & Sandelin, Albin Gustav, 2020, In: The Plant Cell. 32, 6, p. 1845-1867 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Comprehensive profiling of the fission yeast transcription start site activity during stress and media response
Thodberg, Malte, Thieffry, A., Lange, Jette Bornholdt, Boyd, M., Holmberg, Christian, Azad, A., Workman, C. T., Chen, Y., Ekwall, K., Nielsen, Olaf & Sandelin, Albin Gustav, 28 Feb 2019, In: Nucleic Acids Research. 47, 4, p. 1671-1691 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
Boyd, M., Thodberg, M., Vitezic, M., Lange, J. B., Vitting-Seerup, K., Chen, Y., Coskun, M., Li, Y., Lo, B. Z. S., Klausen, P., Schweiger, P., Pedersen, A. G., Rapin, N. P. J-P., Skovgaard, K., Dahlgaard, K., Andersson, R., Terkelsen, T. B., Lilje, B., Troelsen, J. T., Petersen, A. M. & 7 others, , 2018, In: Nature Communications. 9, 19 p., 1661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The RNA exosome contributes to gene expression regulation during stem cell differentiation
Llinares, M. L., Karadoulama, Evdoxia, Chen, Y., Wojenski, L. A., Villafano, G. J., Lange, Jette Bornholdt, Andersson, Robin, Core, L., Sandelin, Albin Gustav & Jensen, T. H., 2018, In: Nucleic Acids Research. 46, 21, p. 11502-11513Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new class of genic nuclear RNA species in Arabidopsis
van Wonterghem, M., Thieffry, A., Boyd, M., Lange, Jette Bornholdt & Brodersen, Peter, 2018, In: FEBS Letters. 592, 4, p. 631-643 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels
Chen, Y., Salem, M., Boyd, M., Lange, Jette Bornholdt, Li, Yuan, Coskun, M., Seidelin, Jakob Benedict, Sandelin, Albin Gustav & Nielsen, Ole Haagen, 2017, In: npj Genomic Medicine. 2, 11 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of gene transcription start sites and enhancers responding to pulmonary carbon nanotube exposure in Vivo
Lange, Jette Bornholdt, Saber, A. T., Lilje, B., Boyd, M., Jørgensen, M., Chen, Y., Vitezic, M., Jacobsen, N. R., Poulsen, S. S., Berthing, T., Bressendorff, Simon, Vitting-Seerup, K., Andersson, Robin, Hougaard, K. S., Yauk, C. L., Halappanavar, S., Wallin, E. H. R., Vogel, U. & Sandelin, Albin Gustav, 2017, In: A C S Nano. 11, 4, p. 3597-3613 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
On-the-fly selection of cell-specific enhancers, genes, miRNAs and proteins across the human body using SlideBase
Ienasescu, H., Li, K., Andersson, Robin, Vitezic, M., Rennie, Sarah, Chen, Y., Vitting-Seerup, K., Lagoni, E., Boyd, M., Lange, Jette Bornholdt, de Hoon, M. J. L., Kawaji, H., Lassmann, T., FANTOM Consortium, F. C., Hayashizaki, Y., Forrest, A. R. R., Carninci, P. & Sandelin, Albin Gustav, 2016, In: Database: The Journal of Biological Databases and Curation. 2016, 0, 10 p., baw144.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulating retrotransposon activity through the use of alternative transcription start sites
Persson, J., Steglich, B., Smialowska, A., Boyd, M., Lange, Jette Bornholdt, Andersson, Robin, Schurra, C., Arcangioli, B., Sandelin, Albin Gustav, Nielsen, Olaf & Ekwall, K., 2016, In: E M B O Reports. 17, 5, p. 753-768 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity
Rydén, M., Hrydziuszko, O., Mileti, E., Raman, A., Lange, Jette Bornholdt, Boyd, M., Toft, E., Qvist, V., Näslund, E., Thorell, A., Andersson, D. P., Dahlman, I., Gao, H., Sandelin, Albin Gustav, Daub, C. O. & Arner, P., 2016, In: Cell Reports. 16, 9, p. 2317-2326 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
An atlas of active enhancers across human cell types and tissues
Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Lange, J. B., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., Suzuki, T., Ntini, E., Arner, E., Valen, E., Li, K., Schwarzfischer, L., Glatz, D., Raithel, J., Lilje, B., Rapin, N., Bagger, F. O. & 30 others, , 2014, In: Nature. 507, 7493, p. 455-461 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nuclear stability and transcriptional directionality separate functionally distinct RNA species
Andersson, Robin, Refsing Andersen, P., Valen, E., Core, L. J., Lange, Jette Bornholdt, Boyd, M., Jensen, T. H. & Sandelin, Albin Gustav, 2014, In: Nature Communications. 5, 10 p., 5336.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2
Boyd, M., Coskun, M., Lilje, B., Andersson, Robin, Hoof, I., Lange, Jette Bornholdt, Dahlgaard, K., Olsen, Jørgen, Vitezic, M., Bjerrum, Jakob Tveiten , Seidelin, Jakob Benedict, Nielsen, Ole Haagen, Troelsen, J. & Sandelin, Albin Gustav, 2014, In: D N A Research. 21, 6, p. 569-583 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Detection of Active Matriptase using a Biotinylated Chloromethyl Ketone Peptide
