Henriette Pilegaard

Hepatic PGC-1α has minor regulatory effect on the liver transcriptome and metabolome during high fat high fructose diet and exercise training

Rasmussen, M. K., Thøgersen, R., Horsbøl Lindholm, P., Bertram, H. C. & Pilegaard, Henriette, 2023, In: Gene. 851, 14 p., 147039.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of Aging and Lifelong Exercise Training on Mitochondrial Function and Network Connectivity in Human Skeletal Muscle

Jørgensen, Stine Ringholm, Gudiksen, Anders, Halling, Jens Frey, Qoqaj, A., Rasmussen, P. M., Prats Gavalda, Clara, Plomgaard, Peter Stendahl & Pilegaard, Henriette, 2023, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 78, 3, 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Muscle PGC-1α modulates hepatic mitophagy regulation during aging

Christensen, N. M., Jørgensen, Stine Ringholm, Buch, B. T., Gudiksen, Anders, Halling, Jens Frey & Pilegaard, Henriette, 2023, In: Experimental Gerontology. 172, 9 p., 112046.

Research output: Contribution to journal › Journal article › Research › peer-review

Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes

Maurer, J., Zhao, X., Irmler, M., Gudiksen, Anders, Pilmark, N. S., Li, Q., Goj, T., Beckers, J., Hrabě De Angelis, M., Birkenfeld, A. L., Peter, A., Lehmann, R., Pilegaard, Henriette, Karstoft, Kristian, Xu, G. & Weigert, C., 2023, In: American Journal of Physiology: Cell Physiology. 325, 4, p. C1131-C1143 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction

Kjøbsted, Rasmus, Kristensen, Jonas Møller, Eskesen, N. O., Kido, K., Fjorder, Klara, Damgaard, D. F., Larsen, Jeppe Kjærgaard, Andersen, Nicoline Resen, Birk, Jesper Bratz, Gudiksen, Anders, Treebak, Jonas Thue, Schjerling, Peter, Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2023, In: Diabetes. 72, 7, p. 857-871 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ameliorating effects of lifelong physical activity on healthy aging and mitochondrial function in human white adipose tissue

Gudiksen, Anders, Qoqaj, A., Jørgensen, Stine Ringholm, Wojtaszewski, Jørgen F P, Plomgaard, Peter Stendahl & Pilegaard, Henriette, 2022, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 77, 6, p. 1101-1111 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Beta₂-agonist increases skeletal muscle interleukin 6 production and release in response to resistance exercise in men

Hostrup, Morten, Knudsen, Jakob Grunnet, Maag Kristensen, C., Jessen, Søren Kaare, Pilegaard, Henriette & Bangsbo, Jens, 2022, In: Scandinavian Journal of Medicine & Science in Sports. 32, 7, p. 1099-1108 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans

Plomgaard, Peter Stendahl, Hansen, J. S., Townsend, L. K., Gudiksen, Anders, Secher, Niels H., Clemmesen, J. O., Støving, R. K., Goetze, Jens P. , Wright, D. C. & Pilegaard, Henriette, 2022, In: Frontiers in Endocrinology. 13, 1037948.

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of 2 randomised, clinical trials

Pilmark, N. S., Oberholzer, L., Halling, Jens Frey, Kristensen, Jonas Møller, Bønding, C. P., Elkjær, I., Lyngbæk, M., Elster, G., Siebenmann, C., Holm, N. F., Birk, Jesper Bratz, Larsen, E. L., Meinild-Lundby, A., Wojtaszewski, Jørgen F P, Pilegaard, Henriette, Poulsen, H., Pedersen, Bente Klarlund, Hansen, K. B. & Karstoft, Kristian, 2022, In: Applied Physiology, Nutrition and Metabolism. 47, 3, p. 309-320 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9

Feng, Weijia, Arrey Tané, Gerard, Zole, Egija, Iv, W., Liang, Xue, Han, Peng, Mohiyuddin, M., Pilegaard, Henriette & Regenberg, Birgitte, 2022, In: Computational and Structural Biotechnology Journal. 20, p. 3059-3067 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Time-dependent regulation of hepatic cytochrome P450 mRNA in male liver-specific PGC-1α knockout mice

Sundekilde, U. K., Kristensen, C. M., Olsen, M. A., Pilegaard, Henriette & Rasmussen, M. K., 2022, In: Toxicology. 469, 8 p., 153121.

Research output: Contribution to journal › Journal article › Research › peer-review

High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells

Hansen, Camilla Collin, Olsen, K., Pilegaard, Henriette, Bangsbo, Jens, Gliemann, Lasse & Hellsten, Ylva, 2021, In: Physiological Reports. 9, 14, 17 p., e14855.

Research output: Contribution to journal › Journal article › Research › peer-review

Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner

Buch, B. T., Halling, Jens Frey, Jørgensen, Stine Ringholm, Gudiksen, Anders, Kjøbsted, Rasmus, Olsen, M. A., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2020, In: F A S E B Journal. 34, 6, p. 8653-8670

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of insulin on natriuretic peptide gene expression in porcine heart

Terzic, D., Zois, N. E., Hunter, I., Christoffersen, Christina, Plomgaard, Peter Stendahl, Olsen, Lisbeth Høier, Jørgensen, Stine Ringholm, Pilegaard, Henriette & Goetze, Jens P. , 2020, In: Peptides. 131, 10 p., 170370.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise: from physiology to bedside to physiology

Han, J., Neufer, D. & Pilegaard, Henriette, 2020, In: Pflügers Archiv - European Journal of Physiology. 472, 2, p. 135

Research output: Contribution to journal › Editorial › Research › peer-review

Hepatic PGC-1α is not essential for fasting-induced cytochrome p450 regulation in mouse liver

Thøgersen, R., Maag Kristensen, C., Olsen, M. A., Bertram, H. C., Pilegaard, Henriette & Rasmussen, M. K., 2020, In: Biochemical Pharmacology. 172, 7 p., 113736.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises

Bertholdt, L., Gudiksen, Anders, Jørgensen, Stine Ringholm & Pilegaard, Henriette, 2020, In: Pflügers Archiv - European Journal of Physiology. 472, 2, p. 217-233 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Inducible deletion of skeletal muscle AMPKα 1 reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Hingst, J. R., Kjøbsted, R., Birk, J. B., Jørgensen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., Holm, S., Fritzen, A. M., Dohlmann, T. L., Larsen, S., Foretz, M., Viollet, B., Schjerling, P., Overby, P., Halling, J. F., Pilegaard, H. & 2 others, Hellsten, Ylva & Wojtaszewski, Jørgen F P, 2020, In: Molecular Metabolism. 40, 17 p., 101028.

