Hans Bräuner

Hans Bräuner

Prodekan for forskning

ORCID: 0000-0001-9495-7388

Publication year:
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  1. 1993
  2. Published

    Muscarinic acetylcholine receptor subtypes: localization and structure/function

    Brann, M. R., Ellis, J., Jørgensen, H., Hill-Eubanks, D., Jones, S. V. & Bräuner, Hans, 1993, In: Progress in Brain Research. 98, p. 121-7

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Studies of the pharmacology, localization, and structure of muscarinic acetylcholine receptors

    Brann, M. R., Jørgensen, H. B., Burstein, E. S., Spalding, T. A., Ellis, J., Jones, S. V., Hill-Eubanks, D. & Bräuner, Hans, 20 Dec 1993, In: Annuals of the New York Academy of Sciences. 707, p. 225-36

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 1995

  5. Constitutive activation of muscarinic receptors by the G-protein Gq

    Burstein, E. S., Spalding, T. A., Bräuner, Hans & Brann, M. R., 24 Apr 1995, In: F E B S Letters. 363, 3, p. 261-3

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells

    Messier, T. L., Dorman, C. M., Bräuner, Hans, Eubanks, D. & Brann, M. R., May 1995, In: Basic & Clinical Pharmacology & Toxicology. 76, 5, p. 308-11

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 9 Jun 1995, In: Journal of Medicinal Chemistry. 38, 12, p. 2188-95

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis

    Spalding, T. A., Burstein, E. S., Bräuner, Hans, Hill-Eubanks, D. & Brann, M. R., Dec 1995, In: Journal of Pharmacology and Experimental Therapeutics. 275, 3, p. 1274-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1996

  10. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells

    Bräuner, Hans & Brann, M. R., 4 Jan 1996, In: European Journal of Pharmacology. 295, 1, p. 93-102

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis

    Hill-Eubanks, D., Burstein, E. S., Spalding, T. A., Bräuner, Hans & Brann, M. R., 9 Feb 1996, In: Journal of Biological Chemistry. 271, 6, p. 3058-65

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid

    Bräuner, Hans, Sløk, F. A., Skjaerbaek, N., Ebert, B., Sekiyama, N., Nakanishi, S. & Krogsgaard-Larsen, Povl, 2 Aug 1996, In: Journal of Medicinal Chemistry. 39, 16, p. 3188-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Functional partial agonism at cloned human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 10 Oct 1996, In: European Journal of Pharmacology. 313, 1-2, p. 145-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 1997

  16. Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals

    Burstein, E. S., Bräuner, Hans, Spalding, T. A., Conklin, B. R. & Brann, M. R., Feb 1997, In: Journal of Neurochemistry. 68, 2, p. 525-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    New analogues of ACPD with selective activity for group II metabotropic glutamate receptors

    Bräuner, Hans, Madsen, Ulf, Mikiciuk-Olasik, E. & Curry, K., 13 Aug 1997, In: European Journal of Pharmacology. 332, 3, p. 327-31 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

    Bräuner, Hans, Nielsen, Birgitte, Stensbøl, T. B., Johansen, Tommy Nørskov, Skjaerbaek, N. & Krogsgaard-Larsen, Povl, 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

    Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 1998
  21. Published

    Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Jan 1998, In: British Journal of Pharmacology. 123, 2, p. 269-74

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid

    Johansen, Tommy Nørskov, Ebert, B., Bräuner, Hans, Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, Ulf, Krogsgaard-Larsen, Povl & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors

    Bräuner, Hans, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 5 Jun 1998, In: European Journal of Pharmacology. 350, 2-3, p. 311-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid

    Madsen, Ulf, Dumpis, M. A., Bräuner, Hans & Piotrovsky, L. B., 16 Jun 1998, In: Bioorganic & Medicinal Chemistry Letters. 8, 12, p. 1563-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity

    Conti, P., De Amici, M., De Sarro, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & De Micheli, C., 24 Sep 1998, In: Journal of Medicinal Chemistry. 41, 20, p. 3759-62

