Helle S. Waagepetersen

Helle S. Waagepetersen

Guest Researcher

ORCID: 0000-0003-4583-8379

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  1. Published

    Prenatal stress effect on glutamate metabolism, evaluated with mass espectroscopy-liquid cromatography

    Adrover, E., Katunar, M. R., Waagepetersen, Helle S., Schousboe, Arne & Antonelli, M. C., 2009, In: Journal of Neurochemistry. Suppl. 2, p. 172-172

    Research output: Contribution to journal › Conference abstract in journal › Research

  2. Published

    Glutamate neurotransmission is affected in prenatally stressed offspring

    Adrover, E., Pallarés, M. E., Baier, C. J., Monteleone, M. C., Giuliani, F. A., Waagepetersen, Helle S., Brocco, M. A., Cabrera, R., Sonnewald, U., Schousboe, Arne & Antonelli, M. C., Sep 2015, In: Neurochemistry International. 88, p. 73-87 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Glutamine in the central nervous system: function and dysfunction

    Albrecht, J., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2007, In: Frontiers in Bioscience. 12, p. 332-343

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells

    Aldana, Blanca, Waagepetersen, Helle S., Schousboe, Arne, White, H. S., Bulaj, G. & Walls, Anne Byriel, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2286-2296 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons

    Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

    Aldana, Blanca, Zhang, Y., Jensen, P., Chandrasekaran, Abinaya, Christensen, S. K., Nielsen, T. T., Nielsen, Jørgen Erik, Hyttel, P., Larsen, M. R., Waagepetersen, Helle S. & Freude, Kristine, 2020, In: Molecular Brain. 13, 1, 7 p., 125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease

    Aldana, Blanca, Salcedo, C., Freude, Kristine & Waagepetersen, Helle S., 2021, Current Progress in iPSC-derived Cell Types. Birbrair, A. (ed.). Elsevier, p. 205-221 17 p. (Advances in Stem Cell Biology, Vol. 10).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  8. Published

    Augmented cerebral mitochondrial function and hippocampal ketone body metabolism in Db/db mice

    Andersen, J., Nissen, J., Christensen, S. & Waagepetersen, Helle S., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  9. Published

    Improved cerebral energetics and ketone body metabolism in db/db mice

    Andersen, Jens Velde, Christensen, S. K., Nissen, J. D. & Waagepetersen, Helle S., Mar 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 1137–1147 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease

    Andersen, Jens Velde, Christensen, S. K., Aldana, Blanca, Nissen, J. D., Tanila, H. & Waagepetersen, Helle S., Jun 2017, In: Neurochemical Research. 42, 6, p. 1589–1598

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

    Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria

    Andersen, Jens Velde, Jakobsen, Emil, Waagepetersen, Helle S. & Aldana, Blanca, 2019, In: Journal of Neuroscience Research. 97, p. 961–974

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

    Andersen, Jens Velde, Christensen, S. K., Westi, Emil Winther, Diaz-delcastillo, M., Tanila, H., Schousboe, Arne, Aldana, Blanca & Waagepetersen, Helle S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

    Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Aldana, Blanca, Nørremølle, Anne & Waagepetersen, Helle S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus

    Andersen, Jens Velde, Nissen, J. D., Christensen, S. K., Markussen, K. H. & Waagepetersen, Helle S., 2017, In: Neural Plasticity. 2017, p. 2107084 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

    Andersen, Jens Velde, McNair, Laura M., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice

    Arildsen, L., Andersen, Jens Velde, Waagepetersen, Helle S., Nissen, J. B. D. & Sheykhzade, Majid, 2019, In: Diabetes and Vascular Disease Research. 16, 6, p. 539 548 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?