Research output: Contribution to journal › Journal article › Research › peer-review

Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2x2 factorial, randomised, crossover study in human individuals

Hjelholt, A. J., Charidemou, E., Griffin, J. L., Pedersen, S. B., Gudiksen, Anders, Pilegaard, Henriette, Jessen, N., Møller, N. & Jørgensen, J. O. L., 2020, In: Diabetologia. 63, 12, p. 2641-2653 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α-mediated regulation of mitochondrial function and physiological implications

Halling, Jens Frey & Pilegaard, Henriette, 2020, In: Applied Physiology, Nutrition and Metabolism. 45, 9, p. 927-936 10 p.

Research output: Contribution to journal › Review › Research › peer-review

Exercise physiology: future opportunities and challenges

Han, J., Neufer, D. & Pilegaard, Henriette, 2019, In: Pflügers Archiv - European Journal of Physiology. 471, 3, p. 381 1 p.

Research output: Contribution to journal › Editorial › Research › peer-review

Inclusion of sprints in moderate intensity continuous training leads to muscle oxidative adaptations in trained individuals

Gunnarsson, T. G. P., Brandt, N., Fiorenza, Matteo, Hostrup, Morten, Pilegaard, Henriette & Bangsbo, Jens, 2019, In: Physiological Reports. 7, 4, 15 p., e13976.

Research output: Contribution to journal › Journal article › Research › peer-review

Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle

Sailani, M. R., Halling, Jens Frey, Møller, H. D., Lee, H., Plomgaard, Peter Stendahl, Pilegaard, Henriette, Snyder, M. P. & Regenberg, Birgitte, 2019, In: Scientific Reports. 9, p. 1-11 3272.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

Halling, Jens Frey, Jessen, H., Nøhr-Meldgaard, J., Buch, B. T., Christensen, N. M., Gudiksen, Anders, Jørgensen, Stine Ringholm, Neufer, P. D., Prats Gavalda, Clara & Pilegaard, Henriette, 2019, In: American journal of physiology. Endocrinology and metabolism. 317, 3, p. E513-E525

Research output: Contribution to journal › Journal article › Research › peer-review

Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men

Høgild, M. L., Gudiksen, Anders, Pilegaard, Henriette, Stødkilde-Jørgensen, H., Pedersen, S. B., Møller, N., Jørgensen, J. O. L. & Jessen, N., 2019, In: Physiological Reports. 7, 21, 15 p., e14285.

Research output: Contribution to journal › Journal article › Research › peer-review

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Møller, H. D., Mohiyuddin, M., Prada Luengo, Inigo, Sailani, M. R., Halling, Jens Frey, Plomgaard, Peter Stendahl, Maretty, L., Hansen, Anders Johannes, Snyder, M. P., Pilegaard, Henriette, Lam, H. Y. K. & Regenberg, Birgitte, 1 Dec 2018, In: Nature Communications. 9, 12 p., 1069.

Research output: Contribution to journal › Journal article › Research › peer-review

Training state and skeletal muscle autophagy in response to 36 h of fasting

Dethlefsen, M. M., Bertholdt, L., Gudiksen, Anders, Stankiewicz, T., Bangsbo, Jens, van Hall, Gerrit, Plomgaard, Peter Stendahl & Pilegaard, Henriette, Nov 2018, In: Journal of Applied Physiology. 125, 5, p. 1609-1619 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle

Brandt, N., Nielsen, L., Buch, B. T., Gudiksen, Anders, Jørgensen, Stine Ringholm, Hellsten, Ylva, Bangsbo, Jens & Pilegaard, Henriette, 1 Jan 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 1, p. E1-E20 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Beta₂-adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men

Hostrup, Morten, Reitelseder, S., Jessen, Søren Kaare, Kalsen, A., Nyberg, M. P., Egelund, J., Kreiberg, M., Maag Kristensen, C., Thomassen, Martin, Pilegaard, Henriette, Backer, Vibeke, Jacobson, G. A., Holm, L. & Bangsbo, Jens, 2018, In: Journal of Physiology. 596, 17, p. 4121-4139 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise and exercise training-induced increase in autophagy markers in human skeletal muscle

Brandt, N., Gunnarsson, T. G. P., Bangsbo, Jens & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 7, 12 p., e13651.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of fasting followed by short-term exposure to interleukin-6 on cytochrome P450 mRNA in mice

Rasmussen, M. K., Bertholdt, L., Gudiksen, Anders, Pilegaard, Henriette & Knudsen, Jakob Grunnet, 2018, In: Toxicology Letters. 282, p. 93-99 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of liver PGC-1α on exercise and exercise training-induced regulation of hepatic autophagy and mitophagy in mice on HFF

Dethlefsen, M. M., Kristensen, C. M., Tondering, A. S., Lassen, S. B., Jørgensen, Stine Ringholm & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 13, p. 1-16 e13731.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting

Bertholdt, L., Gudiksen, Anders, Jessen, H. & Pilegaard, Henriette, 2018, In: Pflügers Archiv - European Journal of Physiology. 470, 11, p. 1597-1613

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of training state on fasting-induced regulation of adipose tissue metabolism in humans

Bertholdt, L., Gudiksen, Anders, Stankiewicz, T., Villesen, I., Tybirk, J., van Hall, Gerrit, Bangsbo, Jens, Plomgaard, Peter Stendahl & Pilegaard, Henriette, 2018, In: Journal of Applied Physiology. 124, 3, p. 729-740 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Metabolic stress-dependent regulation of the mitochondrial biogenic molecular response to high-intensity exercise in human skeletal muscle

Fiorenza, Matteo, Gunnarsson, T. P., Hostrup, Morten, Iaia, F. M., Schena, F., Pilegaard, Henriette & Bangsbo, Jens, 2018, In: Journal of Physiology. 596, 14, p. 2823-2840 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Muscle PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

Maag Kristensen, C., Jessen, H., Jørgensen, Stine Ringholm & Pilegaard, Henriette, 2018, In: Acta Physiologica. 224, 4, p. 1-17 e13158.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

Kristensen, C. M., Olsen, M. A., Jessen, H., Brandt, N., Meldgaard, J. N. & Pilegaard, Henriette, 2018, In: Pflügers Archiv - European Journal of Physiology. 470, 10, p. 1431-1447

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α in hepatic UPR during high-fat high-fructose diet and exercise training in mice

Kristensen, C. M., Dethlefsen, M. M., Tøndering, A. S., Lassen, S. B., Meldgaard, J. N., Ringholm, S. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 15, p. 1-15 e13819.

