Jens Bukh

Jens Bukh

Professor

Member of:


    1. Published

      In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms

      Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, A. & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus

      Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.

      Kuiken, C., Combet, C., Bukh, Jens, Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J., Simmonds, P. & Los Alamos HIV Database Group, L. A. H. D. G., 2006, In: Hepatology. 44, 5, p. 1355-61 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

      Fahnøe, Ulrik, Ronit, A., Berg, Ronan Martin Griffin, Jørgensen, S. E., Mogensen, T. H., Underwood, Alexander Paul James, Scheel, Troels Kasper Høyer, Bukh, Jens & Plovsing, R. R., 2022, In: The Journal of Infectious Diseases. 226, 12, p. 2137–2141

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

      Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      A milestone for hepatitis C virus research: a virus generated in cell culture is fully viable in vivo.

      Bukh, Jens & Purcell, R. H., 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3500-1 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus

      Pedersen, M. S., Fahnøe, Ulrik, Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2018, In: Journal of Clinical Virology. 105, p. 49-56 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

      Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

      Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

      Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085

      Research output: Patent

    11. Published

      Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

      Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

      Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published
    14. Published

      Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines

      Sølund, C., Underwood, Alexander Paul James, Fernandez-Antunez, C., Bollerup, S., Mikkelsen, L. S., Villadsen, S. L., Fahnøe, Ulrik, Winckelmann, Anni Assing, Feng, S., Nørløv Vinten, C. A., Dalegaard, M. I., Vizgirda, G., Sørensen, A. L., Ramirez Almeida, Santseharay, Bukh, Jens & Weis, Nina, 2022, In: Vaccines. 10, 1, 75.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

      Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

      Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

      Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Animal models for the study of hepatitis C virus infection and related liver disease

      Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development

      Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

      Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

      Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

      Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      At the Core of Depression: A Diagnostic Interview of the Core Features of Depression

      Bukh, Jens, Fabrazzo, M., Christensen, E. M., Mikkelsen, R. L., Larsen, J. K., Hageman, I., Bendsen, B. B., Bolwig, T., Vinberg, Maj, Bech, P., Dam, O. H., Maj, M. & Kessing, Lars Vedel, 11 Mar 2022, In: Psychopathology. 55, 3-4, p. 219–225 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

      Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

      Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design

      Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentø, Jannick, Velázquez-Moctezuma, R., Walker, Melanie Rose, Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, Jens, Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2C

      Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y. P. & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584

      Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083

      Research output: Patent

    29. Published

      Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model

      Liang, T. J., Law, J. L. M., Pietschmann, T., Ray, S. C., Bukh, Jens, Bull, R., Chung, R. T., Tyrrell, D. L., Houghton, M. & Rice, C. M., 2023, In: Clinical Infectious Diseases. 77, p. S257-S261

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

      Bukh, Jens, Meuleman, P., Tellier, R., Engle, R. E., Feinstone, S. M., Eder, G., Satterfield, W. C., Govindarajan, S., Krawczynski, K., Miller, R. H., Leroux-Roels, G. & Purcell, R. H., 1 May 2010, In: Journal of Infectious Diseases. 201, 9, p. 1381-9 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease

      Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Characterization of a novel hepatitis C virus genotype 1 subtype from a patient failing 4 weeks of glecaprevir-pibrentasvir treatment

      Pedersen, M. S., Fahnøe, Ulrik, Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, Jens, 2021, In: Microbiology resource announcements. 10, 41, e00755.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

      Carlsen, T. H. R., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Foung, S. K. H. & Bukh, Jens, 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system

      Fernandez-Antunez, C., Wang, K., Fahnøe, Ulrik, Mikkelsen, L. S., Gottwein, Judith Margarete, Bukh, Jens & Ramirez Almeida, Santseharay, 2023, In: Hepatology. 78, 2, p. 621-636 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

      Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

      Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

      Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort

      Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

      Bartenschlager, R., Baumert, T. F., Bukh, Jens, Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., 2018, In: Virus Research. 248, p. 53-62 10 p.

      Research output: Contribution to journalReviewResearchpeer-review

    40. Published
    41. Published

      Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead

      Mikkelsen, M. & Bukh, Jens, 2007, In: Current Infectious Disease Reports. 9, 2, p. 94-101 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

      Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

      Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

      Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

      Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

      Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Development of a TaqMan assay for the six major genotypes of hepatitis C virus: Comparison with commercial assays

      Engle, R. E., Russell, R. S., Purcell, R. H. & Bukh, Jens, 2008, In: Journal of Medical Virology. 80, 1, p. 72-9 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

      Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Differential activity of nucleotide analogs against tick-borne encephalitis and yellow fever viruses in human cell lines

      Binderup, A., Galli, Andrea, Fossat, Nicolas Julien, Fernandez-Antunez, C., Mikkelsen, L. S., Rivera, Lizandro, Scheel, Troels Kasper Høyer, Fahnøe, Ulrik, Bukh, Jens & Ramirez, S., 2023, In: Virology. 585, p. 179-185 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

      Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

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