    Bak, Lasse Kristoffer, Mueller, M. S., Fox, R., Pedersen, Sofie E., Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Jakobsen, E., Schousboe, Arne & Waagepetersen, Helle S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  21. Published

    Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Astrocytic glycogen metabolism in the healthy and diseased brain

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

    Bak, Lasse Kristoffer, Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Oct 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 10, p. 1285-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures

    Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, Jan 2004, In: Neurochemical Research. 29, 1, p. 257-65 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

    Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

    Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  32. Published

    Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

    Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Glutamate and glutamine in brain disorders

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  34. Published

    Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  36. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Fluidic system for long-term in vitro culturing and monitoring of organotypic brain slices

    Bakmand, T., Troels-Smith, A. R., Dimaki, M., Nissen, J. D., Andersen, K. B., Sasso, L., Waagepetersen, Helle S., Gramsbergen, J. B. & Svendsen, W. E., 1 Aug 2015, In: Biomedical Microdevices. 17, 4, 71.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

    Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Azevedo, C., Roybon, L., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 297.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

    Brekke, E., Morken, T. S., Walls, Anne Byriel, Waagepetersen, Helle S., Schousboe, Arne & Sonnewald, U., 2016, The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Springer, Vol. 13. p. 43-58 16 p. (Advances in Neurobiology, Vol. 13).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  40. Published

    Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

    Brekke, E., Walls, Anne Byriel, Nørfeldt, L., Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Glia. 60, 1, p. 147-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

    Brekke, E. M., Walls, Anne Byriel, Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1788-1799 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

    Larsen, Birger Brodin, Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, Helle S., 2013, In: Lægemiddelforskning. 2013, p. 47-49 3 p.

    Research output: Contribution to journal › Journal article › Communication

  43. Published

    In-vitro models of the blood brain barrier

    Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  44. Published

    Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter

    Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, Trine Meldgaard, Schousboe, Arne, Waagepetersen, Helle S. & Ransom, B. R., 2005, In: Journal of Neuroscience Research. 79, 1-2, p. 74-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    The role of astrocytes in seizure generation: Insights from a novel in vitro seizure model based on mitochondrial dysfunction

    Chan, F., Lax, N. Z., Voss, C. M., Aldana, B. I., Whyte, S., Jenkins, A., Nicholson, C., Nichols, S., Tilley, E., Powell, Z., Waagepetersen, Helle S., Davies, C. H., Turnbull, D. M. & Cunningham, M. O., 1 Feb 2019, In: Brain. 142, 2, p. 391-411 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Glutamine and ammonia in hepatic encephalopathy

    Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  47. Published

    Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

    Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

    Dadsetan, S., Kukolj, E., Bak, Lasse Kristoffer, Sørensen, M., Ott, P., Vilstrup, H., Schousboe, Arne, Keiding, S. & Waagepetersen, Helle S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  52. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    State-Dependent Changes in Brain Glycogen Metabolism

    DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  54. Published

    Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

    Fries, A. W., Dadsetan, S., Keiding, S., Bak, Lasse Kristoffer, Schousboe, Arne, Waagepetersen, Helle S., Simonsen, M., Ott, P., Vilstrup, H. & Sørensen, M., Mar 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 460-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

    Frigerio, F., Karaca, M., De Roo, M., Mlynárik, V., Jensen, Dorte Skytt, Carobbio, S., Pajęcka, K., Waagepetersen, Helle S., Gruetter, R., Muller, D. & Maechler, P., Nov 2012, In: Journal of Neurochemistry. 123, 3, p. 342-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

    Frigerio, F., Karaca, M., De Roo, M., Mlynarik, V., Jensen, Dorte Skytt, Carobbio, S., Pajecka, K., Waagepetersen, Helle S., Gruetter, R., Muller, D. & Maechler, P., 2012, In: Journal of Neurochemistry. 123, 3, p. 342-348

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Metabolic impairments in neurons and astrocytes derived from human induced pluripotent stem cells of Alzheimer's disease patients

    Garcia, B. A., Salcedo, C., Hyttel, P., Waagepetersen, Helle S. & Freude, Kristine, 2019, p. 111-111.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  58. Published

    Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.

    Research output: Contribution to conference › Poster › Communication

  59. Published

    Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.

    Research output: Contribution to conference › Conference abstract for conference › Research

  60. Published

    Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

    Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Hjernens forsvarsmur kortlagt og kopieret

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010, In: Lægemiddelforskning. 2010, p. 22-24

    Research output: Contribution to journal › Journal article › Communication

  62. Published

    Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Characterisation of in-vitro blood-brain barrier models

    Helms, H. C., Eriksson, A. H., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2009.