Research output: Contribution to journal › Journal article › Research › peer-review

Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training

Dethlefsen, M. M., Halling, Jens Frey, Møller, H. D., Plomgaard, Peter Stendahl, Regenberg, Birgitte, Jørgensen, Stine Ringholm & Pilegaard, Henriette, 2018, In: Experimental Gerontology. 111, p. 141-153

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

Brandt, N., Kotowska, D., Kristensen, C. M., Olesen, J., Lützhøft, Ditte Olsen, Halling, Jens Frey, Hansen, M., Al-Soud, W. A., Hansen, Lars Hestbjerg, Kiilerich, P. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 20, p. 1-11 e13881.

Research output: Contribution to journal › Journal article › Research › peer-review

Training state and fasting-induced PDH regulation in human skeletal muscle

Gudiksen, Anders, Bertholdt, L., Stankiewicz, T., Villesen, I., Bangsbo, Jens, Plomgaard, Peter Stendahl & Pilegaard, Henriette, 2018, In: Pflügers Archiv - European Journal of Physiology. 470, 11, p. 1633-1645 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise

Knudsen, Jakob Grunnet, Gudiksen, Anders, Bertholdt, L., Overby, P., Villesen, I., Schwartz, C. L. & Pilegaard, Henriette, 18 Dec 2017, In: PLoS ONE. 12, 12, 19 p., e0189301.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver

Maag Kristensen, C., Brandt, C. T., Jørgensen, Stine Ringholm & Pilegaard, Henriette, Nov 2017, In: Experimental Gerontology. 98, p. 124-133 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

Halling, Jens Frey, Jørgensen, Stine Ringholm, Olesen, J., Prats Gavalda, Clara & Pilegaard, Henriette, 1 Oct 2017, In: Experimental Gerontology. 96, p. 1-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Autophagy-dependent beneficial effects of exercise

Halling, Jens Frey & Pilegaard, Henriette, Aug 2017, In: Cold Spring Harbor Perspectives in Medicine. 7, 8, a029777.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α and fasting-induced PDH regulation in mouse skeletal muscle

Gudiksen, Anders & Pilegaard, Henriette, 10 Apr 2017, In: Physiological Reports. 5, 7, 15 p., e13222.

Research output: Contribution to journal › Journal article › Research › peer-review

Lack of skeletal muscle IL-6 influences hepatic glucose metabolism in mice during prolonged exercise

Bertholdt, L., Gudiksen, Anders, Schwartz, C. L., Knudsen, Jakob Grunnet & Pilegaard, Henriette, 7 Apr 2017, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 312, 4, p. R626-R636 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Muscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle

Gudiksen, Anders, Bertholdt, L., Vingborg, M. B., Hansen, H. W., Jørgensen, Stine Ringholm & Pilegaard, Henriette, 2 Mar 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 312, 3, p. E204-E214 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of training status on PDH regulation in human skeletal muscle during exercise

Gudiksen, Anders, Bertholdt, L., Stankiewicz, T., Tybirk, J., Plomgaard, Peter Stendahl, Bangsbo, Jens & Pilegaard, Henriette, 2017, In: Pflügers Archiv - European Journal of Physiology. 469, 12, p. 1615-1630 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Opposite regulation of insulin sensitivity by dietary lipid versus carbohydrate excess

Lundsgaard, Anne-Marie, Sjøberg, K. A., Høeg, L. D., Jeppesen, J., Jordy, A. B., Serup, A. K. L., Fritzen, Andreas Mæchel, Pilegaard, Henriette, Myrmel, L. S., Madsen, L., Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2017, In: Diabetes. 66, 10, p. 2583-2595 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α and exercise intensity dependent adaptations in mouse skeletal muscle

Brandt, N., Dethlefsen, M. M., Bangsbo, Jens & Pilegaard, Henriette, 2017, In: P L o S One. 12, 10, 21 p., e0185993.

Research output: Contribution to journal › Journal article › Research › peer-review

Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1α and PDK4 mRNA response in trained human muscle

Skovgaard, C., Brandt, N., Pilegaard, Henriette & Bangsbo, Jens, 2016, In: Physiological Reports. 4, 14, 14 p., e12864.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of adrenaline and metabolic stress on exercise-induced intracellular signaling and PGC-1α mRNA response in human skeletal muscle

Brandt, N., Gunnarsson, T. G. P., Hostrup, Morten, Tybirk, J., Nybo, Lars, Pilegaard, Henriette & Bangsbo, Jens, 2016, In: Physiological Reports. 4, 14, 13 p., e12844.

Research output: Contribution to journal › Journal article › Research › peer-review

Lack of skeletal muscle IL-6 affects pyruvate dehydrogenase activity at rest and during prolonged exercise

Gudiksen, Anders, Schwartz, C. L., Bertholdt, L., Joensen, E., Knudsen, Jakob Grunnet & Pilegaard, Henriette, 2016, In: P L o S One. 11, 6, 17 p., e0156460.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle

Halling, Jens Frey, Jørgensen, Stine Ringholm, Nielsen, M. M., Overby, P. & Pilegaard, Henriette, 2016, In: Physiological Reports. 4, 3, 11 p., e12698.

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training

Knudsen, Jakob Grunnet, Joensen, E., Bertholdt, L., Jessen, H., van Hauen, L., Hidalgo, J. & Pilegaard, Henriette, 2016, In: Physiological Reports. 4, 9, 9 p., e12788.

Research output: Contribution to journal › Journal article › Research › peer-review

5´AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4

Fritzen, Andreas Mæchel, Lundsgaard, Anne-Marie, Jeppesen, J., Christiansen, M. L. B., Biensø, R. S., Dyck, J. R. B., Pilegaard, Henriette & Kiens, Bente, 2015, In: Journal of Physiology. 593, 21, p. 4765-4780 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle

Fentz, J., Kjøbsted, Rasmus, Maag Kristensen, C., Hingst, J. R., Birk, Jesper Bratz, Gudiksen, Anders, Foretz, M., Schjerling, Peter, Viollet, B., Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 309, 11, p. E900-E914 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ammonium chloride ingestion attenuates exercise-induced mRNA levels in human muscle

Edge, J., Muendel, T., Pilegaard, Henriette, Hawke, E., Leikis, M., Lopez-Villalobos, N., Oliveira, R. S. F. & Bishop, D. J., 2015, In: P L o S One. 10, 12, 14 p., e0141317.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of exercise training on regulation of skeletal muscle glucose metabolism in elderly men