Godiksen, S., Soendergaard, C., Friis, S., Jensen, J. K., Lange, Jette Bornholdt, Sales, K. U., Huang, M., Bugge, T. H. & Vogel, Lotte, 2013, In: P L o S One. 8, 10, 10 p., e77146.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase
Larsen, B. R., Steffensen, S. D. R., Nielsen, N. V. L., Friis, S., Godiksen, S., Lange, Jette Bornholdt, Soendergaard, C., Nonboe, Annika Weile, Andersen, M. N., Poulsen, Steen Seier, Szabo, R., Bugge, T. H., Lin, C., Skovbjerg, H., Jensen, J. K. & Vogel, Lotte, 1 Apr 2013, In: Experimental Cell Research. 319, 6, p. 918-929 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality
Ntini, E., Järvelin, A. I., Lange, Jette Bornholdt, Chen, Y., Boyd, M., Jørgensen, M., Andersson, Robin, Hoof, I., Schein, A., Andersen, P. R., Andersen, P. K., Preker, P., Valen, E., Zhao, X., Pelechano, V., Steinmetz, L. M., Sandelin, Albin Gustav & Jensen, T. H., 2013, In: Nature Structural and Molecular Biology. 20, p. 923-928 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair
Vestentoft, P. S., Jelnes, P., Andersen, Jesper Bøje, Tran, T. A. T., Jørgensen, T., Rasmussen, M., Lange, Jette Bornholdt, Grøvdal, L. M., Jensen, C. H., Vogel, Lotte, Thorgeirsson, S. S. & Bisgaard, Hanne Cathrine, 2013, In: Fibrogenesis & Tissue Repair. 6, 1, 15 p., 21.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase
Friis, S., Godiksen, S., Lange, Jette Bornholdt, Selzer-Plon, J., Rasmussen, Hanne Borger, Bugge, T. H., Lin, C. & Vogel, Lotte, 2011, In: The Journal of Biological Chemistry. 286, 7, p. 5793-802 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The level of claudin-7 is reduced as an early event in colorectal carcinogenesis
Lange, Jette Bornholdt, Friis, S., Godiksen, S., Poulsen, Steen Seier, Santoni Rugiu, Eric, Bisgaard, Hanne Cathrine, Lothe, I. M. B., Ikdahl, T., Tveit, K. M., Johnson, E., Kure, E. H. & Vogel, Lotte, 2011, In: B M C Cancer. 11, p. 65 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer
Lorentzen, A. B., Lewinsky, R., Lange, Jette Bornholdt, Vogel, Lotte & Mitchelmore, C., 1 Jan 2011, In: BMC Cancer. 11, p. 14Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer
Holmila, R., Lange, Jette Bornholdt, Heikkilä, P., Suitiala, T., Févotte, J., Cyr, D., Hansen, J., Snellman, S., Dictor, M., Steiniche, T., Schlünssen, V., Schneider, T., Pukkala, E., Savolainen, K., Wolff, H., Wallin, H., Luce, D. & Husgafvel-Pursiainen, K., 2010, In: International Journal of Cancer. 127, 3, p. 578-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Profile of TP53 gene mutations in sinonasal cancer
Holmila, R., Lange, Jette Bornholdt, Suitiala, T., Cyr, D., Dictor, M., Steiniche, T., Wolff, H., Wallin, H., Luce, D. & Husgafvel-Pursiainen, K., 2010, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 686, 1-2, p. 9-14 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation
Saber, A. T., Halappanavar, S., Folkmann, J. K., Lange, Jette Bornholdt, Boisen, A. M. Z., Møller, Peter, Williams, A., Yauk, C., Vogel, U., Loft, Steffen & Wallin, H., 2009, In: Particle and Fibre Toxicology. 6, p. 12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis
Selzer-Plon, J., Lange, Jette Bornholdt, Friis, S., Bisgaard, Hanne Cathrine, Lothe, I., Tveit, K., Kure, E., Vogel, U. & Vogel, Lotte, 2009, In: BMC Cancer. 9, 1, p. 201 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
K-ras mutations in sinonasal cancers in relation to wood dust exposure
Lange, Jette Bornholdt, Hansen, J., Steiniche, T., Dictor, M., Antonsen, A., Wolff, H., Schlünssen, V., Holmila, R., Luce, D., Vogel, U., Husgafvel-Pursiainen, K. & Wallin, H., 2008, In: BMC Cancer. 8, p. 53Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of wood dust:Inflammation, Genotoxicity and Cancer.
Lange, Jette Bornholdt, 2008, Museum Tusculanum.Research output: Book/Report › Ph.D. thesis › Research
- Published
Effekter af træstøv; inflammation, gentoksicitet og cancer
Lange, Jette Bornholdt, 2008, In: Miljø og Sundhed. 14, 3, p. 29-31 3 p.Research output: Contribution to journal › Journal article › Communication
- 2007
Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549
Lange, Jette Bornholdt, Saber, A. T., Sharma, A. K., Savolainen, K., Vogel, U. & Wallin, H., 2007, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 632, 1-2, p. 78-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33667728
Most downloads
-
1910
downloads
Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1504
downloads
Detection of Active Matriptase using a Biotinylated Chloromethyl Ketone Peptide
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
246
downloads
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
Research output: Contribution to journal › Journal article › Research › peer-review
Published