    Research output: Contribution to conference › Poster › Research

  64. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Characterization of in-vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, Aug 2009.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  66. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  67. Published

    In vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 18 Jul 2009.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  68. Published

    Glutamate Transporters in the Blood-Brain Barrier

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2017, Glial Amino Acid Transporters. Vol. 16. p. 297-314 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  69. Published

    Transport pathways mediating blood-to-brain L-glutamate efflux

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  70. Published

    Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  71. Published

    The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  72. Published

    Characterization of in vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S., Walls, Anne Byriel & Larsen, Birger Brodin, 9 Aug 2009. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  73. Published

    Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

    Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  74. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  75. Published

    Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

    Hertz, L., Chen, Y. & Waagepetersen, Helle S., Jul 2015, In: Journal of Neurochemistry. 134, 1, p. 7-20 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23

    Hohnholt, M. C., Blumrich, E., Waagepetersen, Helle S. & Dringen, R., Jan 2017, In: Neurochemistry International. 102, p. 13-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation

    Hohnholt, M. C., Andersen, V. H., Andersen, Jens Velde, Christensen, S. K., Karaca, M., Maechler, P. & Waagepetersen, Helle S., Oct 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 10, p. 1754–1768

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

    Hohnholt, M. C., Blumrich, E., Waagepetersen, Helle S. & Dringen, R., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2307-2320 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals

    Hohnholt, M. C., Andersen, V. H., Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 1, p. 191-201 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

    Huyghe, D., Denninger, A. R., Voss, C. M., Frank, P., Gao, N., Brandon, N., Waagepetersen, Helle S., Ferguson, A. D., Pangalos, M., Doig, P. & Moss, S. J., 21 May 2019, In: Frontiers in Molecular Neuroscience. 12, 14 p., 120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes

    Ilieva, M., Aldana, Blanca, Vinten, K. T., Hohmann, S., Woofenden, T. W., Lukjanska, R., Waagepetersen, Helle S. & Michel, T. M., 2022, In: Molecular Psychiatry. 27, p. 3749–3759

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

    Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

    Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen

    Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

    Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

    Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    ATP induce an increase in intracellular Ca2+ in pericytes of the blood-brain barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  89. Published

    Rises in intracellular calcium in primary brain pericytes are caused by ATP

    Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  90. Published

    Purinergic Signaling in Pericytes of the Blood-Brain Barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jul 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  91. Published

    ATP induce intracellular calcium rises in cultures of primary brain pericytes

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  92. Published

    The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

    Johansen, M. L., Bak, Lasse Kristoffer, Schousboe, Arne, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Gjedde, A., Ott, P. & Waagepetersen, Helle S., 2007, In: Neurochemistry International. 50, p. 1042-1051

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

    Karaca, M., Frigerio, F., Migrenne, S., Martin-Levilain, J., Jensen, Dorte Skytt, Pajecka, K., Martin-del-Rio, R., Gruetter, R., Tamarit-Rodriguez, J., Waagepetersen, Helle S., Magnan, C. & Maechler, P., 13 Oct 2015, In: Cell Reports. 13, 2, p. 365-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy

    Keiding, S., Iversen, P., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Gjedde, A., Schousboe, Arne & Vilstrup, H., 2009, In: Journal of Neurochemistry. s1, p. 269-270

    Research output: Contribution to journal › Conference abstract in journal › Research

  95. Published

    Knockdown of GDH indicates its potential impact in sustaining glutamate homeostasis and neurotransmission

    Klawonn, A. M., Bolanos, J. P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s2, p. 105

    Research output: Contribution to journal › Conference abstract in journal › Research

  96. Published

    Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice

    Koivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Barrera, G. A., Stridh, M. H., Waagepetersen, Helle S., Tiainen, M., Soininen, P., Zilberter, Y. & Tanila, H., 2016, In: Frontiers in Aging Neuroscience. 8, p. 1-14 14 p., 41.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

    Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.

    Research output: Contribution to journal › Review › Research › peer-review

  98. Published

    Primary cultures of astrocytes: their value in understanding astrocytes in health and disease

    Lange, S. C., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Dynamic changes in cytosolic ATP levels in cultured glutamatergic neurons during NMDA-induced synaptic activity supported by glucose or lactate

    Lange, S. C., Winkler, U., Andresen, Lars, Byhrø, M., Waagepetersen, Helle S., Hirrlinger, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2517-2526 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex

    Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635

    Research output: Contribution to journal › Journal article › Research › peer-review

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