Biensø, R. S., Olesen, J., Gliemann, Lasse, Schmidt, J. F., Matzen, M. S., Wojtaszewski, Jørgen F P, Hellsten, Ylva & Pilegaard, Henriette, 2015, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 70, 7, p. 866-872 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise-induced AMPK and pyruvate dehydrogenase regulation is maintained during short-term low-grade inflammation

Biensø, R. S., Olesen, J., van Hauen, L., Meinertz, S., Halling, J. F., Gliemann, Lasse, Plomgaard, P. & Pilegaard, Henriette, 2015, In: Pflügers Archiv - European Journal of Physiology. 467, 2, p. 341-350 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise-induced regulation of key factors in substrate choice and gluconeogenesis in mouse liver

Knudsen, Jakob Grunnet, Biensø, R. S., Hassing, H. A., Jakobsen, A. H. & Pilegaard, Henriette, 2015, In: Molecular and Cellular Biochemistry. 403, 1-2, p. 209-217 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of training status on LPS-induced acute inflammation in humans

Olesen, J., Biensø, R. S., Meinertz, S., van Hauen, L., Rasmussen, S. M., Gliemann, Lasse, Plomgaard, Peter Stendahl & Pilegaard, Henriette, 2015, In: Journal of Applied Physiology. 118, 7, p. 818-829 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

New Nordic Diet induced weight loss is accompanied by changes in metabolism and AMPK signalling in adipose tissue

Fritzen, Andreas Mæchel, Lundsgaard, Anne-Marie, Jordy, A. B., Poulsen, S. K., Stender, Steen, Pilegaard, Henriette, Astrup, A., Larsen, T. M., Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 9, p. 3509-3519 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training

Knudsen, Jakob Grunnet, Bertholdt, L., Joensen, E., Lassen, S. B., Hidalgo, J. & Pilegaard, Henriette, 2015, In: Obesity. 23, 8, p. 1616-1624 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle

Biensø, R. S., Knudsen, Jakob Grunnet, Brandt, N., Pedersen, Per Amstrup & Pilegaard, Henriette, 2014, In: Pflügers Archiv - European Journal of Physiology. 466, 8, p. 1647-1657 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

Olesen, J., Gliemann, Lasse, Biensøe, R. S., Schmidt, J. F., Hellsten, Ylva & Pilegaard, Henriette, 2014, In: Journal of Physiology. 592, 8, p. 1873-1886 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes 2012;61:1090-1099

Biensø, R. S., Ringholm, S., Kiilerich, K., Aachmann-Andersen, N., Krogh-Madsen, Rikke, Guerra, B., Plomgaard, Peter Stendahl, van Hall, Gerrit, Treebak, Jonas Thue, Saltin, B., Lundby, C., Calbet, J. A. L., Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2014, In: Diabetes. 63, 9, 1 p., 3159.

Research output: Contribution to journal › Comment/debate › Research

Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

Nellemann, B., Vendelbo, M. H., Nielsen, Thomas Svava, Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, Henriette, Møller, N., Jessen, N. & Jørgensen, J. O. L., 2014, In: Acta Physiologica. 210, 2, p. 392-402 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: Effect of a 3-day, high-fat diet

Jordy, A. B., Serup, A. K., Karstoft, K., Pilegaard, Henriette, Kiens, Bente & Jeppesen, J. F., 2014, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 307, 9, p. R1136-R1145 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Leptin signaling in skeletal muscle after bed rest in healthy humans

Guerra, B., Ponce-Gonzalez, J. G., Morales-Alamo, D., Guadalupe-Grau, A., Kiilerich, K., Fuentes, T., Jørgensen, Stine Ringholm, Biensø, R. S., Santana, A., Lundby, C., Pilegaard, Henriette & Calbet, J. A. L., 2014, In: European Journal of Applied Physiology. 114, 2, p. 345-357 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I. P., Gudiksen, Anders, Solagna, F., Albiero, M., Moretti, I., Eckel-Mahan, K. L., Baldi, P., Sassone-Corsi, P., Rizzuto, R., Bicciato, S., Pilegaard, Henriette, Blaauw, B. & Schiaffino, S., 2014, In: Molecular Metabolism. 3, 1, p. 29-41 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Reply from Lasse Gliemann, Jesper Olesen, Rasmus Sjørup Biensø, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten

Gliemann, Lasse, Olesen, J., Biensø, R. S., Mortensen, S. P., Nyberg, M. P., Schmidt, J. F., Bangsbo, Jens, Pilegaard, Henriette & Hellsten, Ylva, 2014, In: Journal of Physiology. 592, 3, p. 553 1 p.

Research output: Contribution to journal › Comment/debate › Research

Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue

Knudsen, Jakob Grunnet, Murholm, M., Carey, A. L., Biensø, R. S., Basse, A. L., Allen, T. L., Hidalgo, J., Kingwell, B. A., Febbraio, M. A., Hansen, Jacob B. & Pilegaard, Henriette, 2014, In: P L o S One. 9, 1, 8 p., e84910.

Research output: Contribution to journal › Journal article › Research › peer-review

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

Brandauer, J., Vienberg, S. G., Andersen, M. A., Jørgensen, Stine Ringholm, Risis, S., Larsen, P., Kristensen, Jonas Møller, Frøsig, C., Leick, L., Fentz, J., Jørgensen, S. B., Kiens, Bente, Wojtaszewski, Jørgen F P, Richter, Erik A., Zierath, Juleen R, Goodyear, L. J., Pilegaard, Henriette & Treebak, Jonas Thue, 2013, In: Journal of Physiology. 591, p. 5207-5220 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Both short intense and prolonged moderate in vitro stimulation reduce the mRNA expression of calcium-regulatory proteins in rat skeletal muscle

Mänttäri, S., Ørtenblad, N., Madsen, K. & Pilegaard, Henriette, 2013, In: Molecular and Cellular Biochemistry. 373, 1-2, p. 171-178 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Direct effects of TNF-α on local fuel metabolism and cytokine levels in the placebo controlled bilaterally infused human leg: increased insulin sensitivity, increased net protein breakdown and increased IL-6 release

Bach, E., Nielsen, R. R., Vendelbo, M., Møller, A. B., Jessen, N., Buhl, M., Hafstrøm, T. K., Holm, L., Pedersen, S. B., Pilegaard, Henriette, Biensøe, R. S., Jørgensen, J. O. L. & Møller, N., 2013, In: Diabetes. 62, 12, p. 4023-4029

Research output: Contribution to journal › Journal article › Research › peer-review

Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg

Buhl, M., Bosnjak, E., Vendelbo, M. H., Gjedsted, J., Nielsen, R. R., Hafstrøm, T. K., Vestergaard, E. T., Jessen, N., Tønnesen, E., Møller, A. B., Pedersen, S. B., Pilegaard, Henriette, Biensø, R. S., Jørgensen, J. O. L. & Møller, N., 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 5, p. 2090-2099 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle

Mortensen, B., Hingst, J. R., Frederiksen, N., Hansen, R. W. W., Christiansen, C. S., Iversen, N., Friedrichsen, M., Birk, Jesper Bratz, Pilegaard, Henriette, Hellsten, Ylva, Vaag, Allan & Wojtaszewski, Jørgen F P, 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 304, 12, p. E1379-E1390 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice: impact of PGC-1α

Jørgensen, Stine Ringholm, Olesen, J., Pedersen, J. T., Brandt, C. T., Halling, J. F., Hellsten, Ylva, Prats Gavalda, Clara & Pilegaard, Henriette, 2013, In: Experimental Gerontology. 48, 11, p. 1311-1318 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles

Sjøgaard, G., Zebis, M. K., Kiilerich, K., Saltin, B. & Pilegaard, Henriette, 2013, In: Journal of Biomedicine and Biotechnology. 2013, 12 p., 984523.

Research output: Contribution to journal › Journal article › Research › peer-review

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

Lindegaard, Birgitte, Matthews, V. B., Brandt, C., Hojman, P., Allen, T. L., Estevez, E., Watt, M. J., Bruce, C. R., Mortensen, Ole Hartvig, Syberg, S., Rudnicka, C., Abildgaard, J., Pilegaard, Henriette, Hidalgo, J., Ditlevsen, Susanne, Alsted, T. J., Madsen, A. N., Pedersen, Bente Klarlund & Febbraio, M. A., 2013, In: Diabetes. 62, 9, p. 3064-3074 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Menopause is associated with decreased whole body fat oxidation during exercise

Abildgaard, J., Pedersen, Anette Tønnes, Green, C. J., Majlund Harder-Lauridsen, N., Solomon, T. P., Thomsen, C., Juul, A., Pedersen, M., Pedersen, J. T., Mortensen, Ole Hartvig, Pilegaard, Henriette, Pedersen, Bente Klarlund & Lindegaard, B., 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 304, 11, p. E1227-E1236 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α Is Required for Exercise- and Exercise Training-Induced UCP1 Up-Regulation in Mouse White Adipose Tissue.

Jørgensen, Stine Ringholm, Knudsen, Jakob Grunnet, Leick, L., Lundgaard, A., Munk Nielsen, M. & Pilegaard, Henriette, 2013, In: PloS one. 8, 5, p. 1-6 6 p., e64123.

Research output: Contribution to journal › Journal article › Research › peer-review

Reply from Lasse Gliemann, Jakob Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten

Gliemann, Lasse, Schmidt, J., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., Mortensen, S. P., Nyberg, M., Bangsbo, Jens, Pilegaard, Henriette & Hellsten, Ylva, 2013, In: Journal of Physiology. 591, 20, p. 5253 1 p.

Research output: Contribution to journal › Comment/debate › Research

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

Gliemann, Lasse, Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., Mortensen, S. P., Nyberg, M. P., Bangsbo, Jens, Pilegaard, Henriette & Hellsten, Ylva, 2013, In: Journal of Physiology. 591, 20, p. 5047-5059 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation

Olesen, J., Jørgensen, Stine Ringholm, Nielsen, M. M., Brandt, C. T., Pedersen, J. T., Halling, J. F., Goodyear, L. J. & Pilegaard, Henriette, 2013, In: Experimental Gerontology. 48, 11, p. 1274-1284 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Subcellular localization and mechanism of secretion of vascular endothelial growth factor in human skeletal muscle

Høier, B., Prats Gavalda, Clara, Qvortrup, Klaus, Pilegaard, Henriette, Bangsbo, Jens & Hellsten, Ylva, 2013, In: F A S E B Journal. 27, 9, p. 3496-3504 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

Christensen, B., Lundby, C., Jessen, N., Nielsen, Thomas Svava, Vestergaard, P. F., Møller, N., Pilegaard, Henriette, Pedersen, S. B., Kopchick, J. J. & Jørgensen, J. O. L., 2012, In: P L o S One. 7, 2, 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

Biensø, R. S., Jørgensen, Stine Ringholm, Kiilerich, K., Aachmann-Andersen, N. J., Krogh-Madsen, Rikke, Guerra, B., Plomgaard, Peter Stendahl, van Hall, Gerrit, Treebak, Jonas Thue, Saltin, B., Lundby, C., Calbet, J. A. L., Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2012, In: Diabetes. 61, 5, p. 1090-1099 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice

Brandt, C., Jakobsen, A. H., Hassing, H. A., Olesen, Jes, Iversen, N., Kristensen, Jonas Møller, Hojman, P., Wojtaszewski, Jørgen F P, Hidalgo, J. & Pilegaard, Henriette, 2012, In: Acta Physiologica (Print). 205, 2, p. 224-235 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Role of vitamin C and E supplementation on IL-6 in response to training

Yfanti, C., Fischer, C. P., Nielsen, S., Åkerström, T., Nielsen, A. R., Veskoukis, A. S., Kouretas, D., Lykkesfeldt, Jens, Pilegaard, Henriette & Pedersen, Bente Klarlund, 2012, In: Journal of Applied Physiology. 112, 6, p. 990-1000 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle PGC-1a is required for maintaining an acute LPS-induced TNFa response

Olesen, J., Larsson, S., Iversen, N., Yousafzai, S., Hellsten, Ylva & Pilegaard, Henriette, 2012, In: P L o S One. 7, 2, p. e32222 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle

Jørgensen, Stine Ringholm, Biensø, R. S., Kiilerich, K., Guadalupe-Grau, A., Aachmann-Andersen, N. J., Saltin, B., Plomgaard, Peter Stendahl, Lundby, C., Wojtaszewski, Jørgen F P, Calbet, J. A. & Pilegaard, Henriette, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 301, 4, p. E649-E658 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression

Pedersen, L., Pilegaard, Henriette, Hansen, J., Brandt, C., Adser, H., Hidalgo, J., Olesen, J., Pedersen, Bente Klarlund & Hojman, P., 2011, In: Journal of Physiology. 589, 6, p. 1409-20 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest

Kiilerich, K., Jørgensen, Stine Ringholm, Biensø, R. S., Fisher, J. P., Iversen, N., van Hall, Gerrit, Wojtaszewski, Jørgen F P, Saltin, B., Lundby, C., Calbet, J. A. L. & Pilegaard, Henriette, 2011, In: Journal of Applied Physiology. 111, 3, p. 751-757 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Interleukin-6 modifies mRNA expression in mouse skeletal muscle