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 1999
  27. Published

    Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

    Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline

    Pedersen, H., Bräuner, Hans, Ball, R. G., Frydenvang, Karla Andrea, Meier, E., Bøgesø, K. P. & Krogsgaard-Larsen, Povl, 1999, In: Bioorganic & Medicinal Chemistry. 7, 5, p. 795-809 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

    Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists

    Conti, P., De Amici, M., De Sarro, G., Rizzo, M., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 7 Oct 1999, In: Journal of Medicinal Chemistry. 42, 20, p. 4099-107

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

    Zimmermann, D., Janin, Y. L., Brehm, L., Bräuner, Hans, Ebert, B., Johansen, Tommy Nørskov, Madsen, Ulf & Krogsgaard-Larsen, Povl, 1 Nov 1999, In: European Journal of Medicinal Chemistry. 34, 11, p. 967-976

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Dec 1999, In: British Journal of Pharmacology. 128, 7, p. 1370-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2000
  35. Published

    Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

    Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

    Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Øget forståelse af vigtig receptor i hjernen

    Jensen, Anders A. & Bräuner, Hans, 2000, In: Lægemiddelforskning. p. 28-29

    Research output: Contribution to journal › Journal article › Communication

  38. Published

    Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist

    Madsen, Ulf, Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Lützhøft, H. H., Poulsen, M. V., Eriksen, L. & Krogsgaard-Larsen, Povl, Jan 2000, In: European Journal of Medicinal Chemistry. 35, 1, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain

    Bräuner, Hans & Krogsgaard-Larsen, Povl, 15 Apr 2000, In: Genomics. 65, 2, p. 121-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Ligands for glutamate receptors: design and therapeutic prospects

    Bräuner, Hans, Egebjerg, J., Nielsen, E. O., Madsen, Ulf & Krogsgaard-Larsen, Povl, 13 Jul 2000, In: Journal of Medicinal Chemistry. 43, 14, p. 2609-45

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

    Bräuner, Hans, Hermit, M. B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Johansen, Tommy Nørskov, 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2001
  43. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor

    Jensen, Anders A., Sheppard, P. O., Jensen, L. B., O'Hara, P. J. & Bräuner, Hans, 2001, In: Journal of Biological Chemistry. 276, 13, p. 10110-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

    Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

    Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

    Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  48. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

    Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands

    Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2002
  51. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

    Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)

    Jensen, Anders A., Hansen, J. L., Sheikh, S. P. & Bräuner, Hans, 2002, In: European Journal of Biochemistry. 269, 20, p. 5076-87 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors

    Jensen, Anders A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, Tommy Nørskov, Abrahamsen, B., Mattsson, J., Lehmann, A., Bettler, B. & Bräuner, Hans, 2002, In: Molecular Pharmacology. 61, 6, p. 1377-84 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    The dance of the clams: twists and turns in the family C GPCR homodimer

    Jensen, Anders A., Greenwood, J. R. & Bräuner, Hans, 2002, In: Trends in Pharmacological Sciences. 23, 11, p. 491-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology

    Stensbøl, T. B., Uhlmann, P., Morel, S., Eriksen, B. L., Felding, J., Kromann, H., Hermit, M. B., Greenwood, J. R., Braüner-Osborne, H., Madsen, Ulf, Junager, F., Krogsgaard-Larsen, Povl, Begtrup, M., Vedsø, P. & Bräuner, Hans, 3 Jan 2002, In: Journal of Medicinal Chemistry. 45, 1, p. 19-31

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids

    Kromann, H., Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 14 Feb 2002, In: Journal of Medicinal Chemistry. 45, 4, p. 988-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid

    Clausen, Rasmus Prætorius, Bräuner, Hans, Greenwood, J. R., Hermit, M. B., Stensbøl, T. B., Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 12 Sep 2002, In: Journal of Medicinal Chemistry. 45, 19, p. 4240-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid

    Conti, P., De Amici, M., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., Nov 2002, In: Farmaco. 57, 11, p. 889-95

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1302910