Hassing, H. A., Wojtaszewski, Jørgen F P, Jakobsen, A. H., Kiilerich, K., Hidalgo, J. & Pilegaard, Henriette, 2011, In: Acta Physiologica. 202, 2, p. 165-173 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

LIF is a contraction-induced myokine stimulating human myocyte proliferation

Broholm, C., Laye, M. J., Brandt, C., Vadalasetty, R., Pilegaard, Henriette, Pedersen, Bente Klarlund & Schéele, Camilla Charlotte Nielsen, 2011, In: Journal of Applied Physiology. 111, 1, p. 251-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, Thomas Elbenhardt, Frøsig, C., Birk, Jesper Bratz, Bisiani, B., Hiscock, N., Pilegaard, Henriette, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2011, In: Diabetes. 60, 1, p. 64-73 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly

Iversen, N., Krustrup, P., Rasmussen, H. N., Feldt-Rasmussen, Ulla, Saltin, B. & Pilegaard, Henriette, 2011, In: Experimental Gerontology. 46, 8, p. 670-678 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1a

Ingwersen, M. S., Kristensen, M., Pilegaard, Henriette, Wojtaszewski, Jørgen F P, Richter, Erik A. & Juel, C., 2011, In: Journal of Membrane Biology. 242, 1, p. 1-10 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Role of PGC-1{alpha} in exercise and fasting induced adaptations in mouse liver

Haase, T. N., Jørgensen, S. R., Leick, L., Biensø, R. S., Kiilerich, K., Johansen, S., Nielsen, M. M., Wojtaszewski, Jørgen F P, Hidalgo, J., Pedersen, Per Amstrup & Pilegaard, Henriette, 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 5, p. R1501-R1509 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice

Ma, Tao, Liaset, B., Hao, Q., Petersen, R. K., Fjære, E., Ngo, H. T., Lillefosse, H. H., Jørgensen, Stine Ringholm, Sonne, Si Brask, Treebak, Jonas Thue, Pilegaard, Henriette, Frøyland, L., Kristiansen, Karsten & Madsen, L., 2011, In: P L o S One. 6, 6, 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Attenuated purinergic receptor function in patients with type 2 diabetes

Thaning, P., Bune, L. T., Hellsten, Ylva, Pilegaard, Henriette, Saltin, B. & Rosenmeier, J. B., 2010, In: Diabetes. 59, 1, p. 182-189 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bed Rest-Induced Changes in TBC1D4 Phosphorylation and Glycogen Synthase Activity. Effects of Acute Exercise

Bienso, R. S., Ringholm, S., Lundby, C., Achman-Andersen, N. J., Plomgaard, Peter Stendahl, Krogh-Madsen, Rikke, Kiilerich, K., Guerra, B., Treebak, Jonas Thue, Calbet, J. A., Pilegaard, Henriette & Wojtaszewski, J. J. F., 2010, In: Diabetes.

Research output: Contribution to journal › Journal article › Research › peer-review

Contraction induced changes in skeletal muscle Na⁺, K⁺ pump mRNA expression - importance of exercise intensity and Ca²⁺ mediated signalling

Nordsborg, Nikolai Baastrup, Kusuhara, K., Hellsten, Ylva, Lyngby, S., Lundby, C., Madsen, K. & Pilegaard, Henriette, 2010, In: Acta Physiologica (Print Edition). 198, 4, p. 487-498 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Contraction-induced changes in skeletal muscle Na(+), K(+) pump mRNA expression - importance of exercise intensity and Ca(2+)-mediated signalling

Nordsborg, Nikolai Baastrup, Kusuhara, K., Hellsten, Ylva, Lyngby, A. S. B., Lundby, C., Madsen, K. & Pilegaard, Henriette, 2010, In: Acta Physiologica (Print). 198, 4, p. 487-98

Research output: Contribution to journal › Journal article › Research › peer-review

Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery

Leick, L., Plomgaard, Peter Stendahl, Grønløkke, L., Al-Abaiji, F., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: Scandinavian Journal of Medicine & Science in Sports. 20, 4, p. 593-599 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Endurance training enhances BDNF release from the human brain

Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P. K., Nordby, P., Stallknecht, Bente Merete, Hassing, H. A., Jakobsen, A. H., Pilegaard, Henriette, Nielsen, H. M. B. & Secher, Niels H., 2010, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 298, 2, p. R372-R377 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle

Kiilerich, K., Gudmundsson, M., Birk, Jesper Bratz, Lundby, C., Taudorf, S., Plomgaard, Peter Stendahl, Saltin, B., Pedersen, Per Amstrup, Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: Diabetes. 59, 1, p. 26-32 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1alpha is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle

Leick, L., Lyngby, S. S., Wojtaszewski, Jørgen F P, Wojtasewski, J. F. P. & Pilegaard, Henriette, 2010, In: Experimental Gerontology. 45, 5, p. 336-342 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1{alpha} increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, Per Amstrup, Hardie, D. G., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 299, 5, p. R1350-R1359 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α is required for AICAR induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

Leick, L., Fentz, J., Biensø, R. S., Knudsen, Jakob Grunnet, Jeppesen, J., Kiens, Bente, Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 299, 3, p. E456-E465 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1α-mediated adaptations in skeletal muscle

Olesen, J., Kiilerich, K. & Pilegaard, Henriette, 2010, In: Pflügers Archiv - European Journal of Physiology. 460, 1, p. 153-162 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Relative workload determines exercise-induced increases in PGC-1alpha mRNA

Nordsborg, Nikolai Baastrup, Lundby, C., Leick, L. & Pilegaard, Henriette, 2010, In: Medicine and Science in Sports and Exercise. 42, 8, p. 1477-1484 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

Hidalgo, J., Florit, S., Giralt, M., Ferrer, B., Keller, C. & Pilegaard, Henriette, 2010, In: Brain, Behavior, and Immunity. 24, 1, p. 119-26 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

ATP induced vasodilatation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins and adenosine

Mortensen, S. P., Gonzalez-Alonso, J., Bune, L., Saltin, B., Pilegaard, Henriette & Hellsten, Ylva, 2009, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 296, 4, p. R1140-R1148

Research output: Contribution to journal › Journal article › Research › peer-review

Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle

Coffey, V. G., Pilegaard, Henriette, Garnham, A. P., O'Brien, B. J. & Hawley, J. A., 2009, In: Journal of Applied Physiology. 106, 4, p. 1187-97 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

Rasmussen, P., Brassard, P., Adser, H., Pedersen, M. V., Leick, L., Hart, E., Secher, N. H., Pedersen, B. K. & Pilegaard, Henriette, 2009, In: Experimental Physiology. 94, 10, p. 1062-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice

Leick, L., Hellsten, Ylva, Fentz, J., Lyngby, S. S., Wojtaszewski, Jørgen F P, Hidalgo, J. & Pilegaard, Henriette, 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 1, p. E92-E103 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

Treebak, Jonas Thue, Frøsig, C., Pehmøller, C., Chen, S., Maarbjerg, S. J., Brandt, N., Mackintosh, C., Zierath, J. R., Hardie, D. G., Kiens, Bente, Richter, Erik A., Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2009, In: Diabetologia. 52, 5, p. 891-900 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle

Adhihetty, P. J., Uguccioni, G., Leick, L., Hidalgo, J., Pilegaard, Henriette & Hood, D. A., 2009, In: American Journal of Physiology: Cell Physiology. 297, 1, p. C217-25

Research output: Contribution to journal › Journal article › Research › peer-review

Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle

Lundby, C., Hellsten, Ylva, Jensen, M. B. F., Munch, A. S. & Pilegaard, Henriette, 2008, In: Journal of Applied Physiology. 104, 4, p. 1154-1160 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

Leick, L., Wojtaszewski, Jørgen F P, Johansen, S. T., Kiilerich, K., Comes, G., Hellsten, Ylva, Hidalgo, J. & Pilegaard, Henriette, 2008, In: American Journal of Physiology: Endocrinology and Metabolism. 294, 2, p. E463-E474 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1alpha: important for exercise performance?

Pilegaard, Henriette & Richter, Erik A., 2008, In: Journal of Applied Physiology. 104, 5, p. 1264-1265 2 p.

Research output: Contribution to journal › Editorial › Research

Regulation of PDH in human arm and leg muscles at rest and during intense exercise

Kiilerich, K., Birk, Jesper Bratz, Damsgaard, R., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2008, In: American Journal of Physiology: Endocrinology and Metabolism. 294, 1, p. E36-E42 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise

Leick, L., Lindegaard, Birgitte, Stensvold, D., Plomgaard, Peter Stendahl, Saltin, B. & Pilegaard, Henriette, 2007, In: Obesity. 15, 2, p. 356-63 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle

Hellsten, Ylva, Nielsen, Jens Jung, Lykkesfeldt, J., Bruhn, M., Silveira, L., Pilegaard, Henriette & Bangsbo, Jens, 2007, In: Free Radical Biology & Medicine. 43, 3, p. 353-361 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression

Kusuhara, K., Madsen, K., Jensen, L., Hellsten, Ylva & Pilegaard, Henriette, 2007, In: Biological Chemistry. 388, 5, p. 481-488 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition

Nielsen, A. R., Mounier, R., Plomgaard, Peter Stendahl, Mortensen, Ole Hartvig, Penkowa, M., Speerschneider, T., Pilegaard, Henriette & Pedersen, Bente Klarlund, 2007, In: Journal of Physiology. 584, Pt 1, p. 305-12 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic priming of a proinflammatory profile predicts low IQ in octogenarians

Krabbe, K. S., Mortensen, Erik Lykke, Avlund, K., Pilegaard, Henriette, Christiansen, L., Pedersen, A. N., Schroll, M., Jørgensen, T., Pedersen, Bente Klarlund & Kemp, H. B., 2007, In: Neurobiology of Aging. 30, p. 769-781

Research output: Contribution to journal › Journal article › Research › peer-review

Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise

Helge, J. W., Rehrer, N. J., Pilegaard, Henriette, Manning, P., Lucas, S. J. E., Gerrard, D. F. & Cotter, J. D., 2007, In: Acta Physiologica (Print Edition). 191, 1, p. 77-86 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise

Klein, D. K., Pilegaard, Henriette, Treebak, Jonas Thue, Jensen, Thomas Elbenhardt, Viollet, B., Schjerling, Peter & Wojtaszewski, Jørgen F P, 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 5, p. E1242-E1249 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle

Steensberg, A., Keller, C., Hilling, T., Frøsig, C., Wojtaszewski, Jørgen F P, Pedersen, Bente Klarlund, Pilegaard, Henriette & Sander, M., 2007, In: The FASEB Journal. 21, 11, p. 2683-2694 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family.

Mortensen, Ole Hartvig, Plomgaard, Peter Stendahl, Fischer, C. P., Hansen, A. K., Pilegaard, Henriette & Pedersen, Bente Klarlund, 2007, In: Journal of Applied Physiology. 103, 5, p. 1536-42 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle

Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, Henriette, Viganò, A., Santambrogio, P., Cerretelli, P., Calbet, J. A. L., Moutereau, S. & Lundby, C., 2007, In: Blood. 109, 11, p. 4724-31 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Brain-derived neurotrophic factor (BDNF) and type 2 diabetes.

Krabbe, K. S., Nielsen, A. R., Krogh-Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., Fischer, C. P., Fischer, C. P., Lindegaard, B., Petersen, A. M., Taudorf, S., Secher, N. H., Pilegaard, Henriette, Bruunsgaard, H. & Pedersen, B. K., 2006, In: Diabetologia. 50 (2), p. 431-8

Research output: Contribution to journal › Journal article › Research › peer-review

Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids.

Mourtzakis, M., Saltin, B., Graham, T. & Pilegaard, Henriette, 2006, In: Journal of Applied Physiology. 100, 6, p. 1822-30

Research output: Contribution to journal › Journal article › Research › peer-review

Control of gene expression and mitochondrial biogenesis in the muscular adaption to endurance exercise

Joseph, A. M., Pilegaard, Henriette, Leick, L. & Hood, D. A., 2006, In: Essays in Biochemistry. 42, p. 13-29

Research output: Contribution to journal › Journal article › Research › peer-review

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion

Carey, A., Wolsk, E., Bruce, C., Southgate, R., Pilegaard, Henriette, Hawley, J. A., Pedersen, B. K. & Febrario, M., 2006, In: Diabetologia. 49, 5, p. 1000-1007

Research output: Contribution to journal › Journal article › Research › peer-review

Higher skeletal muscle alpha₂AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise

Roepstorff, C., Thiele, M., Hillig, T., Pilegaard, Henriette, Richter, Erik A., Wojtaszewski, Jørgen F P & Kiens, Bente, 2006, In: Journal of Physiology. 574, 1, p. 125-138 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion

Pilegaard, Henriette, Birk, Jesper Bratz, Sacchetti, M., Mourtzakis, M., Hardie, D. G., Stewart, G., Neufer, P. D., Saltin, B., van Hall, Gerrit & Wojtaszewski, Jørgen F P, 2006, In: Diabetes. 55, 11, p. 3020-3027 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species

Silveira, L. R., Pilegaard, Henriette, Kusuhara, K., Curi, R. & Hellsten, Ylva, 2006, In: BBA General Subjects. 1763, 9, p. 969-976

Research output: Contribution to journal › Journal article › Research › peer-review

The mRNA expression profile of metabolic genes relative to MHC isoform pattern in human skeletal muscles

Plomgaard, Peter Stendahl, Penkowa, M., Leick, L., Pedersen, Bente Klarlund, Saltin, B. & Pilegaard, Henriette, 2006, In: Journal of Applied Physiology. 101, 3, p. 817-25 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes

Wojtaszewski, Jørgen F P, Birk, Jesper Bratz, Frøsig, C., Holten, M., Pilegaard, Henriette & Dela, Flemming, 2005, In: Journal of Physiology. 564, 2, p. 563-573 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Contraction-induced increases in Na⁺-K⁺-ATPase mRNA levels in human skeletal muscle are not amplified by activation of additional muscle mass

Nordsborg, Nikolai Baastrup, Thomassen, Martin, Lundby, C., Pilegaard, Henriette & Bangsbo, Jens, 2005, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 289, 1, p. R84-R91 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle

Jørgensen, S. B., Wojtaszewski, Jørgen F P, Viollet, B., Andreelli, F., Birk, Jesper Bratz, Hellsten, Ylva, Schjerling, Peter, Vaulont, S., Neufer, P. D., Richter, Erik A. & Pilegaard, Henriette, 2005, In: The FASEB Journal. 19, 9, p. 1146-1148 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies

Lundby, C., Nordsborg, Nikolai Baastrup, Kusuhara, K., Kristensen, K. M., Neufer, P. D. & Pilegaard, Henriette, 2005, In: European Journal of Applied Physiology. 95, 4, p. 351-360 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions

Lundby, C., Gassmann, M. & Pilegaard, Henriette, 2005, In: European Journal of Applied Physiology. 96, 4, p. 363-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

Pilegaard, Henriette, Osada, T., nzt356, nzt356, Helge, Jørn Wulff, Saltin, B. & Neufer, P. D., 2005, In: Metabolism - Clinical and Experimental. 54, 8, p. 1048-55

Research output: Contribution to journal › Journal article › Research › peer-review

Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle.

Lundby, C., Pilegaard, Henriette, Andersen, J. L., van Hall, Gerrit, Sander, M. & Calbet, J. A. L., 2004, In: Journal of Experimental Biology. 207, Pt 22, p. 3865-71 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

Lindegaard, B., Hansen, A. B., Pilegaard, Henriette, Keller, P., Gerstoft, J. & Pedersen, B. K., 2004, In: AIDS. 18, 14, p. 1956-1958

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle

Jensen, L., Pilegaard, Henriette, Neufer, P. D. & Hellsten, Ylva, 2004, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 287, 2, p. R397-R402 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle

Fischer, C. P., Plomgaard, P., Hansen, A. K., Pilegaard, Henriette, Saltin, B. & Pedersen, B. K., 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, p. E-1189-E1194

Research output: Contribution to journal › Journal article › Research › peer-review

Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise

Pilegaard, Henriette & Neufer, P. D., 2004, In: roceedings of the Nutrition Society. 63, p. 221-226

Research output: Contribution to journal › Journal article › Research › peer-review

Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration

hildebrandt, A. L., Pilegaard, Henriette & Neufer, P. D., 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, p. E1021-E1027

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

Pilegaard, Henriette, Saltin, B. & Neufer, P. D., 2003, In: Diabetes. 52, p. 657-662

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of high-intensity training on exercise-induced gene expression specific to ion homeostasis and metabolism

Nordsborg, Nikolai Baastrup, Bangsbo, Jens & Pilegaard, Henriette, 2003, In: Journal of Applied Physiology. 95, 3, p. 1201-1206 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exercise induces transient transcriptional activation of the PGC-1a gene in human skeletal muscle

Pilegaard, Henriette, Saltin, B. & Neufer, P. D., 2003, In: Journal of Physiology. 546, pt. 3, p. 851-858

Research output: Contribution to journal › Journal article › Research › peer-review

Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxia.

Lundby, C., Pilegaard, Henriette, van Hall, Gerrit, Sander, M., Calbet, J., Loft, Steffen & Møller, Peter, 2003, In: Toxicology. 192, 2-3, p. 229-36 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Resistance exercise alters MRF and IGT-I mRNA content in human skeletal muscle

Psilander, N., Damsgaard, R. & Pilegaard, Henriette, 2003, In: Journal of Applied Physiology. 95, p. 1038-1044

Research output: Contribution to journal › Journal article › Research › peer-review

Vascular endothelial growth factor mRNA expression and arteriovenous balance in resonse to prolonged, submaximal exercise in humans

Hiscock, N., Fischer, C. P., Pilegaard, Henriette & Pedersen, B. K., 2003, In: Am J Physiol - Heart Circ Physiol. 285, p. H1759-H1763

Research output: Contribution to journal › Journal article › Research › peer-review

5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle

Nielsen, J. N., Mustard, K. J. W., Graham, D. A., Yu, H., MacDonald, C. S., Pilegaard, Henriette, Goodyear, L. J., Hardie, D. G., Richter, Erik A. & Wojtaszewski, Jørgen F P, 2002, In: Journal of Applied Physiology. 94, 2, p. 631-41 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise

Wojtaszewski, Jørgen F P, Mourtzakis, M., Hillig, T., Saltin, B. & Pilegaard, Henriette, 2002, In: Biochemical and Biophysical Research Communications. 298, 3, p. 309-316 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes.

Pilegaard, Henriette, Keller, C., Steensberg, A., Helge, Jørn Wulff, Pedersen, Bente Klarlund, Saltin, B. & Neufer, P. D., 2002, In: Journal of Physiology. 541, Pt 1, p. 261-71 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Interstitial K⁺ in human skeletal muscle during and after dynamic graded exercise determined by microdialysis

Juel, C., Pilegaard, Henriette, Nielsen, Jens Jung & Bangsbo, Jens, 2000, In: Am. J. Physiol. Regulatory Integrative Comp. Physiol.. 278, p. R400-R406

Research output: Contribution to journal › Journal article › Research › peer-review